GTSF1 is an essential activating cofactor for PIWI proteins in many metazoans. In the nematode Caenorhabditis elegans, however, GTSF-1 does not bind PIWI, but is associated with the RNA-dependent RNA ...

Proteome-wide prediction and structural modeling of disordered protein interaction interfaces advance characterization of disease-associated variants in disordered protein regions.

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Honeybees (Apis mellifera) are highly effective pollinators of flowering plants, including many food crops. However, managed honeybee colonies ...

GTSF1 is an essential activating cofactor for PIWI proteins in many metazoans. In the nematode Caenorhabditis elegans, however, GTSF-1 does not bind PIWI, but associates with the RNA-dependent RNA pol...

imageimageAn intergenerational cycle between HRDE-1 and WAGO-3 drives RNAi inheritance in C. elegans, where HRDE-1 drives silencing in both parent and offspring and WAGO-3 transmits the RNAi response ...

Kar et al. demonstrate that Balbiani body (Bb) formation is achieved via developmental condensation in zebrafish oogenesis, driven by Buc phase separation and evolving from a dynamic liquid-like state into a solid-like stable compartment. Multistep regulation by microtubules controls condensation, ensuring proper Bb formation and oocyte polarity.

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FMI researchers have developed a new tool that maps how proteases —enzymes that process proteins— cut their targets. This innovation offers new insight into the highly selective nature of proteases, w...

piRNAdise lost: piRNAs, a key component of the defense against transposable elements appeared very early in animal evolution. Remarkably however, they have been lost multiple times independently in d...

Zhou et al. discovered a specific role of adenosine modifications in the coding region of mRNAs. These chemical alterations slow down the movement of the ribosome during translation and trigger degrad...

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Karttunen et al. identify the contribution of transposable elements to gene regulatory function in colorectal and liver cancer cell lines.