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Milo Imbeni

@pyramidalmilo.bsky.social
248 followers 1.1K following 24 posts

PhD in Maastricht, microglia and microscopes

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Reposted by Milo Imbeni
worm @rfksbrainworm.bsky.social · 02/10/2026
If you ever wondered why visible light is those particular wavelengths, it's because life evolved to see in the narrow range where water is transparent
Diagram of absorption of emf by water. There's a gap right that dips in the 500 nm range
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Dale Moulding @dalemoulding.bsky.social · 01/10/2026
Having seen the news: www.bbc.co.uk/news/article... thought I'd share a cilia movie captured at UCL GOS ICH with Eriomina Shahaj & Vanesa Papastavrou using simple DIC on a Nikon Ti2 with DIC at 60x1.4. 500 fps here slowed down 20 times. Processed with Nikon's denoiseAI and an unsharp mask in Fiji.
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Johannes Soltwedel @jo-soltwedel.bsky.social · 01/10/2026
Just released the napari-clusters-plotter 0.11.0 github.com/BiAPoL/napar..., a little passion-project of mine for interactive exploration of datasets and attached features in @napari.org Two cool things to take note of 👇
github.com
GitHub - BiAPoL/napari-clusters-plotter: A napari plugin for clustering objects according to their properties.
A napari plugin for clustering objects according to their properties. - BiAPoL/napari-clusters-plotter
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Chise @sailorrooscout.bsky.social · 28/09/2026
A quiet discovery inside a familiar soil microbe is reshaping how we think about the future of antibiotics. Researchers at McMaster University have identified a compound that could help fight drug-resistant infections, a growing global health threat. Their study introduces an
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Panos Roussos @panosroussos.bsky.social · 26/09/2026
Thrilled to see the PsychAD package published! 🧠 Launched in 2019: 60+ investigators, 8 institutions, 1,494 human brains—illuminating brain aging and disease. Supported by NIA. Deeply grateful to all donors and families. psych-ad.org www.nature.com/collections/...
psych-ad.org
PsychAD
The PsychAD Consortium builds population-scale, single-cell models of the human brain to uncover the molecular mechanisms behind neuropsychiatric symptoms in Alzheimer’s disease, related dementias, an...
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Milo Imbeni @pyramidalmilo.bsky.social · 24/09/2026
Really cool!! Must be in my wife's lineage given the tempeature of her showers
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David Gokhman @david-gokhman.bsky.social · 23/09/2026
This leaves some fascinating questions: why would such a costly change evolve instead of being purged? Was there an evolutionary trade-off? And what did this shift do in other organs where GAGs are important (brain, skin)?
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Prof. Keiko Torii @keikoutorii.bsky.social · 23/09/2026
Torii lab's research featured by @hhmi-science.bsky.social "Reading the Leaves: Decoding the Secret Cellular Language of Plants"🌱🧬🦠! ペプチドホルモンー受容体キナーゼを介した植物の気孔の発生への免疫シグナル経路の介入など、私の研究グループの取り組みに関するハワードヒューズ医学研究所の紹介記事です🌱🧬🦠 www.hhmi.org/news/reading...
hhmi.org
Reading the Leaves: Decoding the Secret Cellular Language of Plants | HHMI
Early in her career, HHMI Investigator Keiko Torii figured out how plant cells talk to each other. Three decades later, she’s still listening — and uncovering exactly what they’re saying.
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Reposted by Milo Imbeni
Ctenophores Rock! @ctenophoresrock.bsky.social · 23/09/2026
This is Bob. They are a hermaphroditic comb jelly that recently underwent reverse development from adult lobate to larval cydippid, following a period of stress. The event reduced our colony to just Bob. Once our food source stabilized, Bob began to flourish & what was 1 Bob is now 500+ Bobettes! 🦑
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Milo Imbeni @pyramidalmilo.bsky.social · 23/09/2026
Insane stuff, it keeps coming, one more beautiful than the next, claude is worth the money sometimes
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Reposted by Milo Imbeni
Loïc A. Royer 💻🔬🧪 @loicaroyer.bsky.social · 23/09/2026
What if any dataset, any size, any number of dimensions, opened in a browser tab from a link? 🔬🧪💻 Luxar is out today: write it in Python, share it as a link, explore it in any browser. Open source. 🧵 @biohub.org Preprint: doi.org/10.5281/zen... Code: github.com/royerlab/luxar
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Nicole Rust @nicolecrust.bsky.social · 04/09/2026
The superposition of these two studies — both incredible — reflect a snapshot of "one big thing" systems neuroscience has yet to resolve. In mice: 1. Task-related signals are everywhere. 2. Absent large swaths of "everywhere," suprisingly sophisticated learning & behavior remains.
Post by Enny van Beest, "Brainwide representation of navigation"Post by Jieyu Zheng, "How fast can mice learn complex mazes?"
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Tonni Andersen @tonnigrubeandersen.bsky.social · 22/09/2026
Check out our new preprint: a very cool fluorescence tool developed by @samwalds.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
