SERPINE1 and SERPINB2-driven fibrin-rich niches locally programme immunosuppressive macrophages and exclude T cells, enabling spatially organized immune evasion in pancreatic ductal carcinoma.

The seven-year competition just named its top 10 finalists.

The authors present a framework for the selection of immune aging biomarkers suitable for clinical trials in geroscience, alongside a translational roadmap for biomarker development to support the nex...

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11th Edition Theme: Targeting Immune Aging | Time: 9:00am-1.15pm NYC; 14:00-18.15h Paris; 10:00am-2.15pm Sao Paulo

Abstract. Immune checkpoint blockade (ICB) has revolutionized treatment for urothelial bladder cancer (UC), yet response rates remain limited. Inflammation promotes disease progression and treatment r...

Park and colleagues propose a conceptual framework in which dysregulation of resident tissue macrophages is both a central contributor to how an aging immune system causes diseases, including cancer, ...

11th Edition Theme: Targeting Immune Aging | Time: 9:00am-1.15pm NYC; 14:00-18.15h Paris; 10:00am-2.15pm Sao Paulo

Early-life exposure to allergens triggers a distinct local mode of dendritic cell activation in neonatal skin without requiring migration to lymph nodes, which shapes responses to allergens in later l...

Tumor-associated macrophages (TAM) are among the most abundant immune cells in tumors and exhibit striking functional plasticity, enabling them to eit…

Miriam Merad was a force in establishing the first virtual International School of Immunotherapy that aims to give the field a more global outlook

Early-life exposure to allergens triggers a distinct local mode of dendritic cell activation in neonatal skin without requiring migration to lymph nodes, which shapes responses to allergens in later l...

Tumor-associated macrophages (TAMs), which commonly express FOLR2 or TREM2, are enriched in solid tumors and keep the tumor microenvironment (TME) imm…

Nature Reviews Nephrology - This Review discusses the latest advances in natural killer cell biology, including insights into population heterogeneity, and examines the roles of these innate...

Nature Reviews Clinical Oncology - A recent Nature article reports that mRNA vaccines against SARS-CoV-2 confer improved survival among patients with advanced-stage non-small-cell lung cancer or...

Kim explores the significance of inflammation in dermatology, revealing its connections to various diseases and the importance of focused research.

Allergies can persist even in the absence of allergen exposure. Miranda-Waldetario et al. find that IgE-producing plasma cells mature, acquire survival adaptations, and persist for extended periods of...

Nature Microbiology - A long-read metagenomics method empowers faecal microbiota transplantation studies by precisely tracking bacteria from donors to recipients, distinguishing co-existing strains...

The contribution of T cells to neuroinflammation after aneurysmal subarachnoid hemorrhage (SAH) remains poorly understood. Using a murine pre-chiasmatic injection model of SAH we demonstrate that T ce...