The Hanna H. Gray Fellows Program supports postdoctoral scientists as they launch careers in academic science, equipping them to pursue scientific research at the highest levels and to recruit, mentor...

The Freeman Hrabowski Scholars Program offers comprehensive support to outstanding early career faculty committed to scientific excellence in their own research, and to fostering labs that expand the ...

Two researchers who study the debilitating sleep disorder have won a prestigious Lasker Award. Their research in animals laid the groundwork for a new drug that addresses the conditions’s root cause.

The Freeman Hrabowski Scholars Program offers comprehensive support to outstanding early career faculty committed to scientific excellence in their own research, and to fostering labs that expand the ...

The Gilliam Fellows Program supports PhD students and their faculty thesis advisors in advancing cutting-edge research and fostering inclusive scientific training environments, while supporting the tr...

Sex-specific RNA splicing is a conserved mechanism for generating sexual dimorphism in insects, with the best-studied examples being fruitless and doublesex. To ask whether additional sex-specifically...

Quantifying animal behavior often requires segmenting continuous actions into discrete, interpretable states, yet most automated pipelines infer actions from keypoint dynamics and are limited by keypo...

Long before they land, mosquitoes are reading our body signals from afar. Find out if you feature high on the bloodsuckers' hit list.

Zoom is the leader in modern enterprise video communications, with an easy, reliable cloud platform for video and audio conferencing, chat, and webinars across mobile, desktop, and room systems. Zoom ...

Billions of people each year are at risk from infection by dengue, Zika, yellow fever, and chikungunya viruses, which are transmitted by female Aedes aegypti mosquitoes. Mosquitoes themselves are infected by these arboviruses, but how the mosquito nervous system responds to arboviral infection is unknown. We combined whole-mount immunofluorescence with single-head bulk RNA-sequencing to characterize dengue virus (DENV) infection in the brain of Aedes aegypti. DENV productively infects brain cells in a bimodal pattern: individual brains showed either sparse or widespread infection, with no intermediate phenotypes. An infectious blood meal altered thousands of genes, including 64 immunity genes, at 7 days post-feeding (DPF), yet active viral replication in the head did not increase the transcriptional response. Heads with and without detectable DENV showed minimal transcriptional differences, with no induction of canonical immune effectors. Despite productive infection, the mosquito brain tolerates DENV replication with minimal transcriptional response.

Billions of people each year are at risk from infection by dengue, Zika, yellow fever, and chikungunya viruses, which are transmitted by female Aedes aegypti mosquitoes. Mosquitoes themselves are infe...

Billions of people each year are at risk from infection by dengue, Zika, yellow fever, and chikungunya viruses, which are transmitted by female Aedes aegypti mosquitoes. Mosquitoes themselves are infe...

In this preprint the authors propose a shift in what counts in the biomedical sciences: researchers should be recognized for what they choose to share on their own terms and timeline (for example as p...

Background: Smell testing is increasingly recognized as essential in rhinology practice but remains underutilized because of time constraints and limited clinical resources. This study aimed to evalua...

Primary Work Address: 4000 Jones Bridge Road, Chevy Chase, MD, 20815 Current HHMI Employees, click here to apply via your Workday account. The Howard Hughes Medical Institute (HHMI) advances the disco...

The Cech Fellows Program is a paid, nine-week summer research experience empowering the next generation of scientific leaders.

Animal behavior unfolds continuously in time, yet quantitative analyses often require segmenting it into discrete, interpretable states. Although manual annotation can achieve this, it remains slow, s...

The Cech Fellows Program is a paid, nine-week summer research experience empowering the next generation of scientific leaders.

Researchers have discovered the first evidence of what happens when a female mosquito chooses to mate for the one and only time in her life.

Peer review is widely viewed as a critical aspect of biomedical communication. Ideally, it provides authors with feedback so they can improve manuscripts and gives readers, particularly nonspecialists...