Here, they generate salivary gland epithelial progenitors hPSCs by mimicking in vivo salivary gland development. These progenitors self-assemble into salivary gland organoids in vitro and reconstitute...

In this study, Pinto et al. reveal early postnatal life as a critical window in which fetal-derived CX3CR1+ cells and AQP1+ intermediates establish the synovial macrophage lining. This work shows how ...

Our study establishes macrophages as necessary components of the developing tooth microenvironment to maintain their morphology and function. By integrating complementary experimental approaches, we s...

In one email, an AI researcher suggested it’s “hard to be brilliant if you are worrying if you look fat or why another woman hates you.”

PhD Project - Targeting macrophages to protect fertility after chemotherapy at University of Edinburgh, listed on FindAPhD.com

In recent days there have been a number of reports about cuts to UKRI budgets and grant funding pauses. Here we summarise events so far, and set out why we believe UKRI should explain how and why deci...

Science, Innovation and Technology Committee

Radiation-induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate th...

Here the authors identify adenophages, a previously unknown macrophage population present in exocrine glands in mice and humans. These cells are dependent on ILC2-derived GM-CSF and support glandular ...

Here, the authors show that a single Lgr5 stem cell population in the posterior tongue produces taste buds, salivary glands, and epithelium, representing unified chemosensory units.

imageimageRegulatory mechanisms governing stem cell quiescence in glandular organs remain ill-defined. Here, multi-omics profiling uncovers novel stem cell-like populations in mouse salivary gland organoids and reveals Notch signaling as a ...

Regenerative responses in salivary gland organoids after irradiation are mediated by IFN-I signaling.

Background Bacterial translocation in cirrhosis can trigger infection and hepatic decompensation, leading to systemic inflammation, organ failure and increased mortality. These infections often origin...

Macrophages are crucial for the maintenance of intestinal homeostasis, are considered key proinflammatory effector cells during intestinal inflammatio…

Journot et al. explore fate specification during embryonic development and regeneration of bilayered glandular epithelia. They uncover conserved molecular mechanisms linking tissue architecture with c...

Radiotherapy (RT) is essential in treating abdominal and pelvic cancers but often damages the healthy tissues, particularly the intestines, leading to…

Salivary glands (SGs) produce saliva essential for digestion, mucosal immunity, and as a source of non-invasive biomarkers. The health and pathology of SGs h...

Specialized macrophages are known to persist within tissue niches, but the molecular mechanisms guiding their sustained functional adaptation remain unclear. Kolter and Döring et al. show that local i...

John Gurdon is at the Wellcome Trust/Cancer Research UK Institute of Cancer and Developmental Biology in Cambridge. Educated at Eton and Christ Church, Oxford, he changed from classics to zoology. Dur...

An exciting opportunity has arisen to join the Emmerson lab within the Institute for Regeneration and Repair at the University of Edinburgh. This three year, BBSRC-funded postdoctoral research associa...

Flowing from the principles of bioorthogonality, the introduction of abiotic transition metals for the catalytic production of drugs at specific anatomical locations has carved new paths to face chall...

The HPV vaccine programme, which started in 2008, has been hugely successful across Scotland.