Reposted by Milo Imbeniworm @rfksbrainworm.bsky.social · 02/10/2026If you ever wondered why visible light is those particular wavelengths, it's because life evolved to see in the narrow range where water is transparent 8648551392
Reposted by Milo ImbeniDale Moulding @dalemoulding.bsky.social · 01/10/2026Having seen the news: www.bbc.co.uk/news/article... thought I'd share a cilia movie captured at UCL GOS ICH with Eriomina Shahaj & Vanesa Papastavrou using simple DIC on a Nikon Ti2 with DIC at 60x1.4. 500 fps here slowed down 20 times. Processed with Nikon's denoiseAI and an unsharp mask in Fiji. 98622
Reposted by Milo ImbeniJohannes Soltwedel @jo-soltwedel.bsky.social · 01/10/2026Just released the napari-clusters-plotter 0.11.0 github.com/BiAPoL/napar..., a little passion-project of mine for interactive exploration of datasets and attached features in @napari.org Two cool things to take note of 👇github.comGitHub - BiAPoL/napari-clusters-plotter: A napari plugin for clustering objects according to their properties.A napari plugin for clustering objects according to their properties. - BiAPoL/napari-clusters-plotter 13113
Reposted by Milo ImbeniChise @sailorrooscout.bsky.social · 28/09/2026A quiet discovery inside a familiar soil microbe is reshaping how we think about the future of antibiotics. Researchers at McMaster University have identified a compound that could help fight drug-resistant infections, a growing global health threat. Their study introduces an 120112
Reposted by Milo ImbeniPanos Roussos @panosroussos.bsky.social · 26/09/2026Thrilled to see the PsychAD package published! 🧠 Launched in 2019: 60+ investigators, 8 institutions, 1,494 human brains—illuminating brain aging and disease. Supported by NIA. Deeply grateful to all donors and families. psych-ad.org www.nature.com/collections/...psych-ad.orgPsychADThe PsychAD Consortium builds population-scale, single-cell models of the human brain to uncover the molecular mechanisms behind neuropsychiatric symptoms in Alzheimer’s disease, related dementias, an... 174
Milo Imbeni @pyramidalmilo.bsky.social · 24/09/2026Really cool!! Must be in my wife's lineage given the tempeature of her showers 010
Reposted by Milo ImbeniDavid Gokhman @david-gokhman.bsky.social · 23/09/2026This leaves some fascinating questions: why would such a costly change evolve instead of being purged? Was there an evolutionary trade-off? And what did this shift do in other organs where GAGs are important (brain, skin)? 112
Reposted by Milo ImbeniProf. Keiko Torii @keikoutorii.bsky.social · 23/09/2026Torii lab's research featured by @hhmi-science.bsky.social "Reading the Leaves: Decoding the Secret Cellular Language of Plants"🌱🧬🦠! ペプチドホルモンー受容体キナーゼを介した植物の気孔の発生への免疫シグナル経路の介入など、私の研究グループの取り組みに関するハワードヒューズ医学研究所の紹介記事です🌱🧬🦠 www.hhmi.org/news/reading...hhmi.orgReading the Leaves: Decoding the Secret Cellular Language of Plants | HHMIEarly in her career, HHMI Investigator Keiko Torii figured out how plant cells talk to each other. Three decades later, she’s still listening — and uncovering exactly what they’re saying. 0205
Reposted by Milo ImbeniCtenophores Rock! @ctenophoresrock.bsky.social · 23/09/2026This is Bob. They are a hermaphroditic comb jelly that recently underwent reverse development from adult lobate to larval cydippid, following a period of stress. The event reduced our colony to just Bob. Once our food source stabilized, Bob began to flourish & what was 1 Bob is now 500+ Bobettes! 🦑 15019
Milo Imbeni @pyramidalmilo.bsky.social · 23/09/2026Insane stuff, it keeps coming, one more beautiful than the next, claude is worth the money sometimes 000
Reposted by Milo ImbeniLoïc A. Royer 💻🔬🧪 @loicaroyer.bsky.social · 23/09/2026What if any dataset, any size, any number of dimensions, opened in a browser tab from a link? 🔬🧪💻 Luxar is out today: write it in Python, share it as a link, explore it in any browser. Open source. 🧵 @biohub.org Preprint: doi.org/10.5281/zen... Code: github.com/royerlab/luxar 614457
