Reposted by Quaid MorrisCaroline Bartman @cbartman.bsky.social · 26/09/2026Are there key discoveries made with spatial RNA seq? Or what are your favorite spatial rna seq papers? Pls reski! 31615
Reposted by Quaid MorrisAsher Cutter @asherdcutter.bsky.social · 17/09/2026Come to @romtoronto.bsky.social and EEB in Toronto! ROM is seeking entomologist/arachnologist curator who would also be faculty in EEB at UofT royalontariomuseum.applytojob.com/apply/mdMTpA...royalontariomuseum.applytojob.comCurator of Insects & Arachnids - Royal Ontario Museum - Career PageApply to Curator of Insects & Arachnids at Royal Ontario Museum in Toronto, ON, Canada. 02431
Reposted by Quaid MorrisTanja Stadler @tanjastadler.bsky.social · 15/09/2026🚀 Interested in joining our Computational Evolution group at ETH Zürich in Basel @bsse.ethz.ch as a Postdoc? We will be hosting ETH AI Center's Postdoc Fellows on AI x evolution, AI x single cell biology as well as AI x public health. Apply now 👉 ai.ethz.ch/apply Deadline: Oct 27, 2026ai.ethz.chFellowship ProgramsThe application portal for the ETH AI Center Fellowship Programs is now closed. The deadline for submitting reference letters is 23:59 CET on November 14, 2025. 01210
Reposted by Quaid MorrisGeorge O'Toole (he/him/his) @geiselbiofilm.bsky.social · 15/09/2026Pls share: Princeton has an open rank faculty search in the areas of cancer biology, cancer prevention, and cancer-relevant computational science, including connections between cancer and immunology or metabolism. apply.interfolio.com/191852 11514
Quaid Morris @quaidmorris.bsky.social · 04/09/2026Probably what Toronto accent mapped to the USA should look like: SW Ontario, a bit of Vancouver and some snowbirds in South Florida 010
Reposted by Quaid MorrisJudith Kribelbauer @jk-swietek.bsky.social · 10/08/2026Huge undertaking of many labs for many years, highlighting the power of multi-platform comparisons and open collaborations! So many Zoom meetings, bridging an 11h+ time zone difference to make it all happen! 0144
Quaid Morris @quaidmorris.bsky.social · 07/08/2026Excited to share the results of the Codebook Project, an international effort to identify accurate DNA-binding motifs and genomic binding loci for >300 uncharacterized human transcription factors (TFs) www.nature.com/articles/s41...nature.comAn expanded codebook of human transcription factor DNA-binding specificity - NatureResults from a panel of assays that analyse different aspects of DNA sequence specificity reveal more than 100 new motifs to aid the characterization of putative human transcription factors. 14710
Reposted by Quaid MorrisMartin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 01/08/2026Riboseek is a fast RNA/DNA search. More sensitive than nhmmer at 250x speed. Structure-aware realignment produces MSAs approaching rMSA quality. Plus 1.7M precomputed RNA MSAs, and an API to search your own 📄 www.biorxiv.org/content/10.6... 💾 github.com/steineggerla... 🌐 search.foldseek.com/riboseek 217874
Reposted by Quaid MorrisStirling Churchman @stirlingchurchman.bsky.social · 28/07/2026RNA-seq tells us how much RNA is present in the cell. But to understand gene regulation, we need to easily measure the synthesis and decay rates driving this abundance. We introduce AIR-seq: analog intrinsic recoding sequencing. (1/6) www.biorxiv.org/content/10.6...biorxiv.orgAnalog intrinsic recoding measures RNA dynamics without chemical conversionSteady-state RNA abundance measurements mask the synthesis and decay rates that shape gene expression. Analog intrinsic recoding sequencing (AIR-seq) repurposes the base-pairing properties of N4-hydro... 215361
