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@hhmi-science.bsky.social
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We invest in scientists at all career stages who make discoveries that advance human health for decades to come.

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HHMI @hhmi-science.bsky.social · 29/09/2026
Like humans, zebra finches learn to vocalize by imitation — a trait found in only a handful of species. #HHMIInvestigator Erich Jarvis's lab has assembled the first complete songbird genome, & it could hold the key to understanding how vocal learning evolved: bit.ly/4A74dHu.
Erich Jarvis standing with arms crossed in a laboratory filled with chemical bottles and lab equipment.
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HHMI @hhmi-science.bsky.social · 29/09/2026
Meet Tremella mesenterica (aka "witches' butter”), shown here at the cellular level via confocal microscopy. This fungus's polysaccharides may hold medical potential — research has shown immune-stimulating, anti-inflammatory, & antiallergic effects. 📸: Igor Siwanowicz, HHMI Janelia Research Campus
Tremella mesenterica (aka "witches' butter”), shown here at the cellular level via confocal microscopy. It looks like red and yellow water drops falling
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HHMI @hhmi-science.bsky.social · 28/09/2026
Our bodies create around 330 billion new cells every day through cell division. Andrew Moore at our Janelia Research Campus captured that process in stunning detail — a feat that earned him 4th place in Nikon's 2026 Small World in Motion Competition. bit.ly/4yT5d0k
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HHMI @hhmi-science.bsky.social · 24/09/2026
Congrats to #HHMIInvestigator Catherine Dulac (@harvard.edu), winner of @rockefeller.edu's 2026 Pearl Meister Greengard Prize! Dulac's research changed science's understanding of instinctive behaviors such as mating, parenting, & aggression by revealing the underlying neural circuits: bit.ly/4iHU7Xl
Catherine wearing a flower-print shirt in her office
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HHMI @hhmi-science.bsky.social · 23/09/2026
ERG, activated by gene fusion in ~50% of prostate cancers in men w/European ancestry, was long considered undruggable. Now #HHMIInvestigator Arul Chinnaiyan & co have developed a molecule probe that binds to ERG, killing cancer cells & preventing tissue invasion in preclinical models bit.ly/46wb7bv
Arul Chinnaiyan in a suite in his office
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HHMI @hhmi-science.bsky.social · 22/09/2026
Plant cells have their own language, & #HHMIInvestigator Keiko Torii has spent 30 years decoding it. Her team’s new work on how cells communicate to guide stomatal development — & how plants balance that with pathogen defense — could help scientists develop more resilient crops: bit.ly/4hFvOIy.
HHMI Investigator Keiko Torii in her lab, surrounded by plants.
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HHMI @hhmi-science.bsky.social · 20/09/2026
Snakes evolved resistance to their own venom over millions of years — & now #HHMIInvestigator Sean Carroll & collaborators are harnessing vipers' toxin-blocking proteins to build a better antivenom. In lab tests, optimized combinations were ~10x more potent than current treatments bit.ly/4bzdwW5
Western diamondback rattlesnake, courtesy of Sean Carroll.
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HHMI @hhmi-science.bsky.social · 19/09/2026
Lighting up your screen: a larval zebrafish's cellular activity. Developed by researchers at our Janelia Research Campus, WHaloCaMP is a biosensor that detects calcium signals — a key part of cellular communication — & offers a window into how cells & organs work together. 🎥 Helen Farrants, HHMI JRC
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HHMI @hhmi-science.bsky.social · 18/09/2026
Postdoctoral scientist or early career faculty? Registration is now open for our #FreemanHrabowski Scholars & #HannaGray Fellows Programs! Register to check your eligibility & unlock resources like 1:1 office hours, example research proposals, & more. Link on your program page at hhmi.org/programs 🧪
hhmi.org
Becoming an HHMI Scientist | HHMI Science Programs | HHMI
HHMI invests in scientists at all career stages who drive biomedical research, expand the pool of scientific talent, and make discoveries that advance human health for decades to come.
