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Andrew G. York

@andrewgyork.bsky.social
900 followers 711 following 81 posts

I'm a physicist; I invent techniques to measure and control biological systems. Homepage: andrewgyork.github.io

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Andrew G. York @andrewgyork.bsky.social · 15/09/2026
Asimov Press is back! Happy to see the good news from @nikomccarty.bsky.social et al. press.asimov.com/articles/back
press.asimov.com
Asimov Press is Back
Asimov Press returns with a renewed focus on original reporting, investigations, and thesis-driven philanthropy.
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Andrew G. York @andrewgyork.bsky.social · 11/09/2026
Really happy to see this work from the Shapiro lab. New colleagues in an exciting new field!
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Quantum Biology DAO @quantumbiodao.bsky.social · 30/08/2026
Scientists at the @quantumbioorg.bsky.social have developed an open-source imaging platform that can test the effects of precisely controlled magnetic fields on living bacterial colonies. The researchers are making everything openly available, allowing other labs to reproduce and adapt the system.
biorxiv.org
An Open-Source Magnetofluorescence Imaging Platform for Plate-Scale Screening of Magnetic Field Effects in Live Bacteria
Magnetic field effects (MFEs) in biological systems are typically small and experimentally challenging to measure reproducibly across large sample populations. Existing approaches to measure such effe...
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Tanner Fadero @tanner-fadero.bsky.social · 27/07/2026
ASI has begun offering large aperture tube lenses! Really useful for large-FOV imaging at a variety of focal lengths. The large aperture is also useful if you need to put the tube lens in a 4f-configuration without clipping! @jsdaniel02.bsky.social www.asiimaging.com/product/sm2-...
asiimaging.com
SM2-TUBE-200C: Plan-corrected tube lens assembly with 200 mm focal length and SM2 interface – ASI
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Alfred Millett-Sikking @amsikking.bsky.social · 20/07/2026
Ultrafast 3D imaging just got faster! Introducing: "Instant dual-view Snouty (iDV-Snouty) light-sheet microscopy" -> Double the data rate of a Snouty microscope by adding a 2nd view! Use the extra view for a variety of imaging modes! Article here: amsikking.github.io/idv-snouty_l...
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Torsten Wittmann @microtubule.bsky.social · 22/05/2026
A day in the life of a growing hiPSC spheroid expressing endogenously mStayGold-tagged histone 3.3 for #FluorescenceFriday and the #Snouty aficionados. 28 hours (and >50,000 exposures) later and they are still going! Home-brewed volume projection.
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Julia Lazzari-Dean @jlazzaridean.bsky.social · 12/05/2026
We invented “triplet tumbling microscopy” (TTM) to track protein-protein interactions in living cells! Tag your protein with GFP and see it interact with *untagged* binding partners www.biorxiv.org/content/10.6...
A cartoon overview of triplet tumbling microscopy, comparing data from bound and unbound samples.
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Gabriel Abrahams @gabriel-abrahams.bsky.social · 01/05/2026
MagLOV 2 plasmid is (finally!) available on Addgene 🎉🧲🧫 Any GFP capable imaging setup + benchtop power supply + off the shelf electromagnet is all you need to get started - let us know if you need help of course. www.addgene.org/252303/ @andrewgyork.bsky.social @mariaingaramo.bsky.social 🧪
addgene.org
Addgene: pGA-01-47
Plasmid pGA-01-47 from Dr. Harrison Steel's lab contains the insert MagLOV 2 and is published in Nature. 2026 Jan 21. doi: 10.1038/s41586-025-09971-3. This plasmid is available through Addgene.
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Andrew G. York @andrewgyork.bsky.social · 29/04/2026
Meet MagLuc: a magnetically-controlled luminescent protein. This is a foundational tool for remote control of biological processes, also known as "magnetogenetics". Can you tell when the magnetic field turns on and off? From @mariaingaramo.bsky.social and the team at @nonfictionlabs.bsky.social
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adamezracohen.bsky.social @adamezracohen.bsky.social · 25/04/2026
I concur with Andrew's skepticism.
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Andrew G. York @andrewgyork.bsky.social · 24/04/2026
I've been getting questions about this paper all week: www.cell.com/cell/abstrac... They make EXTRAORDINARY claims - fortunately, these are trivial to verify/falsify. Unfortunately, there's other concerns.
cell.com
Electromagnetic field-inducible in vivo gene switch for remote spatiotemporal control of gene expression
The EMF-inducible gene switch (Ei) platform provides precise spatiotemporal control of gene expression through Cyb5b-mediated calcium oscillations. This system enables Ei-OSK-driven in vivo rejuvenati...
