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Discovery Immunology

@discovimmunol.bsky.social
464 followers 37 following 184 posts

🔍 New discoveries in cellular & molecular #immunology New #OpenAccess journal from @britsocimm

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Discovery Immunology @discovimmunol.bsky.social · 22h
🧬 Open‑access research reveals that CASPASE‑8 supports αβ T‑cell survival through mechanisms independent of RIPK1‑mediated necroptosis, with key roles in CD8 T‑cell maintenance and NKT cell development. 👉 vist.ly/5kqxj #Immunology #TCells #CellDeath #OpenAccess
doi.org
Evidence for a RIPK1-independent survival mechanism for CASPASE-8 in αβ T cells
AbstractIntroduction. CASPASE8 promotes both cell death and survival by acting as a trigger of apoptosis and a repressor of necroptosis. In T cells, the fu
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Discovery Immunology @discovimmunol.bsky.social · 30/09/2026
🧬 Open‑access study shows spermidine dampens dendritic cell activation via eIF5A hypusination and metabolic adaptation, reducing DC–T cell interactions and shaping immune regulation. 👉 vist.ly/5kesn #Immunology #DendriticCells #CellMetabolism #OpenAccess
Diagram showing reduced DC and T cell activation with eIF5a and spermidine.
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Discovery Immunology @discovimmunol.bsky.social · 28/09/2026
🔬 Open‑access research shows how different cytokines trigger distinct gene expression programs in human neutrophils, revealing their flexibility in shaping immune and inflammatory responses, far beyond frontline defence. 👉 vist.ly/5k59z #Immunology
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Discovery Immunology @discovimmunol.bsky.social · 25/09/2026
High‑throughput long‑read sequencing uncovers how chickens diversify their Ig genes: dominant somatic gene conversion, biased pseudogene usage, and focused CDR‑targeted insertions. A look into avian antibody evolution: bit.ly/45wSe95
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Discovery Immunology @discovimmunol.bsky.social · 23/09/2026
Measuring immune function in the wild is key to understanding resilience and disease. New open‑access research presents a practical immune toolkit for wild ungulates, revealing variation across individuals, populations and landscapes in bighorn sheep. vist.ly/5jhn6
doi.org
Out of the shed and into the field: an immune toolkit for measuring wild ungulate immune phenotypes at multiple scales
Here we demonstrate the utility of our field-tested “immune toolkit” in describing the immune phenotypic heterogeneity of bighorn sheep (Ovis Canadensis) a
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Discovery Immunology @discovimmunol.bsky.social · 21/09/2026
Wild mice show large, robust T‑cell receptor repertoires that stay broad across age and sex, while older mice develop more dominant clones, likely from lifelong pathogen exposure. A fascinating look at how immunity adapts in natural environments. vist.ly/5j8gx
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Discovery Immunology @discovimmunol.bsky.social · 18/09/2026
Research from Priscilla Y. L. Tng et al. shows how virulent ASFV strains disrupt the innate–adaptive immune axis in vivo, key insight for developing safer, more effective ASF vaccines. Read the article here: vist.ly/5ixap #CelebrateVaccines #Immunology #VaccinesWork
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Reposted by Discovery Immunology
British Society for Immunology @britsocimm.bsky.social · 17/09/2026
It's #PeerReviewWeek and we want to recognise the valuable contributions of peer reviewers for their vital role in ensuring science can be shared in a timely way. Thank you to all who generously give their time and expertise to improve the quality of research published in our journals and beyond!
Thank you to our reviewers poster with immunology journal covers.
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Reposted by Discovery Immunology
British Society for Immunology @britsocimm.bsky.social · 14/09/2026
We're at #BSICambridge26 today! if you're attending, do come and say hello and ask us about our membership, journals and professional development opportunities.
