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NicolasAvilaLab

@nicolasavilalab.bsky.social
108 followers 156 following 36 posts

Assistant Professor at #CVRI @UCSF studying immune-parenchymal cell crosstalk and its impact on tissue function, with special focus in the ❤.

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Reposted by NicolasAvilaLab
Ivan Zanoni @lozanzi.bsky.social · 05/09/2026
#WeekendRead! #SharingIsCaring! Pena-Caruso Munoz @drusqui.bsky.social @nicolasavilalab.bsky.social &co show #ScienceImmunology that macrophages support muscle activity by taking up mitochondria from myofibroblasts that in turn tune macrophage numbers by controlling CSF1/fibroblast abundance!
science.org
Tissue mitochondrial activity dictates the macrophage pool size
Tissue mitochondrial activity controls macrophage abundance by regulating CSF1 availability, thereby enabling efficient waste removal.
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NicolasAvilaLab @nicolasavilalab.bsky.social · 05/09/2026
Thrilled to share our latest work, out in @sciimmunology.bsky.social ! We show that tissues match their #macrophage numbers to #mitochondrial_activity , ensuring efficient #waste_clearance and #tissue_fitness . A tour de force by Laura Pena-Couso, in collab with @drusqui.bsky.social & Pura Muñoz🧵
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Amy C Fan (she/her) @amycfanphd.bsky.social · 29/04/2026
Excited to announce our new study (w/ @maxkrummel.bsky.social) published today @nature.com: Macrophages “hold our living identities” by taking tiny bites from living cells and presenting this information to CD8 T cells. www.nature.com/articles/s41... #immunology #cellbiology @immunox.bsky.social
nature.com
Submicrometre sampling of living cells by macrophages - Nature
Macrophages can sample antigens from living cells through a trogocytosis-like mechanism that routes ingested material away from degradation, a finding that delineates a previously unknown pathway...
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NicolasAvilaLab @nicolasavilalab.bsky.social · 10/04/2026
Do not miss this great issue on #extracellular #mitochondria in ❤ #cardiovascular patho-physiology‼️ Great opportunity to catch up with literature and very interesting insights from leaders in the field. 👀 www.ahajournals.org/doi/10.1161/...
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NicolasAvilaLab @nicolasavilalab.bsky.social · 10/04/2026
Excited to share our latest review in #CircRes! We discuss current knowledge of #extracellular #mitochondria forms, mechanisms of release, and #pathophysiological relevance. Great work by Laura Pena and Magda Makuch in leading this effort! www.ahajournals.org/doi/10.1161/... #Mitochondria
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Reposted by NicolasAvilaLab
Hao Yin @haoyin.bsky.social · 07/09/2025
A new model of #TumorNecrosis👹 Tumor CXCL1➡️myeloid skewing➡️ Ly6C-low Neutrophil forms intravascular #NeutrophilExtracellularTrap➡️ Intratumoral vascular occlusion➡️ Pleomorphic Necrosis-to-Metastasis a role of TGFβ @adrover.bsky.social @megeblad.bsky.social Nature 2025 www.nature.com/articles/s41...
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Reposted by NicolasAvilaLab
Eric Topol @erictopol.bsky.social · 26/08/2025
Blocking interleukin-6 to prevent the inflammation underpinning cardiovascular disease, genetically informed, without increased risk of infection www.nature.com/articles/s44... www.nature.com/articles/s44...
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Abby Buchwalter @abbybuch.bsky.social · 14/08/2025
The basic sciences are HIRING at UCSF: open recruitment in the Department of Biochemistry & Biophysics. Please share and please apply! aprecruit.ucsf.edu/JPF05702
aprecruit.ucsf.edu
Ladder Rank Faculty Position – Assistant Professor
University of California, San Francisco is hiring. Apply now!
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Reposted by NicolasAvilaLab
Jose M. Adrover @adrover.bsky.social · 17/07/2025
I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13) www.nature.com/articles/s41...
nature.com
Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
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Reposted by NicolasAvilaLab
@KingOfPathogens @kingofpathogens.bsky.social · 07/06/2025
