Priming of CD8+ T cells by peripheral dendritic cells exacerbates tau-mediated neurodegeneration *Speaker: Hao Hu (Washington University in St. Louis) *Moderator: Jerry Lin (Massachusetts General…

Immune plasticity during the perinatal period enables mammalian offspring to successfully navigate the transition from prenatal, intrauterine life to postnatal, extrauterine life. This Review highligh...

The metabolic state of NK cells affects their innate immune function, and although cell-intrinsic pathways are better known, their cellular environment could provide cues that are less studied. Here t...

SERPINE1 and SERPINB2-driven fibrin-rich niches locally programme immunosuppressive macrophages and exclude T cells, enabling spatially organized immune evasion in pancreatic ductal carcinoma.

Speaker: Julia Belk Title: Microglia replacement during human aging Paper: Somatic mutations reveal the ontogeny of microglia in human aging (Nature 2026)

Tissue mitochondrial activity controls macrophage abundance by regulating CSF1 availability, thereby enabling efficient waste removal.

Speaker: Jing Chen Paper: Transcription factor Maf promotes expression of repressor Zeb2 to drive microglia development in primitive hematopoiesis (Immunity 2026) Moderator: Anna Salamero Boix (Open…

Researchers from Cambridge and Basel have developed small molecules that could make cancer immunotherapies more effective. They work in two ways: They prompt macrophages to engulf cancer cells and alt...

Neurons actively shape immune responses that maintain central nervous system integrity. We identify SPP1 (secreted phosphoprotein 1) as a neuron-derived signal that reprograms microglia into a neuropr...

Most individuals infected with Mycobacterium tuberculosis never develop active disease, yet the airway immune events determining outcome remain poorly understood. Branchett and colleagues prospectively profiled bronchoalveolar lavage from recent tuberculosis contacts, revealing that progression reflects a dynamic competition between opposing local immune states rather than a single immunological failure.

In this study, Pinto et al. reveal early postnatal life as a critical window in which fetal-derived CX3CR1+ cells and AQP1+ intermediates establish the synovial macrophage lining. This work shows how ...

In this study, Miserocchi et al. find that Tgf-β receptor signaling is a conserved, cell-intrinsic regulator of microglial differentiation in zebrafish. Disrupting this pathway blocks acquisition and ...

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Reviewers may use AI to support their evaluation, but it must not replace their own judgment. Proposal data must remain confidential.

Mitochondria drive cellular reprogramming by integrating metabolism and signaling. In macrophages, mitochondria are central to immunometabolic responses to external cues, but the extent to which they ...