Sign in

Gabriel Abrahams

@gabriel-abrahams.bsky.social
677 followers 908 following 34 posts

DPhil student in the Engineered Biotechnology Group, University of Oxford. steel.ac ORCID: 0000-0002-2360-7150

PostsRepliesMedia
Reposted by Gabriel Abrahams
Scott Stacey @scottstacey.bsky.social · 27/05/2026
Very excited to share that our preprint on synthetic bacterial sponge RNAs is now out. This paper is for you if you're interested in RNA synthetic biology, quantitative gene circuit characterisation, resource competition, or post-transcriptional regulation. (1/11)
253
Reposted by Gabriel Abrahams
Julia Lazzari-Dean @jlazzaridean.bsky.social · 12/05/2026
We invented “triplet tumbling microscopy” (TTM) to track protein-protein interactions in living cells! Tag your protein with GFP and see it interact with *untagged* binding partners www.biorxiv.org/content/10.6...
A cartoon overview of triplet tumbling microscopy, comparing data from bound and unbound samples.
416654
Gabriel Abrahams @gabriel-abrahams.bsky.social · 01/05/2026
MagLOV 2 plasmid is (finally!) available on Addgene 🎉🧲🧫 Any GFP capable imaging setup + benchtop power supply + off the shelf electromagnet is all you need to get started - let us know if you need help of course. www.addgene.org/252303/ @andrewgyork.bsky.social @mariaingaramo.bsky.social 🧪
addgene.org
Addgene: pGA-01-47
Plasmid pGA-01-47 from Dr. Harrison Steel's lab contains the insert MagLOV 2 and is published in Nature. 2026 Jan 21. doi: 10.1038/s41586-025-09971-3. This plasmid is available through Addgene.
0156
Reposted by Gabriel Abrahams
Andrew G. York @andrewgyork.bsky.social · 29/04/2026
Meet MagLuc: a magnetically-controlled luminescent protein. This is a foundational tool for remote control of biological processes, also known as "magnetogenetics". Can you tell when the magnetic field turns on and off? From @mariaingaramo.bsky.social and the team at @nonfictionlabs.bsky.social
310138
Gabriel Abrahams @gabriel-abrahams.bsky.social · 22/03/2026
Quantum biological control, now in a multicellular organism! Super exciting to see this work from @scburd.bsky.social et al 🧪
nature.com
Magnetic resonance control of spin-correlated radical pair dynamics in vivo - Nature
Magnetic resonance control of spin-correlated radical pairs alters red fluorescent protein emission in transgenic Caenorhabditis elegans, demonstrating in vivo magnetic field modulation of biomolecula...
1236
Reposted by Gabriel Abrahams
Vera Marie Titze @veratitze.bsky.social · 01/03/2026
Excited to be starting my group “Ecophotonics” with a Minerva FastTrack fellowship! Big thanks to @vignolinilab.bsky.social for your support! Also grateful to my PhD supervisor Malte Gather, and collaborators & students from marine biology to physics. 🧪👩🏼‍🔬💡https://www.mpikg.mpg.de/6920542/ecophotonics
mpikg.mpg.de
“Ecophotonics”:Turning Nature’s Light Management Strategies into Sustainable Technology
4297
Gabriel Abrahams @gabriel-abrahams.bsky.social · 21/01/2026
Magnetically sensitive proteins could lead to new imaging tools and remote-controlled drugs | Science | AAAS 🧪 www.science.org/content/arti...
science.org
Magnetically sensitive proteins could lead to new imaging tools and remote-controlled drugs
New study shows how engineered proteins can be tracked with an MRI-like approach
0114
Gabriel Abrahams @gabriel-abrahams.bsky.social · 21/01/2026
‘Remote controlled’ proteins illuminate living cells www.nature.com/articles/d41... 🧪
nature.com
‘Remote controlled’ proteins illuminate living cells
The discovery that some fluorescent proteins are sensitive to magnets could lead to the development of switchable drugs and biosensors.
