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Vicki Metzis

@vmetzis.bsky.social
636 followers 605 following 58 posts

Developmental biologist. Interested in how cells make decisions, genetics, genomics, gene regulation and stem cells. Group leader @mrc-lms.bsky.social ‪@imperialmed.bsky.social

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Reposted by Vicki Metzis
Teresa Rayon @trayon.bsky.social · 15/08/2026
Our work on the role of the proteasome in developmental tempo is out!!!! 🐭⌛️👤⏳ Six years after identifying an association between protein stability and developmental tempo, we now demonstrate a causal link between protein turnover and developmental tempo through proteasomal degradation
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Reposted by Vicki Metzis
Christos Kalaitzis @christos-kltzs.bsky.social · 18/07/2026
So glad to see our pre-print finally out! Excited to share work stemming my PhD work, which I had the pleasure of developing alongside with my co-first author, Irene Amblard. 🤓
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Vicki Metzis @vmetzis.bsky.social · 17/07/2026
How does an embryo generate the right cells in the right place? Delighted to share our latest findings on how neural crest cells acquire vagal or trunk identities Spoiler alert: The timing & combination of CDXs preconfigures cell identity & distinct HOX states www.biorxiv.org/content/10.6...
biorxiv.org
Temporally distinct CDX programmes preconfigure vagal and trunk neural crest
Neural crest cells (NCCs) are progenitor cells vital in establishing the head, heart, gut and peripheral nervous system of vertebrate embryos. Disruptions to NCC development underlie neurocristopathie...
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Reposted by Vicki Metzis
James Briscoe @jamesbriscoe.bsky.social · 15/07/2026
New from @vmetzis.bsky.social & co Vagal & trunk neural crest cells share transient epiblast origin, but temporal regionalisation preconfigures their identity before crest induction Cdx1 acts before Cdx2, setting distinct chromatin and HOX state in the epiblast www.biorxiv.org/content/10.6...
biorxiv.org
Temporally distinct CDX programmes preconfigure vagal and trunk neural crest
Neural crest cells (NCCs) are progenitor cells vital in establishing the head, heart, gut and peripheral nervous system of vertebrate embryos. Disruptions to NCC development underlie neurocristopathie...
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Reposted by Vicki Metzis
British Society for Developmental Biology @bsdb.bsky.social · 06/05/2026
Save the date! The 2027 BSDB Spring Meeting will take place on 19 - 22 April in Edinburgh. An exciting programme with a fantastic lineup of speakers showcasing developmental biology across scales! More details soon!
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Reposted by Vicki Metzis
the Node @the-node.bsky.social · 15/04/2026
An illustrated summary of the BSDB Spring Meeting 2026 In this post, @alexneaverson.bsky.social shares her insights on using illustration to share the joy of developmental biology at the 2026 @bsdb.bsky.social meeting. thenode.biologists.com/an-illustrat... #SciArt
thenode.biologists.com
An illustrated summary of the BSDB Spring Meeting 2026 - the Node
I recently attended the BSDB Spring Meeting, and decided to spend most of my time at the conference sketching. The result is this illustrated summary -
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Reposted by Vicki Metzis
Ingrid Tsang @ingridtsang.bsky.social · 15/04/2026
Had so much fun at @bsdb.bsky.social a few weeks go and am very excited about all the upcoming stories I saw. Check out the #preprint list I've collated from the meeting, now on @prelights.bsky.social👇 prelights.biologists.com/prelists/bsd... And please do let me know if there are any I missed 👀
prelights.biologists.com
BSDB Spring Meeting: Molecules to Morphogenesis - preLights
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Reposted by Vicki Metzis
Teresa Rayon @trayon.bsky.social · 15/04/2026
It’s official! @bertacava26.bsky.social has received a Marie Skłodowska-Curie European Postdoctoral Fellowship 🚀🚀🚀 She will study proteostasis during embryo dormancy @babrahaminst.bsky.social Very well deserved. proud of this achievement & excited for the discoveries ahead 🐭⌛️
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Vicki Metzis @vmetzis.bsky.social · 26/03/2026
And that’s a wrap! From all of us @bsdb.bsky.social - thank you everyone for making this a very special meeting, from Molecules to Morphogenesis
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Reposted by Vicki Metzis
James Briscoe @jamesbriscoe.bsky.social · 25/03/2026
Honoured and overwhelmed to receive the 2026 Waddington Medal. Science is a team effort, and I've been fortunate to work alongside exceptional people asking hard questions. Thank you to the BSDB and to everyone who has been part of the journey. bsdb.org/2026/03/24/2...
