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Filipa Simões

@simoesfilipa.bsky.social
3.3K followers 737 following 162 posts

Development and Regeneration of the Heart | Cardio-Immuno Genomics | Group Leader University of Oxford IDRM-DPAG | playing with zebrafish & cardiac organoids | academic mama of 2 children & 1 dog | curiosity led

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Reposted by Filipa Simões
Sumru Bayin @sumrubayin.bsky.social · 29/09/2026
An exciting milestone for the Bayin lab! Our first PhD thesis submitted! Congratulations @jensbager.bsky.social 🍾🍾 #proudPI 😍 Part of Jens’ PhD work can be found in our latest publication. journals.biologists.com/dev/article/...
journals.biologists.com
A conserved differentiation programme facilitates inhibitory neuron production in the developing mouse and human cerebellum
Summary: Single cell RNA-sequencing establishes core components of the gene regulatory network that drive Nestin-expressing progenitor to inhibitory neuron differentiation in the developing mouse and ...
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Cathy Abbott @cathyabbott.bsky.social · 23h
Great reporting from @robinbisson.bsky.social on an absolutely dire funding situation…
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Mathilda Lennartz @mathilda95.bsky.social · 30/09/2026
UPDATE!: I am absolutely stoked that the second paper of my PhD is now out in @natcellbio.nature.com :D. We combined lipid imaging, STED microscopy, and mathematical modelling in a super cool team effort to quantify lipid partitioning inside clathrin-coated pits. www.nature.com/articles/s41....
nature.com
Quantification of lipid sorting during clathrin-mediated endocytosis - Nature Cell Biology
Lennartz et al. evaluate lipid enrichment in clathrin-coated pits and observe that the differential lipid partitioning into clathrin-coated pits is largely driven by the lipid asymmetry of the plasma ...
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University of Oxford @ox.ac.uk · 22h
NEW: Oxford has been named the world's number one University for a record-breaking 11th consecutive year in the Times Higher Education World University Rankings. Oxford has held the top spot since 2017 – the longest run at number one in the rankings' history. [1/3]
Aerial view of Oxford’s Radcliffe Camera and surrounding University buildings at sunset. Text reads: ‘Oxford named best university in the world for record 11 years in a row.’
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PLOS Biology @plosbiology.org · 29/09/2026
How are growing vertebrate organs organized at a single-cell level? This study develops whole adult-organ expansion microscopy (WAO-ExM) to visualize every single hepatocyte in the zebrafish liver during post-embryonic growth. 🧪 #AcademicSky #Development plos.io/4d9Y9UM
Light-sheet microscopy view of a 10× expanded zebrafish liver, revealing its cellular architecture with hepatocyte membranes in green, hepatocyte nuclei in red, and nuclei of other cell types in blue.
Image credit: Image acquisition, Xuejiao Tian; image processing, Hsiao-Yuh Roan and Hsin Chen.
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 29/09/2026
For the last 34 years I have been on the faculty of the UNC-Chapel Hill Department of Biology and have never regretted that decision. This year we are hiring TWO new Assistant Professors in the broad area of Molecular, Cell, Developmental Biology 1/n bio.unc.edu
Front page of the website
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Tessa Montague @tessamontague.bsky.social · 29/09/2026
I'm excited to share our new preprint: Generation of a transgenic cephalopod tinyurl.com/pc86jxz8 Cephalopods (cuttlefish, octopus & squid) are crazy critters that dynamically camouflage to their surroundings by changing the color, pattern, & texture of their skin, which they control w their brain.
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Wolfgang Huber @wkhuber.bsky.social · 28/09/2026
I've been trying to respond with a personal email to every request for a PhD or Master thesis placement in my group. But with the flood of AI generated applications that's now coming in every day, this has become impossible.
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Wouter Masselink @woutermasselink.bsky.social · 25/09/2026
Just got back home from Krems after attending the EMBO regeneration meeting. It was an absolutely fantastic week full of super exciting science. I’m already looking forward to the 2028 edition.
