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Michael Lin, MD PhD

@michaelzlin.bsky.social
2.8K followers 211 following 332 posts

Harvard → UCLA → HMS → UCSD → Associate Prof. of Neurobiology & Bioengineering at Stanford → Molecules, medicines, & SARSCoV2. Bad manners blocked.

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Michael Lin, MD PhD @michaelzlin.bsky.social · 29/09/2026
Excited to share a new study from our lab in Cell: “Non-invasive control of gene editing in vivo by photoswitchable Cas12f and focused ultrasound” We engineered a compact CRISPR system that can be activated at specific locations in the body using focused ultrasound (🧵) www.cell.com/cell/fulltex...
cell.com
Non-invasive control of gene editing in vivo by photoswitchable Cas12f and focused ultrasound
Remote activation of a single-AAV-deliverable photoswitchable Cas12f system enables precise spatial and temporal control of genome editing in deep tissues without surgery or implanted devices.
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Sarafan ChEM-H @stanford-chemh.bsky.social · 25/09/2026
#ICYMI Faculty Fellow @michaelzlin.bsky.social and team have developed RASER, a novel therapeutic approach that sharpens the precision of certain cancer treatments while sparing healthy tissue: med.stanford.edu/cancer/about...
med.stanford.edu
Cutting through cancer with RASER: A new approach to metastatic disease
By prioritizing treatment precision and minimizing toxicity, the RASER system offers hope for patients living with metastatic cancers.
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Michael Lin, MD PhD @michaelzlin.bsky.social · 17/06/2026
Today I’m excited to share our new study in Nature Biomedical Engineering, in which we used protein engineering to create a therapeutic able to completely eradicate metastatic ovarian cancer in mice. 🧵 www.nature.com/articles/s41...
nature.com
Rewiring oncogenic signalling to precision ablation of metastatic cancer - Nature Biomedical Engineering
An engineered ErbB oncogene-selective virus shows improved safety and efficacy for treating mouse models of ErbBr/HER2 positive ovarian cancer, showing promise for curing early cases and substantially...
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Michael Lin, MD PhD @michaelzlin.bsky.social · 02/06/2026
Excited to announce big steps for electrical imaging in the brain! In 4 preprints, we and collaborators present 2 new GFP-based voltage sensors: ASAP6c for high-throughput spike recordings, and ASAP7y for subthreshold 1P and 2P imaging bit.ly/4x3k3kX bit.ly/3RKZhq3 bit.ly/4o4fKl3 bit.ly/4uHXuk3 🧵
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Michael Lin, MD PhD @michaelzlin.bsky.social · 20/05/2026
The Lin Lab is hiring! We're seeking motivated postdocs for projects on voltage imaging and optogenetics in the brain. If you're excited to develop new methods to undersatand and correct brain diseases, working together with other neuroscience labs at Stanford, drop us a line!
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Michael Lin, MD PhD @michaelzlin.bsky.social · 19/05/2026
Happy to reveal our latest work, Microbe-Independent Deep Assembly and Screening (MIDAS), a method for engineering proteins >10x more cheaply and quickly than before. MIDAS addresses the slowest step in protein engineering — construction and expression of variants — by skipping cloning entirely
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Michael Lin, MD PhD @michaelzlin.bsky.social · 07/05/2026
It is with a heavy heart that I share the devastating news that my wonderful PhD student, Pengli Wang, passed away on Friday, May 1, at the age of 28, in an unexpected accident. I’ve struggled to write this because it is hard to put into words just how much Pengli meant...
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Michael Lin, MD PhD @michaelzlin.bsky.social · 03/05/2026
Small selection of classroom doors decorated for Teachers Appreciation Week. It’s just Palo Alto School District, no pressure or anything 😄
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Robert Reich @rbreich.bsky.social · 24/04/2026
The richest man owns X. The second and fourth richest men control Google. The third richest man owns The Washington Post. The fifth richest man owns Facebook, Instagram, and WhatsApp. And now the sixth richest could soon take over both Paramount and Warner Bros. See the problem here?
