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Paul Sauer

@paulsauer.bsky.social

67 followers 37 following 2 posts

Structural Biologist and outdoor enthusiast

Posts Replies Media

Reposted by Paul Sauer

Marisa Kabas @marisakabas.bsky.social · 29/01/2025

🚨 BREAKING: OMB has just issued a memo *rescinding* the previous memo freezing all federal financial assistance programs. Full text, per government source:

January 29, 2025
M-25-14
MEMORANDUM FOR HEADS OF EXECUTIVE DEPARTMENTS AND AGENCIES
FROM: Matthew J. Vaeth, Acting Director, Office of Management and Budget Me
SUBJECT: Rescission of M-25-13
OMB Memorandum M-25-13 is rescinded. If you have questions about implementing the
President's Executive Orders, please contact your agency General Counsel.

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Paul Sauer @paulsauer.bsky.social · 22/01/2025

Our first paper here at #interdictbio!

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Reposted by Paul Sauer

Karolin Luger @nucleosomepolice.bsky.social · 21/01/2025

As someone who grew up in Austria I am really concerned about the apparent lack of concern. y'all should distribute the small book 'Biedermann und die Brandstifter' by Max Frisch ("The Fire Raisers: A Morality Without a Moral,"), which lays it out in detail. 🧵

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Reposted by Paul Sauer

Steven Cheng @scheng23.bsky.social · 10/01/2025

"On a molecular level, our structural studies reveal that interdictors bind in a linkerless heterobifunctional manner to both the rRNA and the nascent peptide chain ... much the way a PROTAC can be modularly designed and constructed"

Figure 3. (A) Representative cryo-EM map of a stalled RNC with a tRNA in the P site, bound to IDB-001.
Inset shows a closeup of the PTC containing the IDB-001 (yellow), P-site tRNA (green), nascent
chain (salmon), rRNA (dark blue), and signal for ions and water molecules (red).

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Reposted by Paul Sauer

John Prensner @johnprensner.bsky.social · 10/01/2025

Is RNA translation the next hot area in #cancer therapeutics? Take a look and make a decision for yourself! #RNAsky #ONCSky 🧬 💻 #genomics www.biorxiv.org/content/10.1...

biorxiv.org

Context-dependent translation inhibition as a novel oncology therapeutic modality

Inhibitors of protein synthesis, including anisomycin, homoharringtonine, and other natural products bind in the peptidyl-transferase center (PTC) of the eukaryotic ribosome to inhibit translation. Re...

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Paul Sauer @paulsauer.bsky.social · 10/01/2025

Congratulations @trinitycookis.bsky.social for a great paper! Biochemical and structural disscection of PRC2 activation and inhibition by modified histones!

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