iiinova — where your digital self keeps evolving

Reposted by Daniel Krüger

Hans Clevers @hansclevers.bsky.social · 10/05/2026

Short write-up of our journey. Searching for T cell transcription factors, Marc v/d Wetering stumbled across Wnt signaling. Vladja Korinek linked Wnt to colon cancer and crypt biology. Nick Barker discovered the gut stem cell. Toshi Sato invented organoids authors.elsevier.com/a/1n3No6tu0C...

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Reposted by Daniel Krüger

Marija Matejčić (mateytch-itch) @marija-matejcic.bsky.social · 07/11/2025

Intestinal villus cells extrude living, following a calcium pulse. Unlike from extruding apoptotic cells, Ca2+ messaging stops at the first neighbors! #FluorescenceFriday Part of our TrepatLab preprint: www.biorxiv.org/content/10.1... Video by @ronjahoutekamer.bsky.social @gloerichlab.bsky.social

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Daniel Krüger @danielkrueger.bsky.social · 12/09/2025

Great to see our conclusions align with the beautiful work from @marija-matejcic.bsky.social in the Trepat lab 3D force mapping, Ca²⁺-triggered myosin-IIA meshwork dissolution, and neighbour lamellipodia generating traction. Great synergy, highlighting the role of tension in extrusion regulation.

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Daniel Krüger @danielkrueger.bsky.social · 12/09/2025

Thanks for highlighting this! My background in fly morphogenesis shaped how I think about tissue forces, their interplay with signaling, and experimental design. An experience I’d wholeheartedly recommend — Drosophila remains a rich source of inspiration, continuing to reveal fundamental concepts.

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Reposted by Daniel Krüger

Levayer Lab @levayerr.bsky.social · 09/09/2025

This is very complementary with the recent preprint of @xaviertrepat.bsky.social and Maria Matejcic using 2D organoids and providing 3D mechanical characterisation of the process

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Reposted by Daniel Krüger

Levayer Lab @levayerr.bsky.social · 09/09/2025

Important story dissecting the mechanism of gut cell extrusion using organoids. Local heterogeneity of tension promotes live extrusion and basal relaxation is sufficient to kick the cell out. Nice combination of optogenetics and live imaging to demonstrate this www.science.org/doi/abs/10.1...

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Daniel Krüger @danielkrueger.bsky.social · 06/09/2025

👉 Check out our key findings in this detailed thread by Hans Clevers.

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Daniel Krüger @danielkrueger.bsky.social · 06/09/2025

Out in @science.org! We found that the intestine doesn’t just push out cells when crowded. Instead, cells are in a mechanical tug-of-war, and weaker ones are extruded. A new view of how our gut keeps its balance and stays healthy. www.science.org/doi/10.1126/...

science.org

Epithelial tension controls intestinal cell extrusion

Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...

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Reposted by Daniel Krüger

Vlad Bondarenko @vladbndk.bsky.social · 05/09/2025

📣 It is my pleasure to announce our recent review with Margherita on the current approaches, challenges, and perspectives in studying human maternal-fetal interface using in vitro models www.cell.com/cell-stem-ce... 🚀✨️

cell.com

Modeling the human maternal-fetal interface

This review explores the advances in stem cell and organoid models of the endometrium, placenta, and embryo, outlining challenges in integrating them to capture spatiotemporal dynamics and functional ...

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Reposted by Daniel Krüger

Robert Haase @haesleinhuepf.bsky.social · 13/12/2024

Jeey! @nfdi4bioimage.bsky.social published their #RDM-related postcards FAIRly (made by Henning Falk, licensed CC-BY 4.0) 🔬💾😍 github.com/NFDI4BIOIMAG...

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Reposted by Daniel Krüger

Henning Falk Illustrations @falk-illustrations.de · 21/12/2024

First time that my cartoons are printed on postcards! Have a look 👇

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Hans Clevers @hansclevers.bsky.social · 03/12/2024

Exciting study by Amanda Andersson Rolf et al: In vitro expansion of a human fetal #pancreas #stemcell that generates all three pancreatic cell lineages”. www.cell.com/cell/fulltex... New #organoid protocol allows the seemingly indefinite expansion of human fetal pancreatic Lgr5+ stem cell 1/

cell.com

Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages

Identification of an LGR5 as a marker for a tripotent stem/progenitor cell of the human fetal pancreas. Organoids derived from single LGR5+ cells are capable of long-term expansion in vitro and genera...

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Annette Dittert @annettedittert.bsky.social · 12/10/2023

"The state of German-Polish relations is a European tragedy in the same way that the Warschauer Kniefall was a moment of European reconciliation." Brilliant analysis by @JeremyCliffe and also an important read before the Polish elections this weekend. There is so much at stake.

newstatesman.com

Europe’s east-west divide is widening

Relations between Germany and Poland define the continent. But, ahead of the latter’s election this weekend, they are in crisis and getting worse.

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Akrotelm 🌾 @akrotelm.bsky.social · 06/10/2023

Anhören! Wie sich große branchenfremde Investoren (ALDI, Immobilien etc) riesengroße Ackerflächen 🚜 in Ostdeutschland kaufen. Am Staat vorbei, ohne Steuern zu zahlen, mit dem Segen des Bauernverbandes und zum Schaden der kleinen Landwirtschaftsbetriebe. 👇

share.deutschlandradio.de

Warum Investoren immer mehr Ackerland kaufen

Überregionale Investoren kaufen immer mehr Ackerland in Sachsen-Anhalt auf, die Preise sind stark gestiegen. Seit der Energiewende gibt es noch mehr Konkurrenz.

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Reposted by Daniel Krüger

Markus Winkler @markuswinkler.bsky.social · 04/10/2023

Jugendarbeitslosigkeit in der EU, August 2023: 🇪🇸26.8% 🇪🇪23.5% 🇬🇷22.5% 🇷🇴22.3% 🇮🇹22.0% 🇸🇪21.1% 🇵🇹20.3% 🇭🇷20.0% 🇸🇰19.8% 🇱🇺19.2% 🇨🇾16.3% 🇫🇮16.1% 🇫🇷16.0% 🇧🇪14.2% 🇪🇺14.0% 🇭🇺12.8% 🇧🇬11.8% 🇩🇰11.6% 🇦🇹11.4% 🇮🇪11.2% 🇵🇱11.1% 🇸🇮10.4% 🇱🇻9.0% 🇲🇹9.0% 🇳🇱8.7% 🇱🇹8.6% 🇨🇿8.5% 🇩🇪5.7% via: ec.europa.eu/eurostat/doc...

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