Reposted by Quaid MorrisAlejandro Montenegro @aemonten.bsky.social · 25/07/2026"We show here that the protein sequence is insufficient for the biogenesis of fully active IDR-containing transcriptional regulators in cells, suggesting that mRNA 3′ UTRs control their activity by preventing co-translational misfolding" doi.org/10.1016/j.ce... 1157
Reposted by Quaid MorrisBenjamin D. Greenbaum @bengrbm.bsky.social · 21/07/2026Matching T cells to their cognate peptides presented on MHC molecules from sequence data is a key unsolved problem in computational immunology. A transformative collaboration with @quaidmorris.bsky.social. Led by Olga Lyudovyk, @levinejon.bsky.social & Melissa Pathil! 👇 @mskcancercenter.bsky.social 0137
Quaid Morris @quaidmorris.bsky.social · 21/07/2026Can we predict which T cells recognize which peptides? A lot of the signal is hiding in AlphaFold3's (AF3's) hallucinations. enFoldX: instead of one predicted structure, we use the whole noisy ensemble to predict TCR:pMHC binding. www.biorxiv.org/content/10.6... 💻 🧬 github.com/jonlevi/enFoldXbiorxiv.orgEnsembles of in silico structures enable T cell peptide-MHC binding predictionAdaptive immunity relies on T-cell receptor (TCR) recognition of peptides presented by the major histocompatibility complex (pMHC). Accurate prediction of TCR:pMHC binding pairs from sequence data rem... 13113
Reposted by Quaid MorrisAndrew Gordon Wilson @andrewgwils.bsky.social · 14/07/2026How far can we compress billion-parameter LLMs? We introduce requential coding, which achieves < 1-bit per param compression, and explains why scaling doesn't hit a generalization wall! arxiv.org/pdf/2607.11883 w/ Shikai Qiu, Marc Finzi, Yujia Zheng, Kun Zhang 1/🧵 27512
Reposted by Quaid MorrisDr. Samantha Montano @samlmontano.bsky.social · 02/07/2026Sorry if this is a silly question but do you not put tenure on your CV? I googled it and it seems like you don’t? Surely that is worthy of note? 9121
Reposted by Quaid MorrisKate Cook @eskay8.bsky.social · 10/06/2026Getting there. I signed up for a sale at the end of the month (my first!) and am trying to get a bunch of stuff finished 221
Reposted by Quaid MorrisMolly Knight @mollyknight.bsky.social · 31/05/2026Are we rooting for the Thunder or the Spurs 46311
Reposted by Quaid MorrisMann Lab @mannlab.bsky.social · 28/05/20261/5 Cell identity is written in the proteome, not in the DNA, and not always in the RNA. Out on bioRxiv today: The first cell type-resolved, MS-based proteomic atlas of the human body. www.biorxiv.org/content/10.6...biorxiv.org 310030
Reposted by Quaid MorrisDoug Gordon @brooklynspoke.bsky.social · 28/05/2026Pedestrianizing the Financial District would be another one of those projects where as soon as it went into effect people would wonder why New York didn't do it earlier and, before too long, even more people would forget it was ever any different.nyc.streetsblog.orgData Show Why Mamdani Must Pedestrianize the Financial District - Streetsblog New York CityPeople walk in the Financial District, but the neighborhood's business group prioritizes the car. 1011516
Reposted by Quaid MorrisLarry Hunter @proflhunter.bsky.social · 20/05/2026New family of generative DNA language models trained on 1T 6-mer DNA tokens in long genomic contexts. Open weights, open source, open training data... h/t @mmitchell.bsky.social huggingface.co/spaces/Huggi...huggingface.coCarbon - a Hugging Face Space by HuggingFaceBioEnter a DNA string and the Carbon model can continue the sequence, score genetic variants, or predict the protein’s 3‑D structure. You can also explore gene‑embedding visualisations and see the ful... 0173
Reposted by Quaid MorrisDr. Julie Claycomb @farmgirlphd.bsky.social · 13/05/2026Attention all #RNA26 Montreal @rnasociety.bsky.social attendees! Get your special edition @rnacanada.ca RNEh? tshirt to celebrate your Canadian RNA pride. Order here: gametime.gearware.com/stores/rna thru Friday, May 29th. Delivery ONLY to RNA2026 in MTL/no shipping. Image design by Jasmine Tsang. 1125
