🧬 Open‑access research reveals that CASPASE‑8 supports αβ T‑cell survival through mechanisms independent of RIPK1‑mediated necroptosis, with key roles in CD8 T‑cell maintenance and NKT cell development.
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#Immunology #TCells #CellDeath #OpenAccess
doi.org
Evidence for a RIPK1-independent survival mechanism for CASPASE-8 in αβ T cells
AbstractIntroduction. CASPASE8 promotes both cell death and survival by acting as a trigger of apoptosis and a repressor of necroptosis. In T cells, the fu