Reposted by Milo ImbeniNicole Rust @nicolecrust.bsky.social · 04/09/2026The superposition of these two studies — both incredible — reflect a snapshot of "one big thing" systems neuroscience has yet to resolve. In mice: 1. Task-related signals are everywhere. 2. Absent large swaths of "everywhere," suprisingly sophisticated learning & behavior remains. 1011838
Reposted by Milo ImbeniTonni Andersen @tonnigrubeandersen.bsky.social · 22/09/2026Check out our new preprint: a very cool fluorescence tool developed by @samwalds.bsky.social www.biorxiv.org/content/10.6...biorxiv.orgIntronised fluorophores improve reporter output and biosensor expression in plantsGenetically encoded biosensors are central to plant cell biology, but low reporter signal can limit their use. Here, we developed modular intronised fluorophores to improve reporter output in transien... 06932
Reposted by Milo ImbeniJames Manton @jamesdmanton.bsky.social · 21/09/2026I very much enjoyed Lisa Cuneo's talk at FOM2026 on a new approach to deconvolution, so it's great to see the preprint is now out: www.biorxiv.org/content/10.6... @vicidominilab.bsky.socialbiorxiv.orgIndependent noise realizations enable morphologically agnostic image reconstruction in single-photon-sensitive microscopyAdvances in single-photon sensitive detectors are rapidly expanding the adoption of photon-counting fluorescence microscopy. Under the Poisson photon-counting statistics, iterative Richardson-Lucy (RL... 194
Reposted by Milo ImbeniJeff Spence @jeffspence.github.io · 19/09/2026Not a blog post, but @yundeng.bsky.social and co. convincingly showed (IMO) that it was a statistical artifact here: academic.oup.com/genetics/art...academic.oup.comA previously reported bottleneck in human ancestry 900 kya is likely a statistical artifactHu et al. (Science, 2023) recently inferred a severe ancient bottleneck around 900 thousand years (kya) ago in African ancestry but found no similar eviden 2103
Reposted by Milo ImbeniQuanta Magazine @quantamagazine.org · 18/09/2026This is a comb jelly — an elegant, voracious predator that lives in the deep sea, the cold poles and the warm tropics. The ribbonlike 𝘊𝘦𝘴𝘵𝘶𝘮 𝘷𝘦𝘯𝘦𝘳𝘪𝘴, or Venus’ girdle, is one of the largest species. It grows up to 1.5 meters in length. www.quantamagazine.org/ctenophores-... 2417
Reposted by Milo ImbeniFernando Garcia-Moreno @phylobrain.bsky.social · 18/09/2026The cerebral cortex that is reading this sentence (yours, to be explicit) did not come out of nowhere. It has evolved over hundreds of millions of years... To study this evolutionary process, we decided to focus on non-avian reptiles for our new paper in Cerebral Cortex 🐢🦎🧠 🧵 24120
Reposted by Milo ImbeniVinny Costa @vincentcostaphd.bsky.social · 13/09/2026Apparently the lesson of the digital sphinx by @tuthill.bsky.social & @bingbrunton.bsky.social has already been forgotten. The fly isn’t “playing Doom”. elifesciences.org/reviewed-pre...elifesciences.orgThe digital sphinx: Can a worm brain control a fly body? 1164
Reposted by Milo Imbeniburn it all down @russbengtson.bsky.social · 16/09/2026*suspicious lobster wife* where did you get that shrimp *still confused lobster* you're never gonna believe this 32526501
Reposted by Milo ImbeniSteve Ramirez @okaysteve.bsky.social · 16/09/2026🚨 new work from the lab! "Hippocampal astrocytic sequences emerge during learning and memory recall" by @ryguy.io & @rsuthard.bsky.social thank you to the entire team for your camaraderie and for muscling through science together 🧠 -- we welcome all feedback! nature.com/articles/s41...nature.comHippocampal astrocytic sequences emerge during learning and memory recallNature Neuroscience - Senne, Suthard and colleagues show that dorsal hippocampal astrocytes display time-compressed calcium-event sequences after foot shock and upon context re-exposure, and that... 79331