044
Gabriel Abrahams @gabriel-abrahams.bsky.social · 21/01/2026
Our research on magneto-sensitive fluorescent proteins and some of their applications has now been published! Huge thank you to the many many people involved in making this happen. 🧪 www.nature.com/articles/s41...
nature.com
Quantum spin resonance in engineered proteins for multimodal sensing - Nature
A recently developed class of magneto-sensitive fluorescent proteins are engineered to alter the properties of their response to magnetic fields and radio frequencies, enabling multimodal sensing of b...
12914
Reposted by Gabriel Abrahams
EngBio CDT @engbiocdt.bsky.social · 20/01/2026
Our next student-led seminar is coming up! Organised by James Bridson (Oxford) & Sam Kemery (Bristol), we’re excited to welcome Assistant Professor Jennifer Brophy as our speaker. Jenn is a plant synthetic biologist at Stanford University. The lab's work explores how the form of a plant affects...
131
Reposted by Gabriel Abrahams
Andrew G. York @andrewgyork.bsky.social · 13/01/2026
Great news! @mariaingaramo.bsky.social 's company (Nonfiction Labs) made a remote-controlled antibody. Its binding turns on and off with a magnet. This is a HUGE step towards our dream of magnetically controlled drugs. Imagine a cancer drug that ONLY attacks the tumor, not the rest of your body.
47620
Reposted by Gabriel Abrahams
Department of Engineering Science, University of Oxford @oxengsci.bsky.social · 24/11/2025
Oxford researchers will lead a new £6M BBSRC-funded project nature’s “quantum compass” to uncover, how animals sense Earth’s magnetic field and turn this knowledge into innovative biotechnologies. 🧭 #QuantumBiology #BBSRC #OxfordResearch Read more: eng.ox.ac.uk/news/new-pro...
The Oxford team: Mark Hankins, Kevin Henbest, Madhavi Krishnan, Harrison Steel, Andrew Baldwin, Justin Benesch, Christiane Timmel, Chris Schofield, Achillefs Kapanidis, Stuart Mackenzie, Stuart Peirson, Sabine Huth-Rauschenbach. Photo credit: Thomas Player, University of Oxford.
041
Reposted by Gabriel Abrahams
Alex Fedorec @ajfedorec.bsky.social · 20/10/2025
1 week left to apply for a postdoctoral position in my group to lead the experimental component of a 5 year BBSRC project on synthetic microbial communities www.ucl.ac.uk/work-at-ucl/...
ucl.ac.uk
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
074
Reposted by Gabriel Abrahams
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 28/09/2025
Generative design of synthetic gene circuits for functional and evolutionary properties www.biorxiv.org/content/10.1101/202…
053
Reposted by Gabriel Abrahams
Oxford Protein Informatics Group (OPIG) @opig.stats.ox.ac.uk · 17/09/2025
🚨 We’re hiring! The OPIG group is looking for multiple postdocs to join OpenBind, an open science initiative generating foundational structural biology data to power the next era of AI/ML for drug discovery. opig.stats.ox.ac.uk openbind.uk
openbind.uk
OpenBind
122
Gabriel Abrahams @gabriel-abrahams.bsky.social · 16/09/2025
www.sciencenews.org/article/biol...
sciencenews.org
Scientists made a biological quantum bit out of a fluorescent protein
Researchers could use quantum effects to develop new types of medical imaging inside cells themselves.
0102
Reposted by Gabriel Abrahams
Michael Booth @drmikebooth.bsky.social · 02/09/2025
We’ve developed the first-ever method to control nucleic acid activity and gene-expressing synthetic cells with a deeply tissue penetrating alternating magnetic field 🧬 🧪 🧲!!! Published in *Nature Chemistry* Led by Ellen Parkes @syncelleu.bsky.social #chemsky www.nature.com/articles/s41...
nature.com
Magnetic activation of spherical nucleic acids enables the remote control of synthetic cells - Nature Chemistry
The programmability of synthetic cells, comprising lipid vesicles that are capable of imitating the structure and function of living cells, facilitates their application as drug delivery devices. Now,...