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Gabriel Abrahams @gabriel-abrahams.bsky.social · 22/03/2026
Quantum biological control, now in a multicellular organism! Super exciting to see this work from @scburd.bsky.social et al 🧪
nature.com
Magnetic resonance control of spin-correlated radical pair dynamics in vivo - Nature
Magnetic resonance control of spin-correlated radical pairs alters red fluorescent protein emission in transgenic Caenorhabditis elegans, demonstrating in vivo magnetic field modulation of biomolecula...
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Nature @nature.com · 21/01/2026
Researchers have engineered magnetically controlled fluorescent proteins that can be remotely dimmed and brightened in cells and living animals go.nature.com/3NUSY12
go.nature.com
‘Remote controlled’ proteins illuminate living cells
The discovery that some fluorescent proteins are sensitive to magnets could lead to the development of switchable drugs and biosensors.
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Gabriel Abrahams @gabriel-abrahams.bsky.social · 21/01/2026
‘Remote controlled’ proteins illuminate living cells www.nature.com/articles/d41... 🧪
nature.com
‘Remote controlled’ proteins illuminate living cells
The discovery that some fluorescent proteins are sensitive to magnets could lead to the development of switchable drugs and biosensors.
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Gabriel Abrahams @gabriel-abrahams.bsky.social · 21/01/2026
Our research on magneto-sensitive fluorescent proteins and some of their applications has now been published! Huge thank you to the many many people involved in making this happen. 🧪 www.nature.com/articles/s41...
nature.com
Quantum spin resonance in engineered proteins for multimodal sensing - Nature
A recently developed class of magneto-sensitive fluorescent proteins are engineered to alter the properties of their response to magnetic fields and radio frequencies, enabling multimodal sensing of b...
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Neuronal Signalling Lab @mjc-lab.bsky.social · 19/01/2026
Our snouty v3 (AMS-AGY v3) objective arrived today! Looking forward to getting it installed on our single objective light sheet system very soon...
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Andrew G. York @andrewgyork.bsky.social · 13/01/2026
Great news! @mariaingaramo.bsky.social 's company (Nonfiction Labs) made a remote-controlled antibody. Its binding turns on and off with a magnet. This is a HUGE step towards our dream of magnetically controlled drugs. Imagine a cancer drug that ONLY attacks the tumor, not the rest of your body.
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Hamamatsu Corporation @hamamatsucorp.bsky.social · 25/11/2025
We’re thrilled to feature Dr. Tanner Fadero from the Chan Zuckerberg Imaging Institute in an upcoming Nature-hosted webinar about... PHOTONS! 😎 Join the webinar to learn and take part in the live Q&A. 👉 Register here: ow.ly/vsyn50XkZ88 #FluorescenceMicroscopy #LightSheetMicroscopy
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Gabriel Abrahams @gabriel-abrahams.bsky.social · 21/08/2025
MagLOV quantum sensing update! Much improved imaging (>10% single cell ODMR contrast), detailed characterisation and simulation, and new experimental demonstrations taking us a step closer to applications. www.biorxiv.org/content/10.1... SI: www.biorxiv.org/content/10.1...
A. Structure of AsLOV2 PDB~2V1A (Halavaty, 2007) with mutations resulting in MagLOV~2 highlighted. Spin transitions driven by radio-frequency (RF) fields in the presence of a static magnetic field are optically detected via fluorescence measurements on an otherwise standard widefield microscope. Similar effects have recently been observed in other protein systems (Burd 2025, Meng 2025, Feder 2025).
B. Simplified photocycle diagram in the case of a large external magnetic field.
C. A single cell expressing MagLOV 2 displaying an MFE of ~50% (measured as a change in fluorescence intensity in the presence of an applied field). For MFE measurements, the magnetic field was switched  between 0 mT and 10 mT.
D. Black dots: data from a single cell expressing MagLOV 2 displaying an ODMR signal with ~10% contrast. The static field B_0 is ~21.6 mT. Blue line (shade): the mean (std) of all single cell data in a field of view (~1000 cells). 
E. The static magnetic field B_0 was varied by adjusting the magnet's position, and ODMR spectra recorded. Red-lines are Lorentzian fits. Blue line is a theoretical prediction (i.e. is not a fit) of the expected resonance frequency of an electron spin with $\bar\gamma_e$=28 MHz/mT.