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HHMI @hhmi-science.bsky.social · 18/09/2026
For #GilliamFellow Angelique Allen, questions about how the brain perceives the world started in the air & undersea. Her take on Gilliam? “Full of people who care about each other & are trying to push each other — & the boundaries of science.” Applications close 10/27! bit.ly/gilliam26
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HHMI @hhmi-science.bsky.social · 17/09/2026
Congratulations to #HHMIInvestigator Edward Chouchani (danafarber.bsky.social), recipient of @asbmb.bsky.social sky.social’s Earl and Thressa Stadtman Young Scholar Award — an honor recognizing early career excellence in biochemistry & molecular biology: bit.ly/4xg9hGI.
Earl and Theressa Stadtman Young Scholar Award
Edward Chouchani
HHMI Investigator
Dana-Farber Cancer Institute
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HHMI @hhmi-science.bsky.social · 16/09/2026
(1/2) Serious science, unexpected fun. A fruit fly wiring diagram from our Janelia Research Campus & collaborators is being used to play Minecraft, parallel park (badly), & dance to '70s disco. That’s the joy of open science. More from @nytimes.com: bit.ly/4htsTm6.
The wiring diagram of the central nervous system of an adult male fruit fly will help researchers better understand how the brain enables complex action, from sensory perception to behavior. Credit: Data acquired and analyzed by the FlyEM Project Team at HHMI’s Janelia Research Campus, the Cambridge Connectomics Group, and Google Research. Image by Philip Hubbard/HHMI Janelia Research Campus
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HHMI @hhmi-science.bsky.social · 09/09/2026
An animal’s body is in constant conversation with itself — & HHMI Janelia scientists have built a way to listen in. WHOLISTIC simultaneously records real-time activity from nearly every cell in a living larval zebrafish, a 1st step in understanding more complex bodies like ours: bit.ly/4xMR1Ww.
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HHMI @hhmi-science.bsky.social · 03/09/2026
(1/2) When Janelia set out to map every neuron in the fly brain in 2008, many thought it couldn’t be done. Nearly 20 years later, a complete wiring diagram of the 166,000+ neurons of the adult male fruit fly is helping to reveal the brain’s secrets: bit.ly/4zT7jPf.
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HHMI @hhmi-science.bsky.social · 02/09/2026
Proud to recognize #HHMIInvestigator Huda Zoghbi, a 2026 recipient of @columbiauniversity.bsky.social's Louisa Gross Horwitz Prize. Her pioneering epigenetics work, particularly in Rett syndrome, helped transform our understanding of how gene regulation drives brain disease: bit.ly/4x1xvEA.
2026 Louisa Gross Horwitz Prize
Huda Y. Zoghbi
HHMI Investigator, Baylor College of Medicine
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HHMI @hhmi-science.bsky.social · 01/09/2026
Celebrating #HHMIInvestigator Bonnie Bassler, winner of the @royalsociety.org’s '26 Copley Medal. Her discovery that bacteria communicate & coordinate with each other, known as quorum sensing, is paving the way for therapies that fight infection by disrupting that communication: bit.ly/4zV2fKg.
2026 recipient of the Royal Society's Copley Medal
Bonnie Bassler
HHMI Investigator
Princeton University
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HHMI @hhmi-science.bsky.social · 01/09/2026
Calling all 2nd- & 3rd-year PhD students in the biological/biomedical sciences: #GilliamFellows applications are NOW OPEN! Robust research support, an incredible scientific community, & professional development for you & your mentor. But don’t just take *our* word for it: bit.ly/gilliam26. 🧪
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HHMI @hhmi-science.bsky.social · 28/08/2026
Antibiotic resistance isn't just a genetic problem; it's ecological. New research from #HHMIInvestigator Harmit Malik & co shows that when a dangerous bacterium shares space w/a common fungus, it can be pushed toward resistance it wouldn't develop alone — but with a built-in weakness bit.ly/4g1jLnZ
Photo of Harmit Malik
Credit: Fred Hutch Cancer Center
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HHMI @hhmi-science.bsky.social · 27/08/2026
(1/2) "Everything’s going to change.” Meet the Model Hardware Standard: Begun as a collaboration between our Janelia Research Campus & @anthropic.com, MHS allows AI agents to safely operate physical equipment in scientific research & advanced manufacturing: bit.ly/4wPWWsM.
