Wadjet is an SMC-based prokaryotic defense system that eliminates plasmid DNA. Roisné-Hamelin et al. present structures capturing key steps of its DNA-loading mechanism. This work reveals how Wadjet t...

Wadjet are SMC-based prokaryotic defense systems that cleave plasmid DNA. Roisné-Hamelin et al. reconstitute a type II Wadjet and demonstrate that it exhibits substrate selection and cleavage properti...

Analikwu et al. show that dense linear arrays of the telomeric protein Rap1 on DNA block DNA loop extrusion by condensin. Rap1-induced stalling depends on array length and protein density and leads to a local chromatin decompaction during anaphase, revealing how protein arrays can regulate SMC-driven genome organization.

DNA loop-extruding SMC complexes play vital roles in genome maintenance and DNA immunity. However, the ability of these ring-shaped DNA motors to navigate large DNA-bound obstacles, such as DNA/RNA po...

Pour cette toute première mise au concours en cryo-microscopie électronique, la Commission de la Recherche de la FBM a retenu 4 projets innovants qui seront menés au sein des Départements de microbiol...