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Discovery Immunology @discovimmunol.bsky.social · 03/09/2026
Are you working at the intersection of immunology and ecology? We’d love to hear from you! Join us in exploring how ecological factors shape immune responses in wild animals and humans. 🔬🌳 Find out more and submit: vist.ly/5h6xs
Cover of Discovery Immunology and text about ecoimmunology special collection.
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Discovery Immunology @discovimmunol.bsky.social · 28/08/2026
🔬 Open‑access research shows how different cytokines trigger distinct gene expression programs in human neutrophils, revealing their flexibility in shaping immune and inflammatory responses, far beyond frontline defence. 👉 vist.ly/5gfpa #Immunology
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Discovery Immunology @discovimmunol.bsky.social · 26/08/2026
🧬 Open‑access study shows spermidine dampens dendritic cell activation via eIF5A hypusination and metabolic adaptation, reducing DC–T cell interactions and shaping immune regulation. 👉 vist.ly/5g6y5 #Immunology #DendriticCells #CellMetabolism #OpenAccess
Diagram showing reduced DC and T cell activation with eIF5a and spermidine.
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Discovery Immunology @discovimmunol.bsky.social · 18/08/2026
📢 A recent open-access study shows that individuals with type 2 diabetes develop senescent-like CD4+ EMRA T cells due to elevated glucose levels and mitochondrial dysfunction, which may clarify the reduced effectiveness of COVID-19 vaccines in T2D patients. 🔗 vist.ly/5f8t5
doi.org
📢 A recent open-access study shows that individuals with type 2 diabetes develop senescent-like CD4+ EMRA T cells due to elevated glucose levels and mitochondrial dysfunction, which may clarify the reduced effectiveness of COVID-19 vaccines in T2D patients. 🔗 vist.ly/5f8t5
📢 A recent open-access study shows that individuals with type 2 diabetes develop senescent-like CD4+ EMRA T cells due to elevated glucose levels and mitochondrial dysfunction, which may clarify the reduced effectiveness of COVID-19 vaccines in T2D patients. 🔗 vist.ly/5f8t5
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Discovery Immunology @discovimmunol.bsky.social · 14/08/2026
🐴🔬 New single-cell RNA-seq analysis reveals unexpected diversity among equine blood dendritic cells, including cDC1, cDC2, pDC, tDC and DC3-like populations, providing a valuable resource for equine and comparative immunology. 📖 vist.ly/5essw
Dendritic-cell diversity in equine blood revealed by single-cell transcriptomics
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Discovery Immunology @discovimmunol.bsky.social · 11/08/2026
🚀 Neutrophils are more than first responders. New RNA-seq data reveal cytokine-specific transcriptional programs shaping immune regulation, cell migration, apoptosis, and inflammatory responses. 🔗 vist.ly/5ecfr #Neutrophils #Immunology #Inflammation
doi.org
Cytokine-induced transcriptional changes in human neutrophils reveal immune regulatory plasticity
AbstractIntroduction. Neutrophils are innate immune cells that play a central role in the inflammatory response. They produce an array of destructive molec
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Discovery Immunology @discovimmunol.bsky.social · 07/08/2026
🧬 IL-15 is a cytokine with two faces: at normal levels it helps maintain immune cells, but when overproduced it can drive inflammation and autoimmunity. This review explores the signalling pathways behind these contrasting roles and their potential as therapeutic targets. 🔗 vist.ly/5dyfw
Signalling mechanisms driving homeostatic and inflammatory effects of interleukin-15 on tissue lymphocytes
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Discovery Immunology @discovimmunol.bsky.social · 05/08/2026
CASPASE‑8 supports T cell survival through mechanisms beyond repressing RIPK1‑dependent necroptosis. Conditional deletion studies reveal its essential role in CD8⁺ T cell maintenance and NKT cell development. Read more: vist.ly/5dp8w
Diagram showing the role of CASPASE8 in T cells across various stages with labels.
