The eORFeome, a large-scale collection of open reading frames encoding viral proteins and secreted bacterial and parasite effectors, enables functional genomics across diverse pathways and pathogens. ...

Nuclear protein homeostasis relies on proteasome import into the nucleus. Here the authors identify how assembled human proteasomes are transported across the nuclear pore complex and reveal a mechani...

Abstract. Formation of the eukaryotic ribosomal subunits follows a strict regime to assemble ribosomal proteins (r-protein) with ribosomal RNAs (rRNA) whil

The Center for Molecular Biology of Heidelberg University (ZMBH) and the Faculty of Biosciences invite applications for a   Tenure Track Professors...

IMB Mainz

Phase separation of proteins plays a critical role in cellular organisation. How phase separated protein condensates underpin biological function and how condensates achieve specificity remain elusive...

Intracellular pathogens hijack host gene expression to subvert cellular processes. Here, the authors show that Legionella pneumophila’s PieF effector inhibits the human CCR4-NOT deadenylation machiner...

Join theMax Perutz Labs as Full Professor to unravel disease mechanisms—from metabolism and stress to RNA regulation, epigenetics, and immunity.

Intrinsically disordered regions (IDRs) in proteins play essential roles in cellular function. A growing body of work has shown that IDRs often interact with partners in a manner that does not depend ...

YouTube video by Johan Gibcus

Rivera et al. discover Drosophila Flamenco piRNA cluster enhancers bound and activated by the Traffic Jam transcription factor. Traffic Jam also binds many follicle cell genes including activating mul...

Assistant Professor (tenure track) - Chromatin Regulation, Genetic Regulatory Mechanisms, Epigenetics, Epigenomics

Researchers at academic institutions nationwide say that U.S. science is being dismantled.

Ubiquitin chains determine the fates of their modified proteins, including proteasomal degradation. Kiss et al. present UbiREAD, a technology to monitor cellular degradation and deubiquitination at hi...

Establishing the composition of RNAs and proteins that defines the identities and functions of cells relies not only on the regulated biosynthesis of these molecules, but also equally importantly, on…

Discovery of heterodimeric, microtubule-forming tubulins in Asgard archaea, the closest known relatives of eukaryotes, reveals snapshots of microtubule evolution.