66115
Gabriel Abrahams @gabriel-abrahams.bsky.social · 21/08/2025
MagLOV quantum sensing update! Much improved imaging (>10% single cell ODMR contrast), detailed characterisation and simulation, and new experimental demonstrations taking us a step closer to applications. www.biorxiv.org/content/10.1... SI: www.biorxiv.org/content/10.1...
A. Structure of AsLOV2 PDB~2V1A (Halavaty, 2007) with mutations resulting in MagLOV~2 highlighted. Spin transitions driven by radio-frequency (RF) fields in the presence of a static magnetic field are optically detected via fluorescence measurements on an otherwise standard widefield microscope. Similar effects have recently been observed in other protein systems (Burd 2025, Meng 2025, Feder 2025).
B. Simplified photocycle diagram in the case of a large external magnetic field.
C. A single cell expressing MagLOV 2 displaying an MFE of ~50% (measured as a change in fluorescence intensity in the presence of an applied field). For MFE measurements, the magnetic field was switched  between 0 mT and 10 mT.
D. Black dots: data from a single cell expressing MagLOV 2 displaying an ODMR signal with ~10% contrast. The static field B_0 is ~21.6 mT. Blue line (shade): the mean (std) of all single cell data in a field of view (~1000 cells). 
E. The static magnetic field B_0 was varied by adjusting the magnet's position, and ODMR spectra recorded. Red-lines are Lorentzian fits. Blue line is a theoretical prediction (i.e. is not a fit) of the expected resonance frequency of an electron spin with $\bar\gamma_e$=28 MHz/mT.
Electronics, radio electronics, optical parts, and an animal sized MRI coil are assembled to perform fluorescence MRI measurements using MagLOV.
0102
Reposted by Gabriel Abrahams
adamezracohen.bsky.social @adamezracohen.bsky.social · 15/05/2025
Now out in JACS. pubs.acs.org/doi/full/10.... Grateful to thoughtful reviewers who found some errors in our model and encouraged us to make a better one! A renaissance in magnetobiology is coming...
pubs.acs.org
Mechanism of Giant Magnetic Field Effect in a Red Fluorescent Protein
Several fluorescent proteins, when expressed in E. coli, are sensitive to weak magnetic fields. We found that mScarlet3 fluorescence in E. coli reversibly decreased by 21% in the presence of a 60 mT m...
0257
Reposted by Gabriel Abrahams
Michelle Frei @michellefrei17.bsky.social · 08/04/2025
My lab at @ethzurich.bsky.social is looking for a motivated PhD student. We develop chemical tools for advanced fluorescence microscopy 🔬 and work at the interface of synthetic chemistry ⚗️ and protein engineering 🦠. Sharing with skilled Master students appreciated. More info at tinyurl.com/2dbjk5ty
Advertisement for PhD position
12418
Reposted by Gabriel Abrahams
Kirill Sechkar @ksechkar.bsky.social · 04/04/2025
NEW PREPRINT! Do you think we can do better when characterising resource competition properties of gene circuit modules? If no, think again; if yes, you’re in for a pitch how exactly we can do that – automated culturing, cybergenetic control and all! 1/ doi.org/10.1101/2025...
164
Gabriel Abrahams @gabriel-abrahams.bsky.social · 14/03/2025
New spin resonance measurements with fluorescent proteins out this month from Burd et al., following the still mind-blowing result from @andrewgyork.bsky.social and @mariaingaramo.bsky.social that if you create a selection pressure for a quantum system, nature will oblige! 🧪
120
Reposted by Gabriel Abrahams
Michael Booth @drmikebooth.bsky.social · 12/03/2025
New preprint 🎇 We developed oligonucleotide PROTACs (OligoPROTACs), which show comparable activity to small molecule equivalents - but can be *switched off*, using DNA nanotech, to restore protein levels! Last of Disha's trilogy! #chemsky 🧪 @uclchemistry.bsky.social chemrxiv.org/engage/chemr...
chemrxiv.org
DNA-programmable Protein Degradation: Dynamic Control of PROTAC Activity via DNA Hybridization and Strand Displacement
Targeted protein degradation is a powerful therapeutic approach: expanding the druggable proteome, providing enhanced selectivity, and having the ability to overcome conventional resistance mechanisms...