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Discovery Immunology @discovimmunol.bsky.social · 30/07/2026
How does BCG vaccination affect NK cells? This study found increased NK cell frequency in draining lymph nodes following vaccination, with no significant changes in their spatial organisation. 🔗 vist.ly/5cybd
Vaccination of calves with Bacille Calmette Guerin increased the frequency but did not affect aggregation or clustering of natural killer cells in draining lymph nodes
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Discovery Immunology @discovimmunol.bsky.social · 29/07/2026
New open‑access study by Maria Z. Krauss et al. shows how amino acid uptake and mTOR signalling in CD4⁺ T cells power immunity to Trichuris muris. SLC7A5 proves essential, and loss of mTOR leads to chronic infection. 🔗vist.ly/5cvng
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Discovery Immunology @discovimmunol.bsky.social · 27/07/2026
🐖 New research shows pigs generate both strain-specific and broadly reactive influenza antibodies, including stem-targeting mAbs with cross-subtype recognition. A valuable tool for understanding influenza immunity and improving vaccine design. 📖 vist.ly/5ck5w
Diagram showing H3, H5, and H7 influenza antibodies interacting with virus proteins in different ways.
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Discovery Immunology @discovimmunol.bsky.social · 23/07/2026
💊🧫 Antibiotics can do more than kill bacteria. This study shows that the fluoroquinolone levofloxacin directly alters macrophage biology, driving mitochondrial hyperpolarization and modulating iNOS expression in specific monocyte-derived macrophage populations. 📖 vist.ly/5c7t7
doi.org
Fluoroquinolones directly drive mitochondrial hyperpolarization and modulate iNOS expression in monocyte-derived macrophage populations
AbstractIntroduction. The fluoroquinolone levofloxacin is often selected for use prophylactically as well as during respiratory infections. However, studie
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Discovery Immunology @discovimmunol.bsky.social · 22/07/2026
🧬 Innate lymphoid cells are emerging as key players in cancer immunity. This review explores the diversity, plasticity, and anti-tumour functions of type 1 innate lymphoid cells (ILC1s), with a focus on the immune checkpoint receptor PD-1. 📖 vist.ly/5c3ub #Immunology
Diagram comparing mouse and human ILC1 with markers like NKp46, CD49a, IFNγ, TNF, and differences in Tbet and EOMES.
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Discovery Immunology @discovimmunol.bsky.social · 21/07/2026
🦠 Our epithelial barriers are home to complex interactions between T cells and the microbiota. This review explores how bacterial communities at the skin and intestinal surfaces shape T-cell function, balancing host defence, tolerance, and tissue repair. 📖 vist.ly/5bwzb
T cell and bacterial microbiota interaction at intestinal and skin epithelial interfaces
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Discovery Immunology @discovimmunol.bsky.social · 17/07/2026
How do human ILCs adapt to lung niches? Single‑cell profiling shows distinct vascular vs. tissue programs and a shared extravascular “tissue signature” with NK cells. Read here: vist.ly/5bip9
Diagram of mouse model for single-cell RNA sequencing showing lungs and immune cells.
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Discovery Immunology @discovimmunol.bsky.social · 15/07/2026
Weinstein et al. measured 18 immunological traits in 581 wild bighorn sheep and found significant variation at both individual and metapopulation scales. A valuable new toolkit for wildlife health, disease ecology, and conservation research. 🐑 📖 vist.ly/5ba5u
doi.org
Out of the shed and into the field: an immune toolkit for measuring wild ungulate immune phenotypes at multiple scales
Here we demonstrate the utility of our field-tested “immune toolkit” in describing the immune phenotypic heterogeneity of bighorn sheep (Ovis Canadensis) a
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Discovery Immunology @discovimmunol.bsky.social · 14/07/2026
High‑throughput long‑read sequencing uncovers how chickens diversify their Ig genes: dominant somatic gene conversion, biased pseudogene usage, and focused CDR‑targeted insertions. A look into avian antibody evolution: vist.ly/5b78n
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Discovery Immunology @discovimmunol.bsky.social · 09/07/2026
CCR2− Tph-like cells may help orchestrate local immune niches in human tumors, balancing immune activation and suppression. A promising new player in tumor immunity and immunotherapy response. 🔬 vist.ly/5an36
CCR2− T peripheral helper cells as potential coordinators of local immune architecture in human cancer
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Discovery Immunology @discovimmunol.bsky.social · 07/07/2026
🧬 New research shows lung basal cell–derived PROS1 reduces COVID‑19‑induced inflammation and enhances antigen presentation in monocytes. Read the study: vist.ly/5adqg #COVID19Research #Immunology
Diagram showing immune response with MERTK monocytes and mild COVID-19.
