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Pim Huis in 't Veld

@huis.bsky.social
870 followers 707 following 64 posts

Chromosome biology and genome stability | @vienabiocenter, University of Vienna, Austria | www.maxperutzlabs.ac.at/research/re…

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Reposted by Pim Huis in 't Veld
Mark A. Hanson @hansonmark.bsky.social · 26/09/2026
I'm surprised a community of publishing writers can blame AI for the problems of peer review when those same writers cite our study, "the strain on scientific publishing", which characterizes how this problem existed before AI. bit.ly/StrainQSS It's the incentives structure, not the AI. 1/n
scholarlykitchen.sspnet.org
Ask the Chefs: Peer Review Capacity — Uncomfortable Truths and Overlooked Conversations - The Scholarly Kitchen
For Peer Review Week 2026, we asked the Chefs two questions: What is one uncomfortable truth about peer review that the scholarly publishing community doesn’t talk about enough? And, beyond recruiting...
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Pim Huis in 't Veld @huis.bsky.social · 24/09/2026
a glimpse into the future: www-cdn.anthropic.com/22573675ada5... described here: www.anthropic.com/news/claude-... with an expert first author: doi.org/10.1126/scie... doi.org/10.1126/scie... following the pattern from this excellent piece: giorgio.gilest.ro/the-weimar-o...
anthropic.com
Claude discovers a novel enzyme system
In early results from our new life sciences research lab, Claude agents found an enzyme system whose function is still unknown.
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Giorgio Gilestro @giorgio.gilest.ro · 20/09/2026
Academia has seen inflation in the past 30 years but it is now entering Republic of Weimar territory, with value of knowledge moving from "paper to land". In all this, Open hardware is an act of armed resistance to Technofeudalism. giorgio.gilest.ro/the-weimar-o...
giorgio.gilest.ro
The Weimar of knowledge – la bottega
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Martin Pacesa @martinpacesa.bsky.social · 21/09/2026
ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/Bi...
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Richard Sever @richardsever.bsky.social · 20/09/2026
"All corners of academia will soon be flooded with AI-generated research....Maths and CS go first because their entire output is symbol manipulation...Biology comes later not because biologists are cleverer but because the rate-limiting step is physical" giorgio.gilest.ro/the-weimar-o...
giorgio.gilest.ro
The Weimar of knowledge – la bottega
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Jens Schmidt @jenscs83.bsky.social · 15/09/2026
We are recruiting a postdoctoral fellow to study DNA damage repair via the homologous recombination pathway using quantitative cell biology approaches. The position will be initially supported for two years by the MSU Research Foundation Postdoctoral Scholars program. Please share! 1/5
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Scott Barolo @sbarolo.bsky.social · 15/09/2026
🧵 Short thread: I give a seminar to 1st-year biomed PhD students in my program about how to critically read a paper, how to extract VAST amounts of information from the title, and why reading AI summaries instead of struggling with papers is *particularly* bad for trainees. 🧪
A comparative analysis of two paper titles, focusing what exactly we can expect to see in each paper. The verb choice alone shows that one is primarily a techniques paper.
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Reposted by Pim Huis in 't Veld
Chenxin Li, PhD @chenxinli2.bsky.social · 13/09/2026
They hate immigrants doing farm work and construction, and they hate immigrants working in research labs. They hate immigrants speaking languages they can't understand, and they hate immigrants speaking perfect English. Their little White Nationalist worldview just can't handle it.
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Pim Huis in 't Veld @huis.bsky.social · 09/09/2026
Fresh preprint from the lab: CIP2A tetramerization is required for mitotic DNA repair. A fantastic collaboration with @marcelvanvugt.bsky.social. By @laurendehaan.bsky.social, @rebeccaschneeweiss.bsky.social, and colleagues from Groningen, Vienna, Leiden, and Amsterdam 🙌 doi.org/10.64898/202...
Electron micrograph of full-length human CIP2A and a corresponding Alphafold model
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Harmit Singh Malik @harmitmalik.bsky.social · 08/09/2026
So (if I understand this correctly), the way AI (companies) will "solve" all the major problems in maths, biology, and medicine in the next 5 years will be by stealing and building on the ideas of researchers naive enough to think their chats with AI companies would be private.