Electronics, radio electronics, optical parts, and an animal sized MRI coil are assembled to perform fluorescence MRI measurements using MagLOV.
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Tanner Fadero @tanner-fadero.bsky.social · 19/08/2025
How many photons are in a GFP? — more than last year, and more than you thought. Here's a simple, cheap, and practical method to break a fundamental limit in fluorescence microscopy. But it only works in light sheet!
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Kyle A DeMarr @kdmr.bsky.social · 26/07/2025
Very lucky to be at UCSF with such great microscopy facilities. These instruments are definitely pushing the limits of what we thought feasible in live imaging! Excited to keep exploring how these single cells organize and secrete such precise morphologies.
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Jon Daniels @jsdaniel02.bsky.social · 09/07/2025
Production has started for a new #Snoutscope objective, AMS-AGY v3. It has significantly larger FOV and some other tweaks from v1 and v2. Currently accepting pre-orders. The price will need to increase modestly after deliveries start late October.
comparison table for v2 and v3
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Tanner Fadero @tanner-fadero.bsky.social · 21/06/2025
I got a text from Yovan Bodal, who just used our #snoutscope @UCSF to image fly embryos. His quote says it all! "This was the best results we've gotten on any instrument, possibly for the least amount of work on my end. Here's a GIF of individual mRNAs coming off the gene as they get transcribed:"
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Julian Gargiulo @nano-juli.bsky.social · 26/02/2025
HIGH-RESOLUTION IN VIVO BRAIN IMAGING OF DROSOPHILA 🪰 New Preprint by Tassara et al.! www.biorxiv.org/content/10.1... #FluorescenceMonday #SnoutClub 1/6
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Alfred Millett-Sikking @amsikking.bsky.social · 12/02/2025
I recommend these optomechanics for 'O2-O3' in a single-objective light-sheet (SOLS) microscope: -> Mechanically and thermally stable. -> Relatively straightforward to align. -> 10 popular configurations. Make your own: github.com/amsikking/SO... Or buy it from @jsdaniel02.bsky.social at ASI!
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Alfred Millett-Sikking @amsikking.bsky.social · 29/01/2025
Who else has a #Snouty objective? I currently have 25 members in #SnoutClub! But I think there's a LOT MORE out there... Anyone else care to join? -> Just reply here with a pic of your #Snouty and I'll add you! Why? It helps us promote and develop the technology! amsikking.github.io/snoutclub/
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Andrew G. York @andrewgyork.bsky.social · 26/01/2025
I'll be telling stories about science tonight in San Francisco. Come through! partiful.com/e/ldwWPLR2fO... The real draw is the crew hosting me, though. The local biotech hacker/maker/entrepreneur scene is PACKED with brilliant, inspiring folks. No slides, just stories.
partiful.com
RSVP to Lecture night with Andrew York | Partiful
Gather round the fire and make new friends! Andrew is a physicist at Calico and recently co-discovered magnetic responsivity in fluorescent proteins. It’s one of my favorite discoveries because it’s ...
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Andrew G. York @andrewgyork.bsky.social · 12/12/2024
This is such a fun project! I love the kind of work that F.R.O.s attack.
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Andrew G. York @andrewgyork.bsky.social · 22/11/2024
MagLOV! MagLOV is a fluorescent protein you can "turn off" with a handheld magnet, engineered by @mariaingaramo.bsky.social. We think/hope we can use it to turn arbitrary proteins (including drugs!) on and off in opaque creatures (including humans!). bsky.app/profile/addg...
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Marc Somssich @somssich.bsky.social · 04/06/2024
"Magnetic control of the brightness of fluorescent proteins" 🧲💡 Andrew G. York is one of very few scientists, who are not just scientists - but also real inventors! Now, fluorescent proteins that can be tuned by a magnet. 😲 andrewgyork.github.io/gfp_magnetof... #Microscopy #FluorescentProteins
andrewgyork.github.io
Protein Magnetofluorescence
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Addgene @addgene.bsky.social · 25/09/2024
If you like engineering fluorescent proteins, you'll want to check out our latest blog post! The York lab's MagLOV is a fluorescent protein that responds to magnetic fields, a promising starting point for a potential new class of tools. blog.addgene.org/mag...
blog.addgene.org
Magnetic Control of Proteins: More than a Dream
Magnetoresponsive proteins have seemed like a dream... but Andrew York's lab has developed and deposited one, opening the possibility of magnetoresponsive tools!
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