Reposted by Milo ImbeniDrug Monkey @drugmonkey.bsky.social · 15/09/2026I probably should have noted that the Broken Earth trilogy is so excellent IMO in large part because it IS a very tough read for many audiences. Most especially mothers and the Black readers who know exactly who she is really talking about. sorry for not including a TW in the first place. 183
Reposted by Milo ImbeniVolt Europa @volteuropa.org · 14/09/2026From 14 to 62 seats! 🥳 Yesterday, Volt won 62 seats in local elections across Lower Saxony, according to the preliminary results. This is an increase of 48 (!) compared to the last election. 🎉 (1/3) 79835
Reposted by Milo ImbeniTimnit Gebru @timnitgebru.blacksky.app · 14/09/2026The only person in public service who has consistently made 100% sense on issues of "AI," which is why they hate her so much. 192027659
Reposted by Milo ImbeniDr. Émile P. Torres @xriskology.bsky.social · 14/09/2026If you want to understand the current debate about ASI extinction risk, please please read this. I explain how you've almost certainly been misled into thinking this is about saving humanity--it's NOT. The term "human extinction" doesn't mean what you think it does!realtimetechpocalypse.comThe ASI Extinction Debate Is the Opposite of What You ThinkThe media needs to wake up, fast. (3,100 words.) 88842
Reposted by Milo ImbeniJohn Smillie @johnsmillie42.bsky.social · 12/09/2026www.agriculture.com/heat-drought... One of my pet ideas is a concerted push by land grant universities, state govts, solar and ag industry assocs, etc. to figure out how to deploy vertical agrivoltaics on semi-arid row crops fields to save their own agricultureagriculture.comHeat, Drought Take Toll on Kansas Corn CropCorn and soybean conditions are poor after drougth and intense heat have plagued the state for weeks. Here’s a closer look at what farmers face in Kansas. 73412
Reposted by Milo ImbeniMoustafa Algamal @moustafaalgamal.bsky.social · 12/09/2026Microglia on the move! Here’s microglial clustering around amyloid plaques (cyan) after one week of aducanumab treatment. Our new preprint shows this response begins within 18–48 hours. Pretty exciting to watch it unfold in the living brain! www.biorxiv.org/content/10.6... 022
Reposted by Milo ImbeniJess Miers 🦝 @jmiers230.bsky.social · 13/09/2026Most if not all of the current hacks can be chalked up to security engineers moving too fast and misconfiguring their own testing environments. Like agents accessing libraries that should have been sealed off, Internet access being enabled when it shouldn't have been... 672792
Reposted by Milo ImbeniElise Thomas @elisethomas.bsky.social · 12/09/2026I think there's actually quite an easy and obvious way to solve the collective action problem of how to make the AI companies stop conducting risky research, and it's to make it very clear that they're legally liable for anything their models do. www.politico.com/news/2026/09...politico.comAnthropic CEO seeks immediate slowdown on AIDario Amodei warned that recent advances have begun to outpace the industry’s ability to fully understand and control the technology. 1286
Reposted by Milo ImbeniGrace Lindsay @neurograce.bsky.social · 27/08/2026MIT has put out an "AI and Education" report summarizing what they've found at their own institution. Seems thoughtful. aiandeducation.mit.edu/report/ 421868
