SERPINE1 and SERPINB2-driven fibrin-rich niches locally programme immunosuppressive macrophages and exclude T cells, enabling spatially organized immune evasion in pancreatic ductal carcinoma.

Tertiary lymphoid structures (TLSs) are associated with immunotherapy response, yet the mechanisms controlling their formation and maintenance remain unclear. Using spatial transcriptomics and multipl...

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Park and colleagues propose a conceptual framework in which dysregulation of resident tissue macrophages is both a central contributor to how an aging immune system causes diseases, including cancer, ...

Cancer-derived paracrine factors create distinct “neighborhoods” in the tumor microenvironment, promoting clonal selection and tumor heterogeneity. In ovarian cancer, IL-4 originating from a minority ...

ACLY-deficient CAR T cells targeting the tumor-associated antigen disialoganglioside GD2 (GD2 CAR T cells) also resisted acquiring TEX-like properties, exhibiting reduced CD39 expression when co-cultu...