Reposted by Quaid MorrisDavid A Knowles @davidaknowles.bsky.social · 06/05/2026#MLCB2026 will be November 16-17 at (once again) @nygenome.org, NYC! Paper/abstract deadline is July 1st, more deets at mlcb.org. We'll be opening in-person registration alongside paper decisions. Mailing list to stay in the loop: groups.google.com/g/mlcb. Keynotes TBA! Please RP! 074
Reposted by Quaid MorrisNature Methods @natmethods.nature.com · 29/04/2026Orthus: an RNA foundation model pretrained via contrastive learning based on splicing isoforms and orthologous transcripts. @phil-fradkin.bsky.social @heyitsmeianshi.bsky.social @taykhoomdalal.bsky.social @bowang87.bsky.social @quaidmorris.bsky.social www.nature.com/articles/s41...nature.comOrthrus: toward evolutionary and functional RNA foundation models - Nature MethodsOrthrus is an RNA foundation model pretrained via contrastive learning based on splicing isoforms and orthologous transcripts. This pretraining strategy leads to its strong performances in various tas... 1143
Reposted by Quaid MorrisHarvard_MCB @harvardmcb.bsky.social · 16/04/2026Small Model, Big Insight: RNA Structure Rules Emerge from Minimal Data 🧬 #AcademicSky #higherEd #RNA www.mcb.harvard.edu/department/n... @rachellegaudet.bsky.social @naoshigeuchida.bsky.social @nature.com @harvard.edumcb.harvard.eduSmall Model, Big Insight: RNA Structure Rules Emerge from Minimal Data - Harvard University - Department of Molecular & Cellular BiologyMCB Senior Research Fellow Elena Rivas and colleagues have demonstrated that the fundamental rules governing RNA structure can be learned using a remarkably simple computational model—challenging assu... 0175
Reposted by Quaid MorrisMemorial Sloan Kettering Cancer Center @mskcancercenter.bsky.social · 16/04/2026New research from MSK, led by Dr. Scott Lowe, Dr. Dana Pe'er, & colleagues, shows how pancreatic cells can shift from a benign state to cancer — revealing a key “switch” in this process. The study, published in @cellpress.bsky.social, identifies a critical window for early detection and prevention.mskcc.orgFrom Benign Growth to Pancreatic Cancer: New Study Shows How the Switch Gets Flipped | Memorial Sloan Kettering Cancer CenterAn MSK study reveals new details about how pancreatic cells carrying oncogenic mutations transition from benign to malignant — shining new light on the ecosystems that supports emerging tumors. 062
Reposted by Quaid MorrisTineke Lenstra @tinekelenstra.bsky.social · 12/03/2026Ever wondered how a eukaryotic transcription factor finds its specific DNA motif in the vast genome? In this preprint, we directly measured the dynamics of this search process in living cells, revealing a cooperative mechanism mediated by disordered regions. 1/10 doi.org/10.64898/202...doi.org 19740
Reposted by Quaid MorrisDonnelly Centre @donnellycentre.bsky.social · 17/02/2026The Donnelly Centre is hiring a new Research and Communications Officer! As a vital part of our administration team, this role covers the external and internal communications of our community. Learn more about the role and apply at the link below: jobs.utoronto.ca/job/Toronto-...jobs.utoronto.caResearch & Communications OfficerResearch & Communications Officer 022
Reposted by Quaid MorrisEMBL-EBI @ebi.embl.org · 10/02/2026We’re hiring: Research Group Leader in computational biology. Are you generating more research ideas than you can explore? Lead cutting-edge AI & biology research at EMBL-EBI. Apply by 11 April 2026: embl.wd103.myworkdayjobs.com/en-US/EMBL/j... #ScienceCareers @ewaldlab.org @embl.org 03950