Intronised fluorophores improve reporter output and biosensor expression in plants
Genetically encoded biosensors are central to plant cell biology, but low reporter signal can limit their use. Here, we developed modular intronised fluorophores to improve reporter output in transien...
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Milo Imbeni @pyramidalmilo.bsky.social · 22/09/2026
Lets go Bob my hero
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ryan cooper @ryanlcooper.com · 22/09/2026
this is excellent
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James Manton @jamesdmanton.bsky.social · 21/09/2026
I very much enjoyed Lisa Cuneo's talk at FOM2026 on a new approach to deconvolution, so it's great to see the preprint is now out: www.biorxiv.org/content/10.6... @vicidominilab.bsky.social
biorxiv.org
Independent noise realizations enable morphologically agnostic image reconstruction in single-photon-sensitive microscopy
Advances in single-photon sensitive detectors are rapidly expanding the adoption of photon-counting fluorescence microscopy. Under the Poisson photon-counting statistics, iterative Richardson-Lucy (RL...
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Jeff Spence @jeffspence.github.io · 19/09/2026
Not a blog post, but @yundeng.bsky.social and co. convincingly showed (IMO) that it was a statistical artifact here: academic.oup.com/genetics/art...
academic.oup.com
A previously reported bottleneck in human ancestry 900 kya is likely a statistical artifact
Hu et al. (Science, 2023) recently inferred a severe ancient bottleneck around 900 thousand years (kya) ago in African ancestry but found no similar eviden
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Quanta Magazine @quantamagazine.org · 18/09/2026
This is a comb jelly — an elegant, voracious predator that lives in the deep sea, the cold poles and the warm tropics. The ribbonlike 𝘊𝘦𝘴𝘵𝘶𝘮 𝘷𝘦𝘯𝘦𝘳𝘪𝘴, or Venus’ girdle, is one of the largest species. It grows up to 1.5 meters in length. www.quantamagazine.org/ctenophores-...
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Fernando Garcia-Moreno @phylobrain.bsky.social · 18/09/2026
The cerebral cortex that is reading this sentence (yours, to be explicit) did not come out of nowhere. It has evolved over hundreds of millions of years... To study this evolutionary process, we decided to focus on non-avian reptiles for our new paper in Cerebral Cortex 🐢🦎🧠 🧵
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Vinny Costa @vincentcostaphd.bsky.social · 13/09/2026
Apparently the lesson of the digital sphinx by @tuthill.bsky.social & @bingbrunton.bsky.social has already been forgotten. The fly isn’t “playing Doom”. elifesciences.org/reviewed-pre...
elifesciences.org
The digital sphinx: Can a worm brain control a fly body?
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burn it all down @russbengtson.bsky.social · 16/09/2026
*suspicious lobster wife* where did you get that shrimp *still confused lobster* you're never gonna believe this
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Steve Ramirez @okaysteve.bsky.social · 16/09/2026
🚨 new work from the lab! "Hippocampal astrocytic sequences emerge during learning and memory recall" by @ryguy.io & @rsuthard.bsky.social thank you to the entire team for your camaraderie and for muscling through science together 🧠 -- we welcome all feedback! nature.com/articles/s41...
nature.com
Hippocampal astrocytic sequences emerge during learning and memory recall
Nature Neuroscience - Senne, Suthard and colleagues show that dorsal hippocampal astrocytes display time-compressed calcium-event sequences after foot shock and upon context re-exposure, and that...
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Drug Monkey @drugmonkey.bsky.social · 15/09/2026
I probably should have noted that the Broken Earth trilogy is so excellent IMO in large part because it IS a very tough read for many audiences. Most especially mothers and the Black readers who know exactly who she is really talking about. sorry for not including a TW in the first place.
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Volt Europa @volteuropa.org · 14/09/2026
From 14 to 62 seats! 🥳 Yesterday, Volt won 62 seats in local elections across Lower Saxony, according to the preliminary results. This is an increase of 48 (!) compared to the last election. 🎉 (1/3)
Volt-branded graphic on a light purple background. A banner at the top reads "🤩 Lower-Saxony:" above a very large number 62 and the words "SEATS FOR VOLT". Below, a simple bar chart with a green arrow curving steeply upward from a short bar labelled "14 seats" and "2021" to a tall bar labelled "62 seats" and "2026", the taller bar containing a map of Germany with Lower Saxony highlighted in purple. The Volt logo sits in the top right corner.
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Timnit Gebru @timnitgebru.blacksky.app · 14/09/2026
The only person in public service who has consistently made 100% sense on issues of "AI," which is why they hate her so much.
Law enforcers already have authority to charge companies and their CEOs for creating and releasing dangerous, unvetted, or defective products. We shouldn’t let discussions about new legal regimes distract from the fact that there’s no AI exemption from laws already on the books — a point 
@FTC
 emphasized repeatedly during my tenure.