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HHMI @hhmi-science.bsky.social · 26/08/2026
A new molecular shuttle developed by #HHMIInvestigator Viviana Gradinaru & team offers a better way to transport a broad range of medicines across the brain’s protective blood-brain barrier, potentially enabling the delivery of targeted, life-changing therapies to the brain: bit.ly/4y21v47.
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HHMI @hhmi-science.bsky.social · 24/08/2026
Smarter in 90 seconds? EASY — just crash a meetup of our NYC-area Cech Fellows. Psst: Rising junior or senior? Apps for our ‘27 Cech Fellows Program open 11/10! hhmi.org/cechfellows Facts via Ava B, Axel BC, Brooke H, Clara P, Djina A, Isaiah B, Marissa W, Naiara G, Norah H, Shafin J, and Yael F.
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HHMI @hhmi-science.bsky.social · 23/08/2026
2 genetically identical mice. Same infection, same bacterial load, but only 1 lives. Why? #HHMIInvestigator Janelle Ayres spent decades finding out, & her answer — survival can come through cooperating w/pathogens, not just killing them — could reshape how we treat infectious disease: bit.ly/4qsuWJW
Janelle Ayres in her lab.
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HHMI @hhmi-science.bsky.social · 22/08/2026
Confocal microscopy captures one thin layer of a sample at a time, revealing structures other imaging methods can miss. Imaged by Igor Siwanowicz at our Janelia Research Campus, this view of the underside of a bitter bolete mushroom cap demonstrates the technique's power in awe-inspiring detail.
Confocal microscopy image of the underside of a bitter bolete mushroom cap against a black background. Dense rows of elongated blue tube-like structures — the spore-bearing cells (basidia) — curve in an arc from upper right to lower frame. Along their inner edge, clusters of orange and yellow globular structures are scattered among smaller bright yellow droplets. Isolated bright red oval shapes appear at the lower left. The overall composition is strikingly ornate, revealing microscopic detail invisible to the naked eye.
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HHMI @hhmi-science.bsky.social · 21/08/2026
When discoveries about chromatin remodeling complexes sparked a drug development frenzy, #HHMIInvestigator Cigall Kadoch took a different path — a methodical, decade-long approach that's now laying the groundwork for a new class of precision cancer therapeutics: bit.ly/45nXJFP.
Image of Cigall Kadoch in her lab
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Reposted by HHMI
National Academy of Sciences @nasonline.org · 20/08/2026
What if we could stop malaria without eliminating mosquitoes? 🦟 On #WorldMosquitoDay, learn how #NASmember Flaminia Catteruccia is developing bed nets that target malaria parasites inside mosquitoes before they infect people. Read in @hhmi-science.bsky.social: www.hhmi.org/news/antimal...
hhmi.org
A New Front in the Fight Against Malaria | HHMI
HHMI Investigator Flaminia Catteruccia is betting that the key to beating malaria lies not in killing mosquitoes, but in defeating the parasite inside them.
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HHMI @hhmi-science.bsky.social · 20/08/2026
Hesitating to apply? #GilliamFellow Tyreek Jenkins can relate. Smaller institution, in a small lab, "You're always facing the imposture syndrome. But if you're passionate about your research … that's enough." 2nd-/3rd-year PhD students: Apps open 9/1 for our biggest cohort yet! bit.ly/gilliam26
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HHMI @hhmi-science.bsky.social · 11/08/2026
Congratulations to #HHMIInvestigator Jennifer Doudna (@ucberkeleyofficial.bsky.social), named a 2026 @acs.org Fellow in recognition of her outstanding achievements & contributions to science: bit.ly/4wqSXTp.
