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Cedric Boeckx

@cedricboeckx.bsky.social
2.5K followers 345 following 1.2K posts

ICREA Research Professor. Evolution, Genetics, Neuroscience, Linguistic Cognition www.cedricboeckx.com

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Reposted by Cedric Boeckx
Madeline Lancaster @lancasterlab.bsky.social · 20h
Cool proteomics work showing how similar organoid synapses are to in vivo synapses. Great job Stefano and team!
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Stefano Giandomenico @sgiando.bsky.social · 30/09/2026
Can a brain organoid grown in a dish build synapses that resemble the real thing at the molecular level? 🧠 We grew mouse forebrain organoids for 35 days and compared their synaptic proteome to that of the adult mouse cortex 🧪 www.biorxiv.org/content/10.6... 🧵 1/5
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Apurva Ratan Murty @apurvaratan.bsky.social · 02/10/2026
Excited to first share @alishdipani.bsky.social 's study. Alish asked a (deceptively) simple Q: Are category-selective units in ANNs actually like category-selective regions in the brain? (why is this imp? read until the end). #neuroskyence #neuroscience #brain #neuroai
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Cedric Boeckx @cedricboeckx.bsky.social · 20h
Very cool @nature.com study led by @masakanai.bsky.social tackling the very difficult problem of going from variants to disease-relevant regulatory mechanisms 🧪🧬 👇
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Eric Denovellis @eric-denovellis.bsky.social · 02/10/2026
I wanted to highlight the work of Alison Comrie et al. that recently came out in Neuron and I don’t think it is getting enough attention: paper: cell.com/neuron/fulltext/S0896-6273(26)00674-4 #neuroskyence
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Simon Evans @sevans.bsky.social · 03/10/2026
Evolution and adaptation are frequently used interchangeably when describing trait change. Does it really matter? Our new paper in PLOS Biology shows that yes, it really does. journals.plos.org/plosbiology/... Buckle up, we're going for a ride...
journals.plos.org
Gene flow drives periods of both evolutionary stasis and change in a wild bird population
Why do we not see evolutionary change in heritable, fitness-related traits of free-living populations? This multi-decade study of the evolution of clutch size in populations of great tits before, duri...
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Ben Hayden @benhayden.bsky.social · 02/10/2026
New paper from the Neurosurgery research team at BCM! 🧵 "A population code for semantics in human hippocampus" led by Melissa Franch. We recorded hippocampus single neurons while people listened to podcasts. www.nature.com/articles/s41...
nature.com
A population code for semantics in human hippocampus - Nature Neuroscience
Franch et al. show that human hippocampal neurons encode the meanings of the words we hear through distributed, context-sensitive population activity that mirrors some features of large language model...
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Cedric Boeckx @cedricboeckx.bsky.social · 02/10/2026
Great new study from @knoblich-lab.bsky.social, led by @saku-wong.bsky.social, showing that human cerebral organoids cultured for over six months can recapitulate postnatal interneuron migration 🧪🧬🧫🧠 www.biorxiv.org/content/10.6...
biorxiv.org
Cerebral organoids recapitulate interneuron chain migration in the human cortex
The human brain is incomplete at birth, with streams of late-born interneurons migrating into the postnatal cortex. This process is absent in rodents, limiting mechanistic investigation to post-mortem...
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Amirmasoud Ahmadi @amirmasoud92.bsky.social · 01/10/2026
Our paper just dropped in the Journal of Neuroscience! How does the brain segment continuous audio into distinct units for speech perception? We show that the auditory forebrain actively decodes temporal landmarks to make this happen. www.jneurosci.org/content/earl... #Neuroscience
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PLOS Biology @plosbiology.org · 30/09/2026
How do intrinsic timescales, which reflect the temporal window of neural processing, mature during development? This study by @goliashf.bsky.social @ted-satterthwaite.bsky.social &co identifies a hierarchical trajectory, from sensorimotor to association cortices. 🧪 #NeuroSky plos.io/46RzqRG
Developmental patterns of intrinsic timescale.
(a) Average timescale increases during development in youth  (b) Age effects quantified as partial R2 are depicted across the cortex, displaying a heterogeneous spatial distribution. (c) Age effects on intrinsic timescale were compared to the S–A axis, identifying a hierarchical pattern of developmental patterns in intrinsic timescale along the S–A axis. The results demonstrate that intrinsic timescale in association regions increases during development in youth while it remains relatively stable in sensorimotor regions.