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Discovery Immunology @discovimmunol.bsky.social · 03/07/2026
Lymphoid stromal cells actively shape immune responses, not just tissue architecture. New research shows they directly sense TLR signals, increasing ICAM-1/VCAM-1 expression and secreting inflammatory mediators. 📖 vist.ly/59xt5 #Immunology
Histograms showing VCAM-1 and ICAM-1 expression in fibroblasts and LEC with colored overlays.
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Discovery Immunology @discovimmunol.bsky.social · 02/07/2026
CASPASE‑8 plays a crucial role in T cell survival via mechanisms that extend beyond inhibiting RIPK1-dependent necroptosis. Conditional deletion analyses highlight its vital function in the maintenance of CD8⁺ T cells and the development of NKT cells. Read more: vist.ly/59ur8
Diagram showing the role of CASPASE8 in T cells across various stages with labels.
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Discovery Immunology @discovimmunol.bsky.social · 01/07/2026
Wild mice show large, robust T‑cell receptor repertoires that stay broad across age and sex, while older mice develop more dominant clones, likely from lifelong pathogen exposure. A fascinating look at how immunity adapts in natural environments. vist.ly/59qu4
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Discovery Immunology @discovimmunol.bsky.social · 26/06/2026
A linear Doggybone™ DNA influenza vaccine induced immune responses to both HA and NA without interference, supporting NA inclusion to broaden protection and improve resilience to HA mismatch. 📖 vist.ly/595zv #Vaccines #Influenza #DNAVaccines
doi.org
Optimizing a linear ‘Doggybone’ DNA vaccine for influenza virus through the incorporation of DNA targeting sequences and neuraminidase antigen
Abstract. Influenza virus represents a challenge for traditional vaccine approaches due to its seasonal changes and potential for zoonotic transmission. Nu
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Discovery Immunology @discovimmunol.bsky.social · 25/06/2026
🔬 PD-1 may help prevent autoimmunity triggered by mutation-derived neoantigens. New mouse data sheds light on immune-related adverse events seen with PD-1 blockade. vist.ly/593e2
Granulomatous inflammatory responses are elicited in the liver of PD-1 knockout mice by de novo genome mutagenesis
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Discovery Immunology @discovimmunol.bsky.social · 24/06/2026
Obesity disrupts dendritic cell responses to viral infection, reducing cytokine production and altering cellular metabolism in a mouse model. 📖 vist.ly/58wx2 #Immunology #Obesity #ViralInfection #DendriticCells
doi.org
Obesity drives dysregulation in DC responses to viral infection
AbstractIntroduction. Obesity is a worldwide epidemic, with over 1 billion people worldwide living with obesity. It is associated with an increased risk of
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Reposted by Discovery Immunology
Oxford Academic @academic.oup.com · 17/06/2026
Discover the benefits available when peer reviewing for the @britsocimm.bsky.social journals, including a chance to work with immunology experts to advance research. 🔗 oxford.ly/4fWq6kZ #ImmunoSky | @ceijournal.bsky.social | @imtadvances.bsky.social | @discovimmunol.bsky.social
Call for reviewers: become an ad hoc reviewer for the BSI journals
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Discovery Immunology @discovimmunol.bsky.social · 18/06/2026
🧬 Neutrophils are more adaptable than we thought. This research shows different cytokines trigger distinct gene expression programmes, influencing immune regulation, inflammation and interactions with T cells. 🔗 vist.ly/588kp #Immunology #Neutrophils
doi.org
Cytokine-induced transcriptional changes in human neutrophils reveal immune regulatory plasticity
AbstractIntroduction. Neutrophils are innate immune cells that play a central role in the inflammatory response. They produce an array of destructive molec
