Reposted by Vicki MetzisTeresa Rayon @trayon.bsky.social · 15/08/2026Our work on the role of the proteasome in developmental tempo is out!!!! 🐭⌛️👤⏳ Six years after identifying an association between protein stability and developmental tempo, we now demonstrate a causal link between protein turnover and developmental tempo through proteasomal degradation 712947
Reposted by Vicki MetzisChristos Kalaitzis @christos-kltzs.bsky.social · 18/07/2026So glad to see our pre-print finally out! Excited to share work stemming my PhD work, which I had the pleasure of developing alongside with my co-first author, Irene Amblard. 🤓 181
Vicki Metzis @vmetzis.bsky.social · 17/07/2026How does an embryo generate the right cells in the right place? Delighted to share our latest findings on how neural crest cells acquire vagal or trunk identities Spoiler alert: The timing & combination of CDXs preconfigures cell identity & distinct HOX states www.biorxiv.org/content/10.6...biorxiv.orgTemporally distinct CDX programmes preconfigure vagal and trunk neural crestNeural crest cells (NCCs) are progenitor cells vital in establishing the head, heart, gut and peripheral nervous system of vertebrate embryos. Disruptions to NCC development underlie neurocristopathie... 16724
Reposted by Vicki MetzisJames Briscoe @jamesbriscoe.bsky.social · 15/07/2026New from @vmetzis.bsky.social & co Vagal & trunk neural crest cells share transient epiblast origin, but temporal regionalisation preconfigures their identity before crest induction Cdx1 acts before Cdx2, setting distinct chromatin and HOX state in the epiblast www.biorxiv.org/content/10.6...biorxiv.orgTemporally distinct CDX programmes preconfigure vagal and trunk neural crestNeural crest cells (NCCs) are progenitor cells vital in establishing the head, heart, gut and peripheral nervous system of vertebrate embryos. Disruptions to NCC development underlie neurocristopathie... 0205
Reposted by Vicki MetzisBritish Society for Developmental Biology @bsdb.bsky.social · 06/05/2026Save the date! The 2027 BSDB Spring Meeting will take place on 19 - 22 April in Edinburgh. An exciting programme with a fantastic lineup of speakers showcasing developmental biology across scales! More details soon! 03222
Reposted by Vicki Metzisthe Node @the-node.bsky.social · 15/04/2026An illustrated summary of the BSDB Spring Meeting 2026 In this post, @alexneaverson.bsky.social shares her insights on using illustration to share the joy of developmental biology at the 2026 @bsdb.bsky.social meeting. thenode.biologists.com/an-illustrat... #SciArtthenode.biologists.comAn illustrated summary of the BSDB Spring Meeting 2026 - the NodeI recently attended the BSDB Spring Meeting, and decided to spend most of my time at the conference sketching. The result is this illustrated summary - 01811
Reposted by Vicki MetzisIngrid Tsang @ingridtsang.bsky.social · 15/04/2026Had so much fun at @bsdb.bsky.social a few weeks go and am very excited about all the upcoming stories I saw. Check out the #preprint list I've collated from the meeting, now on @prelights.bsky.social👇 prelights.biologists.com/prelists/bsd... And please do let me know if there are any I missed 👀prelights.biologists.comBSDB Spring Meeting: Molecules to Morphogenesis - preLights 093
Reposted by Vicki MetzisTeresa Rayon @trayon.bsky.social · 15/04/2026It’s official! @bertacava26.bsky.social has received a Marie Skłodowska-Curie European Postdoctoral Fellowship 🚀🚀🚀 She will study proteostasis during embryo dormancy @babrahaminst.bsky.social Very well deserved. proud of this achievement & excited for the discoveries ahead 🐭⌛️ 1434
Vicki Metzis @vmetzis.bsky.social · 26/03/2026And that’s a wrap! From all of us @bsdb.bsky.social - thank you everyone for making this a very special meeting, from Molecules to Morphogenesis 0231
Reposted by Vicki MetzisJames Briscoe @jamesbriscoe.bsky.social · 25/03/2026Honoured and overwhelmed to receive the 2026 Waddington Medal. Science is a team effort, and I've been fortunate to work alongside exceptional people asking hard questions. Thank you to the BSDB and to everyone who has been part of the journey. bsdb.org/2026/03/24/2...bsdb.org2026 Waddington Medal Winner - James Briscoe - BSDB - British Society for Developmental BiologyWe are very pleased to announce that this year’s Waddington medal winner is James Briscoe. His fundamental discoveries have helped shape our understanding of of how morphogens work, and he has played ... 2626630