bsdb.org
2026 Waddington Medal Winner - James Briscoe - BSDB - British Society for Developmental Biology
We are very pleased to announce that this year’s Waddington medal winner is James Briscoe. His fundamental discoveries have helped shape our understanding of of how morphogens work, and he has played ...
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Reposted by Vicki Metzis
British Society for Developmental Biology @bsdb.bsky.social · 24/03/2026
The most deserving winner of the 2026 BSDB Wolpert Medal is Neil Vargesson. This award recognises his outstanding contributions to the public understanding of chemically-induced birth differences. Many congratulations to Neil! bsdb.org/2026/03/24/2...
bsdb.org
2026 Wolpert Medal Winner - Neil Vargesson - BSDB - British Society for Developmental Biology
Following the sad passing of one of the greats of Developmental Biology, Lewis Wolpert, the BSDB committee has launched a new annual medal in his honour. Lewis was well known for his ability to distil...
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Reposted by Vicki Metzis
British Society for Developmental Biology @bsdb.bsky.social · 24/03/2026
Huge congratulations to James Briscoe @jamesbriscoe.bsky.social for receiving the 2026 BSDB Waddington Medal, recognising an extraordinary career of discovery, mentorship, and leadership in developmental biology. bsdb.org/2026/03/24/2...
bsdb.org
2026 Waddington Medal Winner - James Briscoe - BSDB - British Society for Developmental Biology
We are very pleased to announce that this year’s Waddington medal winner is James Briscoe. His fundamental discoveries have helped shape our understanding of of how morphogens work, and he has played ...
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Reposted by Vicki Metzis
British Society for Developmental Biology @bsdb.bsky.social · 25/03/2026
Many congratulations to Cynthia Andoniadou @pituitarylab.bsky.social, recipient of the 2026 BSDB Cheryll Tickle Medal, honouring her internationally recognised research programme in pituitary gland development and stem cell biology. bsdb.org/2026/03/25/2...
bsdb.org
2026 Cheryll Tickle Medal Winner - Cynthia Andoniadou - BSDB - British Society for Developmental Biology
In 2016, the BSDB introduced the Cheryll Tickle Medal, which is being awarded annually to a mid-career, female scientist for her outstanding achievements in the field of Developmental Biology. The BSD...
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Reposted by Vicki Metzis
British Society for Developmental Biology @bsdb.bsky.social · 25/03/2026
🏆 We’re delighted to announce the winner of the 2026 BSDB Dennis Summerbell Award! This year’s award goes to Sergio Menchero @sermenchero.bsky.social, recognised for exceptional contributions to developmental biology and for carrying forward the curiosity and rigour that Dennis championed.
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Reposted by Vicki Metzis
British Society for Developmental Biology @bsdb.bsky.social · 25/03/2026
🎉 We are thrilled to announce the very first winner of the BSDB Marie Johansson Prize! This year’s award goes to Giulia Boezio @giulia-boezio.bsky.social, recognised for outstanding contributions to developmental biology and for embodying Marie’s scientific originality and rigour.
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Reposted by Vicki Metzis
Development @dev-journal.bsky.social · 20/03/2026
Excited for BSDB's 2026 Meeting organised by @abinagui.bsky.social @vmetzis.bsky.social, @gastruloids.bsky.social & co? Our Reviews Editor @ingridtsang.bsky.social & the Node's Community Manager @andreamurillo.bsky.social will also be attending - come and chat to them about our journal & the Node.