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Richard Sever @richardsever.bsky.social · 20/09/2026
"All corners of academia will soon be flooded with AI-generated research....Maths and CS go first because their entire output is symbol manipulation...Biology comes later not because biologists are cleverer but because the rate-limiting step is physical" giorgio.gilest.ro/the-weimar-o...
giorgio.gilest.ro
The Weimar of knowledge – la bottega
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paveltomancak.bsky.social @paveltomancak.bsky.social · 20/09/2026
21627 applications. Nothing to celebrate here. Impossible to evaluate fairly & safely. Neither the science (too diverse & possibly LLM generated) nor the soft criteria (likely LLM generated). Without an interview stage - a security risk! marie-sklodowska-curie-actions.ec.europa.eu/whats-new/ne...
marie-sklodowska-curie-actions.ec.europa.eu
MSCA Postdoctoral Fellowships 2026 receives record number of applications
The 2026 call has attracted considerable interest from the research community with 21,627 applications submitted.
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Arjuna Rajakumar PhD @arjunarajakumar.bsky.social · 19/09/2026
So proud of my lab mate @sagrill.bsky.social (whose on the job market 👀) for this magnum opus from @remlehmann.bsky.social lab @whiteheadinstitute.bsky.social ScRNA-seq of 🪰 germ cells reveals new biology, answers age old questions, and proposes new paradigms! 1/8 www.biorxiv.org/content/10.6...
Drosophila stage 10b embryo w/HCR staining marking two germ cell clusters. One will successfully colonize the gonad and the other, like tears in the rain, will be lost forever
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Claudio Cantù @claudiocantu81.bsky.social · 20/09/2026
I will hire a Postdoc to study the genomic determinants of tumor heterogeneity Please, get in touch if interested, or help me spread the voice @scilifelab.se @kawresearch.bsky.social @liu.se liu.se/en/research/...
liu.se
The Cantù Lab - Genome Regulation in Development and Disease
The Cantù Lab at LiU is focused on one important goal: to discover the mechanisms of genome regulation that drive cell differentiation and specialization during embryonic development.
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Sophie Acton @actonlab.bsky.social · 16/09/2026
Latest preprint now online! doi.org/10.64898/202... Veronika Lachina generates a vertex model to integrate active cellular forces and passive extracellular mechanics to produce rapid, cyclical tissue remodelling Collaboration with the brilliant @yanlanmao.bsky.social at @lmcb-ucl.bsky.social
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Erdinc Sezgin @sciezgin.bsky.social · 17/09/2026
New paper out: Plasma membrane order maps functional diversity in immune cells We showed how biophysical state of the membranes correlates with the activity of immune cells such as migration and killing. www.nature.com/articles/s41...
nature.com
Plasma membrane order maps functional diversity in immune cells - Nature Chemical Biology
Cells undergo membrane remodeling in response to the environment to perform specific functions. Now, a cytometry-based method with immune cell biomarker analysis captures variations in plasma membrane...
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Teresa Rayon @trayon.bsky.social · 12/09/2026
‼️ Postdoc position open. We study how protein metabolism controls time. If you’re excited by this question, we’d love to hear from you! We’re looking for a motivated & collaborative researcher with a strong track record. 📅 30 September 2026 📢 Please share Apply here 👇👇
babraham.current-vacancies.com
Postdoctoral Research Scientist - Babraham
The lab investigates the molecular mechanisms that control biological timing in mouse and human stem cells (Azzi & Rayon, Curr Opinions 2024; Nakanoh et al., Dev Cell 2026). The central aim of this ex...
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Biology Open @biologyopen.bsky.social · 14/09/2026
For this year's #PeerReviewWeek, we want to thank all the reviewers that have participated in BiO's Fast & Fair - an initiative that aims to provide authors with faster peer review decisions without compromising quality.
Biology Open's practice of compensating reviewers is rare and, in my view, contributes to a more respectful and high-quality review culture.
