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Susan Lea

@smlea.bsky.social
1.8K followers 1.6K following 20 posts

Scientist at St Jude using structural biology to try and understand how things work - views are my own not my institutions

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Reposted by Susan Lea
Jamie Blaza @jnb-lab.bsky.social · 10/08/2026
On a personal note, I took a similar position in 2018 and haven’t looked back since! Applicants are welcome to get in touch with me for an informal chat.
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Jamie Blaza @jnb-lab.bsky.social · 10/08/2026
The successful candidate will be a member of the Department of Chemistry, ultimately teaching on the Biochemistry and Chemistry degree programs. It is roughly equivalent to a tenure-track assistant professor position in the US.
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Jamie Blaza @jnb-lab.bsky.social · 10/08/2026
YSBL has a research culture that is both supportive and ambitious, which we are all enormously proud of. It is also an environment where people readily work together to achieve more than they could alone. To me, it’s a special place to work.
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Jamie Blaza @jnb-lab.bsky.social · 10/08/2026
YSBL is also well equipped for crystallography and protein NMR. Beyond YSBL, the Bioscience Technology Facility houses brilliant facilities for light microscopy, mass spec, and biophysics (amongst many other things!).
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Jamie Blaza @jnb-lab.bsky.social · 10/08/2026
Our Cryo-EM facility, supported by expert technical staff (Johan Turkenburg and Sam Hart), is housed in the custom-built Dodsons Building and has an energy-filter equipped Glacios and an incoming FIB-mill.
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Jamie Blaza @jnb-lab.bsky.social · 10/08/2026
The successful candidate will be a member of the York Structural Biology Laboratory (YSBL), a research centre build around ~15 structural biology groups from the Departments of Chemistry and Biology.
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Jamie Blaza @jnb-lab.bsky.social · 10/08/2026
Permanent academic position as a Lecturer in cryo-ET open at York. We are looking for someone to lead a research program making the most of the stunning advances occurring in cryo-ET. It's a research and teaching post but with a focus on research in the early years. jobs.york.ac.uk/vacancy/lect...
jobs.york.ac.uk
Jobs - The University of York
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Susan Lea @smlea.bsky.social · 18/06/2026
So everyone should want to work @stjuderesearch.bsky.social! Less than 24 hours after the request we have the football on the big screen!
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Susan Lea @smlea.bsky.social · 17/06/2026
The English, Croatians and honorary Croatians gather @stjuderesearch.bsky.social
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Jordan Meier @doc-jlmeier.bsky.social · 16/06/2026
Excited to announce that our research group will be joining the St. Jude Children's Research Hospital Department of Chemical Biology & Therapeutics in September. 🥼 🧬 🧪 @stjuderesearch.bsky.social
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Susan Lea @smlea.bsky.social · 16/06/2026
A lot of work, over many years, and we finally see the missing piece at the heart of type 3 export!
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Phil Biggin @philbiggin.bsky.social · 20/03/2026
Happy to see our work on SLCO2A1 with @smlea.bsky.social, Nakanishi and Newstead labs out now. Important insight into how prostaglandin and many drugs are transported. Hats off to @weitse-hsu.bsky.social for computational work! @oxfordbiochemistry.bsky.social www.nature.com/articles/s41...
nature.com
Structural basis for prostaglandin and drug transport via SLCO2A1
Nature Communications - SLCO2A1 (also known as OATP2A1) is responsible for the transport of eicosanoids, including prostaglandins (PGs), as well as of a subset of nonsteroidal anti-inflammatory...
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Sjors Scheres @sjorsscheres.bsky.social · 16/02/2026
Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...
mrc.tal.net
Research Group Leader Tenure Track - Structural Studies - LMB 2775 - Medical Research Council
Location: Cambridge. Vacancy: Research Group Leader Tenure Track - Structural Studies - LMB 2775. Closing Date: 16/03/2026, 23:55
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Susan Lea @smlea.bsky.social · 06/02/2026
Mechanistic insights into RNA chaperoning by Ro60 and La autoantigens: Cell www.cell.com/cell/fulltex... Excited to share our collaborative work with the Wolin group examining RNA folding
cell.com
Mechanistic insights into RNA chaperoning by Ro60 and La autoantigens
Structural and functional analyses elucidate the mechanisms by which two ATP-independent RNA chaperones, Ro60 and La, recognize and unfold misfolded RNAs. Diverse noncoding RNAs are associated with th...
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Susan Lea @smlea.bsky.social · 06/02/2026
#StJudeResearch Paul Taylor reminding us that mission is where it all starts
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Susan Lea @smlea.bsky.social · 06/02/2026
#StJudeResearch - Jim Downing reminds us of the founding documents for St Jude placing research at the heart of new treatments for catastrophic childhood disease - knowledge generation as our core activity
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Susan Lea @smlea.bsky.social · 06/02/2026
and apparently reanimation as well as Elvis will be in the house later..the full Memphis experience for my first Faculty Retreat #StJudeResearch
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Augustinas Silale @augustsilale.bsky.social · 02/10/2025
Berks and @smlea.bsky.social labs also found yet a different BAM architecture in Flavobacterium johnsoniae, another member of Bacteroidota. doi.org/10.1038/s415...
doi.org
A new paradigm for outer membrane protein biogenesis in the Bacteroidota - Nature