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Reposted by Cedric Boeckx
Development @dev-journal.bsky.social · 30/09/2026
In preprints – is birth driving cortical maturation? @mveronicapravata.bsky.social discusses a preprint by @sroig.bsky.social & co, which raises the possibility that cortical developmental programs may be broadly conserved across species, rather than strictly dependent on the timing of birth.
journals.biologists.com
In preprints – is birth driving cortical maturation?
This article discusses the preprinted work of Morassut et al. (2026 preprint). As a preprint, this work has not yet undergone peer review.
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Masahiro Kanai @masakanai.bsky.social · 30/09/2026
Our single-nucleus immune multiome atlas is now out in @nature.com! 🧬 10M PBMCs from 1,108 @finngen.bsky.social donors recruited by Finnish Blood Service, profiled at @broadinstitute.org with chromatin accessibility and gene expression in the same nuclei, to trace how disease variants act 🧵👇
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Denise J. Cai, Ph.D. @denisejcai.bsky.social · 30/09/2026
NEW: The anterior hypothalamic nucleus acts like a volume knob for stress, scaling the brain’s response to threatening events 🧠 Read the Cai Lab's latest paper, led by @zachtpennington.bsky.social, in @nature.com 🎉 www.nature.com/articles/s41... More: bsky.app/profile/did:...
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Keri Martinowich @martinowk.bsky.social · 28/09/2026
While these reconstructions are beautiful, they are not simply prettier or more complete maps. Spatial topography reflects circuit wiring and function, and if we study only one 2D section, we cannot reconstruct how that wiring diagram changes across the full 3D structure.
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Cedric Boeckx @cedricboeckx.bsky.social · 29/09/2026
Important new work by members of the @manybabies.org consortium (@ingmarvisser.bsky.social et al), failing to replicate a ‘textbook’ finding in developmental cognitive science. 👇 🧪
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Tessa Montague @tessamontague.bsky.social · 29/09/2026
I'm excited to share our new preprint: Generation of a transgenic cephalopod tinyurl.com/pc86jxz8 Cephalopods (cuttlefish, octopus & squid) are crazy critters that dynamically camouflage to their surroundings by changing the color, pattern, & texture of their skin, which they control w their brain.
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Panos Roussos @panosroussos.bsky.social · 26/09/2026
Thrilled to see the PsychAD package published! 🧠 Launched in 2019: 60+ investigators, 8 institutions, 1,494 human brains—illuminating brain aging and disease. Supported by NIA. Deeply grateful to all donors and families. psych-ad.org www.nature.com/collections/...
psych-ad.org
PsychAD
The PsychAD Consortium builds population-scale, single-cell models of the human brain to uncover the molecular mechanisms behind neuropsychiatric symptoms in Alzheimer’s disease, related dementias, an...
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Keri Martinowich @martinowk.bsky.social · 28/09/2026
Very excited to share our newest preprint, led by @rphillips3.bsky.social and @jianingyao.bsky.social , reconstructing the molecular and cellular organization of the nucleus accumbens (NAc) in the human 🧠 in three dimensions.
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Cedric Boeckx @cedricboeckx.bsky.social · 25/09/2026
“Atlas of cell types and regulatory elements underlying human facial diversity” @adameykolab.bsky.social & colleagues 🧪🧬 @natgenet.nature.com www.nature.com/articles/s41...
nature.com
Atlas of cell types and regulatory elements underlying human facial diversity - Nature Genetics
Single-cell transcriptomics, spatial transcriptomics and chromatin accessibility maps of the human craniofacial region in developing embryos provide insights into the mechanisms underlying facial vari...
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Cedric Boeckx @cedricboeckx.bsky.social · 25/09/2026
“Atlas of cell types and regulatory elements underlying human facial diversity” @adameykolab.bsky.social & colleagues 🧪🧬 @natgenet.nature.com www.nature.com/articles/s41...
nature.com
Atlas of cell types and regulatory elements underlying human facial diversity - Nature Genetics
Single-cell transcriptomics, spatial transcriptomics and chromatin accessibility maps of the human craniofacial region in developing embryos provide insights into the mechanisms underlying facial vari...
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Cedric Boeckx @cedricboeckx.bsky.social · 25/09/2026
Great study by @revathe.bsky.social and collaborators 🧪🦧 👇
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Meng Zhu @zhumeng123.bsky.social · 24/09/2026
Two years since the 1st submission, our work on limb heterochrony is finally out! 🎉🎊 @cellcellpress.bsky.social Delayed hindlimb dev vs forelimb is a widely conserved trait in mammals. We show that maternal O2 regulates this phenotype 👉🏻 shorturl.at/MGrwl
shorturl.at
Shifts in embryonic oxygen levels cue heterochrony in limb initiation
Mammalian embryos see a substantial increase in available oxygen once the placenta forms. This increase in oxygen exposure serves as a trigger for initiating the development of the hindlimb, thus cont...