Reposted by Quaid MorrisQuaid Morris @quaidmorris.bsky.social · 29/01/2026In a new paper, we introduce Metient, a new method to reconstruct the migration history of metastatic clones, and learn cancer-type specific patterns of metastatic spread, from bulk or single-cell sequencing data. www.nature.com/articles/s41...nature.comInferring cancer type-specific patterns of metastatic spread using Metient - Nature MethodsMetient is a statistical framework that infers patterns of metastatic spread and reconstructs cancer migration histories. 53513
Reposted by Quaid MorrisŽiga Avsec @avsecz.bsky.social · 28/01/2026AlphaGenome is out in @nature.com today along with model weights! 🧬 📄 Paper: www.nature.com/articles/s41... 💻 Weights: github.com/google-deepm... Getting here wasn’t a straight path. We discussed the story behind the model, paper & API in the following roundtable: youtu.be/V8lhUqKqzUc 48740
Quaid Morris @quaidmorris.bsky.social · 29/01/2026In a new paper, we introduce Metient, a new method to reconstruct the migration history of metastatic clones, and learn cancer-type specific patterns of metastatic spread, from bulk or single-cell sequencing data. www.nature.com/articles/s41...nature.comInferring cancer type-specific patterns of metastatic spread using Metient - Nature MethodsMetient is a statistical framework that infers patterns of metastatic spread and reconstructs cancer migration histories. 53513
Reposted by Quaid MorrisAlex Stark @alex-stark.bsky.social · 29/12/2025Join @stirlingchurchman.bsky.social, @moffittlab.bsky.social, @saramostafavi.bsky.social, me and all speakers for the 2026 CSHL meeting Systems Biology: Global Regulation of Gene Expression, March 11-14. Abstract deadline January 9! More infos and registration at meetings.cshl.edu/meetings.asp... 14822
Reposted by Quaid MorrisMolly Przeworski @mollyprz.bsky.social · 14/11/2025SAVE THE DATE: the yearly NY Population Genetics meeting will be back on March 9 2026, generously hosted by the @simonsfoundation.org. Details to follow. Please RT. 26039
Reposted by Quaid MorrisCaleb Lareau @caleblareau.bsky.social · 14/12/2025We are very excited to share the first preprint of a new direction for our group. Led by the fearless duo of @arthurwchow.bsky.social and @hoyinchu.bsky.social, our foray into computational protein design— 12410
Reposted by Quaid MorrisReactome @reactome.org · 08/12/2025New Reactome paper in NAR 2026 Databases Issue: doi.org/10.1093/nar/... Redesigned Angular interface ReacFoam & entity-level visualizations Multi-omics analysis tools React-to-Me chatbot FAIR-compliant, CoreTrustSeal certified, and ELIXIR-recognized 🖥️🧬doi.orgThe Reactome Knowledgebase 2026Abstract. The Reactome Knowledgebase (https://reactome.org) is a freely accessible, expert-curated, open-source, and open-data resource that describes huma 096
Reposted by Quaid MorrisWyeth Wasserman @wywywa.bsky.social · 03/12/2025It's always exciting when the latest edition of JASPAR comes out. Great leadership by @amathelier.bsky.social and pleased to welcome @anshulkundaje.bsky.social to the journey. #Jaspar2026 academic.oup.com/nar/advance-... 1144
Reposted by Quaid MorrisRandall Munroe @xkcd.com · 26/11/2025Fifteen Years xkcd.com/3172/ 288117072436
Reposted by Quaid MorrisMikko Taipale @miketilapia.bsky.social · 19/11/2025We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...nature.comPOSTDOCTORAL FELLOW - Toronto (City), Ontario (CA) job with Taipale Lab, Donnelly Centre, University of Toronto | 12849004The Taipale lab in the Donnelly CCBR and University of Toronto is looking for a highly motivated Postdoctoral Fellow 03244
