New perspectives, insights and therapy applications can arise from exploring the connections between the immune and nervous systems.

Spatial genomics and single-cell profiling reveal the immune architecture of cutaneous lupus erythematosus, a photosensitive autoimmune skin disease. Wang et...

Tajima et al. show that a transient or continuous high-fat diet induces metabolic changes in CD8+ T cells that lead to increased vulnerability to ferroptosis and reduced antitumor responses.

Hur and colleagues review recent developments to provide insights into the molecular mechanisms and regulatory functions of the transcriptional regulators FOXP3 and AIRE.

Nature Immunology - Xie et al. identify a distinct subset of CD4+ helper T cells expressing EOMES and granzyme K in both mice and human models of colitis.

Nature Immunology - Robin and colleagues describe a population of blood vessel-resident macrophages that function within the vasculature to maintain vascular and blood homeostasis in zebrafish and...

Nature Immunology - Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells....

Sun and colleagues report that the transcription factor TCF19 regulates calcium signaling and cell cycling progression in NK cells and is required for innate and adaptive NK cell responses to viral in...

Nature Immunology - Klein and colleagues show that the lysosomal cysteine protease cathepsin L shapes the diversity and optimizes the fitness of clones that enter the CD4+ T cell repertoire.

Nature Immunology - Fang and colleagues show that the metabolite succinate can inhibit succinylation, and consequently protection from ubiquitin-mediated degradation, of the transcription factor...

Nature Immunology - Here the authors show that PD-1 controls coinhibitory receptor expression by Treg cells. The absence of PD-1 expression could induce CD30 expression, thereby enhancing Treg...

Nature Immunology - Here, the authors use single-cell spatial transcriptomics to profile the airway wall landscape in health and during asthma. Discrete proinflammatory ecosystems containing...

Nature Immunology - Acetylcholine–α9 nAChR signaling regulates thymic negative selection.

Nature Immunology - Kellner et al. develop respiratory and intestinal organoids from Rousettus aegyptiacus to show elevated basal expression of interferon-ε (IFNε) and IFN-stimulated...

Belz and colleagues show that GFI1, a transcriptional repressor that recruits histone-modifying enzymes, is necessary for the generation and maintenance of stem cell memory CD8+ T cells.

Nature Immunology - FitzPatrick et al. use single-cell RNA and spatial transcriptomics to dissect the immune microenvironments within the small bowel mucosa in celiac disease.

Nature Immunology - Iwasaki and colleagues show that an intranasal booster with an unadjuvanted recombinant SARS-CoV-2 spike protein, after intramuscular immunization with an mRNA vaccine encoding...

Nature Immunology - Metabolites in the tumor microenvironment, including adenosine, have been shown to suppress anti-tumor immune responses. Here, the authors show that T cell expression of...

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Nature Cell Biology - Wang, Wilfahrt and colleagues show that phosphoethanolamine, a phospholipid intermediate, is enriched in tumour interstitial fluid and induces T cell dysfunction, in part by...

The role of viral Fc-gamma receptors in rhesus cytomegalovirus (RhCMV) infection is unclear. Here, the authors characterized RhCMV vFcγRs and report that their deletion did not affect virus replication, tropism or superinfection in rhesus macaques but increased susceptibility of the virus to antibody control.

The gut microbiota of mammals possess unique metabolic pathways with untapped therapeutic potential. Using molecular insights into dietary fiber metabolism by the human gut microbiota, we designed a t...

Learn how your immune system changes as you get older, and how vaccines can aid in fighting off infections to help you stay healthy as you age.

Upon intramuscular administration, COVID-19 mRNA vaccines are primarily taken up by macrophages, in which the cellular machinery extends their poly(A) tails, thereby increasing mRNA stability and translation, providing an explanation for the efficacy of these vaccines.