Reposted by Milo Imbenipaveltomancak.bsky.social @paveltomancak.bsky.social · 10/09/2026This article seems to celebrate the shift from poor support for #software #engineers in research to pretending they aren't needed at all. Did we spend 2 decades consolidating fragmented software ecosystems into platforms only to see them dissolve through "vibe coding"? www.nature.com/articles/s41...nature.comDisruption of the research software landscape through AI software generation - Nature MethodsSpecialized research software has historically been costly and time-consuming to create, but large language models (LLMs) have become capable enough at code generation to fundamentally change this. We... 7309
Reposted by Milo ImbeniBernie Mulvey @berniejmulvey.bsky.social · 11/09/2026Excited to share work with cryostat wizard @heenadivecha.bsky.social looking at gene expression in my favorite brain region (LC) in adult postmortem brain! (Long URL to spare the trouble of identifying cars, buses, beds in 5x5 pixel imgs). (1/x) link.springer.com/epdf/10.1007...link.springer.comMolecular programs in human locus coeruleus link APOE and neuromelanin to Alzheimer’s vulnerability 22516
Reposted by Milo ImbeniDavid Ho @davidho.bsky.social · 12/09/2026I wrote this quickly at a bus stop and didn't realize it would go viral, or else I would have worded it better. But the point is that the media is too credulous about AI killing everyone in 10 years (how?) when climate change is killing people now and will only get worse (we know exactly how). 4156771561
Reposted by Milo ImbeniCarl T. Bergstrom @carlbergstrom.com · 11/09/2026"...solving problems is only a tool and proxy for achieving the primary goal of conceptual understanding and insight. Forgetting this in the world of AI may turn the tool against the primary goal." 231788
Reposted by Milo Imbenidaryl "rupert pumpkin" b 🏳️⚧️ @hypercubexl.bsky.social · 09/09/2026GDT's reddit AMA spitting fire www.reddit.com/r/movies/com... 2845491916
Reposted by Milo ImbeniDave Barry @david-j-barry.bsky.social · 10/09/2026Are you a UK-based undergraduate considering a career in research, and looking for an industry placement? 🔬 Want to investigate how light exposure disrupts the cell cycle, using live imaging and AI-powered image analysis? ⏳ Deadline: October 6th 👇 Apply below www.crick.ac.uk/careers-stud...crick.ac.ukInvestigating phototoxicity-induced cell cycle disruption in live cell imaging 248
Milo Imbeni @pyramidalmilo.bsky.social · 10/09/2026I wonder what it is like not to have a cortex! 010
Reposted by Milo ImbeniJieyu Zheng @jieyusz.bsky.social · 10/09/2026An acortical mouse — born without hippocampus and most of its neocortex — learns the Manhattan Maze: a 30× improvement in 5 hours, 18 rewards! Now a question for everyone: How can an acortical brain do this? Leave a comment! Preprint w/ @mameister4.bsky.social: www.biorxiv.org/content/10.6... 68928
Reposted by Milo ImbeniPedro Beltrao @pedrobeltrao.bsky.social · 09/09/2026I made a presentation to other faculty about recent progress in general AI, to facilitate the discussion around the impact for research and teaching in biology. It could be that the slides are useful for others trying to do that same. Feel free to re-use. docs.google.com/presentation...docs.google.comgeneralAI_for research_intro.pptxRecent AI developments and what they mean for us Quick primer on general AI models* State-of-the-art in AI agent capabilities AI agents in biology (examples) Discussion - what does this mean for our r... 79026
Reposted by Milo ImbeniLiisa Galea @liisagalea.bsky.social · 09/09/2026Our new preprint with @ciernialab.bsky.social we investigated transcriptional profiles of microglia (❤️the name) from hAPOEe4/3 female/male mice in HPC &CTX. We saw loads of sex x genotype interactions in both regions Cell cycling, ER stress, lipid metabolism ++ www.biorxiv.org/content/10.6...biorxiv.orgSex and APOE Genotype Differentially Shape Microglial Transcriptomic Profiles Across the Hippocampus and CortexFemale sex and the APOEε4 allele are top risk factors for Alzheimer’s disease (AD). Microglia play a role in the pathogenesis of AD, yet how sex and APOE genotype affect microglia remain poorly unders... 1125