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Philippe Batut @philippebatut.bsky.social · 10/09/2026
🧬🔬 Why are enhancers transcribed and how does that impact gene regulation? I’m really excited to share our new paper in @science.org showing that noncoding RNAs control the timing of gene activation in embryos. With Mike Levine #ScienceResearch @columbiamed.bsky.social A few highlights below... 🧵👇
science.org
Noncoding transcription controls the developmental dynamics of long-range gene regulation
The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely ...
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Addgene @addgene.bsky.social · 10/09/2026
Congratulations to Michael J. Fox on the 2026 Lasker~Bloomberg Public Service Award for his Parkinson’s research advocacy! 🎉 @laskerfdn.bsky.social The Michael J. Fox Foundation shares hundreds of plasmids relevant to Parkinson’s research:
twp.ai
Addgene: Michael J Fox Foundation (MJFF) Plasmid Collection
Browse plasmids expressing genes relevant to Parkinson's disease created by the Michael J. Fox Foundation
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Prisca Liberali @priscaliberali.bsky.social · 08/09/2026
What if we stop asking only how cells build tissues and ask how tissues shape cells? That’s what we’ll explore at Modelling Life from Tissues to Cells 🇨🇭 lakeconferences.org/conf/8334d9b...
lakeconferences.org
Conference - Modelling Life from Tissues to Cells: Coordination and Robustness - Lake Conferences
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Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 07/09/2026
Very happy to share my postdoc paper is out now in @natcellbio.nature.com titled "Tissue flow acts as a guidance cue for immune cell polarization and directional migration". If you love imaging and immune cells, this is for you! #microscopymonday www.nature.com/articles/s41... A 🧵: 1/n
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Sonya Neal @neal-lab.bsky.social · 02/09/2026
Come be my colleague!! 🎉 We’re hiring an Assistant Professor in Developmental Biology at UCSD! If you’re doing exciting work in development or regeneration, come join us!! Please spread the word and apply! apol-recruit.ucsd.edu/JPF04591
apol-recruit.ucsd.edu
Assistant Professor of Developmental Biology
University of California, San Diego is hiring. Apply now!
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Trish Greenhalgh @trishgreenhalgh.bsky.social · 08/08/2026
“Fauci has devoted more than 50 years to public service, leading NIAID and the US through the HIV/AIDS epidemic, the 2001 anthrax attacks, SARS, pandemic influenza, Ebola, Zika, & other infectious disease threats.” Thanks @gavinyamey.bsky.social for honouring this hero. www.bmj.com/content/394/...
bmj.com
Fauci’s Senate hearing riled up the MAGA base—but at the cost of damaging public health
The vilification of Anthony Fauci by Senate Republicans will erode trust in science, curtail international research collaborations, and deter scientists and health experts from entering public service...
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Sigolène Meilhac @meilhacsigolene.bsky.social · 08/08/2026
New publication, new insights into left-right patterning in mice. We revisit the role of the node, from a left-right organiser to one biasing factor among others. www.science.org/doi/10.1126/...
science.org
Wnt and Nodal asymmetries stratify mouse laterality phenotypes in the absence of node flow
Asymmetry establishment without node flow reveals an alternative symmetry-breaking event in the mesoderm involving WNT signaling.
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Rita Mateus @ritamateus.bsky.social · 03/08/2026
New preprint alert!!! Super proud to finally share an authentic 'tour-de-force' from the amazing PhD students Shivani Gunnan @shivanigunnan.bsky.social, Max Kotz and Lucas Ribas, in collaboration with @friedrich-group.bsky.social 👇a small thread www.biorxiv.org/content/10.6...
biorxiv.org
Developmental growth rates adapt to enable self-correction of organ morphology after injury.
Proportional organ growth requires tissue-level control of cell behavior. Yet the cues that adapt growth rates, especially after organ injury, remain unclear. Here, we uncover that developing organs a...