Reposted by Quaid MorrisPlaschka lab @plaschkalab.bsky.social · 21/11/2025Messenger RNA is made in the nucleus before it is exported to the cytoplasm for translation. But how are only correctly made mRNAs chosen and remodeled in the nucleus for export? Our new paper investigates the nuclear events leading to human mRNA export. www.nature.com/articles/s41.... (1/4) 25925
Reposted by Quaid MorrisKieran Campbell @kieranrcampbell.bsky.social · 23/10/2025Great collaboration with @gingraslab.bsky.social & congrats to lead author Vesal. Paper: www.nature.com/articles/s41... Thanks to @sinaihealth.bsky.social 0125
Reposted by Quaid Morriseric lai @lucksmith.bsky.social · 10/11/2025new Lai lab paper @natsmb.nature.com! Dicer is specifically mutated in cancer, but we don't fully understand its molecular/reg impacts. with @danweihuangfu.bsky.social, we characterized the first knockin Dicer hotspot in hESCs, and found unexpected defects in miRNA biogenesis! 🧬 1/4 rdcu.be/eOc0qrdcu.beHuman DICER1 hotspot mutation induces both loss and gain of miRNA functionNature Structural & Molecular Biology - Jee et al. study a cancer hotspot allele of DICER1 that disrupts RNaseIIIb activity. Beyond ablating 5p hairpin cleavage, 3p passenger strands are... 54710
Reposted by Quaid MorrisJerome @fjerome.bsky.social · 02/11/2025Good morning to all the puppies not observing the time change 172
Reposted by Quaid MorrisW. Brent Derry @wbderry.bsky.social · 28/10/2025Fantastic opportunity at The Hospital for Sick Children. Please repost. www.nature.com/naturecareer...nature.comSCIENTIST – Developmental, Stem Cell & Cancer Biology Program - Toronto (City), Ontario (CA) job with The Hospital for Sick Children - Developmental & Stem Cell Biology Program | 12848200Discovery-based and/or translational research using model organism genetics and/or stem cell and organoid platforms to study paediatric cancer. 03540
Reposted by Quaid MorrisJohn Chodera @jchodera.bsky.social · 27/10/2025My institution---the Sloan Kettering Institute, the basic science arm of the Memorial Sloan Kettering Cancer Center---is hiring new faculty this cycle! Applications close Nov 15. www.mskcc.org/research/ski...mskcc.orgFaculty PositionsThe Sloan Kettering Institute is seeking innovative scientists to join our faculty. 01616
Reposted by Quaid MorrisMatthew Hahn @3rdreviewer.bsky.social · 06/10/2025The most important paper in evolutionary biology I'd never heard of: 1/ www.sciencedirect.com/science/arti... 24619
Reposted by Quaid MorrisTim Wu @superwuster.bsky.social · 03/10/2025Finalized my 2025 book tour! Coming through New York, DC, Chicago, Toronto, San Francisco, Los Angeles, London, Oxford and Cambridge. Click here for details: timwu.net#booktour 093
Reposted by Quaid Morrisralucagordan.bsky.social @ralucagordan.bsky.social · 03/10/2025I'm very pleased to announce the official publication of our lab's paper "DNA mutagenesis driven by transcription factor competition with mismatch repair" in today's issue of Cell! www.cell.com/cell/abstrac...cell.comDNA mutagenesis driven by transcription factor competition with mismatch repairCompetition between transcription factors and mismatch repair machinery drives localized hypermutation at regulatory elements, with implications for cancer and genome evolution. 26617
Reposted by Quaid MorrisMax Kozlov @maxkozlov.bsky.social · 30/09/2025Staff members at the NIH seem to have done the impossible: spend the agency's $48 billion budget. “Everyone has been rallying together to clean up the mess, but it’s a mess that did not need to be made,” an NIH program officer told me. www.nature.com/articles/d41...nature.comNIH races to spend its 2025 grant money — but fewer projects win fundingDespite political obstacles, officials are on track to disburse all of the research funds allocated to US biomedical behemoth. 4392121