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marcelvanvugt.bsky.social @marcelvanvugt.bsky.social · 24/08/2026
Very pleased to share this new study: In a truly collaborative effort with the lab of Pim Huis in 't Veld @huis.bsky.social, we combined biochemistry with cell biological and genomic approaches to uncover how CIP2A works in mitotic DNA repair. www.biorxiv.org/content/10.6...
biorxiv.org
CIP2A tetramerization is required for mitotic DNA repair
DNA lesions that persist in mitosis threaten genome stability. These lesions recruit TOPBP1-CIP2A, a complex crucial to tether and process damaged DNA on mitotic chromosomes. Importantly, CIP2A is syn...
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Matthew Cobb @matthewcobb.bsky.social · 07/08/2026
If anyone needs yet another review of Nolan’s THE ODYSSEY, this, by Oxford don and poet A. E. Stallings in today’s TLS is pretty good.
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Aaron Straight @astraight.bsky.social · 03/08/2026
These two reviews on centromeres and kinetochores in @natrevmcb.nature.com cap off @andrea-musacchio.bsky.social sabbatical at @stanfordbiochem.bsky.social from @valleefoundation.bsky.social. Long time in the making! Non-paywall versions rdcu.be/fxD9V, rdcu.be/fxEar
rdcu.be
Structure and function of the centromere and inner kinetochore
Nature Reviews Molecular Cell Biology - The kinetochore is a macromolecular complex that assembles on centromeric chromatin and connects spindle microtubules to the chromosome. This Review...
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Katie Mack @astrokatie.com · 31/07/2026
If this is what happens to a scientific field as a whole when LLMs dominate the workflows of researchers, I can only imagine that the outlook is even worse for any individual researcher who is soldiering on without using them. 😞
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In Preparation @inprep.bsky.social · 26/06/2026
inpreparation.substack.com
Springer Nature CEO Opens Special Bottle Of Wine Upon News of Open Science Self-Cannibalization
LONDON—Springer Nature CEO Willem Klaassen-Hooft opened a 2016 Châteauneuf-du-Pape he had been saving for the right occasion Tuesday evening after reading that an open science advocate had used AI to…
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Pim Huis in 't Veld @huis.bsky.social · 25/06/2026
I'd like to be in cat. 3, but the 1% cut-off locks me in cat. 2.. For me it defeats all possible positive aspects in a dominant negative manner. AI to browse claims across papers would be great. But please avoid quality scores and cut-offs. For one because they focus on words >> data+figure quality
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Vaughn Smider, MD, PhD @vvsmider.bsky.social · 20/06/2026
We lost a scientific hero today, Bob Lehman. Here is a 🧪🧵I posted last year about Bob.
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Reese Richardson @reeserichardson.bsky.social · 28/05/2026
TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...
reeserichardson.blog
How much of Thermo Fisher’s antibody data has been manipulated?
We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog
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Jonathan Eisen @phylogenomics.bsky.social · 30/04/2026
Reposting this from April 1, 2007 in honor of Craig Venter. I did this as an April Fool's joke - sharing it as a PDF. I got stressed when I found out Craig had seen it and knew it was by me. But he loved it and said it was OK to share it more widely. So then I posted it on the web.
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James Gagnon @james-gagnon.bsky.social · 28/04/2026
Using light-activated CRISPR in zebrafish, we triggered synchronized DNA breaks and track the repair process. ⚡🐟⚡ 

 Well ... DNA repair is very different in embryos compared to tissue culture cells. Embryos repair DNA breaks incredibly fast - within minutes! www.biorxiv.org/content/10.6...
A cartoon showing how a caged guide RNA poises CRISPR cleavage until release by light. Below, a cartoon of injection of "light-activated CRISPR" into the embryo, followed by activation.
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Daniel Moser @dmoser.bsky.social · 27/04/2026
Pollution levels in Paris after 10 years of advancing sustainable transport.
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Kenneth Loi @kenjmloi.bsky.social · 27/04/2026
Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR. We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets. Thread + link below.
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Alexey Amunts @amunts.bsky.social · 13/04/2026
Since our preprint on the ETC-ATP synthase supercomplex has attracted attention, I would like to introduce the platform we used, Langtaosha. It was launched by SMART together with several other institutions with support from Open Life Science Alliance, aiming for long-term open infrastructure 1/4
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Daniel Ahmad @zhugeex.com · 07/04/2026
I hate having to do the "look, they're normal just like us" post, but sometimes you have to do that when American propaganda tries to convince everyone Iranians are "animals".