A promotional graphic for Development and The Node announcing attendance at the BSDB 2026 Spring Meeting. The Development logo appears in the top left. In the top right, there is a BSDB 2026 banner with event dates: 23–26 March 2026 at the University of Warwick. Text states that Reviews Editor Ingrid Tsang and Node Community Manager Andrea Murillo will be attending the meeting. Additional text invites attendees to reach out with questions about publishing or other activities from The Company of Biologists, and mentions collecting Development and Node goodies at the booth. Contact email addresses and social media icons with handles for Development and The Node are displayed at the bottom. Two portrait photos appear on the right side of the graphic.
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Vicki Metzis @vmetzis.bsky.social · 11/03/2026
Great to see this work out from our neighbours @mrc-lms.bsky.social driven by Noura Maziak @vaquerizasjm.bsky.social! With Pico-C they reveal a modular regulatory logic driving genome establishment - congrats to all authors!
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Vicki Metzis @vmetzis.bsky.social · 22/01/2026
We've been inundated (!) with abstracts for BSDB 2026!! Thanks to all who've submitted and to those that have registered! The rooms are going fast! Don't miss it! Early-bird registration due Monday 9th Feb 👇👇👇 bsdb.org/meetings/
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Vicki Metzis @vmetzis.bsky.social · 21/01/2026
Delighted to be in Edinburgh visiting the Institute of Genetics and Cancer today! Great to chat gene regulatory logic and development. Many thanks to @hannahlong.bsky.social and Jenny Nichols for hosting me, owner of the world’s best collection of ornamental office mice
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Vicki Metzis @vmetzis.bsky.social · 16/01/2026
Final reminder: abstract deadline today for the @bsdb.bsky.social 2026 meeting! Don’t miss it :) 👇👇👇 bsdb.org/meetings/
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Reposted by Vicki Metzis
British Society for Developmental Biology @bsdb.bsky.social · 09/01/2026
Don't forget to register for our upcoming Spring Meeting: 'Molecules to Morphogenesis' Get your abstracts submitted by the 16th of January! bsdb.org/meetings
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Reposted by Vicki Metzis
Sally Lowell @cellysally.bsky.social · 09/01/2026
This meeting will be so great. Only about a week until the early-bird deadline, 9th Feb. #DevBio
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Vicki Metzis @vmetzis.bsky.social · 06/01/2026
New year, new beginnings! Join us for all things animal & plant devbio at the 2026 @bsdb.bsky.social meeting in Warwick! Abstract submission closing NEXT FRIDAY 16th JAN - join us!
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Vicki Metzis @vmetzis.bsky.social · 12/12/2025
Fantastic to be a part of this devbio symposium today in Oxford - thank you to the organisers for the invitation!
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Vicki Metzis @vmetzis.bsky.social · 09/12/2025
Meeting schedule now online for @bsdb.bsky.social 2026 spring meeting: Molecules to Morphogenesis! ***Abstracts due in by January 16*** Join the outstanding line up! Submit your abstract for a short talk, flash talk, or poster presentation: 👇👇👇 bsdb.org/meetings/
A poster listing the names of invited speakers at the upcoming BSDB 2026 meeting at the University of Warwick, 23-26 March
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Vicki Metzis @vmetzis.bsky.social · 23/10/2025
I am absolutely delighted to share the invited speakers for our upcoming @bsdb.bsky.social "Molecules to Morphogenesis" meeting! Registration and abstract submission is now open - join us! bsdb.org/meetings/ March 23-26, 2026 - UK
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Vicki Metzis @vmetzis.bsky.social · 23/09/2025
Many thanks James - pleased to share this publication and to see it highlighted in the current issue @cp-devcell.bsky.social
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Vicki Metzis @vmetzis.bsky.social · 01/08/2025
Application deadline for up to 5 @mrc-lms.bsky.social postdoc positions in developmental epigenetics closes soon - don’t miss out! Positions across both experimental and computational projects. Come and join our fantastic team science community!