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T Revathe @revathe.bsky.social · 24/09/2026
!! New in @science.org !! How do animals learn broad skills necessary for survival in the wild? Our latest study on wild Sumatran orangutans at Suaq provides answers. 1/11 www.science.org/doi/10.1126/...
science.org
How 8 years of social and individual learning interact to shape ecological competence in orangutans
Cultural learning permeates human skill and knowledge acquisition. To understand its importance for nonhuman apes, we analyzed just under 7000 records of behavioral bouts of social and individual lear...
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Bratislav Misic @misicbata.bsky.social · 24/09/2026
netneurotools: a trainee-oriented approach to network neuroscience | doi.org/10.1038/s415... Our lab’s internal toolkit for accomplishing everyday tasks in brain imaging @natprot.nature.com ⤵️
doi.org
netneurotools: a trainee-oriented approach to network neuroscience - Nature Protocols
This is a Perspective covering a Python toolbox for neuroscience research that enables users to fetch datasets, construct networks and null models, estimate graph metrics, fit statistical models and v...
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Bat1K Genome Project @bat1kgenomes.bsky.social · 23/09/2026
Where did bats come from?🦇🌍 After decades of debate, the biggest bat genome + fossil study ever done has an answer - and it’s not where anyone expected! 🤩OUR PHASE 1 FLAGSHIP is out today in nature! doi.org/10.1038/s415... A thread 🧵
doi.org
Reference genomes and fossils revise bat family phylogeny and biogeography - Nature
An updated phylogeny of bats is presented, based on new genome assemblies and many ancient fossils and including all known bat families.
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Teif lab @teiflab.bsky.social · 23/09/2026
Zeng et al, 2026. Transcription factors read a second regulatory code in chromatin www.biorxiv.org/content/10.6... "our findings establish that TFs interpret two complementary layers of genomic information: the primary DNA sequence and a second code written into the nucleosome architecture"
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Cedric Boeckx @cedricboeckx.bsky.social · 23/09/2026
Great work by @david-gokhman.bsky.social and collaborators, out in @nature.com “The gene-regulatory evolution of the human skeleton” 🧪🧬💀 www.nature.com/articles/s41...
nature.com
The gene-regulatory evolution of the human skeleton - Nature
Massively parallel reporter assays and human–ape hybrid skeletal cells are used to study the evolution of human cis-regulatory elements (CREs), revealing how differences in CREs have sh...
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Reposted by Cedric Boeckx
Cedric Boeckx @cedricboeckx.bsky.social · 23/09/2026
Reference genomes and fossils revise bat family phylogeny 🧪🦇🧬 @bat1kgenomes.bsky.social www.nature.com/articles/s41...
nature.com
Reference genomes and fossils revise bat family phylogeny and biogeography - Nature
An updated phylogeny of bats is presented, based on new genome assemblies and many ancient fossils and including all known bat families.
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Amanda Heidt @scattercushion.bsky.social · 23/09/2026
🧪Today, the PsychAD Consortium published EIGHT papers across Nature journals detailing their efforts to create the largest map of the human prefrontal cortex. It's hard to overstate the amount of work here, nor the absolute treasure trove this team has created for researchers.
nature.com
Landmark map of human brain’s gene activity holds clues to Alzheimer’s disease and more
The atlas of gene expression in the prefrontal cortex was created using samples from almost 1,500 donors of all ages — from infants to centenarians.
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David Gokhman @david-gokhman.bsky.social · 23/09/2026
Humans are remarkably prone to degenerative skeletal diseases. Other apes, much less so, even in old age. In our new paper in @nature.com , we map the genetic changes that shaped our skeleton and uncover a major clue to why it is so vulnerable to degeneration.🧵👇 www.nature.com/articles/s41...
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Cedric Boeckx @cedricboeckx.bsky.social · 23/09/2026
Reference genomes and fossils revise bat family phylogeny 🧪🦇🧬 @bat1kgenomes.bsky.social www.nature.com/articles/s41...
nature.com
Reference genomes and fossils revise bat family phylogeny and biogeography - Nature
An updated phylogeny of bats is presented, based on new genome assemblies and many ancient fossils and including all known bat families.