Structural and biochemical studies of the β-barrel-assembly machinery from Flavobacterium johnsoniae reveal a subunit composition and assembly that are distinct from those of the canonical Escherichia coli complex.
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Ariane Briegel @arianebriegel.bsky.social · 18/03/2025
Congratulations to Xiaobo @xiaobozhong.bsky.social on his great paper! www.nature.com/articles/s41...
nature.com
The stomatin-like protein StlP organizes membrane microdomains to govern polar growth in filamentous actinobacteria under hyperosmotic stress - Nature Communications
Actinobacteria grow by inserting new cell wall material at the cell poles. Here, Zhong et al. show that a stomatin-like protein modulates polar growth under hyperosmotic stress by facilitating the for...
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Doryen Bubeck @doryenbubeck.bsky.social · 15/03/2025
www.youtube.com/watch?v=H14P...
youtube.com
Big questions, tiny machines
YouTube video by Imperial College London
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Brian Ferguson @viropractor.bsky.social · 07/03/2025
Last few days to apply for this:
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Gabriela K Popescu @popstarlab.bsky.social · 18/02/2025
Less than half an hour ago, a peaceful transfer of power has taken place at #BPS2025! Join me in welcoming Madam President of the @biophysicalsoc.bsky.social, Professor Lynnmarie Thompson! And Madam President Elect, Professor Karen Fleming! 👏👏👏👏👏
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 18/02/2025
A new structural paradigm for outer membrane protein biogenesis in the Bacteroidota www.biorxiv.org/content/10.1101/202…
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Timothy O'Leary @timothyoleary.bsky.social · 26/01/2025
It really is amazing. Another related point is that Academia wouldn't actually be doing its job if it *didn't* send the bulk of its knowledge and highly trained individuals into other parts of society.
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Jens Staal @staal1978.bsky.social · 26/01/2025
Also, it is a pyramidal structure. Not all post docs can progress to become PIs. I would wish that there were some mid-level permanent staff scientist positions for those that would like to continue bench work instead of taking a more administrative role as PI, but as things are now, it is PI or out
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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 17/01/2025
Hive mind: I seem to remember having seen a plot/analysis showing that pLDDT is correlated to conservation but my mind or Google-fu isn’t finding it
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Matt Higgins @parasitematt.bsky.social · 13/01/2025
It is a great honour to invite you to a symposium to celebrate the career of Mark Carrington. An exciting set of talks, particularly if you are fascinated by trypanosomes.
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Oli Clarke @olibclarke.bsky.social · 17/12/2024
1/ Thrilled to announce Dr. Elizabeth Wright as the inaugural winner of the June Almeida Award for #cryoem! 🎉Elizabeth’s pioneering work in both cryo-ET methods and structural virology made her a perfect fit for this award. Congrats, Elizabeth!
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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 17/12/2024
19F modified amino acids such as trifluoromethyl-Phe integrated into proteins can give strong, clean signals for complex samples, but the results are difficult to interpret in terms of structure This study uses "ring current design" to increase 19F chemical shift dispersion and interpretability 🧬🧶🧲
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Our World in Data @ourworldindata.org · 09/12/2024
Americans are now one-third less likely to die from cancer at the same ages as Americans in 1990
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Ákos T Kovács @evolvedbiofilm.bsky.social · 24/11/2024
Clap in the face reminder when judged on PhD/post doc years even after >12 years: "Kovacs' record in microbiology is somewhat lighter, particularly early career lack of first-authored leadership on high level publications" ... and I am still in academic science #nevertheless
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Michael Baym @baym.lol · 23/11/2024
You may recall, we used a similar technique to find plasmid-dependent phages, by putting the same plasmid in two different bacteria. Now we do it for all sorts of phages! www.nature.com/articles/s41...
nature.com
Diverse and abundant phages exploit conjugative plasmids - Nature Communications
Some phages use plasmid-encoded conjugation proteins as receptors to infect their bacterial hosts, making their host range dependent on horizontal transfer of the plasmid. Here, the authors present a ...
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Michael Baym @baym.lol · 23/11/2024
Phages! At the Disco! Here's Ellie (the first author's) thread on our new preprint on how to discover weird new phages using glowing bacteria:
A fluorescent petri dish image becoming a disco ball
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Sonja-Verena Albers @archaellum.bsky.social · 22/11/2024
Visiting @arianebriegel.bsky.social at the Institute Pasteur ! Great to see her new lab!
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Willow Coyote-Maestas @willowcoyote.bsky.social · 18/11/2024
We will be hosting 3rd Full Circle Symposium for Native Biologists hosted at UCSF in April 2025! We aim to build community and provide meaningful opportunities for Native scientists. If you are a Native biologist who is interested plz fill this out to stay up to date: forms.gle/AN7nfkhdB3Fv...
Full Circle Native symposium flyer. It includes a Logo, the date of the event (April 3-4 2025), and confirmed speakers: Casey Dorr (Hennepin Healthcare Research Institute), Rebecca Pollet (Vassar College), Kat MIlligan-McClellan (University of Conneticut), Krystal Tosie (Arizona State University), Lauren W Yowelunh McLester-Davis (UW Madison).
 