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JPWeiland @jpweiland.bsky.social · 25/04/2026
April 24th Update: We are at the lowest transmission levels in almost 5 years, 40% lower than our recent spring lows. This remarkable lull should last 6+more weeks. Estimates: 🔸90,000 new infections/day 🔸~1 in 750 currently reasonably infectious (5 day window)
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Dr. Becca @docbecca.bsky.social · 19/04/2026
Those of us doing research related to women’s health have been hit particularly hard by the govt’s sabotage of the NIH. I spoke to WaPo for this piece, as painful as it was to discuss the reality my lab is facing. www.washingtonpost.com/science/2026...
washingtonpost.com
Where U.S. science has been hit hardest after Trump’s first year
The Trump administration has slashed the number of grants from the National Institutes of Health, with far fewer focused on women, cancer and mental health.
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Vaughn Smider, MD, PhD @vvsmider.bsky.social · 19/04/2026
Our group just received a new R01 that was delayed by many months- it should have been awarded ‘25, like the curve below. This grant had the highest score we’d ever received (2%-ile), yet funding was uncertain. With the delay we had to lay people off. Very inefficient. And we are the lucky ones.
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Michael Lin, MD PhD @michaelzlin.bsky.social · 18/04/2026
“Amid the search for a new CDC director, some well-qualified candidates sought promises of autonomy to be able to fire and hire staff and to keep science insulated from political influence. Those candidates were not selected, sources told the Post.” arstechnica.com/health/2026/...
arstechnica.com
Trump picks qualified, normal health leader to head CDC; experts still cautious
She's well qualified but will need to navigate RFK Jr.'s anti-vaccine agenda.
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Bloomberg Opinion @opinion.bloomberg.com · 17/04/2026
Erica Schwartz could fix the CDC — as long as she’s not blocked by higher-ups
bloom.bg
Trump’s CDC Pick Looks Solid. The Real Risk Is RFK Jr
President Donald Trump has wisely sidestepped controversy by choosing former deputy surgeon general Erica Schwartz to lead the Centers for Disease Control and Prevention.
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Michael Lin, MD PhD @michaelzlin.bsky.social · 13/04/2026
Just came across this wonderful recording of the Mendelssohn Violin Concerto. Soloist Julia Fischer is absolutely amazing. The videography brings out every note and every instrument, better than having a front-row seat. www.youtube.com/watch?v=SshD...
youtube.com
Mendelssohn: Violin Concerto in E minor | Julia Fischer, Dresden Philharmonic & Michael Sanderling
YouTube video by DW Classical Music
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Dan Garisto @dangaristo.bsky.social · 13/04/2026
The NSF GRFP is now out! There are 2,599 awardees, which is the most ever—and a big shift from last year which initially halved awardees (1,000 awardees + an additional 500). I've thrown together a plot to break down the changes by field. www.research.gov/grfp/Awardee...
Plot showing GRFP awards by directorate shows a big dip last year and major increases for engineering and biology (though this only brings it back to parity with 2024).
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Isabel @isabelott.bsky.social · 13/04/2026
At a glance, 2599 recipients - I think the highest total ever? And quite a few in the Life Sciences, which I know was a concern for many - Evolutionary Biology had twice as many recipients (38) as last year (19).
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Michael Lin, MD PhD @michaelzlin.bsky.social · 12/04/2026
Tides do turn
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Michael Lin, MD PhD @michaelzlin.bsky.social · 12/04/2026
Fellow X-scientists! Curious who among you might want human iPSCs stably expressing ASAP-family green fluorescent voltage indicators. Cardiomyocytes and neurons differentiated from these iPSCs can self-report voltage with <1-ms and <1-mV resolution by standard widefield imaging.
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Joshua Weitz @joshuasweitz.bsky.social · 09/04/2026
"The acting director of the Centers for Disease Control and Prevention (Jay Bhattacharya) has delayed publication of a CDC report showing the covid-19 vaccine cut the likelihood of emergency department visits and hospitalizations for healthy adults last winter by about half." !!! 🎁
wapo.st
CDC delays publishing report showing covid vaccine benefits
The acting CDC director cited concerns with the methodology, but the design has long been used to test vaccine effectiveness.