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Cedric Boeckx @cedricboeckx.bsky.social · 23/09/2026
Great work by @david-gokhman.bsky.social and collaborators, out in @nature.com “The gene-regulatory evolution of the human skeleton” 🧪🧬💀 www.nature.com/articles/s41...
nature.com
The gene-regulatory evolution of the human skeleton - Nature
Massively parallel reporter assays and human–ape hybrid skeletal cells are used to study the evolution of human cis-regulatory elements (CREs), revealing how differences in CREs have sh...
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Hyejung Won @hyejungwon.bsky.social · 23/09/2026
1/ I’m excited to share our new work, now out in @natneuro.nature.com! This was a wonderful collaboration with my long-term collaborator @steinlab.bsky.social, led by two fantastic trainees, @nanamatoba.bsky.social and Jessica McAfee. www.nature.com/articles/s41...
nature.com
Massively parallel assessment of gene regulatory activity at human cortical-structure-associated variants - Nature Neuroscience
A large-scale functional screen identified noncoding variants that regulate gene activity during human brain development, providing insights into the molecular mechanisms that shape differences in hum...
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Cedric Boeckx @cedricboeckx.bsky.social · 22/09/2026
Excellent comparative work from members of @nccrlanguage.bsky.social & @isle-uzh.bsky.social, challenging another “only-human” claim about language (we need more of this type of work): “Supra-regular recursion in primate vocal sequences” (Well done @balthasarbickel.bsky.social!) 🧪🗣️
biorxiv.org
Supra-regular recursion in primate vocal sequences
Complex syntax is the widely accepted demarcation between animal and human communication. Although animal vocal systems occasionally contain pockets of syntax-like structures, their grammars are thoug...
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John Timmer @jtimmer.bsky.social · 22/09/2026
Ok, this "there are two separate brains" thing appears to be making the rounds, and I want to be absolutely clear: this is a press office overhyping some perfectly reasonable science that won't come as a surprise to most developmental biologists.
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Kevin Mitchell @wiringthebrain.bsky.social · 21/09/2026
Exome sequencing over 88,000 people with schizophrenia identifies 40 high-risk genes (16 at v high confidence)
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Justus Kebschull @justuskebschull.bsky.social · 21/09/2026
NEW PREPRINT! An evo-devo look at how new cerebellar nuclei are made. Spoiler: it’s all driven by region-specific excitatory progenitors in the early rhombic lip; inhibitory neurons fill in later. If you care about brain evolution or cerebellar development, check it out: tinyurl.com/CNdevelopment
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Cedric Boeckx @cedricboeckx.bsky.social · 21/09/2026
Insightful new work by @luciadehoyos.bsky.social @bstpourcain.bsky.social & collaborators: A Genome-wide analysis of social behaviour across social domains, reporters and developmental stages 🧪🧬 www.nature.com/articles/s41...
nature.com
Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach - Nature Human Behaviour
A genome-wide meta-regression analysis of social behaviour studying ~500,000 observations from ~70,000 individuals, modelling context-specific SNP variation as explained by social domains, informants ...
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Cedric Boeckx @cedricboeckx.bsky.social · 20/09/2026
Amazing work led by @nickjourjine.bsky.social showing how the species-specific temporal structure of neonatal vocalizations in deer mice can be traced back to cerebellar anatomy & maybe even to a genomic locus containing plausible gene candidates [e.g ASTN2, well studied by @mbhatten.bsky.social ]🧪
biorxiv.org
The Genetic Architecture of Neonatal Deer Mouse Cries Implicates the Cerebellum in the Temporal Control of an Infant Social Behavior
Vocal communication is a conserved vertebrate social behavior that begins at birth with the cries of infants. These neonatal vocal signals vary across contexts to elicit parental care that matches inf...
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Nick Jourjine @nickjourjine.bsky.social · 20/09/2026
New preprint! TLDR: We mapped the genetic architecture of neonatal vocalization in deer mice, and found candidate genes expressed in the cerebellum that could be contributing to the evolution of temporal structure in infant cries #Bioacoustics #neuroskyence www.biorxiv.org/content/10.6...
biorxiv.org
The Genetic Architecture of Neonatal Deer Mouse Cries Implicates the Cerebellum in the Temporal Control of an Infant Social Behavior
Vocal communication is a conserved vertebrate social behavior that begins at birth with the cries of infants. These neonatal vocal signals vary across contexts to elicit parental care that matches inf...
