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BrownLab @Mt.Sinai

@brownlab1.bsky.social
102 followers 26 following 11 posts
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Sinai Immuno @sinaiimmuno.bsky.social · 18/06/2026
Meet @bhavyasighs.bsky.social, a PhD student co-mentored by @neoviral.bsky.social & @brownlab1.bsky.social. Her research applies functional spatial genomics to understand how repeat elements shape the tumor immune microenvironment, reflecting the collaborative science at ❤️ of discovery in PrIISM.
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Sinai Immuno @sinaiimmuno.bsky.social · 01/06/2026
How many immunologists do you know? Meet the people behind the science in our new #MeetThePrIISM video series. ⭐ Episode 1: Jared Weiler, who is researching how the gut microbiome in patients with inflammatory bowel disease can cause trouble elsewhere like inflammation in 🦴🧠🫀&💪.
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Reposted by BrownLab @Mt.Sinai
Sinai Immuno @sinaiimmuno.bsky.social · 02/03/2026
At Immunoschool, @gitlinlabmsk.bsky.social will show how VEXAS syndrome is reshaping our understanding of immune aging, late-onset inflammatory disease & new routes to immunotherapy. A powerful 🔗 between clonal hematopoiesis & systemic inflammation. Register FREE: www.eventbrite.com/e/internatio...
eventbrite.com
International Course of Immunotherapy March 23-25, 2026
11th Edition Theme: Targeting Immune Aging | Time: 9:00am-1.15pm NYC; 14:00-18.15h Paris; 10:00am-2.15pm Sao Paulo
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Sinai Immuno @sinaiimmuno.bsky.social · 27/02/2026
When immune cells go senescent, the whole body may follow. But next generation immunotherapies like CAR-T cells and vaccines targeting senoantigens could help us fight back. Don't be a 🧟‍♀️ and 😴 on this opportunity to hear how we can target senescence: FREE sign-up: www.eventbrite.com/e/internatio...
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Icahn Genomics Institute @icahngenomics.bsky.social · 26/02/2026
New @cp-cancercell.bsky.social review by @brownlab1.bsky.social & @miriammerad.bsky.social highlights tools to re-engineer the myeloid system—from CAR-Ts to targeted, TME reprogramming LNPs—and turn immunosuppressive tumor macrophages into potent tumor killers 🧐 www.sciencedirect.com/science/arti...
sciencedirect.com
Macrophages: Targets for next-generation cancer immunotherapy
Tumor-associated macrophages (TAM) are among the most abundant immune cells in tumors and exhibit striking functional plasticity, enabling them to eit…
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Sinai Immuno @sinaiimmuno.bsky.social · 23/02/2026
What if aging begins in the youngest immune cells? Emmanuelle Passegué reveals how changes in hematopoietic stem cells drive declining immunity, inflammaging & disease risk, and how restoring them could rebuild resilience. Program: immunoschool.org Register FREE: www.eventbrite.com/e/internatio...
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Sinai Immuno @sinaiimmuno.bsky.social · 20/02/2026
Guido Kroemer joins the 2026 Immunoschool to highlight the hallmarks of immune aging and how they drive decline. Aging hallmarks—from genomic instability to inflammaging—are interconnected & potentially targetable. See what's on immunoschool.org FREE to register www.eventbrite.com/e/internatio...
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Sinai Immuno @sinaiimmuno.bsky.social · 19/02/2026
The immune system profoundly shapes aging as it interacts with every organ. New single-cell & spatial tools now map where this relationship breaks down and where interventions support healthy longevity. More @ Immunoschool Program: immunoschool.org Register (free): www.eventbrite.com/e/internatio...
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Sinai Immuno @sinaiimmuno.bsky.social · 18/02/2026
3 days. Global faculty and learners of all career stages. Aging, immunity and translation at the cutting edge. Save your spot: www.eventbrite.com/e/internatio... Explore the program: immunoschool.org The second speaker will be Vishwa Deep Dixit of the Yale Univertsity Center for Research on Aging
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Sinai Immuno @sinaiimmuno.bsky.social · 16/02/2026
📣 Immunoschool 2026 is open for registration 📣 Explore how immunotherapy can promote healthy longevity, from targeting senescent cells to rejuvenating exhausted immunity and reducing inflammaging. FREE, online March 23–25. Program: immunoschool.org Register: www.eventbrite.com/e/internatio...