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Holly Dunsworth @dunsworth.bsky.social · 31/03/2026
I'm reviewing Sapiens, one page at a time! It's a little bit fact-checking and a little-bit soul-searching combined into a lot of feelings... ecodevoevo.blogspot.com/2026/03/sapi...
ecodevoevo.blogspot.com
"Sapiens": One page at a time
I've been co-teaching a course for several years in which we read Sapiens . I think I've read it eight times, now. That explains the gumband...
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Reposted by Pim Huis in 't Veld
Alisia Fadini @alisiafadini.bsky.social · 01/04/2026
ROCKET 🚀 inference-time optimization of AlphaFold to fit structural data is published! rdcu.be/fa9YH Since our preprint, we’ve pushed it to regimes where other methods break: low resolution, weak signal, real experimental edge cases. Here’s what we learned: 1/15
rdcu.be
AlphaFold as a prior: experimental structure determination conditioned on a pretrained neural network
Nature Methods - ROCKET improves experimental structure elucidation by integrating implicit structural knowledge from OpenFold, a trainable reimplementation of AlphaFold2, with X-ray...
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Marc Robinson-Rechavi @marcrr.bsky.social · 31/03/2026
This! AlphaFold is PDB + UniProt + Deep learning. No data sharing, no curation, no data standards, no AlphaFold.
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Vladimir Volkov 🇺🇦 @vladimirvolkov.bsky.social · 25/03/2026
In memoriam Fazly Ataullakhanov was a biophysicist with a rich heritage, and a strong scientific legacy. An ethnic Tadjik, born in Samarkand (Soviet Uzbekistan), educated in Moscow, made his best scientific contributions in English, collaborating with international researchers in the USA. /1
A monochrome portrait of Fazly Ataullakhanov - a man in his fifties sitting in a seminar room
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Pim Huis in 't Veld @huis.bsky.social · 22/03/2026
Congratulations Vladimir and team! A lot more in the paper, just posting some of Figure 2 here since growing and shrinking microtubules on the grid before freezing and cryoET is amazing
Tomograms showing the ends of microtubules with multimeric protein assemblies. Fig 2B of the linked paper.Subtomogram averaging of Ndc80 trains on a microtubule. Fig 2E of the linked paper.Tomograms showing the ends of microtubules with multimeric protein assemblies. Fig 2C of the linked paper.
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Bart Penders @penders.bsky.social · 23/02/2026
A week ago, we had an open conversation amongst senior academics in leadership roles and their use of LLMs (in both their leadership capacities and individually). Small group, not representative, but it already taught me a great deal about the diversity of perspectives (& their consequences). 1/
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Bas Heijne @basheijne.bsky.social · 20/02/2026
Lees Huxley.
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Max Haase @maxhaase.bsky.social · 18/02/2026
Our paper is now out in Nature: “Ancient co-option of LTR retrotransposons as yeast centromeres” www.nature.com/articles/s41... A short thread on how retrotransposons helped give rise to yeast point centromeres. 1/14
nature.com
Ancient co-option of LTR retrotransposons as yeast centromeres - Nature
Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...
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BWJones @bwjones.bsky.social · 17/02/2026
If you’ve not stopped using Meta products (Facebook, Instagram, etc…), now is a really good time to stop. This is viscerally horrifying.
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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 28/01/2026
Let's try this #AcademicSky 1 fav, 1 funny, strange, or unexpected scientific anecdote about a paper, a scientist, a fact, hoping that some will be new to you.
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Seychelle Vos @voslab.org · 09/02/2026
🧪🧬New preprint We present cryo-EM structures of reconstituted CTCF–nucleosome complexes, showing CTCF dimerization drives nucleosome oligomerization into defined higher-order assemblies. Disrupting CTCF–CTCF interfaces in mESCs reduces looping and impairs differentiation. tinyurl.com/CTCF-nucleos...
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Ingomar Gutmann @gutmann.bsky.social · 02/02/2026
European Scientists who said NO to Epstein-funding are the heroines of this hour🦸‍♀️ They show: It was your choice to SAY NO to Epstein's $ as scientist- you just had to have ethics & a spine Kudos to Physicist IVETTE FUENTES who said NO She was working at @quantumunivie.bsky.social @univie.ac.at
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Iva Tolić @ivatolic.bsky.social · 28/01/2026
PhD position in my lab!