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Reposted by Michael Lin, MD PhD
The New Republic @newrepublic.com · 30/03/2026
Stephen Miller allegedly urged Department of Homeland Security agents to “force confrontations” with protesters in Minneapolis in order to win a “PR battle." trib.al/NcbpdiX
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Public Citizen @publiccitizen.bsky.social · 30/03/2026
CAN THE GOVERNMENT, JUST ONCE, STOP PUTTING THE WAR MACHINE ABOVE HUMAN NEEDS??? IS THAT TOO MUCH TO ASK FOR???
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Michael Lin, MD PhD @michaelzlin.bsky.social · 30/03/2026
Reposting for the sine
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Michael Lin, MD PhD @michaelzlin.bsky.social · 30/03/2026
Somewhere in the Bay Area not yet ruined by AI
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Michael Lin, MD PhD @michaelzlin.bsky.social · 28/03/2026
A reminder to take a little time to look around you and enjoy the beauty of nature
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Michael Lin, MD PhD @michaelzlin.bsky.social · 27/03/2026
This made me smile Thanks to AtomicAerials of reddit — I really needed that
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Richard Roth @rhroth.bsky.social · 13/03/2026
Very excited to share that I’m starting my lab at the Krembil Brain Institute @kbi-uhn.bsky.social at UHN and the University of Toronto! If you’re interested in motor learning and circuit plasticity, please reach out - we are hiring! www.motor-plasticity.org 1/
motor-plasticity.org
Roth Lab
Welcome! We study the synaptic and circuit bases for motor control and motor learning. The brain’s ability to learn and form new memories relies on the precise reorganization of neuronal circuits, inv...
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Xueling Shirley Zhang @xshirleyz.bsky.social · 04/03/2026
Excited to introduce ScaRCaMP — a highly blue-light resistant red GECI. 🔴 Now live on bioRxiv and marking my first PhD preprint (2nd for the Marko lab). Would love feedback from the community!!
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Michael Lin, MD PhD @michaelzlin.bsky.social · 23/02/2026
NIH funding rate per applicant dropped 38% in FY2025 vs 2022, from 27.1% to 16.7% Here's a breakdown by career stage. Why FY2022 vs FY2025? • FY2022 was first FY with budget passed and administered by Biden • FY2025 budget was in CR until 3/15/2025, so budget and most grants were under the Trump WH
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Michael Lin, MD PhD @michaelzlin.bsky.social · 01/02/2026
Today I'd like to honor the memory of my mentor and friend, Roger Tsien, born 1952 February 1. Today would have been Roger's 74th birthday. Most know Roger for his 2008 Chemistry Nobel Prize with Shimomura and Chalfie. Roger made GFP into the versatile imaging method it is now.
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Tom Scocca @tomscocca.bsky.social · 24/01/2026
In some countries the outbreak of bloodshed inspires the opposition party to call for the leader to resign
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Michael Lin, MD PhD @michaelzlin.bsky.social · 24/01/2026
For #fluorescentfriday, an image contributed by my daughter showing GFP in a vial. Specifically mClover3, of course.
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Stephen Moran. @moranstephen1000.bsky.social · 02/01/2026
Mamdani has only been Mayor for a day & criminals are already fleeing New York
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Michael Lin, MD PhD @michaelzlin.bsky.social · 31/12/2025
Somehow managed to survive crossing these streets until I was 5 years old. Look closely and you'll see the Buddha of Baguashan. Would walk up to it nearly every day, along a stream where housewives did their laundry.
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Michael Lin, MD PhD @michaelzlin.bsky.social · 29/12/2025
Back in my birthplace, Taiwan. Within 2 generations it went from agrarian and poor to creating the 2-nm technology that drives the world economy. My grandparents grew up as farmers, my parents still save every last grain of rice. Step out of Taipei and you realize the old Taiwan is still there.
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Richard M. Carpiano, PhD, MPH @rmcarpiano.medsky.social · 07/12/2025
Immunity debt's "...explanatory power has faded as the number of non-covid infections has kept rising each year... A growing number of scientists believe that the SARS-CoV-2 virus may instead be subtly altering our immune systems." 🛟😷medsky
bmj.com
Why scientists are rethinking the immune effects of SARS-CoV-2
“Immunity debt,” a theory to explain the global surge in non-covid infections since pandemic restrictions were lifted, is increasingly being challenged by emerging evidence. Nick Tsergas reports Myco...