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BrownLab @Mt.Sinai @brownlab1.bsky.social · 22/01/2026
I am thrilled to announce that our latest paper is out now in @cp-cancercell.bsky.social! 1/n www.sciencedirect.com/science/arti...
sciencedirect.com
Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth
Tumor-associated macrophages (TAMs), which commonly express FOLR2 or TREM2, are enriched in solid tumors and keep the tumor microenvironment (TME) imm…
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Reposted by BrownLab @Mt.Sinai
Sinai Immuno @sinaiimmuno.bsky.social · 13/01/2026
New **RESOURCE** in @natcancer.nature.com - a landmark single-cell Immune Atlas of multiple myeloma—1.3M+ bone marrow cells from 337 patients. Led by the Immune Atlas Consortium with major contributions from Sacha Gnjatic, @edgargk.bsky.social & HIMC profiling teams 🧐 www.nature.com/articles/s43...
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NY-CURES @nycures.bsky.social · 06/01/2026
📣 VIRTUAL TOWNHALL 📣 This Friday. Organized by NY-CURES & postdoc unions ✍️ >>> docs.google.com/forms/d/e/1F... Find out how the proposed Empire Biomedical Research Institute can help solve issues NY State is grappling with: affordability, workforce stability and long-term health & economic growth.
docs.google.com
Statewide Town Hall to Fund New York Science
Over the past year, we have been fighting back against attacks on science and higher education. While we’ve made progress, many of us continue to be deeply impacted by cuts to federal grants and the p...
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NY-CURES @nycures.bsky.social · 24/12/2025
New York’s research ecosystem delivered plenty of “nice list” rewards this year. Now we need Albany to deliver EBRI so we can keep that impact growing. Research is the gift that keeps on giving, so for a healthier and wealthier New Year for all New Yorkers, sign our letter to 🎅 >>> c.org/hwy54dWJDb
A whimsical, vintage-style Christmas illustration shows Santa Claus flying in a sleigh over Albany, New York. Santa wears a vibrant blue-green suit with white fur trim and holds a scroll titled "This Year’s Nice List," featuring items like "New tools for prevention, diagnostics, and therapeutics" and "Supported postdocs and early-career scientists." His sleigh, shaded in coordinating tones of teal and blue-green, is overflowing with scientific lab equipment such as test tubes, microscopes, and conical tubes. Cheerful reindeer, each dressed in tiny white lab coats, pull the sleigh through a snowy, star-filled sky. Below, Albany’s Capitol buildings glow warmly amid a snowy landscape, completing the festive and science-themed scene.
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NY-CURES @nycures.bsky.social · 18/12/2025
Need more info before signing petition for state-backed research institute? Get the full behind-the-scenes 🎞️ of how the Empire Biomedical Research Institute proposal came to be, what’s needed to move it forward, and how other states can follow suit: keypoint.keystonesymposia.org/home/shruti-...
keypoint.keystonesymposia.org
Leadership Spotlight on SAB member Dr. Shruti Naik: Re-envisioning the Funding Ecosystem
Keystone Symposia Scientific Advisory Board Member Dr. Shruti Naik leads in innovative effort to reshape the funding ecosystem in the State of New York to ensure the future of science and scientists i...
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NY-CURES @nycures.bsky.social · 16/12/2025
🗞️ in @gothamist.com from @clewisreports.bsky.social. Our 2 cents: EBRI doesn’t compete with other urgent needs — it equips NYS to meet them. Not funding it now worsens pressures; funding it grows the economy to help fix them. State-backed research is a win-win-win-win. gothamist.com/news/ny-medi...
gothamist.com
NY medical schools press Gov. Hochul to put up billions for scientific research
The request comes amid continuing uncertainty over federal funding, with research and thousands of jobs on the line.
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Sinai Immuno @sinaiimmuno.bsky.social · 11/12/2025
🚨 REVIEW 🚨 Amir Horowitz & Peter Heeger in @natrevneph.nature.com highlight how diverse NK cells in the kidney support immune surveillance but also drive injury in many diseases and contribute to transplant damage, with high-resolution profiling revealing new therapeutic targets. 🧐 rdcu.be/eUgor
rdcu.be
Natural killer cells in kidney immune surveillance, injury and fibrosis
Nature Reviews Nephrology - This Review discusses the latest advances in natural killer cell biology, including insights into population heterogeneity, and examines the roles of these innate...
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Mike Feigin 🥯 @mikefeigin.bsky.social · 11/12/2025
Petition for a NY Biomedical Institute. This is a no-brainer to support science in NY, similar to programs in CA/TX. www.change.org/p/support-a-...
change.org
Sign the Petition
Support a New York State Biomedical Institute for a Healthier, More Affordable Future
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NY-CURES @nycures.bsky.social · 04/12/2025
Wondering why you should ✍ our petition? c.org/nDnRNSsVcq In @aai.org, founder @drshrutinaik.bsky.social reveals why the coalition was formed, why NY needs a state-backed research institute, and how scientists should organize for systemic support — here and nationwide. news.aai.org/2025/11/20/n...
news.aai.org
Immunologists Push for State Biomedical Research Funding in New York - AAI News
Dr. Shruti Naik is one of the immunologists in New York state behind NY-CURES, advocating for state investment in biomedical research.
