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Rockefeller University Press @rupress.org · 28/09/2026

In @jem.org, Jensen, Skouboe, Gervais, Mogensen et al. report the finding of #autoantibodies neutralizing type I IFNs in the blood and/or cerebrospinal fluid in a significantly elevated fraction of adults w/ HSV encephalitis (5%) compared w/ the general population rupress.org/jem/article/...

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Rockefeller University Press @rupress.org · 25/09/2026

In @jem.org, Yang Yu, Yanling Zhao, Zhongcheng Shi, Larry L. Wang et al. demonstrate that CAMKV, previously classified as a nonfunctional pseudokinase, possesses intrinsic kinase activity driven by MYC/MYCN oncogenes to promote #neuroblastoma growth. rupress.org/jem/article/...

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Rockefeller University Press @rupress.org · 25/09/2026

Insights @jem.org: Sajiki et al. @arakilab.bsky.social (rupress.org/jem/article/...) show that long-lived naive #CD8 #Tcells accrue tonic TCR signaling during homeostasis, driving their differentiation into functionally superior effectors. By Hee Yeun Won & Jung-Hyun Park rupress.org/jem/article/...

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Rockefeller University Press @rupress.org · 25/09/2026

In @jem.org, Tomás Huerta, Kevin Tracey, Isaac Chiu, and @changsbrain.bsky.social review the organization and function of vagal neuroimmune circuits, from afferent cytokine sensing to organ-specific efferent immune control. rupress.org/jem/article/... #BioelectronicMedicine #Neuroimmunology

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Rockefeller University Press @rupress.org · 25/09/2026

In @jcb.org, Sydir, Lee, Pellman et al. @harvard.edu @danafarber.bsky.social identify an #ESCRT-independent pathway for #NuclearEnvelope assembly in S. japonicus that involves the conserved proteins, Vid27 and Alx1. rupress.org/jcb/article/... #CellCycle #CellDivision #Genetics #Biochemistry

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Rockefeller University Press @rupress.org · 24/09/2026

In @jhumimmunity.org, Patel, Cooper, Zimmerman et al. describe an elderly woman w/ severe chronic #neutropenia caused by mosaic #TLR8 GOF, broadening a primarily pediatric, male disease spectrum & highlighting somatic mosaicism as an important diagnostic consideration rupress.org/jhi/article/...

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Rockefeller University Press @rupress.org · 18/09/2026

In @jhumimmunity.org, Chong et al. examine the clinical utility of skin biopsy, an inexpensive & widely available test, in 16 patients and show that dyskeratotic keratinocytes in the superficial layers are useful for diagnosing #AOSD. rupress.org/jhi/article/...

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Rockefeller University Press @rupress.org · 18/09/2026

In @jem.org, Ovezgeldiyev, Trefzer, Doolan, @boucheryt.bsky.social et al. reveal a metabolic pathway linking lipid mediator production to #macrophage activation during #helminth immunity. rupress.org/jem/article/... #Metabolism #InnateImmunity #inflammation #InfectiousDisease #HostDefense

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Rockefeller University Press @rupress.org · 16/09/2026

“JGP is one of the increasingly rare journals where editorial decisions remain firmly centered on scientific merit.” — Chieko Koike, Ritsumeikan University Learn more about @jgp.org: hubs.la/Q04t83Z10

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Rockefeller University Press @rupress.org · 16/09/2026

In @jem.org, Florez-Paz & Mentis demonstrate the presence of supernumerary synapses during development, resulting in miswired immature spinal circuits. Two molecularly distinct mechanisms are responsible for their refinement, incl. a surprising CD47-dependent mechanism rupress.org/jem/article/...

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Rockefeller University Press @rupress.org · 16/09/2026

In @jhumimmunity.org, Taniguchi et al find the prevalence of autoantibodies neutralizing type I IFNs is significantly higher in Japanese patients w/ hepatitis C than in age-matched healthy controls, & is even higher in those treated w/ IFN-α than in untreated individuals rupress.org/jhi/article/...

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Rockefeller University Press @rupress.org · 16/09/2026

In @jem.org, Zhang et al. identify RalA-dependent signaling as a regulator of age-related #skeletalmuscle dysfunction. Novel compound UA-30 inhibits RalA activity, reduces muscle fibrosis, improves mitochondrial function & mobility & extends health span & survival in mice rupress.org/jem/article/...