2026 American Chemical Society Fellow
Jennifer A. Doudna
HHMI Investigator
University of California, Berkeley
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HHMI @hhmi-science.bsky.social · 11/08/2026
Proud to celebrate @ascbiology.bsky.social’s recognition of #HHMIInvestigator Diana Bautista with the E.E. Just Lecture Award & HHMI Janelia Group Leader Jiefu Li with the Günter Blobel Early Career Award — for research, mentorship, & leadership shaping the future of cell biology: bit.ly/4gpXJvp.
2026 ASCB Honorific Awards
Diana Bautista, HHMI Investigator, University of California, Berkeley
Jiefu Li, Group Leader, HHMI Janelia Research Campus
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HHMI @hhmi-science.bsky.social · 10/08/2026
Meet Janelia Group Leader Ann Hermundstad, now Head of Theory@HHMI. Our newest HHMI Janelia Initiative joins Biology, Tools@HHMI, & AI@HHMI in advancing Janelia’s mission to understand how the brain generates behavior, & in strengthening scientific capability across HHMI: bit.ly/3Stxg73.
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HHMI @hhmi-science.bsky.social · 07/08/2026
Inside a lava lamp? Nope — better. Cryo-CLEM (cryo-correlative light & electron microscopy) is an imaging technique developed by Janelia researchers & #HHMIInvestigator Eric Betzig. Orange blobs = 2 kidney cells; within, endoplasmic reticulum (green) & mitochondria (purple). 📸: Hess & Betzig
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HHMI @hhmi-science.bsky.social · 06/08/2026
Malaria kills 600K people a year — #HHMIInvestigator Flaminia Catteruccia & team @hsph.harvard.edu are opening a new front in the fight against it w/2 compounds engineered to disrupt malaria parasites before they can be transmitted to humans. Field tests begin in Ethiopia this fall bit.ly/4wE0LBW
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HHMI @hhmi-science.bsky.social · 06/08/2026
When zebra finches sleep, their brains keep singing — but not the song you'd expect. #FreemanHrabowski Scholar Walter Gonzalez & team found birds dream in songs they've never sung awake, offering a window into how brains learn, & potentially how conditions like schizophrenia develop: bit.ly/4geBCYF
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HHMI @hhmi-science.bsky.social · 03/08/2026
20 yrs ago, #HHMIInvestigator Helen Hobbs & collaborators ID'd gene mutations that lower “bad” cholesterol & heart disease risk — a groundbreaking discovery now powering a new cholesterol-lowering pill & genetic treatments aimed at combating the #1 cause of death in the US: bit.ly/4w0WasB
bit.ly
A tiny pill could beat the world’s biggest killer
Americans today are dramatically less likely to die of heart disease than they were just a few generations ago.
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Reposted by HHMI
Julia Belk @juliabelk.bsky.social · 30/07/2026
Gaining therapeutic access to the human brain is one of the biggest unsolved problems in biomedical science. Today @nature.com, we uncover a massive influx of immune cells into the human brain during aging, revealing that the brain is more accessible than previously thought. 1/
nature.com
Somatic mutations reveal the ontogeny of microglia in human aging - Nature
Nature - Somatic mutations reveal the ontogeny of microglia in human aging
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HHMI @hhmi-science.bsky.social · 26/07/2026
For years the citrus mealybug was a mystery: essential genes seemed to be missing. Now #HHMIInvestigator John McCutcheon, #HannaGray Fellow Jessica Warren, & team have found them — tucked onto the mirror strand of DNA already carrying another gene. bit.ly/44sh3BH
Image of a citrus mealybug
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HHMI @hhmi-science.bsky.social · 22/07/2026
Scientists long thought they knew what drives skin renewal — now #HHMIInvestigator Valentina Greco (@yaleschoolofmed.bsky.social) and collaborators have upended a 50-year-old assumption, and their findings could unlock new treatments for chronic wounds and aging skin: bit.ly/3SQXHU6
A fibroblast (green) with the outermost layer of skin (red) and collagen fibers (blue). Courtesy of Shuangshuang Du.