1. There is an extensive set of laws that govern dangerous and defective products. For example, releasing unvetted AI models or agents can violate consumer protection laws. Shipping flawed AI tools without implementing adequate measures to detect and stop rogue or defective AI agents can be an “unfair or deceptive” act or practice under the FTC Act (and analogous state laws). And some state AGs are already exploring holding AI firms and their CEOs criminally liable when their models participate in criminal activity.

2. Existing laws also prohibit “unfair methods of competition.” This covers instances where AI firms appropriate the competitively sensitive information of their customers, including through tracking their use of various tools. It can also cover instances where firms pursue dangerous behavior, aware that doing so may compel rivals to do the same.As the Supreme Court has noted: “A method of competition which casts upon one's competitors the burden of the loss of business unless they will descend to a practice which they are under a powerful moral compulsion not to adopt, even though it is not criminal, was thought to involve the kind of unfairness at which the [unfair methods of competition] statute was aimed."

3. The highly concentrated and interconnected structure of these markets could be creating major risks and conflicts of interest. We had started investigating these partnerships and cross-investments across the stack (and released a preliminarily overview of some findings: https://ftc.gov/news-events/news/press-releases/2025/01/ftc-issues-staff-report-ai-partnerships-investments-study). 

Both federal and state enforcers should be scrutinizing these opaque relationships and inter-dependencies. We are already seeing how these relationships could undermine accountability. For example, OpenAI could face liability given the Hugging Face incident, but Hugging Face being bought up by Nvidia means that we’re unlikely to see it file a lawsuit over this — given Nvidia’s strong incentive to see OpenAI continue full speed ahead.4. As AI tools dramatically change the landscape of cybersecurity risks and hacks, all businesses should be doubling down on having core security protections in place. Firms that fail to invest in adequate data security measures or fix known vulnerabilities can also be breaking the law. A recent analysis showed that around 1/3 of Fortune 100 companies do not even have a way to notify them about security issues. During my 
@FTC
 tenure, we sued firms for poor data security practices and held CEOs liable when they were personally responsible.

https://this.weekinsecurity.com/dozens-of-americas-largest-companies-have-no-simple-way-to-report-security-flaws/

https://ftc.gov/news-events/news/press-releases/2022/10/ftc-takes-action-against-drizly-its-ceo-james-cory-rellas-security-failures-exposed-data-25-million