It also includes that text: The goal of the “Full Circle” symposium is to create an opportunity for North American Native and Indigenous, Native Hawaiian, and Alaskan Native scientists to share their research, meet other scientists, and build community. The symposium will take place over two days at the UCSF Mission Bay campus in San Francisco. We will have talks from students, postdocs, and faculty and panel discussions on Native and Indigenous topics in the context of research.

It also contains a QR code that links to: https://forms.gle/AN7nfkhdB3Fvdkkm7
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Neil Ranson @naranson.bsky.social · 18/11/2024
I am about to be recruiting two post-docs to work on cryoEM and cryoET of amyloid aggregates... Anyone interested please drop me a line while the wheels of our HR department turn.............
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adam grieve @adamgrieve.bsky.social · 15/11/2024
Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c
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Susan Lea @smlea.bsky.social · 08/03/2024
Published today Steve and Justin’s story that finally reveals the basis for transmission of uni directional ion flow into bi-directional rotation of the bacterial flagellum doi.org/10.1038/s415...
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Matthew Freeman @mjafreeman.bsky.social · 15/01/2024
Important so please help spread the word... Interested in postgrad research? Maybe do a PhD? Oxford runs a summer internship scheme for UK students from under-represented and disadvantaged backgrounds Stipend, free accommodation, mentoring... Deadline 21 Feb www.ox.ac.uk/admissions/g...
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Susan Lea @smlea.bsky.social · 04/01/2024
Time for puppy to start sciencing….
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Michael Manhart @michaelmanhart.bsky.social · 14/11/2023
For microbiologists seeking faculty jobs: Rutgers has 4+ faculty searches in microbiology right now! Please share widely and see below for details and links on the individual positions 1/5
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Ervin Fodor @efodor.bsky.social · 07/11/2023
A fantastic postdoc opportunity with Jon Grimes at Strubi, University of Oxford, to study the molecular mechanisms of viruses using the latest cryo-ET and cryo-SIM technologies. my.corehr.com/pls/uoxrecru...
my.corehr.com
Job Details
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Matthew Freeman @mjafreeman.bsky.social · 07/11/2023
The Dunn School at University of Oxford just can't stop recruiting! This time an Associate Prof in cell/mol biology with focus on infection, immunology, inflammation Come and join us... Please spread the word www.path.ox.ac.uk/vacancy/asso...
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Silvia Caldararu🌿 @scaldararu.bsky.social · 19/10/2023
Can we please use the term machine learning in scientific publications and not AI? The first is a set of mathematical methods that can be analysed and criticised, the second a divisive buzzword. 🧪 #AcademicSky
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Syma Khalid @sykhalid.bsky.social · 15/10/2023
Come work in my lab in Oxford Biochemistry- Postdoc funded via HECBioSim (EPSRC) in collab with Arvind Ramanathan at Argonne National Lab. We will do massive bacterial membrane simulations augmented with ML. We are friendly, supportive lab in a beautiful city. www.jobs.ac.uk/job/DDF342/p...
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Barbara Mellone 🇺🇦 @centromellone.bsky.social · 27/09/2023
Come be my colleague! The MCB Department at UConn is looking for a TT Assistant Professor in the broad fields of structural biology, biophysics, and biochemistry. Collaborative department, strong graduate program, and state of the art core facilities. academicjobsonline.org/ajo/jobs/25945
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