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Cedric Boeckx @cedricboeckx.bsky.social · 20/09/2026
Amazing work led by @nickjourjine.bsky.social showing how the species-specific temporal structure of neonatal vocalizations in deer mice can be traced back to cerebellar anatomy & maybe even to a genomic locus containing plausible gene candidates [e.g ASTN2, well studied by @mbhatten.bsky.social ]🧪
biorxiv.org
The Genetic Architecture of Neonatal Deer Mouse Cries Implicates the Cerebellum in the Temporal Control of an Infant Social Behavior
Vocal communication is a conserved vertebrate social behavior that begins at birth with the cries of infants. These neonatal vocal signals vary across contexts to elicit parental care that matches inf...
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Cedric Boeckx @cedricboeckx.bsky.social · 20/09/2026
Excellent preprint from @justuskebschull.bsky.social’s lab showing how new cerebellar nuclei arise by excitatory progenitor diversification in the early rhombic lip 🧪🧠🧬 www.biorxiv.org/content/10.6...
biorxiv.org
Evolution of new cerebellar nuclei by excitatory progenitor diversification in the early rhombic lip
The cerebellar nuclei, the output regions of the cerebellum, have evolved via repeated duplication of a conserved cell type set to produce different numbers of nuclei across species. Here, we investig...
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Fernando Garcia-Moreno @phylobrain.bsky.social · 18/09/2026
The cerebral cortex that is reading this sentence (yours, to be explicit) did not come out of nowhere. It has evolved over hundreds of millions of years... To study this evolutionary process, we decided to focus on non-avian reptiles for our new paper in Cerebral Cortex 🐢🦎🧠 🧵
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Richard Sever @richardsever.bsky.social · 18/09/2026
The DOI registration agency Crossref is holding elections for Board Members. I've worked with Crossref for years, and preprints are now a major class of object registered. IMO it's valuable to have that experience represented so am a candidate. Vote for me! www.crossref.org/board-and-go...
crossref.org
Board election 2026 candidates - Crossref
Help elect the incoming class of 2027 Crossref board members
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Adam Auton @adamauton.bsky.social · 18/09/2026
What can we learn about a single rare variant? Published today in Science: the 23andMe Research Institute and Dana-Farber studied the EGFR T790M in 10.1M 23andMe research participants. The variant has OR = 25.2 for lung cancer, rising to 61.7 in never-smokers(!). 🧵
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Omid V. Ebrahimi @omidvebrahimi.bsky.social · 17/09/2026
📜 Out now: ‘Towards a genetics of mental disorders as complex dynamical systems’ After 2 years of work with @michelnivard.bsky.social & @ludvigdb.bsky.social We outline a roadmap to align behavioural genetics with novel dynamic theories of mental disorders A thread 🧵 doi.org/10.31234/osf...
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Cedric Boeckx @cedricboeckx.bsky.social · 17/09/2026
Two very interesting reflections by @sergiuppasca.bsky.social in this nice overview (@iansample.bsky.social) of their latest @nature.com paper (link in quoted post) @theguardian.com www.theguardian.com/science/2026... 🧪🧠🧫
theguardian.com
Scientists create mice with part-human brains
Researchers hope to shed light on conditions such as schizophrenia, epilepsy, cerebral palsy, intellectual disability and rare forms of dementia
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Mathew Summers @summersathome.bsky.social · 16/09/2026
Busy day - our work on the organization of norepinephrine neurons in the locus coeruleus is out today in Nature too. If you're interested in digging deeper, the data and analyses supporting all of our work is hosted in a public CodeOcean collection: codeocean.allenneuraldynamics.org/collections/...
codeocean.allenneuraldynamics.org
Code Ocean
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Ed Yong is offline @edyong209.bsky.social · 17/09/2026
Briefly popping my head back in to unveil the cover of my upcoming book, LIFE BEYOND MEASURE: Nature's Hidden Wonders at Every Scale. It’ll be out on April 6 in the U.S. and April 29 in the U.K. and you can pre-order it right now! www.penguinrandomhouse.com/books/757705... 1/
A book cover featuring a beautiful closely cropped portrait of an Anna's hummingbird. The cover says LIFE BEYOND MEASURE: Nature's Hidden Wonders at Every Scale, by Ed Yong. The image also says US: 4/06/27 and UK: 4/29/27
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Jeremiah Cohen @jeremiahycohen.bsky.social · 16/09/2026
Happy to share the version of record of our locus coeruleus paper here: www.nature.com/articles/s41... Prior thread on some of our discoveries in this study: bsky.app/profile/jere...
nature.com
Topographic structure and function of locus coeruleus noradrenaline neurons - Nature
Dorsal and ventral noradrenergic neurons in the locus coeruleus form topographic subpopulations whose projection patterns and activity encode choice switching, reward-prediction errors and disregard o...
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