Reposted by NicolasAvilaLab
#WeekendRead! #SharingIsCaring! Pena-Caruso Munoz @drusqui.bsky.social @nicolasavilalab.bsky.social &co show #ScienceImmunology that macrophages support muscle activity by taking up mitochondria from myofibroblasts that in turn tune macrophage numbers by controlling CSF1/fibroblast abundance!
science.org
Tissue mitochondrial activity dictates the macrophage pool size
Tissue mitochondrial activity controls macrophage abundance by regulating CSF1 availability, thereby enabling efficient waste removal.