Kir7.1 is an essential potassium channel. The authors report cryo-EM structures in multiple states revealing how bioactive lipids modulate Kir7.1, and define a pharmacological landscape that identifie...

Intrinsically disordered regions (IDRs) in proteins play essential roles in cellular function. A growing body of work has shown that IDRs often interact with partners in a manner that does not depend ...

As HHMI pauses Hanna Gray fellowship applications, opportunities for young scientists shrink further, making them look overseas.

Long Research Group - Univ. Kentucky

Trump policy blocking required notices has frozen reviews of thousands of grants

A new policy for how the National Institutes of Health will reimburse overhead costs associated with research grants could result in the loss of significant funding at institutions like UT Austin.

The TRiC chaperonin is responsible for folding ~5%–10% of the proteome in eukaryotic cells. Our recent cryo-electron microscopy studies of axonemes from diverse mammalian cell types led to the surpri...

Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...

The sperm flagellar-specific CatSper Ca2+ channel is a multiprotein complex critical for successful fertilization. The four ancillary subunits, CATSPERβ, γ, δ, and ε, form a unique canopy structure ov...

Transcription and its regulation pose a major challenge for genome stability. The helicase RECQL5 has been proposed as an important factor to help safeguard the genome, and is the only member of the h...

Structures reveal that histone H3K36me3 and H3K4me3 modifications reduce Polycomb repressive complex 2 (PRC2) function through the inhibition of histone tail engagement and antagonistic binding to the...

Nature Structural & Molecular Biology - Here, the authors reveal the mechanism by which anchors of a tubulin acetyltransferase in the β-tubulin taxane-binding pockets have critical roles...