Inflammatory mischief managed: How retinoic acid calms heart attacks at the (marrow) source | Science Immunology www.science.org/doi/10.1126/...
science.org
Inflammatory mischief managed: How retinoic acid calms heart attacks at the (marrow) source
Targeting vitamin A metabolism limits emergency hematopoiesis and promotes resolution of inflammation in myocardial infarction.
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NicolasAvilaLab @nicolasavilalab.bsky.social · 08/06/2025
This is crazy!
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Reposted by NicolasAvilaLab
Miguel Torres @miguel-torres-1963.bsky.social · 27/05/2025
Here we study the origin of the cardiac cell lineages in the mouse embryo. Separate but coordinated lineages independently specified at gastrulation generate the myocardium and endocardium. Credits: Miquel Sendra & coll: Jorge Dominguez, K. McDole and L. Guinard authors.elsevier.com/sd/article/S...
authors.elsevier.com
ScienceDirect.com | Science, health and medical journals, full text articles and books.
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NicolasAvilaLab @nicolasavilalab.bsky.social · 14/05/2025
Congratulations to Pilar Alcaide for a great presentation and the Presidents Award from #ISHR! 🙌
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NicolasAvilaLab @nicolasavilalab.bsky.social · 11/05/2025
Great opening ceremony of the #ISHR2025 XXV World Congress in Nara. Excited to discuss science with colleagues of the Cardiovascular field during this ISHR meeting.
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NicolasAvilaLab @nicolasavilalab.bsky.social · 12/04/2025
Great experience this week participating in the recently launched @ucsanfrancisco.bsky.social Clinically Inspired Discovery Program. Many interesting talks and stimulating discussions with students.
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Jose M. Adrover @adrover.bsky.social · 30/03/2025
I had a wonderful time! Great conference and speakers! Thanks @casanova-acebes.bsky.social @sancholab.bsky.social and Carlos Silvestre for the great work organizing such an amazing meeting!
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Casanova-Acebes Lab @casanova-acebes.bsky.social · 28/03/2025
@adrover.bsky.social rocking on a fantastic new and vascular-damaging Ly6Clo neutrophils, he will now investigate deeper in his #brandnewlab #EPW2025
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NicolasAvilaLab @nicolasavilalab.bsky.social · 29/03/2025
Hey @ucsanfrancisco.bsky.social students! On April 10, I will be participating in #UREKA, a new program aiming to identify current challenges in the clinic and come up with novel approaches to tackle them. #5k$ prices for proposals presented by attendants to the event. Sign up! ucsfureka.com
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Reposted by NicolasAvilaLab
David Sancho @sancholab.bsky.social · 26/03/2025
#immunosky #epw2025 Fantastic meeting starting! Thx to the wonderful co-organizers @mcasanova.bsky.social & @silvestreroiglab.bsky.social Thx to support by #SEI (Spanish society for immunology), Inmunotek @miltenyibiotec.bsky.social @embo.org @efis-immunology.bsky.social @eurjimmunol.bsky.social
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Reposted by NicolasAvilaLab
Nonia Pariente @npariente.bsky.social · 26/03/2025
Meet @plosbiology.org’s great microbiology and immunology editor ⬇️⬇️ She’s wise, a joy and has been such an asset to the team. You can book office hours with her at the link Mel posted, and with all the other lovely editors. Find the links here: journals.plos.org/plosbiology/...
journals.plos.org
PLOS Biology
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NicolasAvilaLab @nicolasavilalab.bsky.social · 23/03/2025
Last contribution to the understanding of #neutrophil biology. Superb work from Tommaso, @alazozcan.bsky.social, and Jackson that I had the pleasure to contribute to and see growing during my time at @drusqui.bsky.social lab.
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NicolasAvilaLab @nicolasavilalab.bsky.social · 22/03/2025
Finally making the transition from Twitter/X to Bluesky! Excited to keep up with the amazing work of friends and fellow scientists here. Also, follow this account for future updates on our lab work. #blueskyforscience.
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