1287
Reposted by Gabriel Abrahams
adamezracohen.bsky.social @adamezracohen.bsky.social · 28/02/2025
How do tiny magnetic fields affect biochemistry? Overflowing with pride over Katherine Xiang's study on a giant magnetic field effect in a red fluorescent protein, www.biorxiv.org/content/10.1...
biorxiv.org
Mechanism of giant magnetic field effect in fluorescence of mScarlet3, a red fluorescent protein
Several fluorescent proteins, when expressed in E. coli, are sensitive to weak magnetic fields1. We found that mScarlet3 fluorescence in E. coli reversibly decreased by 21% in the presence of a 60 mT ...
14117
Reposted by Gabriel Abrahams
Michael Baym @baym.lol · 21/02/2025
Legitmately thrilled to share our latest work, in which @fernpizza.bsky.social solved an experimental challenge in plasmid biology as old as the field: measuring how plasmids compete and evolve within individual cells!
521887
Reposted by Gabriel Abrahams
Madhu Pai, MD, PhD @madhupai.bsky.social · 21/02/2025
Bravo @plos.org! US exec orders "stand in direct conflict with our core values, our mission, edit policies" "PLOS will not compromise on issues of scientific rigor & editorial integrity... we seek diversity because more expert voices make for better science" theplosblog.plos.org/2025/02/plos...
theplosblog.plos.org
PLOS statement on recent US Executive Orders and scientific integrity - The Official PLOS Blog
Since its founding over twenty five years ago PLOS has been dedicated to advancing open science, ensuring that knowledge is accessible to…
2353115
Reposted by Gabriel Abrahams
Santiago Elena @sfelena.bsky.social · 20/02/2025
Experimental evolution of evolvability | Science www.science.org/doi/10.1126/...
science.org
Experimental evolution of evolvability
Evolvability—the capacity to generate adaptive variation—is a trait that can itself evolve through natural selection. However, the idea that mutation can become biased toward adaptive outcomes remains...
016180
Reposted by Gabriel Abrahams
Stefan Holderbach @sholderbach.bsky.social · 14/02/2025
This Valentine's day I want to share the LOV2 with you! ❤️ Roses are red, the light is blue, stimuli are read by the domain LOV2.
Red colored protein model of the Avena sativa LOV2 domain (PDBID: 7PGY)
132
Gabriel Abrahams @gabriel-abrahams.bsky.social · 13/02/2025
My lab does cool stuff 👇
010
Reposted by Gabriel Abrahams
Thomas Gorochowski @chofski.bsky.social · 01/02/2025
Looking for a #PhD that is at the intersection of #biodesign, #synbio, #openendedness, #evolution? Look no further. Great supervisory team too 😉
11518
Reposted by Gabriel Abrahams
ilesla.bsky.social @ilesla.bsky.social · 16/01/2025
Two weeks to go until the application deadline for ILESLA. If you or anyone you know would benefit from full funding to carry out a PhD in Life and/or Environmental Science please visit/refer to our website page iles.web.ox.ac.uk/how-apply where you can see open day videos and get full guidance.
iles.web.ox.ac.uk
How to Apply and Funding
12027
Reposted by Gabriel Abrahams
Marc Somssich @somssich.bsky.social · 20/05/2024
Do you know who Douglas Prasher is? Many don't, even though he is the person who cloned the original #GFP gene in the late 1980s. In my short history of plant light #microscopy I also cover a bit of his story - & why he is relatively unknown today, despite the importance of his work. See this 🧵👇
A profile picture of Douglas Prasher from Martin Chalfie's Nobel Lecture
3288150
Reposted by Gabriel Abrahams
Michael Booth @drmikebooth.bsky.social · 13/12/2024
The one time @theguardian.com could rightly use a left-handed DNA image... and they choose right-handed 🤦🏻‍♂️🤦🏻‍♂️🤦🏻‍♂️ @iansample.bsky.social
313322
Reposted by Gabriel Abrahams
Alex Fedorec @ajfedorec.bsky.social · 28/11/2024
Reflecting on the two days of #sbuk24 talks on the very slow journey home, I think my favourite was Scott Stacey from Harrison Steel's group. Lovely demonstration of complexity built from simple biology that needs modelling to fully understand an unexpected result
media.tenor.com
a man in a suit and tie is smiling in front of a pile of food with gif-finder.com in the corner
ALT: a man in a suit and tie is smiling in front of a pile of food with gif-finder.com in the corner
2102
Reposted by Gabriel Abrahams
Thomas Gorochowski @chofski.bsky.social · 28/11/2024
Goooo @georgiehs.bsky.social!