Reposted by Vicki MetzisBritish Society for Developmental Biology @bsdb.bsky.social · 24/03/2026The most deserving winner of the 2026 BSDB Wolpert Medal is Neil Vargesson. This award recognises his outstanding contributions to the public understanding of chemically-induced birth differences. Many congratulations to Neil! bsdb.org/2026/03/24/2...bsdb.org2026 Wolpert Medal Winner - Neil Vargesson - BSDB - British Society for Developmental BiologyFollowing the sad passing of one of the greats of Developmental Biology, Lewis Wolpert, the BSDB committee has launched a new annual medal in his honour. Lewis was well known for his ability to distil... 0183
Reposted by Vicki MetzisBritish Society for Developmental Biology @bsdb.bsky.social · 24/03/2026Huge congratulations to James Briscoe @jamesbriscoe.bsky.social for receiving the 2026 BSDB Waddington Medal, recognising an extraordinary career of discovery, mentorship, and leadership in developmental biology. bsdb.org/2026/03/24/2...bsdb.org2026 Waddington Medal Winner - James Briscoe - BSDB - British Society for Developmental BiologyWe are very pleased to announce that this year’s Waddington medal winner is James Briscoe. His fundamental discoveries have helped shape our understanding of of how morphogens work, and he has played ... 29620
Reposted by Vicki MetzisBritish Society for Developmental Biology @bsdb.bsky.social · 25/03/2026Many congratulations to Cynthia Andoniadou @pituitarylab.bsky.social, recipient of the 2026 BSDB Cheryll Tickle Medal, honouring her internationally recognised research programme in pituitary gland development and stem cell biology. bsdb.org/2026/03/25/2...bsdb.org2026 Cheryll Tickle Medal Winner - Cynthia Andoniadou - BSDB - British Society for Developmental BiologyIn 2016, the BSDB introduced the Cheryll Tickle Medal, which is being awarded annually to a mid-career, female scientist for her outstanding achievements in the field of Developmental Biology. The BSD... 0214
Reposted by Vicki MetzisBritish Society for Developmental Biology @bsdb.bsky.social · 25/03/2026🏆 We’re delighted to announce the winner of the 2026 BSDB Dennis Summerbell Award! This year’s award goes to Sergio Menchero @sermenchero.bsky.social, recognised for exceptional contributions to developmental biology and for carrying forward the curiosity and rigour that Dennis championed. 0265
Reposted by Vicki MetzisBritish Society for Developmental Biology @bsdb.bsky.social · 25/03/2026🎉 We are thrilled to announce the very first winner of the BSDB Marie Johansson Prize! This year’s award goes to Giulia Boezio @giulia-boezio.bsky.social, recognised for outstanding contributions to developmental biology and for embodying Marie’s scientific originality and rigour. 0274
Reposted by Vicki MetzisDevelopment @dev-journal.bsky.social · 20/03/2026Excited for BSDB's 2026 Meeting organised by @abinagui.bsky.social @vmetzis.bsky.social, @gastruloids.bsky.social & co? Our Reviews Editor @ingridtsang.bsky.social & the Node's Community Manager @andreamurillo.bsky.social will also be attending - come and chat to them about our journal & the Node. 077
Vicki Metzis @vmetzis.bsky.social · 11/03/2026Great to see this work out from our neighbours @mrc-lms.bsky.social driven by Noura Maziak @vaquerizasjm.bsky.social! With Pico-C they reveal a modular regulatory logic driving genome establishment - congrats to all authors! 051
Vicki Metzis @vmetzis.bsky.social · 22/01/2026We've been inundated (!) with abstracts for BSDB 2026!! Thanks to all who've submitted and to those that have registered! The rooms are going fast! Don't miss it! Early-bird registration due Monday 9th Feb 👇👇👇 bsdb.org/meetings/ 1215
Vicki Metzis @vmetzis.bsky.social · 21/01/2026Delighted to be in Edinburgh visiting the Institute of Genetics and Cancer today! Great to chat gene regulatory logic and development. Many thanks to @hannahlong.bsky.social and Jenny Nichols for hosting me, owner of the world’s best collection of ornamental office mice 1111
Vicki Metzis @vmetzis.bsky.social · 16/01/2026Final reminder: abstract deadline today for the @bsdb.bsky.social 2026 meeting! Don’t miss it :) 👇👇👇 bsdb.org/meetings/ 086
Reposted by Vicki MetzisBritish Society for Developmental Biology @bsdb.bsky.social · 09/01/2026Don't forget to register for our upcoming Spring Meeting: 'Molecules to Morphogenesis' Get your abstracts submitted by the 16th of January! bsdb.org/meetings 0107
Reposted by Vicki MetzisSally Lowell @cellysally.bsky.social · 09/01/2026This meeting will be so great. Only about a week until the early-bird deadline, 9th Feb. #DevBio 182
Vicki Metzis @vmetzis.bsky.social · 06/01/2026New year, new beginnings! Join us for all things animal & plant devbio at the 2026 @bsdb.bsky.social meeting in Warwick! Abstract submission closing NEXT FRIDAY 16th JAN - join us! 097
