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Development depends on gene regulation by enhancers across long genomic distances. This Perspective discusses mechanisms enabling long-range enhancer–promoter communication and the potential advantage...

Murphy and colleagues report that the transcriptional regulator ID2 promotes cDC1 fate specification by antagonizing E protein activity at E-boxes within the Zeb2 enhancer and establish the Zeb2 −165-...

Inside cells, DNA is intimately associated with proteins, forming chromatin. The protein constituents of chromatin vary across the tree of life: histones are the principal building blocks of chromatin...

Nucleosomes with their associated modifications organize and regulate the genome. It is unclear how this is integrated with the requirement of replica…

The vaccine reportedly thwarted the cancer's return and spread.

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The formation of metaphase chromosomes requires the activity of condensins, DNA translocases that reduce chromosomal length through the process of loop extrusion. Reduction of length, however, does no...

On 11 July 2026, neuroscience lost one of its most visionary scientists with the passing of Susumu Tonegawa at the age of 86. Across an extraordinary career spanning more than five decades, Tonegawa p...

Many important biological functions arise not from single genes but from complex interactions encoded by entire genomes. We report the first generative design of complete bacteriophage genomes using g...

The differentiation variability of human pluripotent stem cell lines is diagnosed and corrected.

The protein complex cohesin plays critical roles in genomic stability by tethering together sister chromatids at their pericentric regions and along their arms from S phase until anaphase. Cohesin-med...

In Schizosaccharomyces pombe , the conserved CHD remodeler Mit1 function within the SHREC remodeler-deacetylase complex (a homolog of the metazoan Mi-2/NuRD complex), which is essential for H3K9 methy...

In avocado and certain wild relatives in Lauraceae, a highly synchronized daily rhythm of floral sex timing promotes cross-pollination between two ...

Dosage-sensitive transcription factors (TFs) underlie altered gene regulation in human developmental disorders, and cell type–specific gene regulation is linked to the reorganization of three-dimensio...

Tünnermann et al. use live-cell imaging to study promoter activity under the control of an enhancer inserted at different genomic distances. RNA production from the promoter occurs in clusters of tran...

This study combines single-molecule microscopy and genome editing to characterize the dynamic behaviors of endogenous oncofusion transcription factor EWS::FLI1 in Ewing sarcoma cells. EWS::FLI1 forms...

A dead fly perched high on a blade of grass, wings raised, glued in place by its own mouthparts, might look like something out of a horror movie. […]

Nature Communications - How non-coding mutations in DNA contribute to phenotypes is a largely unresolved question. Here the authors integrate personal genomics and machine learning to identify...