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Nicole Rust

@nicolecrust.bsky.social
15K followers 1.5K following 6.9K posts

Mood & Memory researcher with a computational bent. www.nicolecrust.com. Science advocate. Prof (UPenn Psych) - Author: Elusive Cures. press.princeton.edu/books/hardcover…

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Nicole Rust @nicolecrust.bsky.social · 57m
89% of SBE NSF grants were never awarded!! My field (Cognitive Neuroscience) is included in this gutting, as are so many others. Plenty of horror stories in the same space are also coming from NIH. It’s not just delaying research; it’s labs shutting down and a next gen that won’t be trained.
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Melissa Franch, PhD @mfranch.bsky.social · 18h
Excited to see this work published! We find that the brain codes semantic relationships similar to contextual LLMs (like GPT2) but unlike LLMs, uses contrastive coding to prevent confusion of highly similar words. Many thanks to the reviewers and BCM neurosurgery team! www.nature.com/articles/s41...
nature.com
A population code for semantics in human hippocampus - Nature Neuroscience
Franch et al. show that human hippocampal neurons encode the meanings of the words we hear through distributed, context-sensitive population activity that mirrors some features of large language model...
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Nicole Rust @nicolecrust.bsky.social · 18h
Channeling @sarahmackattack.bsky.social’s love of Philly bugs. A Philly praying mantis!
Big bug on cement wall.
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Nicole Rust @nicolecrust.bsky.social · 01/10/2026
I was so excited to attend our @pennmindcore.bsky.social retreat today and learn that my colleague @neuroetho.bsky.social has also pivoted to work on mood and he thinks about it exactly as I do! Our slides bear a remarkable resemblance!!!
Nacho next to a slide that says mood.
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Kevin Mitchell @wiringthebrain.bsky.social · 29/09/2026
It's done! 😊
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Awais Aftab @awaisaftab.bsky.social · 29/09/2026
I am doing a series of articles (“Therapeutic Window”) for the Science desk at The New York Times. The first article is about whether ADHD is better understood as a disorder of “attention” or something else: www.nytimes.com/2026/09/29/s...
nytimes.com
What If A.D.H.D. Isn’t About Attention at All? (Gift Article)
Evidence suggests that it really affects what psychiatrists like me call sustained engagement — an important difference in understanding how to think about the condition.
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aaron bornstein @aaronbornstein.bsky.social · 29/09/2026
New lab preprint! @khoudary.bsky.social presents a tour-de-force: a new model of how uncertain expectations should help resolve uncertain sensations, supported by re-analysis of four experiments in monkeys (behavior, ephys) and humans (behavior, fMRI, EEG, intracranial) @meganakpeters.bsky.social
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Ignacio Saez, PhD @ignaciosaezphd.bsky.social · 29/09/2026
Thanks to @nicolecrust.bsky.social for visiting Sinai and giving such an incredible talk! Appreciate you highlighting all the great work going on across our teams here 🙌
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Nicole Rust @nicolecrust.bsky.social · 29/09/2026
Excellent to hear what my new faculty colleague @tylerbonnen.bsky.social in @upenn.edu Psychology / @pennmindcore.bsky.social is up to. Exciting application here of cutting edge techniques (AI) to answer age-old questions (about memory).
tyler; title slideTyler
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Nicole Rust @nicolecrust.bsky.social · 29/09/2026
I spied this hanging in a high school biology lab. Terrific outreach, @rodbraga.bsky.social!
I am a cognitive scientist.
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Dr. Jillian Scudder @jillianscudder.com · 27/09/2026
It seems I’ve swept past 6k followers today in part due to a burst of new folks finding me from this starter pack: go.bsky.app/2LmKSDN Let me do a quick introduction thread to me and my books!