5. As policymakers consider new legal regimes, we should be looking to lessons from prior efforts to govern major sectors, such as banking and other networks, platforms, and utilities. Tools like structural separations, nondiscrimination, and supervision could be key, and there’s a rich history of what works and what doesn’t. But we can and must pursue any new efforts alongside enforcing existing laws.
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Dr. Émile P. Torres @xriskology.bsky.social · 14/09/2026
If you want to understand the current debate about ASI extinction risk, please please read this. I explain how you've almost certainly been misled into thinking this is about saving humanity--it's NOT. The term "human extinction" doesn't mean what you think it does!
realtimetechpocalypse.com
The ASI Extinction Debate Is the Opposite of What You Think
The media needs to wake up, fast. (3,100 words.)
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John Smillie @johnsmillie42.bsky.social · 12/09/2026
www.agriculture.com/heat-drought... One of my pet ideas is a concerted push by land grant universities, state govts, solar and ag industry assocs, etc. to figure out how to deploy vertical agrivoltaics on semi-arid row crops fields to save their own agriculture
agriculture.com
Heat, Drought Take Toll on Kansas Corn Crop
Corn and soybean conditions are poor after drougth and intense heat have plagued the state for weeks. Here’s a closer look at what farmers face in Kansas.
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Moustafa Algamal @moustafaalgamal.bsky.social · 12/09/2026
Microglia on the move! Here’s microglial clustering around amyloid plaques (cyan) after one week of aducanumab treatment. Our new preprint shows this response begins within 18–48 hours. Pretty exciting to watch it unfold in the living brain! www.biorxiv.org/content/10.6...
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Jess Miers 🦝 @jmiers230.bsky.social · 13/09/2026
Most if not all of the current hacks can be chalked up to security engineers moving too fast and misconfiguring their own testing environments. Like agents accessing libraries that should have been sealed off, Internet access being enabled when it shouldn't have been...
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Elise Thomas @elisethomas.bsky.social · 12/09/2026
I think there's actually quite an easy and obvious way to solve the collective action problem of how to make the AI companies stop conducting risky research, and it's to make it very clear that they're legally liable for anything their models do. www.politico.com/news/2026/09...
politico.com
Anthropic CEO seeks immediate slowdown on AI
Dario Amodei warned that recent advances have begun to outpace the industry’s ability to fully understand and control the technology.
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Grace Lindsay @neurograce.bsky.social · 27/08/2026
MIT has put out an "AI and Education" report summarizing what they've found at their own institution. Seems thoughtful. aiandeducation.mit.edu/report/
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paveltomancak.bsky.social @paveltomancak.bsky.social · 10/09/2026
This article seems to celebrate the shift from poor support for #software #engineers in research to pretending they aren't needed at all. Did we spend 2 decades consolidating fragmented software ecosystems into platforms only to see them dissolve through "vibe coding"? www.nature.com/articles/s41...
nature.com
Disruption of the research software landscape through AI software generation - Nature Methods
Specialized research software has historically been costly and time-consuming to create, but large language models (LLMs) have become capable enough at code generation to fundamentally change this. We...
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Bernie Mulvey @berniejmulvey.bsky.social · 11/09/2026
Excited to share work with cryostat wizard @heenadivecha.bsky.social looking at gene expression in my favorite brain region (LC) in adult postmortem brain! (Long URL to spare the trouble of identifying cars, buses, beds in 5x5 pixel imgs). (1/x) link.springer.com/epdf/10.1007...
link.springer.com
Molecular programs in human locus coeruleus link APOE and neuromelanin to Alzheimer’s vulnerability
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David Ho @davidho.bsky.social · 12/09/2026
I wrote this quickly at a bus stop and didn't realize it would go viral, or else I would have worded it better. But the point is that the media is too credulous about AI killing everyone in 10 years (how?) when climate change is killing people now and will only get worse (we know exactly how).
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Carl T. Bergstrom @carlbergstrom.com · 11/09/2026
"...solving problems is only a tool and proxy for achieving the primary goal of conceptual understanding and insight. Forgetting this in the world of AI may turn the tool against the primary goal."
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daryl "rupert pumpkin" b 🏳️‍⚧️ @hypercubexl.bsky.social · 09/09/2026
GDT's reddit AMA spitting fire www.reddit.com/r/movies/com...
reddit comment: 

Hello! Did you intend the ending of Pan’s labyrinth to be real or in Ofelia’s mind?

Guillermo Del Toro's reply: 

My interpretation, and it's exclusively mine, is that it's real.

Because there's two things. One is what people call “The Shining Question.” The Shining Question is, Who opens the door for Jack to get out of the fridge? And Ofelia is in an attic with a guard outside her door, and she draws the door with the magic chalk, and she shows up in the labyrinth. So, the only way she could have gone into the labyrinth is the magic chalk. And the flower is real at the end. The flower that blooms in the dead tree. And the reason I think it’s real is because—and this is why I'm in favor of the human factor in art—I think that art does transform the world. You know?