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Rockefeller University Press @rupress.org · 16/09/2026

In @jcb.org, Pengwei Zhao, Mengyuan Zhang, Rongbin Ding et al. develop constitutive and inducible #Golgi reporter mice that enable in vivo visualization of Golgi architecture and Golgiphagy at single-cell resolution. rupress.org/jcb/article/... #Technology #Organelles

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Rockefeller University Press @rupress.org · 15/09/2026

In @jhumimmunity.org, Tomomasa et al. describe a clustering of patients w/ IRAK4 deficiency identified in Okinawa, Japan. All affected families carried the homozygous c.123_124insA variant, which suggests a founder effect & supports the implementation of newborn screening rupress.org/jhi/article/...

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Reposted by Rockefeller University Press

Tim @timisstuck.bsky.social · 11/09/2026

For the 125th birthday of @rockefeller.edu my colleagues at @rupress.org created this beautiful booklet ✨✨

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Rockefeller University Press @rupress.org · 11/09/2026

Dr. Daniel Kastner, former NHGRI Scientific Director, was a visionary physician-scientist whose discoveries transformed the understanding of innate immunity and established the modern field of autoinflammatory diseases. Gupta et al. pay tribute @jhumimmunity.org: rupress.org/jhi/article/...

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Rockefeller University Press @rupress.org · 11/09/2026

In @jcb.org, Gourkanti et al. @neal-lab.bsky.social show that the rhomboid protease Rhbdl2 restrains #macrophage recruitment & wound repair in #zebrafish, positioning Rhbdl2 as a potential brake on macrophage-driven repair rupress.org/jcb/article/... #Migration #motility #Immunology

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Rockefeller University Press @rupress.org · 10/09/2026

Heart rate is controlled, in part, by the opening and closing of the ion channel HCN4. In @jgp.org, Blecker, Bankston and colleagues describe the functionally relevant domains of both the channel and its ER-resident potentiator, IRAG. rupress.org/jgp/article/... #Biophysics #IonChannels

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Rockefeller University Press @rupress.org · 10/09/2026

In @jem.org, Michalets et al. demonstrate that upper respiratory tract tissue-resident memory #CD8⁺ T cells are sufficient to protect against respiratory virus transmission, even in the absence of #CD4 #Tcells, #Bcells, or lower respiratory tract immune responses. rupress.org/jem/article/...

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Rockefeller University Press @rupress.org · 10/09/2026

📢 Attention #undergraduates, #gradstudents, and early-career #postdocs! Apply for @jcb.org's Alan Hall & Norton B. Gilula Travel Awards ✈️ that support your attendance at #CellBio2026 (Dec. 12-15) in San Diego! Apply by October 18 👉 rupress.org/jcb/pages/al... @ascbiology.bsky.social

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Rockefeller University Press @rupress.org · 09/09/2026

Perspective @jcb.org: Lo, Parton et al. provide a perspective on the role of #skeletalmuscle #caveolae, focusing on the cellular processes impaired by caveola dysfunction in muscle disease. They propose a new classification for disease-associated CAV3 variants. rupress.org/jcb/article/...

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Rockefeller University Press @rupress.org · 09/09/2026

In @jcb.org, Jessica Sheu-Gruttadauria et al. show that the material properties of the #nucleolus are shaped by the assembly state of ribosomal precursors, which tune nucleolar dynamics and morphology through their interactions with the nucleolar scaffolding protein NPM1. rupress.org/jcb/article/...

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Rockefeller University Press @rupress.org · 09/09/2026

New @jem.org study by Li et al. identifies that the ATPase Vps4B controls caspase-1 dynamics at the ASC speck to promote #inflammasome activation. This self-rejuvenating mechanism of the ASC speck opens up new avenues for therapeutic intervention in inflammatory diseases. rupress.org/jem/article/...

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Rockefeller University Press @rupress.org · 09/09/2026

In @jcb.org, Vignogna (@rvig.bsky.social) and Fromme (@fromme-lab.bsky.social) identify GAP activity in several DENN domain proteins, revealing unexpected functional diversity within this protein family. rupress.org/jcb/article/... #GolgiTime #GTPases #Biochemistry #StructuralBiology #Golgi

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Rockefeller University Press @rupress.org · 09/09/2026

“JGP’s standards are trusted internationally, publication in the journal can lead to lasting visibility and recognition well beyond the immediate field.” — Chieko Koike, Ritsumeikan University Learn more about @jgp.org: hubs.la/Q04t83Z10

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Rockefeller University Press @rupress.org · 08/09/2026

In @jcb.org, Qian, Good et al. determine that proper spatial patterning of zygotic genome activation is required for #embryogenesis and the existence of a surveillance system for embryo quality control exquisitely tuned to spatiotemporal ordering of genome activation. rupress.org/jcb/article/...