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Michael Lin, MD PhD @michaelzlin.bsky.social · 07/12/2025
Had a really nice visit to UCSB, learning about the awesome neuroscience research there and presenting our work on voltage imaging in the molecular cellular and developmental biology seminar series. Thanks to my host Ikuko Smith, who might have the best office view in all of UC!
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Michael Lin, MD PhD @michaelzlin.bsky.social · 06/12/2025
Had the pleasure of visiting @promegacorporation.bsky.social's chemistry group in beautiful San Luis Obispo. Thanks to Wenhui Zhou and the other amazing chemists for hosting me! Didn't get a photo at Promega itself but here's one from our vineyard visit afterwards. Just a typical SLO evening.
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Michael Lin, MD PhD @michaelzlin.bsky.social · 06/12/2025
Read yet another review today that ascribes GECIs' larger SNR vs GEVIs to their being evolved earlier (suggesting the GECIs are better optimized). This assumption is understandable but incorrect. GEVIs' photonic response per molecule per AP have been as good as GECIs since ASAP3.
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Michael Lin, MD PhD @michaelzlin.bsky.social · 05/12/2025
I always find it interesting how much money and energy society will spend in building and debating uncertain models of the natural world using the same limited knowledge, relative to how much support is given to developing methods to improve the amount and resolution of actual data.
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Michael Lin, MD PhD @michaelzlin.bsky.social · 15/11/2025
The Lin Lab is excited to bring voltage imaging to #SfN2025! On Tuesday we'll present new ASAP sensors for spikes and subthreshold potentials, showing how even simple equipment can record multi-unit electrical activity "at the speed of thought" See you in San Diego @sfn.org!
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Michael Lin, MD PhD @michaelzlin.bsky.social · 13/11/2025
Head-mounted 2-photon miniscope voltage imaging! Weijian Yang's group at UC Davis sped up 2p scanning by multiplexing to achieve 400-Hz voltage imaging of ~20 neurons, using ASAP4e These are the first freely moving single-cell voltage recordings as far as I know. URL: www.cell.com/cell-reports...
cell.com
High-speed neural imaging with multiplexed miniaturized two-photon microscopy
Zhang et al. develop two types of multiplexed miniaturized two-photon microscopes (M-MINI2Ps) that increase imaging speed via beam multiplexing while preserving spatial resolution and demonstrate thei...
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Ming Tommy Tang @tommytang.bsky.social · 05/11/2025
A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers www.cell.com/cancer-cell...
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Michael Lin, MD PhD @michaelzlin.bsky.social · 06/11/2025
Was up until 5:30 am writing a grant, then up again at 730 for another full day to finish it today. Now done! 🎉 As academics know, it's not one job. It might be 4. With funding rates at 5%, grant-writing is 1 full-time job. Then there's letters, reviews, committee work, teaching — endless deadlines
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Cornelius Gati @gati.bsky.social · 05/11/2025
Excited to share our latest @nature.com: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation.💊🧪 🧵👇 www.nature.com/articles/s41...
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Michael Lin, MD PhD @michaelzlin.bsky.social · 21/10/2025
My daughter made a series of Halloween cats using air clay. Can you recognize them all?
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Michael Lin, MD PhD @michaelzlin.bsky.social · 30/09/2025
Had the pleasure of visiting Prague as part of an advisory commission for the Czech Academy of Sciences Institute of Biotechnology. Got to check out exciting science and the impressive ultra-high resolution MS machine. Great to see people working hard to expand knowledge, with public support too!
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Carl T. Bergstrom @carlbergstrom.com · 20/09/2025
I cannot overstate how remarkable it is that under GOP rule, US federal health regulations have been captured by fringe crackpots who espouse views that the vast majority of the US public—and nearly 100% of health professionals—reject. Gift link:
nytimes.com
Kennedy’s Vaccine Panel Votes to Limit Access to Covid Shots
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Michael Lin, MD PhD @michaelzlin.bsky.social · 11/09/2025
First clouds over Stanford since spring
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Michael Lin, MD PhD @michaelzlin.bsky.social · 28/08/2025
I think having an arbitrary threshold for statistical significance does more harm than good. It creates artificially black or white conclusions (there was a significant difference or not, with the word significant often omittted leading to bad misunderstandings) when knowledge is actually all gray.
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