Think about it for a second. One of the goals, with all this movement, is to make you believe that art is vulgar. That art is nothing special, and anybody can do art. That is like me telling you that I'm faster at running than Usain Bolt but I “run” in my motorcycle. Well, that's not the same. That’s not the same at all.

Art is important, and they want you to believe it isn't. It's part of the idea of control. The goal is not to have artificial intelligence. The goal is to foster natural stupidity. The goal is to foster you not looking for answers, and to trust yourself entirely to an engine. Look at the way we are dipping our toes into these things. We are starting to ask the machine, Is this true? For now, there's a correlation between reality and what the answers of the machine are. For now. But soon, we won't even investigate further. We will be told it's true. And if the machine is in the hands of somebody who should not be trusted, then your reality has been completely and utterly fucked. Because your intelligence ends at the question. You don't seek the answer. It's given to you.Q: You recently mentioned that AI creates 'semi-compelling screensavers' and that you'd 'rather die' than use it. As a filmmaker who relies heavily on practical effects and creature design, what do you think is the biggest thing lost when a computer generates an image instead of a human hand?

GDT:

The three quarters of the process that gave you the chance to think of the idea that people don't think about without that process. Meaning, AI can get you to the middle really fast, but there's a dialectic with the process that gets you to that top 10%. I'll give you an example with the Pale Man.

We sculpted it as an old man, with a face. And then I said, Let's take out the face. This happened because I saw a photo of a manta ray and the poster for Don Coscarelli’s Phantasm. That combination, which happened at two different times during a week or a month, are not permutations that are chemically part of an equation. They are alchemy. And then I said, Take out the face, and then I said, Let's put the eyes on the hands. This triangulation happens because I spent a month or two months living with the idea of this creature. And it's not linear.

AI is like a super-fast engine that makes semi-sentient permutations of things that are already done. Creation is things that have never been done. Coming to exist.

And the second thing is the loss of the apprenticeship that one has as an artist. You're never a master; you're always an apprentice. This is a kinship I have with, for example, Chris Nolan. When he showed me The Odyssey, there’s a scene when Matt Damon is floating in the stormy ocean and I asked him—because we were talking about practical effects, and how great it is and that we both always use a maquette or a model—and I asked him, How did you do it? He said, “We put him in a storm in the ocean.”