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Jay Shendure @jshendure.bsky.social · 31/07/2026
Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote 1/n
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MadScientist @mads100tist.bsky.social · 30/07/2026
Super cool mechanism tbh
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Thiago Carvalho @cyrilpedia.bsky.social · 29/07/2026
"One is you have to be very curious about something. No. 2, you have to have an unfailing urge to address the question you have. No. 3, I think it helps to try to combine knowledge in at least two different fields where people don’t necessarily interact.” www.nytimes.com/2026/07/21/s...
nytimes.com
Susumu Tonegawa Dies at 86; Nobel Laureate Showed How Antibodies Fight Infection
The first Japanese scientist to win the Nobel Prize in Physiology or Medicine, he went on to discover how memories are stored, advancing understanding of how the brain works.
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Ana Viñuela @anavinuela.bsky.social · 27/07/2026
Amen!! to all of it. Only to add that as computational biologist, I don't get paid to code. I get paid to turn biological questions into computational experiments, to interpret numbers and tons of data to give biological insights. Learning to write, code or text, is learning to think.
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Ignacio Gallup-Diaz @igallupd.bsky.social · 25/07/2026
“A Penn professor thought she’d sell 1000 copies of her ‘Odyssey’ translation. She sold a million this year alone, thanks to Christopher Nolan.” “West Philly's Emily Wilson, who penned a highly acclaimed translation of the epic poem in 2017, is having a big summer.”
share.inquirer.com
A Penn professor thought she’d sell 1000 copies of her ‘Odyssey’ translation. She sold a million this year alone, thanks to Christopher Nolan.
West Philly's Emily Wilson, who penned a highly acclaimed translation of the epic poem in 2017, is having a big summer.
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Itai Yanai @itaiyanai.bsky.social · 26/07/2026
Creativity is ultimately rooted in the individual –Ruth Lehmann, Director of the Whitehead Institute, MIT
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Benoit Bruneau @benoitbruneau.bsky.social · 23/07/2026
4D Nucleome special issue of Science, featuring our paper "Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor", led by Zoe Grant in my lab and Zhuzhen Kuang in Katie Pollard's lab @gladstoneinst.bsky.social www.science.org/toc/science/...
science.org
Contents | Science 393, 6809
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John Wallingford @jbwallingford.bsky.social · 22/07/2026
A true giant of #DevBiol! For you youngsters who might not know, among her decades of fantastic discoveries was this thing she found in 1981 that she called "Embryonic Stem Cells." I think some people still study them. Thanks to Alex for writing this lovely piece!
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BWJones @bwjones.bsky.social · 20/07/2026
This... I am here for this.
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Itai Yanai @itaiyanai.bsky.social · 19/07/2026
Often people have something that makes them their skin tingle. I'm a believer in that skin tingling. –Sarah Teichmann, on choosing a project (from the Night Science Podcast, episode 5) @teichlab.bsky.social
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Vicki Metzis @vmetzis.bsky.social · 17/07/2026
How does an embryo generate the right cells in the right place? Delighted to share our latest findings on how neural crest cells acquire vagal or trunk identities Spoiler alert: The timing & combination of CDXs preconfigures cell identity & distinct HOX states www.biorxiv.org/content/10.6...
biorxiv.org
Temporally distinct CDX programmes preconfigure vagal and trunk neural crest
Neural crest cells (NCCs) are progenitor cells vital in establishing the head, heart, gut and peripheral nervous system of vertebrate embryos. Disruptions to NCC development underlie neurocristopathie...
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sjvn @sjvn.bsky.social · 16/07/2026
My first search engine.
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Itai Yanai @itaiyanai.bsky.social · 17/07/2026
Maybe creativity is just how big a bag of tricks you have; how many different tricks you've seen, applied in different contexts. And perhaps some people have a little bit more skill remembering all those tricks or applying them in different situations. - Arjun Raj, @arjunraj.bsky.social
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Doudna Lab @doudna-lab.bsky.social · 16/07/2026
Our AI-guided design of RNA-guided nucleases is now out in @science.org 💻🧬 We used structure and evolutionary data to generate minimal, active and divergent gene editors! www.science.org/doi/10.1126/... Congrats to @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social & team!
science.org
Structure and evolution-guided design of minimal RNA-guided nucleases
The design of RNA-guided nucleases with properties not limited by evolution can expand programmable genome-editing capabilities. However, generating diverse multidomain proteins with robust enzymatic ...