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HHMI @hhmi-science.bsky.social · 21/07/2026
Thinking about applying to become a #FreemanHrabowski Scholar, #HannaGray Fellow, or #GilliamFellow? Our Science Programs team went live to cover key program details, elements of a strong application, & to take your questions. Watch the replay! bit.ly/4gS5DOM 🧪
bit.ly
Becoming an HHMI Scientist (for Potential Program Applicants)
HHMI's June 2026 live virtual event was a chance for early career scientists to learn more and ask questions about HHMI's upcoming competitions — the Freeman Hrabowski Scholars and Hanna H. Gray Fellows Programs (applications open Nov. 3, 2026), and the Gilliam Fellows Program (applications open Sept. 1, 2026) — which provide generous support to scientists from graduate training through the early faculty years. Featuring Vice President and Chief Scientific Officer Leslie Vosshall; Scientific Program Officers Josh Hall, Angela DePace, and Jose Faraldo-Gomez; and Senior Science Program Coordinator Adrielle Munger, the event covered everything from the details of each program to what HHMI looks for in candidates, and key elements of a strong application. Visit hhmi.org/programs to learn more, and stay connected via email (https://www.hhmi.org/newsletters) and social (below) for regular updates. _____ Follow HHMI https://www.instagram.com/hhmi_science/ https://www.linkedin.com/company/howard-hughes-medical-institute https://www.facebook.com/HowardHughesMed https://x.com/hhmi_science Bluesky: https://bsky.app/profile/hhmi-science.bsky.social
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HHMI @hhmi-science.bsky.social · 20/07/2026
"We have no business applying to this," #GilliamFellow Sara Makanani told her PI. Her mentor’s reply? "We are worthy of this." // 2nd- or 3rd-year PhD student? Talk to your faculty advisor — apps open 9/1 for our BIGGEST cohort of mentee-mentor pairs yet! bit.ly/gilliam26
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HHMI @hhmi-science.bsky.social · 17/07/2026
This radiating honeycomb is the glass skeleton of a diatom, captured via confocal microscopy from marine sediment off Namibia's coast. Invisible to the naked eye, diatoms & other phytoplankton produce 20%–50% of Earth's oxygen every year. 📷: Igor Siwanowicz, Janelia Research Campus.
Microscopy image of a diatom viewed head-on against a black background, revealing an intricate honeycomb-like silica shell (frustule) in extraordinary detail. Thousands of tiny hexagonal pores cover the circular surface, transitioning from warm amber and gold at the top to vivid teal and blue-green toward the center and bottom. A delicate starburst or rosette pattern is visible at the lower center, converging on a single dark central point. The overall effect is geometric and jewel-like, resembling stained glass or a mosaic.
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HHMI @hhmi-science.bsky.social · 13/07/2026
#FreemanHrabowski Scholar Bianca Jones Marlin is uncovering how sensory cues like a pup’s cry activate oxytocin & reshape neural circuits, enabling caregiving — even in mice that have never given birth. Her research also suggests some experiences may be biologically inherited: bit.ly/4pjJISL
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HHMI @hhmi-science.bsky.social · 13/07/2026
Bone grows from the inside out, and this fluorescence micrograph of a developing mouse femur reveals the choreography underneath: osteoclasts (red) clear cartilage (purple) to make room for blood vessels (yellow), marrow, and new bone. 📸 Paul R. Odgren, @umasschan.bsky.social
Fluorescence micrograph of a cross-section through a developing mouse femur. At the center, densely packed yellow-gold structures — blood vessels — are surrounded by a luminous white interior. Blue-gray osteoclasts ring the inner cavity, and vivid red tissue forms the outer boundary of the developing bone. The surrounding tissue fades to soft purple and pink at the edges. The overall composition is circular and jewel-like, resembling an abstract painting.