And you're gonna find that 30% of a great image occurs accidentally. You know, either a drop of water hits the lens, or the camera shakes. I remember when in 1993, '94, Jim…
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Milo Imbeni @pyramidalmilo.bsky.social · 11/09/2026
Lectins for the win!
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Dave Barry @david-j-barry.bsky.social · 10/09/2026
Are you a UK-based undergraduate considering a career in research, and looking for an industry placement? 🔬 Want to investigate how light exposure disrupts the cell cycle, using live imaging and AI-powered image analysis? ⏳ Deadline: October 6th 👇 Apply below www.crick.ac.uk/careers-stud...
crick.ac.uk
Investigating phototoxicity-induced cell cycle disruption in live cell imaging
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Milo Imbeni @pyramidalmilo.bsky.social · 10/09/2026
I wonder what it is like not to have a cortex!
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Jieyu Zheng @jieyusz.bsky.social · 10/09/2026
An acortical mouse — born without hippocampus and most of its neocortex — learns the Manhattan Maze: a 30× improvement in 5 hours, 18 rewards! Now a question for everyone: How can an acortical brain do this? Leave a comment! Preprint w/ @mameister4.bsky.social: www.biorxiv.org/content/10.6...
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Pedro Beltrao @pedrobeltrao.bsky.social · 09/09/2026
I made a presentation to other faculty about recent progress in general AI, to facilitate the discussion around the impact for research and teaching in biology. It could be that the slides are useful for others trying to do that same. Feel free to re-use. docs.google.com/presentation...
docs.google.com
generalAI_for research_intro.pptx
Recent AI developments and what they mean for us Quick primer on general AI models* State-of-the-art in AI agent capabilities AI agents in biology (examples) Discussion - what does this mean for our r...
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Liisa Galea @liisagalea.bsky.social · 09/09/2026
Our new preprint with @ciernialab.bsky.social we investigated transcriptional profiles of microglia (❤️the name) from hAPOEe4/3 female/male mice in HPC &CTX. We saw loads of sex x genotype interactions in both regions Cell cycling, ER stress, lipid metabolism ++ www.biorxiv.org/content/10.6...
biorxiv.org
Sex and APOE Genotype Differentially Shape Microglial Transcriptomic Profiles Across the Hippocampus and Cortex
Female sex and the APOEε4 allele are top risk factors for Alzheimer’s disease (AD). Microglia play a role in the pathogenesis of AD, yet how sex and APOE genotype affect microglia remain poorly unders...
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American Aging Association @americanaging.bsky.social · 09/09/2026
Sea squirts are unusually rich in plasmalogens — a lipid that declines with age. Fed to aged mice: faster learning, healthier brain synapses, less inflammation, even darker regrown hair 🐙🧠 Animal study only, but a wild new angle on brain aging. doi.org/10.3389/fmol... #GeroScience #BrainHealth
doi.org
Frontiers | Plasmalogens Eliminate Aging-Associated Synaptic Defects and Microglia-Mediated Neuroinflammation in Mice
Neurodegeneration is a pathological condition in which nervous system or neuron losses its structure, function, or both leading to progressive neural degener...
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Jase Gehring @skyjase.bsky.social · 09/09/2026
so when i see OpenAI claim that they didn't use any "specific" information from their competitors, i have no doubt their discovery relied on similar leakage of training data. we have even seen that AI training data can be tainted by mundane shit like Reddit posts.
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Misha Ahrens @mishaahrens.bsky.social · 09/09/2026
Whole-body cellular activity imaging in zebrafish, headed by Virginie Ruetten @vmsruetten.bsky.social - new paper is out: www.nature.com/articles/s41...
nature.com
Imaging cellular activity across all organs reveals body-wide circuits - Nature
An imaging system developed to record cellular activity throughout the whole body of zebrafish captures cellular organ dynamics and identifies multiple distributed circuits.
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DrLachie @drlachie.bsky.social · 10/09/2026
Proud to present the publication of napari-lattice – our solution to the immense computational requirements of Lattice Light Sheet and Oblique Plane Microscopy. onlinelibrary.wiley.com/doi/10.1111/... Before I get into the thread, the important part is on github: github.com/BioimageAnal... (1/n)
onlinelibrary.wiley.com
napari‐lattice: A user‐friendly image processing tool for lattice light‐sheet microscopy data
Lattice light-sheet microscopy (LLSM) enables researchers to capture high-speed 3D videos of living cells with high definition and minimal damage. However, this technology generates terabytes of data....
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Steve Haddock @stevehaddock.bsky.social · 28/08/2025
Our science photo book The Radiant Sea is out Sept 2nd!! 30 years of research, 10 years of "we should", and a year of collating pix and writing. Sönke and I show (mostly for the first time) images of how organisms produce, use, and interact with light in the sea. #bioluminescence #fluorescence 🦑🧪🌊
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Keri Martinowich @martinowk.bsky.social · 08/09/2026
Early data peek at Illumina's new StrataMap spatial transcriptomics cellular resolution platform. Huge capture area (7.5 cm2) - we profiled human 🧠 at level of thalamus - totally 🤩. Kudos to our teams for amazing work w/ nerve wracking sectioning & direct placement of this VERY large tissue section!
Spatial clustering of gene expression in the human brain at level of thalamus. Gene expression clusters in different colors.Tissue block on a cryostat chuck with a slide containing a thin cryosection cut from the block
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Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 07/09/2026
Very happy to share my postdoc paper is out now in @natcellbio.nature.com titled "Tissue flow acts as a guidance cue for immune cell polarization and directional migration". If you love imaging and immune cells, this is for you! #microscopymonday www.nature.com/articles/s41... A 🧵: 1/n
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Saloni @scientificdiscovery.dev · 05/09/2026
This is interesting. You get assigned to being born at a random place and time in history, to see what a typical person's life might have been like then. Unfortunately I was born in 1403 in the valley of Mexico and died at age 4 from dysentery.
anyhumanever.com
Any Human Ever
One life, drawn at random from all who have ever lived.
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