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Discovery Immunology @discovimmunol.bsky.social · 17/06/2026
PD-1 loss + increased mutagenesis triggers liver granulomatous inflammation in mice, supporting a key role for PD-1 in preventing immune responses to neoantigens, relevant to toxicity seen with checkpoint blockade. 🔬 vist.ly/584be #Immunology
doi.org
Granulomatous inflammatory responses are elicited in the liver of PD-1 knockout mice by de novo genome mutagenesis
AbstractIntroduction. Programmed death-1 (PD-1) is a negative regulator of immune responses. Upon deletion of PD-1 in mice, symptoms of autoimmunity develo
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Discovery Immunology @discovimmunol.bsky.social · 16/06/2026
Fluoroquinolones aren’t just antimicrobial, they shape immunity too. Levofloxacin drives mitochondrial hyperpolarization and selectively boosts iNOS in developing macrophages, highlighting stage-specific immune modulation. vist.ly/57yd5
doi.org
Fluoroquinolones directly drive mitochondrial hyperpolarization and modulate iNOS expression in monocyte-derived macrophage populations
AbstractIntroduction. The fluoroquinolone levofloxacin is often selected for use prophylactically as well as during respiratory infections. However, studie
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Discovery Immunology @discovimmunol.bsky.social · 12/06/2026
🧬 New insights into Treg biology! This study uncovers how periodic TCR signaling shapes self-reactive T cells and how HTLV-1 hijacks these pathways. A new 2-axis model links activation dynamics to Foxp3 regulation, opening doors for cancer & immunotherapy research. #Immunology #Tcells
Diagram illustrating the activation of self-reactive T cells and the progression to adult T cell leukemia. Includes TCR signals and HTLV-1 infection pathway.
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Discovery Immunology @discovimmunol.bsky.social · 11/06/2026
CARKL emerges as a key regulator of T-cell function by driving metabolic reprogramming, shaping cytokine output, mitochondrial activity, and migration via CXCR3. A compelling link between immunometabolism and immune regulation. vist.ly/57crf #Immunology #TCells #Immunometabolism
doi.org
The sedoheptulose kinase CARKL controls T-cell cytokine outputs and migration by promoting metabolic reprogramming
AbstractBackground. Immunometabolism is a crucial determinant of immune cell function, influencing cellular activation and differentiation through metaboli
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Discovery Immunology @discovimmunol.bsky.social · 10/06/2026
PROS1 released by lung basal cells may help limit severe COVID‑19 inflammation and promote tissue repair, according to a Discovery Immunology study. 🧬 vist.ly/5792z #COVID19 #Immunology
doi.org
PROS1 released by lung basal cells limits inflammation in epithelial and monocytes during SARS-CoV-2 infection
1. SARS-CoV-2 infection of the epithelium results in the release of IFN. 2. IFN secretion has an autocrine effect on epithelial cells. 3. Infection and IFN
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Discovery Immunology @discovimmunol.bsky.social · 05/06/2026
T cell activation depends on rapid gene expression changes. This study shows RAM is upregulated during activation and is essential for RNA cap formation, driving protein synthesis and CD4 T cell proliferation. 🔗 vist.ly/56rbp #Immunology #TCells
A scientific diagram illustrating T cell activation and pathways of RNA translation, featuring molecular structures and arrows guiding the process.
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Discovery Immunology @discovimmunol.bsky.social · 04/06/2026
γδ T cells in the female reproductive tract, quiet defenders or active players in pregnancy? 🤔 This review unpacks their dynamic, hormone-responsive roles at this unique barrier site ⚖️ Part of our T Cells at Barrier Sites collection🧬 vist.ly/56m3b
doi.org
Gamma delta (γδ) T cells in the female reproductive tract: active participants or indifferent bystanders in reproductive success?