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HHMI @hhmi-science.bsky.social · 07/07/2026
Discoveries can hide in plain sight. #HHMIInvestigator Steven Henikoff's lab found a surprise when revisiting their old data: a region of ribosomal DNA producing microRNAs that can be associated with cancer, revealing a new role for part of the genome overlooked for decades: bit.ly/3RQwTmy.
Steven Henikoff in his lab
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HHMI @hhmi-science.bsky.social · 04/07/2026
Our kind of fireworks: fruit fly neurons stacked in a rapid succession of rainbow colors. This video shows a small sampling of the more than 135,000 neurons in a typical fruit fly's brain, imaged by researchers at our Janelia Research Campus using multicolor flipout technique 🎆
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HHMI @hhmi-science.bsky.social · 30/06/2026
Proud to celebrate #HHMIInvestigator Rachel Green’s (@jhu.edu) election as an Associate Member to @embo.org — a lifelong honor recognizing research excellence & outstanding achievements in the life sciences: bit.ly/4aZ3Kfs.
Newly Elected EMBO Associate Member 
Rachel Green
HHMI Investigator
Johns Hopkins University
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HHMI @hhmi-science.bsky.social · 30/06/2026
Misfolded tau proteins spread between cells & form toxic clumps that drive Alzheimer's, Parkinson's, ALS & more. #HHMIInvestigator Roy Parker's team found a way to target them in real time, reducing their growth & improving brain function in mouse models: bit.ly/4aklodm.
A neuron with clumps of tau (bright dots). Courtesy Kathleen McCann, Parker Lab.
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HHMI @hhmi-science.bsky.social · 29/06/2026
Over a 32-year career as an #HHMIInvestigator, Connie Cepko (@harvardmed.bsky.social) helped transform how we understand the retina, and how blindness might be treated. Her advice? "If you have a novel idea you believe in, go for it." bit.ly/4gN9Zqp
Connie Cepko in her lab
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HHMI @hhmi-science.bsky.social · 28/06/2026
These stunning single-celled organisms can shape-shift & regenerate. Their trumpet-like shape inspired their name: stentor, after the herald in Greek mythology known for his booming voice. 📸: Confocal microscopy by Igor Siwanowicz, HHMI’s Janelia Research Campus
Three stentors
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HHMI @hhmi-science.bsky.social · 25/06/2026
100+ years after “Hechtian structures” were discovered, #HHMIInvestigator José Dinneny & co. have ID'd the purpose of tiny anchors that secure plant cell membranes to their walls — a finding that could help scientists improve crops' drought resistance: bit.ly/3Q7hVbh
Arabidopsis thaliana, grown in the Dinneny lab. Courtesy Yue Rui.
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HHMI @hhmi-science.bsky.social · 23/06/2026
Analyzing large datasets is one of the messiest, most complicated parts of lipid research. So #HHMIInvestigator Tobias Walther's lab @mskcancercenter.bsky.social built LipidCruncher: a free, open-source, step-by-step platform that makes results easier to reproduce & share: bit.ly/3QWca0o.
Tobias Walther in his lab
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HHMI @hhmi-science.bsky.social · 22/06/2026
Could we reprogram the immune system to fight the effects of aging? #FreemanHrabowski Scholar Corina Amor Vegas & team engineered CAR-T cells to recognize & destroy "zombie cells" that accumulate during aging & drive inflammation, frailty, & metabolic decline: bit.ly/4xkeeQh
Corina Amor Vegas in her lab
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