The generation of functional viral genomes has urgent biosafety and biosecurity implications

Fearless molecular biologist who revealed the workings of antibodies and memories.

Transmissible tumors have been reported in a handful of animal species, but never before among fish. Is it possible in humans?

Oatman et al. introduce PyCLM, a Python suite for closed-loop optogenetic experiments combining real-time biosensor measurement and segmentation of thousands of cells. The method is applied to epithel...

Phylogenomic reconstruction of the proteome of the last eukaryotic common ancestor sheds light on the origin of eukaryotes, indicating an important role of horizontal transfer of genes from diverse bacterial and viral donors.

Chen et al. engineer TRANSFER (trogocytosis-inspired receptor transfer and functional effector release), a method to deliver functional cargos from donor to recipient cells in a specific manner via di...

OMEGA enables scalable, low-cost construction of large gene libraries using multiplexed Golden Gate assembly.

Galvanin is an electric-field sensor that links electrical cues to directed migration in rapidly moving cells.

As the British naturalist celebrates a milestone birthday, we take a look at how his work has shaped science.

New evidence suggests that diffusive oxygen transport through the tracheolar–muscle system is not the limiting factor on insect body size.

Mapping behavior of individual vertebrate animals across lifespan could provide an unprecedented view into the lifelong process of aging. We created a platform for high-resolution continuous behaviora...

Peptides are sequenced by converting each amino acid into amplifiable DNA barcodes.

Optovolution leverages optogenetics and the yeast cell cycle to impose rapid, tunable selection, enabling the continuous evolution of light-responsive regulators, logic gates, and other complex protei...

Early mammals were nocturnal while dinosaurs dominated the daytime. Mammalian transition to daytime activity accelerated after the Cretaceous-Paleogene extinction, but the underlying mechanisms remain...

Imbalances in the human gut microbiome, or dysbioses, are associated with multiple diseases but remain poorly understood. Existing biomarkers of dysbiosis fail to capture the ecological mechanisms tha...

Inducible translocation to subcellular compartments is a common strategy for protein switches that control a variety of cell behaviors. However, existing switches achieve translocation through induced...

Inducible translocation to subcellular compartments is a common strategy for protein switches that control a variety of cell behaviors. However, existing switches achieve translocation through induced...

Nature - Scalable and multiplexed recorders of gene regulation dynamics across weeks

Understanding how cells make decisions over time requires the ability to link past molecular states to future phenotypic outcomes. We present TimeVault, a genetically encoded system that records and s...

Conformational biasing (CB) is a rapid and streamlined computational method that uses contrastive scoring by inverse folding models to predict protein variants biased toward desired conformational sta...

Competitive dimerization networks, in which protein monomers dimerize in various combinations, can perform diverse biochemical computations and can adapt those computations for different cell contexts...

Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...

Wang et al. establish an in vivo proteomic labeling (IVPL) system combining the Btn-Ph-3F substrate with APEX2-EGFPf/f Cre crosses to map cell-type-specific proteomes in intact organs and trace patien...