Summary. The female reproductive tract accommodates and balances the unique immunological challenges of protection from sexually transmitted pathogens and
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Discovery Immunology @discovimmunol.bsky.social · 27/05/2026
Abatacept suppresses T cell activation, but how durable is its effect? Research shows its inhibitory impact is short-lived in vivo, diminishing significantly once treatment stops 🧬 🔗 vist.ly/55mmj #Immunology #Tcells #Autoimmunity
doi.org
The effect of abatacept on T-cell activation is not long-lived in vivo
Abstract. Abatacept, a co-stimulatory blocker comprising the extracellular portion of human CTLA-4 linked to the Fc region of IgG1, is approved for the tre
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Discovery Immunology @discovimmunol.bsky.social · 26/05/2026
Pathogenic CD4⁺ T cells in experimental uveitis share key features with those seen across immune-mediated inflammatory diseases, highlighting common pathways driving chronic inflammation 🧬 🔗 vist.ly/55ib7 #Immunology #Autoimmunity #Tcells
doi.org
A pathogenic CD4 T cell phenotype in experimental uveitis shares common features with other immune mediated inflammatory diseases
AbstractIntroduction. Murine ocular autoimmunity develops through 3 stages; prodrome, primary peak and secondary regulation. During the prodromal phase, le
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Discovery Immunology @discovimmunol.bsky.social · 21/05/2026
📢 New in Discovery Immunology New open-access research shows a strikingly shared (“public”) antibody response following PRV vaccination and challenge, revealed through porcine BCR repertoire profiling 🧬 🔗 vist.ly/54z8t #Immunology #Vaccines #Bcells #OpenAccess
doi.org
Pseudorabies Study Overview
AbstractIntroduction. The antibody repertoire reflects the immune history of an individual. In the present study, we characterised the porcine antibody hea
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Discovery Immunology @discovimmunol.bsky.social · 21/05/2026
📢 Call for Papers: Extracellular Vesicles as Regulators of Immune Function Exploring EVs in immune modulation, disease and therapy. Led by Dessi Malinova & Julia Makinde. Submissions open until May 2026. Learn more: vist.ly/54ye2
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Discovery Immunology @discovimmunol.bsky.social · 15/05/2026
RNA capping emerges as a key checkpoint in T cell activation: RAM upregulation is essential for RNA cap formation, gene expression, and proliferation, linking transcriptional control to immune function. 🧬 vist.ly/54bsw #Immunology #Tcells #GeneExpression
Diagram illustrating the pathway from T cell activation to RNA translation, featuring molecules like RNMT, RAM, LARP1, and ribosomes. This scientific graphic is informative and educative in nature.
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Discovery Immunology @discovimmunol.bsky.social · 14/05/2026
Basophils may be rare, but their complexity is anything but, this review highlights their developmental pathways, newly identified progenitors, and unexpected heterogeneity revealed by single-cell tools. 🧬 vist.ly/5472c #Immunology #Basophils
doi.org
The ontogenesis and heterogeneity of basophils
Summary. Basophils are the rarest leukocytes, but they have essential roles in protection against helminths, allergic disorders, autoimmune diseases, and s
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Discovery Immunology @discovimmunol.bsky.social · 13/05/2026
Single-cell insights reveal how “periodic” TCR signalling shapes self-reactive T cells, and how HTLV-1 exploits this pathway. A fresh model with implications for cancer and immunotherapy. 🧬 Read here: vist.ly/543sa #Immunology #Tcells #HTLV1
doi.org
Spectrum of Treg and self-reactive T cells: single cell perspectives from old friend HTLV-1
Summary. Despite extensive regulatory T cell (Treg) research, fundamental questions on in vivo dynamics remain to be answered. The current study aims to di
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