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Charles Keener @charleskeener.bsky.social · 22/01/2026
We speak to Greek economist Yanis Varoufakis about the United States under Donald Trump and its attempts to reshape the post-World War II international consensus. www.democracynow.org/2026/1/22/ya...
democracynow.org
“An Abomination”: Yanis Varoufakis on Trump’s “Board of Peace” & Threat to Democratic World Order
We speak to Greek economist Yanis Varoufakis about the United States under Donald Trump and its attempts to reshape the post-World War II international consensus. “Trump has all his work done for him ...
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Andrew B. Watkins @windjunky.bsky.social · 14/01/2026
Globally, no single day in 2025 was cooler than its 1991-2020 average. climate.copernicus.eu/global-clima...
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Mehdi Hasan @mehdirhasan.bsky.social · 08/01/2026
"Israel Is Banning the 'Last Foreign Witnesses' to Its Genocide in Gaza" In a likely deadly move, the Israeli government told 37 foreign aid groups, including Doctors Without Borders, they could no longer operate in Palestine. Where is the outrage, asks Diana Buttu for Zeteo?
zeteo.com
Israel Is Banning the 'Last Foreign Witnesses' to Its Genocide in Gaza
In a likely deadly move, the Israeli government told 37 foreign aid groups, including Doctors Without Borders, they could no longer operate in Palestine. Where is the outrage?
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dr. thrasher, an american writer in ex(archia)(xile) @thrasherxy.bsky.social · 01/01/2026
“For too long, those fluent in the good grammar of civility have deployed decorum to mask agendas of cruelty.”
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Drop Site @dropsitenews.com · 21/11/2025
On Trump being a fascist👇 Video: Aaron Rupar via X (@atrupar)
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Max Perutz Labs Vienna @maxperutzlabs.ac.at · 06/11/2025
Big news! Group leader Sascha Martens has been awarded a prestigious @erc.europa.eu Synergy Grant for the collaborative project DegrAbility to explore how cells can better recycle harmful protein aggregates linked to diseases like Alzheimer’s ➡️ tinyurl.com/2zuz9jcf @univie.ac.at @meduniwien.ac.at
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Pim Huis in 't Veld @huis.bsky.social · 03/11/2025
Saruman talking. Palantir running. Please help everyone around you to stop paying attention to him and X! If within reach, please alarm employers, politicians, and news agencies (again and again)..
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Max Perutz Labs Vienna @maxperutzlabs.ac.at · 31/10/2025
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
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Nilsson lab @nilssonlab.bsky.social · 23/10/2025
I have a PhD opening in my lab for an exiting project using base editor screens to find novel drug targets. Please help spread the word. candidate.hr-manager.net/ApplicationI...
candidate.hr-manager.net
PhD student position in the Cell Signaling and Cell Cycle group at the Danish Cancer Institute.
The Cell Signaling and Cell Cycle group, headed by Prof. Jakob Nilsson, is looking for a highly motivated and enthusiastic PhD student to establish novel CRISPR
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James Briscoe @jamesbriscoe.bsky.social · 10/10/2025
The @crick.ac.uk is recruiting Early Career Group Leaders - Lab set-up, research costs, salaries for up to 5 researchers - Support for up to 12 years - Access to our core facilities - Competitive salary - Fantastic colleagues - All areas of biology Deadline 27 Nov www.crick.ac.uk/careers-stud...
crick.ac.uk
Early career group leaders
We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.
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Meidas Charise Lee 💙🌊🌴🥥🫘 @chariselee.bsky.social · 08/10/2025
WHAT THE F*CK‼️‼️‼️‼️‼️ Chicago’s Reverend David Black of First Presbyterian has been assaulted multiple times by ICE agents during peaceful protest in the city‼️They shot a some kind of non lethal bullet at his head‼️ #PepperBall
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Governor JB Pritzker @govpritzker.illinois.gov · 08/10/2025
I will not back down. Trump is now calling for the arrest of elected representatives checking his power. What else is left on the path to full-blown authoritarianism?
Donald Trump Truth Social Post: Chicago Mayor should be in jail for failing to protect Ice Officers! Governor Pritzker also.
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Tung Le @tunglejic.bsky.social · 03/10/2025
Independent research fellowships leading to tenured positions at the John Innes Centre. Repost = nice. Thank you very much!!!
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