Vicki Metzis @vmetzis.bsky.social · 12/12/2025Fantastic to be a part of this devbio symposium today in Oxford - thank you to the organisers for the invitation! 030
Vicki Metzis @vmetzis.bsky.social · 09/12/2025Meeting schedule now online for @bsdb.bsky.social 2026 spring meeting: Molecules to Morphogenesis! ***Abstracts due in by January 16*** Join the outstanding line up! Submit your abstract for a short talk, flash talk, or poster presentation: 👇👇👇 bsdb.org/meetings/ 02415
Vicki Metzis @vmetzis.bsky.social · 23/10/2025I am absolutely delighted to share the invited speakers for our upcoming @bsdb.bsky.social "Molecules to Morphogenesis" meeting! Registration and abstract submission is now open - join us! bsdb.org/meetings/ March 23-26, 2026 - UK 16829
Vicki Metzis @vmetzis.bsky.social · 23/09/2025Many thanks James - pleased to share this publication and to see it highlighted in the current issue @cp-devcell.bsky.social 090
Vicki Metzis @vmetzis.bsky.social · 01/08/2025Application deadline for up to 5 @mrc-lms.bsky.social postdoc positions in developmental epigenetics closes soon - don’t miss out! Positions across both experimental and computational projects. Come and join our fantastic team science community! 01011
Vicki Metzis @vmetzis.bsky.social · 14/07/2025Interested in developmental epigenetics? So are we! Apply now to join us for your postdoc! Multiple positions across multiple groups @mrc-lms.bsky.social Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇 lms.mrc.ac.uk/work/vacanci...lms.mrc.ac.ukMRC Postdoctoral Research Scientists x 5 - MRC Laboratory of Medical SciencesApplications are now open for up to five postdoctoral positions in the area of developmental epigenetics. 04538
Reposted by Vicki MetzisChristina Ernst @christinaernst.bsky.social · 11/07/2025My team @ebi.embl.org is open to hosting #ARISE2 fellows! We‘re especially interested in projects that improve access to single-cell & spatial transcriptomics data (e.g. browsers, standards), or enhance AI-readiness. Happy to chat if you are applying! www.embl.org/training/ari...embl.orgARISE2Career Accelerator for Research Infrastructure Scientists 084
Vicki Metzis @vmetzis.bsky.social · 12/07/2025Congratulations to my colleague Will Scott @mrc-lms.bsky.social on his latest work resolving the molecular changes in fat tissue that emerge following weight loss www.nature.com/articles/s41...nature.comSelective remodelling of the adipose niche in obesity and weight loss - NatureAn atlas study of adipose tissue in people with obesity undergoing weight loss and their lean counterparts reveals that weight loss reduces cell senescence but cannot reverse all the metabolic problem... 060
Reposted by Vicki MetzisJuliane Glaser @julianeg.bsky.social · 09/07/2025Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁 Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5nature.comEnhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature GeneticsActivation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c... 15296128
Reposted by Vicki MetzisMRC Laboratory of Medical Sciences @mrc-lms.bsky.social · 04/07/2025Are you a recent UK graduate without an MSc, eager to launch your career in biomedical research? Apply now for our two-year Science Technology Graduate Programme! You'll gain hands-on experience in state-of-the-art research facilities, build technical expertise and earn a competitive salary.lms.mrc.ac.ukScience Technology Graduate Programme - MRC Laboratory of Medical SciencesBioinformatics Facility - Dr George Young and Electron Microscopy Facility - Dr Ricardo Aramayo 055
Reposted by Vicki MetzisHelena Cocheme @cochemelab.bsky.social · 27/06/2025🎉Excited to share our latest paper, published in Nature Communications!🎉 "Enhancing autophagy by redox regulation extends lifespan in Drosophila" #redox #metabolism #ageing #Drosophila @natcomms.nature.com @mrc-lms.bsky.social doi.org/10.1038/s414...doi.orgEnhancing autophagy by redox regulation extends lifespan in Drosophila - Nature CommunicationsRedox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ... 89037
Reposted by Vicki MetzisEvgeny Kvon @evgenykvon.bsky.social · 02/07/2025Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/nature.comRange extender mediates long-distance enhancer activity - NatureThe REX element is associated with long-range enhancer–promoter interactions. 1018791
