BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series

Proximity labeling allows proteomic mapping of subcellular structures. Here, Sroka et al. develop in situ APEX activation (iAPEX) to overcome limitations of labeling specificity and H2O2 toxicity, app...

Yao et al. show that in Europe, forestation’s climate benefits depend on tree species. Converting conifers to broadleaves can reduce summer heat extremes and reverse warming effects of afforestation, ...

A major proportion of retinal disease-causing genes are related to the primary cilium, a microtubule-based signalling organelle essential for multiple developmental pathways. Previous work has shown t...

Redeployment of a developmental program drives the outgrowth of bone tumors in an inherited disease.

The story of the discovery of these molecules 50 years ago shows how the free exchange of ideas can lead to life-changing treatments.

The European Molecular Biology Laboratory (EMBL) is Europe’s flagship life sciences organisation, and one of the world’s leading research institutions. An intergovernmental organisation of 29 Member S...

Molecular recorders based on kinase activity-dependent protein labeling track specific kinase activities to understand their link to cellular phenotypes in heterogeneous cell populations and in vivo.

Tomotsune Ameku tells the story behind the paper "Growth of the maternal intestine during reproduction"

The temporospatial distribution of proteins within cilia is regulated by intraflagellar transport (IFT), wherein molecular trains shuttle between the cell body and cilium. Defects in this process impa...

The Trump administration has canceled funding for an ongoing 30-year, nationwide study tracking patients with prediabetes and diabetes, researchers said.

Peroxiredoxins are highly conserved thiol peroxidases essential for peroxide detoxification, redox signaling, and chaperone activity. Prx1/AhpC-type peroxiredoxins are found throughout the eukaryotic ...

The EU foreign policy chief, Kaja Kallas, said ‘the free world needs a new leader’ and that it was up to Europeans to take this challenge

A small-molecule agonist of transient receptor potential cation channel subfamily M member 4 persistently activates the ion channel and induces necrosis characterized by sodium overload.

Wang et al. develop data-independent acquisition activity-based protein profiling, a quantitative chemoproteomic method to globally profile protein dopamination in the mouse brain, and identify a prot...