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NY-CURES @nycures.bsky.social · 02/12/2025
Run a lab? Work in a lab? Wondering where your future research funding will come from? New York has an unprecedented opportunity on the table — a bold proposal to supercharge biomedical research and innovation across the state. 👉 Sign the petition & share to help make it happen.: c.org/TDMy2H9JTW
c.org
Sign the Petition
Support a New York State Biomedical Institute for a Healthier, More Affordable Future
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Reposted by BrownLab @Mt.Sinai
NY-CURES @nycures.bsky.social · 28/11/2025
We’re in a proud, confident and ambitious Empire State of mind! If you believe in building a better and brighter tomorrow, hustle on over to sign and share the petition for an Empire Biomedical Research Institute to fuel the future and the people like you who power discovery. c.org/hwy54dWJDb
media.tenor.com
a black and white photo of a man and a woman with the words there 's nothing you can 't do
Alt: GIF of Jay-Z and Alicia Keys Empire State of Mind video with the words there 's nothing you can’t do
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NY-CURES @nycures.bsky.social · 24/11/2025
📢 SIGN & SHARE THE PETITION! 📢 New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
c.org
Sign the Petition
Support a New York State Biomedical Institute for a Healthier, More Affordable Future
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BrownLab @Mt.Sinai @brownlab1.bsky.social · 17/10/2025
Our new review in @natbiomedeng.nature.com is out! RNA-loaded lipid nanoparticles (LNPs) have huge potential—but their strong liver and immune cell uptake has mostly confined them to vaccines and liver therapies. We explore how to move beyond those limits. free to read 🔗 rdcu.be/eLxGs
rdcu.be
Targeting and tracking mRNA lipid nanoparticles at the particle, transcript and protein level
Nature Biomedical Engineering - This Review explores strategies for targeting and tracking RNA-LNP drugs, monitoring their in vivo behaviour, enhancing tissue-specific delivery, and using synthetic...
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Andrew Payne @andrewcpayne.bsky.social · 01/10/2025
E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves. Read more: e11.bio/blog/prism
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NY-CURES @nycures.bsky.social · 15/10/2025
Add your name ✍ at www.nycures.org so Albany sees 10,000 scientists calling for the future of biomedical research to be built right here in New York. Our first email to members goes out soon—introducing the statewide biomedical institute we’re proposing and how you can help power it forward.
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NY-CURES @nycures.bsky.social · 09/10/2025
Wondering what *exactly* we’re up to? Our first coalition email is about to go out—introducing the statewide biomedical institute we’re proposing and how you can help power it forward THIS WEEK! Sign up now so you don’t miss it: www.nycures.org/
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NY-CURES @nycures.bsky.social · 08/10/2025
From patient to scientist: Sergei German beat cancer thanks to clinical trials, inspiring him to leave his career in finance and drive research @nygenome.org A NY statewide biomedical institute will make more incredible stories like his possible. Help make this happen, sign up at www.nycures.org/
nycures.org
New York Cures – NY-CURESNew York Cures Website
NY-CURES is working to advance bold, state-backed investment in biomedical research—on the scale of successful initiatives in California and Texas—to grow New York’s leadership in science, innovation, and health.
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NY-CURES @nycures.bsky.social · 07/10/2025
Scientists—let’s use our agency! NY-CURES is championing a landmark statewide biomedical institute for New York, built to restore and grow science for all Working FOR a brighter future gives us hope, purpose, and momentum. Want to be part of it? Follow us + DM—we’ve got many ways to get involved.
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NY-CURES @nycures.bsky.social · 02/10/2025
The BIGGEST impact you can have with 1 minute today ⏱️ Add your name to show NY is ready for a statewide biomedical institute. CA’s CIRM & TX’s CPRIT proved it works—billions returned, jobs created, cures accelerated. Let’s do even better for New York. ✍️ www.nycures.org/
nycures.org
New York Cures – NY-CURESNew York Cures Website
NY-CURES is working to advance bold, state-backed investment in biomedical research—on the scale of successful initiatives in California and Texas—to grow New York’s leadership in science, innovation, and health.