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Evan Bardot (he/him) @ebardot.bsky.social · 13/07/2026
I had the chance to highlight some amazing #DevBio from @gcharras.bsky.social and @herveturlier.bsky.social for @natcellbio.nature.com this month! Check out my Research Highlight www.nature.com/articles/s41... and the original article in @cp-devcell.bsky.social www.sciencedirect.com/science/arti...
nature.com
Relative tension shapes embryos - Nature Cell Biology
Nature Cell Biology - Relative tension shapes embryos
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Ben Lai @benlai-taiwan.bsky.social · 11/07/2026
Excited to share our latest study identifying Scube2 as a novel regulator of coronary vessel formation and heart regeneration, promoting regenerative revascularization through PDGF signaling and EC-mural cell interactions published in ATVB @americanheart.bsky.social ahajournals.org/doi/10.1161/AT…
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Jesse Veenvliet @jesseveenvliet.bsky.social · 08/07/2026
Just approved an order for standard lab consumables. Prices have nearly doubled since starting the lab. Meanwhile, the bar for publishing keeps rising, requiring ever more costly experiments, while grant budgets barely changed. Hard to see how this is a sustainable trajectory for academic research.
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Thiago Carvalho @cyrilpedia.bsky.social · 09/07/2026
'I would not be talking about the fish that my team discovered if we didn’t have long-term funding that allowed me to fail and learn from failures. The only way I was able to learn from failures was to have long-horizon funding, when I wasn’t being measured from year to year'
issues.org
“I Am an Unabashed Optimist About the Long-Term Future of Science.”
The new president of the National Academy of Sciences talks about learning to see as a scientist and communicating science in a noisy information landscape.
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Maureen Barr @barrlab.bsky.social · 09/07/2026
"The university model may have to change." @neilshubin.bsky.social Listen to your inner fish.
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Harmit Singh Malik @harmitmalik.bsky.social · 08/07/2026
The ever amazing Steve Henikoff! @fredhutch.org @basicsci.fredhutch.org
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Dr. Lucky Tran @luckytran.com · 05/07/2026
A hero’s welcome for the Cabo Verde team arriving home ❤️
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TeeDixie ✊🏼 @teedixie.bsky.social · 02/07/2026
Wow who’d have thunk it, vaccines work 🤔 Great news to celebrate.
No women aged 20-24 in England have died from cervical cancer for the first time, thanks to the HPV vaccine.
A landmark study funded by Cancer Research
UK shows the HPV vaccine is making cervical cancer increasingly preventable, with researchers highlighting a major milestone: between 2020 and 2024, no women aged 20-24 in England died from the disease.
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James Briscoe @jamesbriscoe.bsky.social · 02/07/2026
Paying peer reviewers Interview with @danielgorelick.bsky.social about @biologyopen.bsky.social Fast & Fair trial in which peer reviewers were paid £220/review Spoiler: it works - fast, high quality reviews www.nature.com/articles/d41...
nature.com
Why paying peer reviewers works, according to a journal’s editor-in-chief
A biology journal that paid peer reviewers found that the approach cut the time to a first editorial decision by 85% and maintained high-quality reviews.
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Becker Group at CRTD @beckergroup.bsky.social · 01/07/2026
This is the other paper from our group that landed on BioRxiv yesterday, three in a week 😍
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James Briscoe @jamesbriscoe.bsky.social · 01/07/2026
New in @dev-journal.bsky.social: how tissue shape tells cells what to become Using human stem-cell neuruloids, we show how that physical boundaries encode positional information that drives cell fate patterning in a model of trunk formation A thread 🧵 journals.biologists.com/dev/article/...
journals.biologists.com
Boundary constraints can determine pattern emergence
Summary: A reaction-diffusion mechanism recapitulates pattern emergence in an in vitro model of neuromesodermal progenitors under a variety of boundary and geometrical perturbations.
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