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Rockefeller University Press @rupress.org · 08/09/2026

HLA-DQ2.5, the major genetic risk for #celiacdisease, is present across diverse populations. In @jhumimmunity.org, Xin Long et al. from the Kong lab (UTSW) show that its linkage with HLA-B8 varies by genetic ancestry and contributes to differences in disease prevalence. rupress.org/jhi/article/...

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Rockefeller University Press @rupress.org · 08/09/2026

Spotlight @jcb.org: Kops previews work from Tran, @dumontlabucsf.bsky.social et al. (rupress.org/jcb/article/...), which uses super resolution live imaging to show that #condensin is required for local structural organization and microtubule attachment of #kinetochores. rupress.org/jcb/article/...

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Rockefeller University Press @rupress.org · 08/09/2026

In @jem.org, Bolaños, Melero et al. @unav.edu show that tumor necrosis factor sensing by cancer cells through TNFR1 sets in motion forms of immunosuppressive protumor #inflammation that mediate escape from immune surveillance against tumors. rupress.org/jem/article/... #TumorImmunology

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Rockefeller University Press @rupress.org · 08/09/2026

HYOU1 deficiency links ER #proteostasis failure to human #immunodeficiency. In @jhumimmunity.org, Idani, @seiamak.bsky.social et al. identify defective B-cell development, persistent #neutrophil abnormalities, & #interferon pathway dysregulation as key disease mechanisms rupress.org/jhi/article/...

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Rockefeller University Press @rupress.org · 08/09/2026

In @jcb.org: Using iPSC-derived human #neurons gene-edited to express pathogenic #KIF1A variants, @aikenlab.bsky.social et al. demonstrate that distinct alterations in KIF1A motor function disrupt synaptic development through divergent cellular mechanisms. rupress.org/jcb/article/...

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Rockefeller University Press @rupress.org · 07/09/2026

JHI's September cover (rupress.org/jhi/issue/2/5) shows flow-cytometric characterization of TCR Vδ2 cells from two healthy controls & a patient carrying a TCRγδ-specific somatic STAT5B gain-of-function mutation based on expression of 10 different surface markers. Meyer et al. doi.org/10.70962/jhi...

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Rockefeller University Press @rupress.org · 07/09/2026

On @jgp.org's September cover (rupress.org/jgp/issue/15...): Gaitán‑Peñas et al. (doi.org/10.1085/jgp....) show how the VRAC inhibitor DCPIB binds the extracellular selectivity filter through adaptable interactions, providing new insights into the molecular basis of channel inhibition.

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Rockefeller University Press @rupress.org · 07/09/2026

@jem.org September cover (rupress.org/jem/issue/22... ) depicts a confocal image of Ramos B cells extracting surface-bound antigen from plasma membrane sheets. Sheets are labeled w/ fluorescent surrogate antigen (magenta); B cells are marked by CD19 (orange). Berzosa et al.: doi.org/10.1084/jem....

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Rockefeller University Press @rupress.org · 07/09/2026

On @jcb.org September cover (rupress.org/jcb/issue/22...): immunofuorescence image of the anterior part of a #zebrafsh embryo showing the blood vasculature in magenta and endothelial nuclei in cyan. From Janssen and Angulo-Urarte et al. @huveneerslab.bsky.social: doi.org/10.1083/jcb....

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Rockefeller University Press @rupress.org · 04/09/2026

Fagniez et al. identify new patients with inherited RORγT deficiency characterized by impaired TCRα rearrangement, depletion of MAIT and iNKT cells, reduced numbers of TH17, TH1*, and CD8+ T cells, and defective IFN-γ and IL-17 immunity against #Mycobacterium & #Candida. rupress.org/jem/article/...

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Rockefeller University Press @rupress.org · 03/09/2026

Spotlight @jcb.org: @felixmendu.bsky.social et al (rupress.org/jcb/article/...) show that the #Golgi responds to the mechanical force of cell spreading by increasing its secretory output, sustaining spreading thru a self-reinforcing feedback loop. From Hausser: rupress.org/jcb/article/...

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Rockefeller University Press @rupress.org · 03/09/2026

In @jhumimmunity.org, Kadirkamanathan et al use base editors to modify DNA sequences in order to study newly identified mutations, or those of unknown significance, that may be responsible for inherited errors in the cutting & joining of DNA during immune cell development rupress.org/jhi/article/...