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Vicki Metzis @vmetzis.bsky.social · 14/07/2025
Interested in developmental epigenetics? So are we! Apply now to join us for your postdoc! Multiple positions across multiple groups @mrc-lms.bsky.social Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇 lms.mrc.ac.uk/work/vacanci...
lms.mrc.ac.uk
MRC Postdoctoral Research Scientists x 5 - MRC Laboratory of Medical Sciences
Applications are now open for up to five postdoctoral positions in the area of developmental epigenetics.
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Reposted by Vicki Metzis
Christina Ernst @christinaernst.bsky.social · 11/07/2025
My team @ebi.embl.org is open to hosting #ARISE2 fellows! We‘re especially interested in projects that improve access to single-cell & spatial transcriptomics data (e.g. browsers, standards), or enhance AI-readiness. Happy to chat if you are applying! www.embl.org/training/ari...
embl.org
ARISE2
Career Accelerator for Research Infrastructure Scientists
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Vicki Metzis @vmetzis.bsky.social · 12/07/2025
Congratulations to my colleague Will Scott @mrc-lms.bsky.social on his latest work resolving the molecular changes in fat tissue that emerge following weight loss www.nature.com/articles/s41...
nature.com
Selective remodelling of the adipose niche in obesity and weight loss - Nature
An atlas study of adipose tissue in people with obesity undergoing weight loss and their lean counterparts reveals that weight loss reduces cell senescence but cannot reverse all the metabolic problem...
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Reposted by Vicki Metzis
Juliane Glaser @julianeg.bsky.social · 09/07/2025
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁 Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
nature.com
Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics
Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...
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Reposted by Vicki Metzis
MRC Laboratory of Medical Sciences @mrc-lms.bsky.social · 04/07/2025
Are you a recent UK graduate without an MSc, eager to launch your career in biomedical research? Apply now for our two-year Science Technology Graduate Programme! You'll gain hands-on experience in state-of-the-art research facilities, build technical expertise and earn a competitive salary.
lms.mrc.ac.uk
Science Technology Graduate Programme - MRC Laboratory of Medical Sciences
Bioinformatics Facility - Dr George Young and Electron Microscopy Facility - Dr Ricardo Aramayo
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Reposted by Vicki Metzis
Helena Cocheme @cochemelab.bsky.social · 27/06/2025
🎉Excited to share our latest paper, published in Nature Communications!🎉 "Enhancing autophagy by redox regulation extends lifespan in Drosophila" #redox #metabolism #ageing #Drosophila @natcomms.nature.com @mrc-lms.bsky.social doi.org/10.1038/s414...
doi.org
Enhancing autophagy by redox regulation extends lifespan in Drosophila - Nature Communications
Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...
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Reposted by Vicki Metzis
Evgeny Kvon @evgenykvon.bsky.social · 02/07/2025
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
nature.com
Range extender mediates long-distance enhancer activity - Nature
The REX element is associated with long-range enhancer–promoter interactions.
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Vicki Metzis @vmetzis.bsky.social · 28/06/2025
Many thanks to @drsingleman.bsky.social for interviewing us about our latest work @imperialmed.bsky.social @mrc-lms.bsky.social - here’s her news story in GEN www.genengnews.com/topics/genom...
genengnews.com
Genetic “Dimmer Switch” Offers Precise Gene Expression Control
The duration of expression of the gene Cdx2 is tightly regulated by a newly identified DNA sequence element called an “attenuator.”
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Reposted by Vicki Metzis
Damir Baranasic @da-bar.bsky.social · 28/06/2025
I am happy and extremely proud to be able to contribute to this work with Irène Amblard and @vmetzis.bsky.social, where by changing one motif we completely rewired the function of a regulatory element!🔬🧬 Now out in Developmental Cell!