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NY-CURES @nycures.bsky.social · 29/09/2025
“States like New York have an opportunity to position ourselves as real leaders in so many different areas.” @governor.ny.gov Like her, we believe NY is ready for revitalization—by launching a state-wide biomedical institute that boosts jobs, the economy & cures. www.youtube.com/watch?v=WVtF...
youtube.com
A Conversation with New York Governor Kathy Hochul | 2025 Concordia Annual Summit
YouTube video by Concordia
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NY-CURES @nycures.bsky.social · 25/09/2025
Behind every scientist is an army of workers who keep the biomedical research ecosystem running. Hear from these workers and how they contribute at www.nycures.org/ and SIGN UP to have your voice heard!
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Samarth Hegde @samhegde.bsky.social · 22/09/2025
🔬Our paper from the @miriammerad.bsky.social lab is now online! This is a story shaped over years of cross-disciplinary endeavor at @sinaiimmuno.bsky.social and labs across the world. 🧵: www.nature.com/articles/s41...
nature.com
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours - Nature
An understanding of the molecular mechanisms promoting the generation of immunoregulatory and tumour-promoting monocytes and macrophages is key to breaking the cycle of tumour myelopoiesis and develop...
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NY-CURES @nycures.bsky.social · 18/09/2025
Research powerhouses 💪 in @forbes.com Best-in-State list with @roswellpark.bsky.social in NY top10 🏆. Also listed: @stonybrooku.bsky.social @mskcancercenter.bsky.social @northwellhealth.bsky.social. To keep more talent here we must invest statewide in biomedicine. www.forbes.com/lists/best-e...
forbes.com
Forbes Best Employers By State 2025 List - Best Companies To Work For
Forbes ranks the best employers to work for in each state. Discover companies with great benefits, excellent workplace culture, and high employee satisfaction.
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NY-CURES @nycures.bsky.social · 16/09/2025
New York leads in science & medicine but without state investment, we risk losing talent, cures, jobs, & billions in economic return. Every $1 California invested in biomedical research returned $4 to the state economy. This isn’t just science—it’s smart economics: www.cirm.ca.gov/our-impact/
cirm.ca.gov
Impact Across California – CIRM
For two decades, CIRM has been at the forefront of regenerative medicine, funding over 100 clinical trials and building the infrastructure that drives innovation in stem cell and gene therapies.
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BrownLab @Mt.Sinai @brownlab1.bsky.social · 15/09/2025
Science transforms lives and now New York has a chance to lead with NY-CURES! This new coalition is pushing for statewide commitment to research that fuels discoveries, therapies, and opportunity. Learn more & sign up today to help make it happen: nycures.org
nycures.org
New York Cures – NY-CURESNew York Cures Website
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Chiara Falcomatà @chiarafalcomata.bsky.social · 18/06/2025
🚨 Our new #preprint is out! doi.org/10.1101/2025... We used #PerturbMap spatial functional genomics in pancreatic cancer to track tumor clone dynamics and uncover how extracellular factors like Serpine1 and Serpinb2 drive immune evasion. 🧵 (1/8)
doi.org
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BrownLab @Mt.Sinai @brownlab1.bsky.social · 12/02/2025
We need to let elected Reps know how destructive White House policies are for medical science. American Institute for Medical & Bio Eng has a link to send your senators and representatives an email (below). Easy to do. make your voice heard and share with colleagues. aimbe.org/advocate/wri...
aimbe.org
Write Your Lawmakers - AIMBE
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BrownLab @Mt.Sinai @brownlab1.bsky.social · 15/01/2025
First lab Bluesky post! Happy to share new papers: PRINT: Using Perturb-map, we show in @cellpress.bsky.social how ovarian tumors resist immunotherapy > www.cell.com/cell/abstrac... PREPRINT We developed a new technology to easily generate cell-targeted LNP-RNA > www.biorxiv.org/content/10.1...
cell.com
Ovarian cancer-derived IL-4 promotes immunotherapy resistance
Cancer-derived paracrine factors create distinct “neighborhoods” in the tumor microenvironment, promoting clonal selection and tumor heterogeneity. In ovarian cancer, IL-4 originating from a minority ...
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BrownLab @Mt.Sinai @brownlab1.bsky.social · 15/01/2025
First lab Bluesky post! Happy to share new papers: PRINT: Using Perturb-map, we show in @cellpress.bsky.social how ovarian tumors resist immunotherapy > www.cell.com/cell/abstrac... PREPRINT We developed a new technology to easily generate cell-targeted LNP-RNA > www.biorxiv.org/content/10.1...
cell.com
Ovarian cancer-derived IL-4 promotes immunotherapy resistance
Cancer-derived paracrine factors create distinct “neighborhoods” in the tumor microenvironment, promoting clonal selection and tumor heterogeneity. In ovarian cancer, IL-4 originating from a minority ...
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