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Nicole Rust @nicolecrust.bsky.social · 27/09/2026
A new awesome addition to this starter pack: @neuroecologylab.bsky.social. Congrats on the book launch! Ordered. Can’t wait to read it. press.princeton.edu/books/ebook/...
press.princeton.edu
The Fox, the Shrew, and You
A leading neuroscientist describes the long evolutionary process that led to the human brain
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Anthony (Tony) J. Martin @ichnologist.bsky.social · 27/09/2026
Pleased to see I've gained a few more followers through my inclusion in a Bluesky starter pack, 'Scientists Who Write Science Books.' For my followers, check out this list & find your favorite scientist authors who you might not have known are here! go.bsky.app/2LmKSDN
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Nicole Rust @nicolecrust.bsky.social · 26/09/2026
I'm so impressed with all that's going on at @sinaibrain.bsky.social. Here are 5 highlights. 1. @bshev.bsky.social ++ are measuring dopamine and serotonin *in living human brains* and using them to predict treatment outcomes. Wow. www.biorxiv.org/content/10.6...
Dopamine and serotonin transients predict depressive symptom relief following deep brain stimulation of human subcallosal cingulate cortex
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Nicole Rust @nicolecrust.bsky.social · 23/09/2026
Great metaphor for how the brain probably works in terms of how the activity of individual neurons/regions shapes behavior. It has important implications for interpreting experiments that stimulate/inactivate.
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McGill Research + Innovation @mcgill-research.bsky.social · 22/09/2026
Congratulations to Prof. Blake Richards on winning the 2026 Schmidt Sciences Polymaths Award🎉 With the $2.5M prize, his team will build AI models that capture the uniqueness of individual minds, potentially advancing mental health care👏 🔗Read more: reporter.mcgill.ca/blake-richar...
A red slide with Prof. Richards' photo, title, departments, and the title of the award.
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Blake Richards @tyrellturing.bsky.social · 22/09/2026
My hot take: We were *already* in a state of being overwhelmed by reviewing grants, scholarships, and papers prior to generative AI. Now it's not even close to tenable. The time to start rethinking the entire peer review model in #academia was 10 years ago. Hopefully this will force it!
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Blair Shevlin @bshev.bsky.social · 22/09/2026
Been raising that alarm internally at Sinai and Yale, but if our field wants to continue to rely on virtual data collection then we need to develop better bot detection tools. Glad to be collaborating with @kiante.bsky.social on these efforts. His work at UCLA is leading the way survey-shield.com
survey-shield.com
Survey Shield
Survey Shield - AI-powered survey bot-detection analysis
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The Rockefeller University @rockefeller.edu · 22/09/2026
We are thrilled to announce that molecular biologist and neuroscientist Catherine Dulac of @harvardmcb.bsky.social is the 2026 winner of Rockefeller's Pearl Meister Greengard Prize! Register now for the award ceremony on Oct 20. #WomenInScience 🔗: bit.ly/3V2pZMA
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Kevin Mitchell @wiringthebrain.bsky.social · 22/09/2026
A short survey from @brainfacts.org collecting information on how people use their site (a great resource for info about the brain, by the way!) www.brainfacts.org/about/websit...
brainfacts.org
Website Survey
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Nicole Rust @nicolecrust.bsky.social · 21/09/2026
Supporting @cdelawalla.bsky.social with a photo of my new chrome manicure. No rationale for it beyond a fondness for shiny. My eye for detail makes me a better scientist, not a worse one.
Shiny painted fingers.
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Nicole Rust @nicolecrust.bsky.social · 21/09/2026
Who teaches (early) undergraduate courses on emotions, moods and such? I'm just gearing up to do this and I'd love to ask a few quick questions (textbook, approach). Please DM! Thank you. #affectivescience
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Nancy Kanwisher @nancykanwisher.bsky.social · 20/09/2026
Me & John & Shiloh out protesting AGAIN. Maybe it does nothing. But maybe one person thinks: If these guys can be out here every Saturday I should take action as well, by checking my voter registration, asking my friends to do same, making a plan to vote early, supporting competitive candidates.....
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Ethan Solomon @esolomon.bsky.social · 18/09/2026
Excited to share a new discovery from @stanfordpntlab.bsky.social about the effects of neurostimulation on brain activity. www.medrxiv.org/content/10.6... With our colleagues at the University of Iowa, we explored how intermittent theta burst stimulation (iTBS) changes neural excitability. A 🧵
medrxiv.org
iTBS induces a suppression-rebound pattern in human cortical excitability
Intermittent theta burst stimulation (iTBS) is a widely used form of brain stimulation, developed on the premise that it promotes long-term potentiation (LTP) and neural excitation. However, this is n...
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Nicole Rust @nicolecrust.bsky.social · 17/09/2026
More of this in my feed, please!
