Nature Reviews Cancer, Published online: 16 January 2026; doi:10.1038/s41568-025-00905-9Pancreatic ductal adenocarcinoma is defined by a fibroinflammatory microenvironment, which influences both disease progression and therapy response. In this Review, Arnold et al. outline our current understanding of the complex interplay between the stromal elements of the tumour microenvironment in pancreatic ductal adenocarcinoma and present ways we might use this knowledge to develop better therapeutic strategies for patients with pancreatic cancer.

Nature Biomedical Engineering - This Review explores strategies for targeting and tracking RNA-LNP drugs, monitoring their in vivo behaviour, enhancing tissue-specific delivery, and using synthetic...

Eventbrite - Precision Immunology Institute at the Icahn School of Medicine presents International Course of Immunotherapy March 10-12, 2025 - Monday, March 10, 2025 | Wednesday, March 12, 2025 - Find...

Cancer-derived paracrine factors create distinct “neighborhoods” in the tumor microenvironment, promoting clonal selection and tumor heterogeneity. In ovarian cancer, IL-4 originating from a minority ...

Branched organoids embedded in collagen gels can recapitulate the phenotypic landscape and pronounced molecular and morphological heterogeneity of pancreatic ductal adenocarcinoma.

Inflammatory monocytes are identified as important players in T cell restimulation in the tumour microenvironment.