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Reposted by Vicki Metzis
MRC Laboratory of Medical Sciences @mrc-lms.bsky.social · 27/06/2025
Research published today in Developmental Cell uncovers a new mechanism that controls how genes are switched ‘on’ and ‘off’ during embryonic development. The work holds potential for a variety of biomedical applications by unlocking new ways to control gene expression where and when it’s needed.
lms.mrc.ac.uk
A new genetic tuner for embryo development
A team of scientists at the MRC Laboratory of Medical Sciences (LMS) has uncovered a previously unknown mechanism that controls how genes are switched ‘on’ and ‘off’ during embryonic development. Publ...
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Vicki Metzis @vmetzis.bsky.social · 27/06/2025
Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social
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Louise Fets @louisefets.bsky.social · 25/06/2025
#JobAlert! We have an opening for a postdoctoral scientist in #CancerMetabolism in my lab @mrc-lms.bsky.social. If you're interested in the role of metabolism in drug response and resistance in cancer, and would like to work in a fun and friendly team, check it out: lms.mrc.ac.uk/work/vacanci...
lms.mrc.ac.uk
MRC Postdoctoral Research Scientist - MRC Laboratory of Medical Sciences
The MRC Laboratory of Medical Sciences (LMS) is a biomedical research institute where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. LMS...
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Vicki Metzis @vmetzis.bsky.social · 18/06/2025
Save the date! March 23-26 will be the dates for our 2026 @bsdb.bsky.social annual meeting: Molecules to Morphogenesis! Excited to reveal more details soon! Want to attend with a reduced rate, and have access to conference/travel grants for other meetings too? Don't forget to join the BSDB :)
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Reposted by Vicki Metzis
Christina Ernst @christinaernst.bsky.social · 17/06/2025
Used EMBL-EBI data resources to find, analyse, or archive your data? 🧬 Now’s your turn: tell us how you’ve used them + why they matter. It takes 15 mins and helps keep these services open and free for all. 👉 tinyurl.com/bdf73zpp Closes 16 July #opendata #FAIRdata
tinyurl.com
EMBL-EBI Value and Impact Survey 2025
Take this survey powered by surveymonkey.com. Create your own surveys for free.
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Vicki Metzis @vmetzis.bsky.social · 12/06/2025
How does intra-tumour heterogeneity affect drug uptake and efficacy? Checkout how @louisefets.bsky.social and co dissect this important question in their latest preprint using an array of approaches and patient samples 👇
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Vicki Metzis @vmetzis.bsky.social · 02/05/2025
Job alert! An exciting opportunity for Black heritage PhD graduates looking to progress their academic career @mrc-lms.bsky.social Many exciting labs and opportunities - check it out 👇👇👇
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Vicki Metzis @vmetzis.bsky.social · 25/04/2025
Great to meet new and familiar faces and share our latest thoughts on strategies to finely tune gene expression at #Epigenetics2025!
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Vicki Metzis @vmetzis.bsky.social · 23/04/2025
En route to Belfast - looking forward to catching up with friends and meeting new colleagues at Epigenetics 2025 @gensocuk.bsky.social #regulatorylogic genetics.org.uk/events/epige...
genetics.org.uk
Epigenetics-2025, from mechanisms to disease | Genetics Society
Meeting background This international conference will bring together leading experts to foster dynamic discussions on the latest breakthroughs in epigenetics. It will cover mechanisms of epigenetic re...
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Reposted by Vicki Metzis
Jesse Veenvliet @jesseveenvliet.bsky.social · 19/04/2025
Thanks Vicki!! We had to take down this thread (something with Pacmanoid and copyright) but you can find the thread rework with animated Pacmanoid here: bsky.app/profile/jess...
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Vicki Metzis @vmetzis.bsky.social · 27/03/2025
Nice work from Vanessa Ribes highlighting dual regulatory roles (and a silencer) mediated by Pax TFs in the dorsal neural tube #biologists100
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Vicki Metzis @vmetzis.bsky.social · 27/03/2025
“Play and share” - inspiring and important words from Manu Prakash @prakashlab.bsky.social at this morning’s session #biologists100 @biologists.bsky.social
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