081
Reposted by Gabriel Abrahams
Alex Fedorec @ajfedorec.bsky.social · 28/11/2024
Day 2 of #sbuk24 starts with a session on control opened by Harrison Steel. Lots of excellent stuff (as usual), from directed evolution in microfluidics to "magnetogenetics"
1111
Reposted by Gabriel Abrahams
Alex Fedorec @ajfedorec.bsky.social · 28/11/2024
Scott Stacey uses sponge RNAs to control synthetic circuits but finds some unexpected resource competition #sbuk24
121
Gabriel Abrahams @gabriel-abrahams.bsky.social · 28/11/2024
Some exciting results to share! The MagLOV and related proteins from @andrewgyork.bsky.social and @mariaingaramo.bsky.social are quantum. We measured 4% optically detected magnetic resonance contrast in living bacterial cells at room temperature. www.biorxiv.org/content/10.1...
A. Structure of AsLOV2 [PDB 2V1A] with mutations resutling in MagLOV~2 highlighted. For the first time, quantum sensing in living cells using a fluorescent protein-based sensor can be performed by driving spin transitions using radio-frequency (RF) fields in the presence of a static magnetic field. B. Simplified photocycle diagram in the case of a large external magnetic field. 
C. Microscope image cropped to a single cell expressing MagLOV 2. Scalebar is 1 um.
D. For MFE measurements the magnetic field was modulated between 0 mT and 10 mT, here with a period 10 seconds. The intensity over time is integrated over pixels covering the single cell, with an exponential decay (due to photobleaching) removed.
E. A single cell expressing MagLOV 2 displaying an ODMR signal 4% contrast.
6209
Reposted by Gabriel Abrahams
Kirill Sechkar @ksechkar.bsky.social · 28/11/2024
The Biochemical Society's #SBUK2024 conference: Day 2 Starting in a few minutes with a session on Control Systems, which among other things includes 2 (two!) talks from our Steel Lab 1/multiple #BiochemEvent
111
Reposted by Gabriel Abrahams
Michael Prattes @hexamergraphics.bsky.social · 24/11/2024
Hi Bluesky 👋 I thought, I'd say hello with a protein butterfly 🦋 (pdb 6of3) I'm a scientist, graphic designer, blender enthusiast, science communicator, media relations specialist ... a bit of everything. Looking forward to the journey here! 🎶 "blue skies, smiling at me, nothing but blue skies ..."
A protein structure that is shaped like a butterfly on toon style with a white body and blue wings, both with black outlines. Below the words "Hello, Bluesky!".
48110
Reposted by Gabriel Abrahams
Joachim Goedhart @joachimgoedhart.bsky.social · 11/11/2024
Here's a starter pack that focuses on engineers/builders/makers/enablers of optical tools for (cell) biology. I'm pretty sure that the pack is incomplete - if you want to join the list, please reply with your favorite probe (that you made or used) and I'll add you 🤓 go.bsky.app/2YVvYER
5417568
Gabriel Abrahams @gabriel-abrahams.bsky.social · 20/11/2024
Q: I've been asked by a theoretical physicist (think spin models) about transitioning to biology. There are so many important & hard problems to tackle (eg designing dynamic proteins and enzymes, understanding folding), but is there need for new theory or is it all about getting more data & ML? 🧪
110