Complement component 3 (C3) is crucial for host defense against bacteria. While the liver is the primary source of circulating C3, local C3 production at barrier surfaces such as the lung is key in ea...

Tissue-resident memory T (TRM) cells are heterogeneous, but how pathogenic subsets drive relapse in allergic dermatitis remains unclear. Asahina et al. identify a pathogenic CXCR6+ CD4+ TRM subset sustained through CXCL16-dependent clustering with CD301b+ cDC2s, revealing the TRM-DC niche as a potential therapeutic target for allergic dermatitis.

Summary. Basophils are the rarest leukocytes, but they have essential roles in protection against helminths, allergic disorders, autoimmune diseases, and s

An annual scientific meeting organized by the Lausanne MD-PhD Commission UNIL and EPFL. Medical students interested in combining medicine and research are warmly welcome.

Karl Deisseroth, Peter Hegemann and Georg Nagel win the 2026 Nobel Prize in Physiology or Medicine for their work on optogenetics, which has revolutionized neuroscience.

The SNSF will continue its successful funding from 2029 to 2032, strengthening research that is collaborative, bold and forward-looking.

Blood-stage malaria transiently depletes and remodels splenic macrophages, but how distinct subsets recover remains unclear. A recent report by Mauel et al. shows that a yolk sac-derived CD163high red pulp macrophage subset is selectively and durably lost after malaria, disrupting a growth differentiation factor 15-dependent circuit that supports marginal metallophilic macrophages.

Circumventricular organs are specialized brain regions lacking a blood-brain barrier. Van Hove et al. reveal that these regions harbor unique microglia and border-associated macrophage populations tha...

Qi and colleagues show that TMEM119 constitutively restrains microglial phagocytosis by sequestering tankyrase from axin and thereby limiting APC-driven actin assembly. Genetic TMEM119 ablation or interference of TMEM119-tankyrase binding by a brain-penetrant peptide enhances synapse elimination and attenuates established fear memory, opening a new way for pharmacological memory manipulation.

Type 2 inflammation trains nerve- and airway-associated macrophages to confer disease tolerance against lethal influenza by limiting immunopathology and promoting tissue repair without enhancing viral...

YouTube video by International Eosinophil Society

Type 2 inflammation trains nerve- and airway-associated macrophages to confer disease tolerance against lethal influenza by limiting immunopathology and promoting tissue repair without enhancing viral...

Priming of CD8+ T cells by peripheral dendritic cells exacerbates tau-mediated neurodegeneration *Speaker: Hao Hu (Washington University in St. Louis) *Moderator: Jerry Lin (Massachusetts General…

Immune plasticity during the perinatal period enables mammalian offspring to successfully navigate the transition from prenatal, intrauterine life to postnatal, extrauterine life. This Review highligh...

The metabolic state of NK cells affects their innate immune function, and although cell-intrinsic pathways are better known, their cellular environment could provide cues that are less studied. Here t...

SERPINE1 and SERPINB2-driven fibrin-rich niches locally programme immunosuppressive macrophages and exclude T cells, enabling spatially organized immune evasion in pancreatic ductal carcinoma.

Speaker: Julia Belk Title: Microglia replacement during human aging Paper: Somatic mutations reveal the ontogeny of microglia in human aging (Nature 2026)

Tissue mitochondrial activity controls macrophage abundance by regulating CSF1 availability, thereby enabling efficient waste removal.

Speaker: Jing Chen Paper: Transcription factor Maf promotes expression of repressor Zeb2 to drive microglia development in primitive hematopoiesis (Immunity 2026) Moderator: Anna Salamero Boix (Open…