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Jibran Khokhar @drjkhokhar.bsky.social · 16/09/2026
So grateful to @thetransmitter.bsky.social for the opportunity to talk about a paper that truly shaped how I think about my science by @fowleruci.bsky.social and @paulkennyphd.bsky.social! They helped make causal sense of the association that people call “Mr. Big“ in the context of 🚬!
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Nicole Rust @nicolecrust.bsky.social · 17/09/2026
I'm excited for this visit! My undergrad class just contemplated this firsthand account of an individual who suffered from years of depression and treatments that did not work only to find relief at @sinaibrain.bsky.social. Mindblowing (and a recommended listen). eagleman.com/podcast/can-...
eagleman.com
Can a Depressed Brain Find Its Way Out? with Jon Nelson
What if your brain got stuck in sadness and never reset? What does it feel like when joy disappears completely? Can a person love their family deeply and still want to die? What do you do when trea…
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hakwan lau @hakwan.bsky.social · 17/09/2026
onlinelibrary.wiley.com/doi/10.1111/... Disturbances of conscious experience are central features of many psychiatric and mental health disorders. Experimental studies of conscious perception are therefore increasingly cited ....
onlinelibrary.wiley.com
Hitting and missing on consciousness
Disturbances of conscious experience are central features of many psychiatric and mental health disorders. Experimental studies of conscious perception are therefore increasingly cited in clinical an....
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Jeremy Berg @jeremymberg.bsky.social · 16/09/2026
Developing a plan that captures the best aspects of what NSF and NIH were while addressing some long-standing issues is what the effort at the @standupforscience.net policy shop is developing.
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Jeremiah Cohen @jeremiahycohen.bsky.social · 16/09/2026
Happy to share the version of record of our locus coeruleus paper here: www.nature.com/articles/s41... Prior thread on some of our discoveries in this study: bsky.app/profile/jere...
nature.com
Topographic structure and function of locus coeruleus noradrenaline neurons - Nature
Dorsal and ventral noradrenergic neurons in the locus coeruleus form topographic subpopulations whose projection patterns and activity encode choice switching, reward-prediction errors and disregard o...
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Colette Delawalla, PhD @cdelawalla.bsky.social · 16/09/2026
If this work feels important to you: PLEASE DONATE TO @standupforscience.net! Standupforscience.net/donate
standupforscience.net
Fuel the fight! — STAND UP FOR SCIENCE
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Jeremy Berg @jeremymberg.bsky.social · 15/09/2026
Lots of stories across Pennsylvania about NIH grant terminations at Pitt and Penn. This is why speaking out matters. Even Congress critters who generally support the administration get pressured into actually supporting their constituents. www.wesanews.org/health-scien...
wesanews.org
McCormick, Fetterman question termination of more than 100 health research grants
Pennsylvania’s senators are demanding information about more than 150 health research grants canceled by the U.S. Department of Health and Human Services this summer.
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Juan Gallego @juangallego.bsky.social · 15/09/2026
Just came across this interesting list my @markhisted.org so I thought I'd share it. Thanks Mark for putting it together! (disclosure: contains me) go.bsky.app/RnPdB5N
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Carl T. Bergstrom @carlbergstrom.com · 14/09/2026
When we talk about how science is broken, maybe at least consider how a huge collaboration measured the ripples in spacetime resulting the collision of two black holes 1.3 billion light years away, as counterweight the guy who had to fake his data to show that people who procrastinate fall behind.
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Daniel P. Moriarity @dpmoriarity.bsky.social · 14/09/2026
The topic of integrating biology into the DSM is one that grabs onto different perspectives I hold and twists hard. I'm both someone who finds a lot of biological psych research reductive and also firmly believes that there is potential in biology as *one* guide toward best "plan A" treatments 1/12
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Sarah Heilbronner @srheilbronner.bsky.social · 11/09/2026
Such an inspiring group of people! I came away optimistic (but grounded) about the future of brain therapies. Thank you for visiting us, Nicole!
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Nicole Rust @nicolecrust.bsky.social · 11/09/2026
The Grand Plan for brain & mind research is in terrific hands with the researchers at Baylor College of Medicine! From an excellent panel discussion across silos to many insightful conversations with PIs and trainees, I'm a bit blown away by what they are up to here. Impactful & exciting.