Vicki Metzis @vmetzis.bsky.social · 28/06/2025Many thanks to @drsingleman.bsky.social for interviewing us about our latest work @imperialmed.bsky.social @mrc-lms.bsky.social - here’s her news story in GEN www.genengnews.com/topics/genom...genengnews.comGenetic “Dimmer Switch” Offers Precise Gene Expression ControlThe duration of expression of the gene Cdx2 is tightly regulated by a newly identified DNA sequence element called an “attenuator.” 1100
Reposted by Vicki MetzisDamir Baranasic @da-bar.bsky.social · 28/06/2025I am happy and extremely proud to be able to contribute to this work with Irène Amblard and @vmetzis.bsky.social, where by changing one motif we completely rewired the function of a regulatory element!🔬🧬 Now out in Developmental Cell! 0103
Reposted by Vicki MetzisMRC Laboratory of Medical Sciences @mrc-lms.bsky.social · 27/06/2025Research published today in Developmental Cell uncovers a new mechanism that controls how genes are switched ‘on’ and ‘off’ during embryonic development. The work holds potential for a variety of biomedical applications by unlocking new ways to control gene expression where and when it’s needed.lms.mrc.ac.ukA new genetic tuner for embryo developmentA team of scientists at the MRC Laboratory of Medical Sciences (LMS) has uncovered a previously unknown mechanism that controls how genes are switched ‘on’ and ‘off’ during embryonic development. Publ... 073
Vicki Metzis @vmetzis.bsky.social · 27/06/2025Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social 1811438
Reposted by Vicki MetzisLouise Fets @louisefets.bsky.social · 25/06/2025#JobAlert! We have an opening for a postdoctoral scientist in #CancerMetabolism in my lab @mrc-lms.bsky.social. If you're interested in the role of metabolism in drug response and resistance in cancer, and would like to work in a fun and friendly team, check it out: lms.mrc.ac.uk/work/vacanci...lms.mrc.ac.ukMRC Postdoctoral Research Scientist - MRC Laboratory of Medical SciencesThe MRC Laboratory of Medical Sciences (LMS) is a biomedical research institute where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. LMS... 0169
Vicki Metzis @vmetzis.bsky.social · 18/06/2025Save the date! March 23-26 will be the dates for our 2026 @bsdb.bsky.social annual meeting: Molecules to Morphogenesis! Excited to reveal more details soon! Want to attend with a reduced rate, and have access to conference/travel grants for other meetings too? Don't forget to join the BSDB :) 02412
Reposted by Vicki MetzisChristina Ernst @christinaernst.bsky.social · 17/06/2025Used EMBL-EBI data resources to find, analyse, or archive your data? 🧬 Now’s your turn: tell us how you’ve used them + why they matter. It takes 15 mins and helps keep these services open and free for all. 👉 tinyurl.com/bdf73zpp Closes 16 July #opendata #FAIRdatatinyurl.comEMBL-EBI Value and Impact Survey 2025Take this survey powered by surveymonkey.com. Create your own surveys for free. 024
Vicki Metzis @vmetzis.bsky.social · 12/06/2025How does intra-tumour heterogeneity affect drug uptake and efficacy? Checkout how @louisefets.bsky.social and co dissect this important question in their latest preprint using an array of approaches and patient samples 👇 042
Vicki Metzis @vmetzis.bsky.social · 02/05/2025Job alert! An exciting opportunity for Black heritage PhD graduates looking to progress their academic career @mrc-lms.bsky.social Many exciting labs and opportunities - check it out 👇👇👇 012
Vicki Metzis @vmetzis.bsky.social · 25/04/2025Great to meet new and familiar faces and share our latest thoughts on strategies to finely tune gene expression at #Epigenetics2025! 0102
Vicki Metzis @vmetzis.bsky.social · 23/04/2025En route to Belfast - looking forward to catching up with friends and meeting new colleagues at Epigenetics 2025 @gensocuk.bsky.social #regulatorylogic genetics.org.uk/events/epige...genetics.org.ukEpigenetics-2025, from mechanisms to disease | Genetics SocietyMeeting background This international conference will bring together leading experts to foster dynamic discussions on the latest breakthroughs in epigenetics. It will cover mechanisms of epigenetic re... 1181
Reposted by Vicki MetzisJesse Veenvliet @jesseveenvliet.bsky.social · 19/04/2025Thanks Vicki!! We had to take down this thread (something with Pacmanoid and copyright) but you can find the thread rework with animated Pacmanoid here: bsky.app/profile/jess... 011
Vicki Metzis @vmetzis.bsky.social · 27/03/2025Nice work from Vanessa Ribes highlighting dual regulatory roles (and a silencer) mediated by Pax TFs in the dorsal neural tube #biologists100 020
Vicki Metzis @vmetzis.bsky.social · 27/03/2025“Play and share” - inspiring and important words from Manu Prakash @prakashlab.bsky.social at this morning’s session #biologists100 @biologists.bsky.social 0184