Reposted by Milo ImbeniAmerican Aging Association @americanaging.bsky.social · 09/09/2026Sea squirts are unusually rich in plasmalogens — a lipid that declines with age. Fed to aged mice: faster learning, healthier brain synapses, less inflammation, even darker regrown hair 🐙🧠 Animal study only, but a wild new angle on brain aging. doi.org/10.3389/fmol... #GeroScience #BrainHealthdoi.orgFrontiers | Plasmalogens Eliminate Aging-Associated Synaptic Defects and Microglia-Mediated Neuroinflammation in MiceNeurodegeneration is a pathological condition in which nervous system or neuron losses its structure, function, or both leading to progressive neural degener... 122
Reposted by Milo ImbeniJase Gehring @skyjase.bsky.social · 09/09/2026so when i see OpenAI claim that they didn't use any "specific" information from their competitors, i have no doubt their discovery relied on similar leakage of training data. we have even seen that AI training data can be tainted by mundane shit like Reddit posts. 141
Reposted by Milo ImbeniMisha Ahrens @mishaahrens.bsky.social · 09/09/2026Whole-body cellular activity imaging in zebrafish, headed by Virginie Ruetten @vmsruetten.bsky.social - new paper is out: www.nature.com/articles/s41...nature.comImaging cellular activity across all organs reveals body-wide circuits - NatureAn imaging system developed to record cellular activity throughout the whole body of zebrafish captures cellular organ dynamics and identifies multiple distributed circuits. 110341
Reposted by Milo ImbeniDrLachie @drlachie.bsky.social · 10/09/2026Proud to present the publication of napari-lattice – our solution to the immense computational requirements of Lattice Light Sheet and Oblique Plane Microscopy. onlinelibrary.wiley.com/doi/10.1111/... Before I get into the thread, the important part is on github: github.com/BioimageAnal... (1/n)onlinelibrary.wiley.comnapari‐lattice: A user‐friendly image processing tool for lattice light‐sheet microscopy dataLattice light-sheet microscopy (LLSM) enables researchers to capture high-speed 3D videos of living cells with high definition and minimal damage. However, this technology generates terabytes of data.... 13213
Reposted by Milo ImbeniSteve Haddock @stevehaddock.bsky.social · 28/08/2025Our science photo book The Radiant Sea is out Sept 2nd!! 30 years of research, 10 years of "we should", and a year of collating pix and writing. Sönke and I show (mostly for the first time) images of how organisms produce, use, and interact with light in the sea. #bioluminescence #fluorescence 🦑🧪🌊 1521770
Reposted by Milo ImbeniKeri Martinowich @martinowk.bsky.social · 08/09/2026Early data peek at Illumina's new StrataMap spatial transcriptomics cellular resolution platform. Huge capture area (7.5 cm2) - we profiled human 🧠 at level of thalamus - totally 🤩. Kudos to our teams for amazing work w/ nerve wracking sectioning & direct placement of this VERY large tissue section! 1458
Reposted by Milo ImbeniAnh Hoang Le, PhD 🏳️🌈🏴🇻🇳 @anhhle2702.bsky.social · 07/09/2026Very happy to share my postdoc paper is out now in @natcellbio.nature.com titled "Tissue flow acts as a guidance cue for immune cell polarization and directional migration". If you love imaging and immune cells, this is for you! #microscopymonday www.nature.com/articles/s41... A 🧵: 1/n 18393106
Reposted by Milo ImbeniSaloni @scientificdiscovery.dev · 05/09/2026This is interesting. You get assigned to being born at a random place and time in history, to see what a typical person's life might have been like then. Unfortunately I was born in 1403 in the valley of Mexico and died at age 4 from dysentery.anyhumanever.comAny Human EverOne life, drawn at random from all who have ever lived. 54547189