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Rockefeller University Press @rupress.org · 03/09/2026

In @jcb.org, Chi, Saeki, Yokomizo et al. demonstrate that 12-HHT-BLT2 signaling protects alveolar epithelial cells from pore-forming toxin-induced damage by promoting membrane repair, suggesting a new therapeutic strategy for bacterial infections. rupress.org/jcb/article/... #Biochemistry #Membrane

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Rockefeller University Press @rupress.org · 03/09/2026

Read a new @jcb.org collection of recent articles to accompany @embo.org workshop, Lipid Code to Life. Selected articles explore mechanisms underlying lipid transport, endosome biogenesis, & the maintenance of lipid homeostasis at ER–plasma membrane contact sites. rupress.org/jcb/collecti...

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Rockefeller University Press @rupress.org · 03/09/2026

Explore @jem.org's new collection highlighting the latest discoveries in #cancer #immunology and #immunotherapy, timed to coincide with the @cshasia.bsky.social meeting on the topic in Suzhou, China. 👉 rupress.org/jem/collecti...

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Rockefeller University Press @rupress.org · 02/09/2026

In @jem.org, Mauro Teixeira and @carolilucas.bsky.social labs show that Qdenga vaccination induces serotype-skewed immunity shaped by both immune imprinting & vaccine’s DENV-2 backbone, limiting balanced tetravalent responses, particularly in dengue-naïve individuals rupress.org/jem/article/...

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Rockefeller University Press @rupress.org · 01/09/2026

#Exome sequencing can stratify the genetic risk of #CeliacDisease among first-degree relatives of affected individuals. A study @jhumimmunity.org from Talha Asif, Xiao-Fei Kong et al. finds that about 10% of first-degree relatives carry a particularly high genetic risk. rupress.org/jhi/article/...

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Rockefeller University Press @rupress.org · 01/09/2026

The presence of type I IFN-neutralizing antibodies is a life-threatening risk factor for multiple infectious diseases. In @jhumimmunity.org, Yang et al report the prevalence of NAbs in dengue patients & indicate patients w/ NAbs may have a higher risk of cardiac injury rupress.org/jhi/article/...

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Rockefeller University Press @rupress.org · 01/09/2026

In @jcb.org, Mishra, @rpadinjat.bsky.social et al. @ncbsbangalore.bsky.social show that CERT protein is required to maintain ER-PM MCS in #Drosophila #photoreceptors, which maintains #phosphoinositide levels at the PM during G-protein–coupled PLC signalling rupress.org/jcb/article/... #Neuroscience

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Rockefeller University Press @rupress.org · 31/08/2026

In @jhumimmunity.org: Aaron T. Chin et al. develop a temporal windowing methodology that groups recurrent sinusitis encounters into discrete episodes in electronic health records and improves #immunodeficiency classification. rupress.org/jhi/article/... #IEIs #Phenocopies #Diagnostics

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Rockefeller University Press @rupress.org · 31/08/2026

New review @jgp.org: Prantl, Atzgerstorfer, Derler et al. @jku.at catalog known disease-associated #Orai1 mutations, explain how they disrupt the activation sequence, and link them to their clinical impact. rupress.org/jgp/article/... #IonChannels #Biophysics #ProteinStructure #MembraneTransport

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Rockefeller University Press @rupress.org · 28/08/2026

In @jem.org, Wu, Geoffroy, de Thé et al. reveal that PML::RARA drives acute promyelocytic #leukemia by bridging the PML-bound SUMO machinery and RARA-bound corepressors, enhancing corepressor #sumoylation, target gene repression, and the differentiation block. rupress.org/jem/article/...

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Rockefeller University Press @rupress.org · 28/08/2026

In @jhumimmunity.org, Timmermans, Naesens et al. report culture-negative septic #arthritis caused by Ureaplasma parvum in a patient with LRBA deficiency, mimicking autoimmune disease. rupress.org/jhi/article/... #Diagnostics #Autoimmunity

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Rockefeller University Press @rupress.org · 27/08/2026

In @jgp.org, Docken, Marquis, Furutani, Lewis, Sack @ucd-physiology.bsky.social et al. test the hypothesis that the antiarrhythmic drug nifekalant opens hERG gates while blocking, revealing a mechanism that may reduce #arrhythmia risk. rupress.org/jgp/article/... #IonChannels #Biophysics

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