Poster for Reimagining Brain Therapies
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Nicole Rust @nicolecrust.bsky.social · 10/09/2026
Well deserved! When I was searching for an example of how a discovery about the brain unlocked an entirely new class of therapies (while writing Elusive Cures), orexin is what I pointed to. It doesn't always happen this way. When it does **it's epic** and we should celebrate.
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Nora Newcombe @noranewcombe.bsky.social · 09/09/2026
Research supported by NIMH Harvard study predicts most suicide attempts a week in advance current.fas.harvard.edu/stories/harv...
current.fas.harvard.edu
Harvard study predicts most suicide attempts a week in advance
Researcher Matthew Nock pioneered the technique of using smartphone technology to survey high-risk adults and adolescents in real time. In a new study, Nock and his team report using the technology to...
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Nicole Rust @nicolecrust.bsky.social · 09/09/2026
Bravo, @7homaslin.com! “Q: Many scholars assume that public writing means simplifying, yet Quanta shows there’s an audience hungry for complexity. Do some public scholars underestimate their audience? A: I think so” A great read for anyone interested in scicomm.
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Thomas Lin @7homaslin.com · 08/09/2026
I enjoyed chatting with Susan D'Agostino for @insidehighered.com at the International Congress of Mathematicians in July and hope readers are interested in learning more about the philosophy behind @quantamagazine.org and @quantabooks.org. www.insidehighered.com/opinion/colu...
insidehighered.com
Quanta’s Thomas Lin Trusts Public Can Handle Complex Ideas
The founding editor built a math and science magazine that high schoolers and Nobel laureates alike read. Now, he’s turned to books.
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Matthew Cobb @matthewcobb.bsky.social · 07/09/2026
I just published a brief account of Jim Watson’s life, aimed at students. It leans heavily on the insights of @nccomfort.bsky.social, whose biography of Watson will be out next year. Free link here: rdcu.be/M91CnnE3N4wa
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Nicole Rust @nicolecrust.bsky.social · 06/09/2026
Intriguing ideas here about how concepts from dynamical systems (like attractor basins) relate to antidepressant use and withdrawal. Now that we can !!!!actually map these systems by large scale high res recordings (eg in animals)!!! I’d love to see more work testing these hypothesized mechanisms.
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Nicole Rust @nicolecrust.bsky.social · 04/09/2026
The superposition of these two studies — both incredible — reflect a snapshot of "one big thing" systems neuroscience has yet to resolve. In mice: 1. Task-related signals are everywhere. 2. Absent large swaths of "everywhere," suprisingly sophisticated learning & behavior remains.
Post by Enny van Beest, "Brainwide representation of navigation"Post by Jieyu Zheng, "How fast can mice learn complex mazes?"
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Ignacio Saez, PhD @ignaciosaezphd.bsky.social · 04/09/2026
📣 We're hiring! The Saez Lab at Mount Sinai is seeking a postdoctoral researcher with experience in intracranial recordings, electrophysiology, BCIs, mood disorders, and/or computational modeling, to explore the neural basis of human cognition. 🗓️ Apply by September 30, 2026. Please share widely!
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Grace Lindsay @neurograce.bsky.social · 04/09/2026
I teach about Ariely's fraud in my methods class and it is probably not the best message to undergrads that he still has his job
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Jonathan Howard @joho.bsky.social · 04/09/2026
Jay did this.
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Nicole Rust @nicolecrust.bsky.social · 03/09/2026
Not stated strongly enough.
Without notifying Congress or the American people, DoD has signed an interagency agreement that could give the Department access to billions of dollars that Congress provided to NIH for critical biomedical research. These funds were provided to support research to develop treatments or cures for infectious diseases such as influenza, malaria, tuberculosis, HIV, Ebola, and other dangerous pathogens.
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Simon W Davis @woodforbrains.bsky.social · 03/09/2026
Ho-LEE fuck democrats-appropriations.house.gov/news/press-r...
democrats-appropriations.house.gov
Defense Officials Attempt to Raid NIH Funds to Cover Department of Defense Activities
House Appropriations Committee Ranking Member Rosa DeLauro (D-CT-03) has learned that officials at the Department of Defense (DoD) are working to divert billions of dollars from the National Institute...
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