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David Gokhman

@david-gokhman.bsky.social
338 followers 260 following 46 posts

Asst Prof @WeizmannScience. Exploring human evolution through the lens of gene regulation🧬 Still rooting for Neanderthals & Denisovans💀❤️ gokhmanlab.com

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David Gokhman @david-gokhman.bsky.social · 23/09/2026
Humans are remarkably prone to degenerative skeletal diseases. Other apes, much less so, even in old age. In our new paper in @nature.com , we map the genetic changes that shaped our skeleton and uncover a major clue to why it is so vulnerable to degeneration.🧵👇 www.nature.com/articles/s41...
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David Gokhman @david-gokhman.bsky.social · 24/11/2025
Such a fantastic resource by @kuhlwilm.bsky.social's lab. We’re using this catalog in half our projects www.nature.com/articles/s41...
nature.com
A curated dataset of great ape genome diversity - Scientific Data
Scientific Data - A curated dataset of great ape genome diversity
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David Gokhman @david-gokhman.bsky.social · 28/08/2025
Another truly amazing work by the Capellini lab
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David Gokhman @david-gokhman.bsky.social · 27/08/2025
Denisovans or their close relatives identified in the fossil record using a gene regulatory phenotyping method. Now out: www.pnas.org/doi/10.1073/...
Credit: Maayan Harel
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Reposted by David Gokhman
Gili Greenbaum @gilig.bsky.social · 01/08/2025
🧵 Excited to share a new preprint from our lab looking into signals of disease-burden in aDNA (doi.org/10.1101/2025...)! It has long been speculated that transition to sedentary, agricultural and urbanized lifestyle increases disease burden, but can we see this in aDNA?
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David Gokhman @david-gokhman.bsky.social · 26/07/2025
Given two genomes, can you tell who’s taller or more prone to a disease? How confident can you be? A fresh take on phenotypic inference, now out: rdcu.be/exW4f See thread🧵👇:
rdcu.be
Predicting the direction of phenotypic difference
Nature Communications - Here authors reveal a method to predict key information on phenotypes - their direction. This is achievable even for phenotypes with incomplete genotype-to-phenotype...
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David Gokhman @david-gokhman.bsky.social · 20/06/2025
6 years ago, we predicted what Denisovans probably looked like. Since then, every new Denisovan specimen💀 - Harbin, Penghu, Xiahe - matched it beautifully. ☑️ Xiahe: 4/4 features match the profile ☑️ Penghu: 5/6 ☑️ and now: Harbin with 16/18! See 🧵 pubmed.ncbi.nlm.nih.gov/31539495/
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David Gokhman @david-gokhman.bsky.social · 18/06/2025
We showed it first: www.biorxiv.org/content/10.1...
biorxiv.org
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David Gokhman @david-gokhman.bsky.social · 18/06/2025
Last year, we posted a preprint providing the first genetic evidence that the Harbin skull likely belonged to a Denisovan: www.biorxiv.org/content/10.1... Today, DNA evidence provided the final proof: www-sciencedirect-com.ezproxy.weizmann.ac.il/science/arti...
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David Gokhman @david-gokhman.bsky.social · 18/04/2025
Super exciting to see the Penghu jaw confirmed as Denisovan— its features line up beautifully with what we predicted Denisovan mandibles to look like! More in the thread 🧵 pubmed.ncbi.nlm.nih.gov/31539495/
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Reposted by David Gokhman
Cedric Boeckx @cedricboeckx.bsky.social · 18/03/2025
Fascinating, really thought-provoking work by Trevor Cousins, @aylwyn-scally.bsky.social and Richard Durbin, now out in @naturegenet.bsky.social 🧪🧬 Deep ancestral structure shared by all modern humans www.nature.com/articles/s41...
nature.com
A structured coalescent model reveals deep ancestral structure shared by all modern humans - Nature Genetics
The cobraa model extends the pairwise sequentially Markovian coalescent to identify structured population history by examination of the model transition matrix. Applied to human polymorphism data, cob...
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David Gokhman @david-gokhman.bsky.social · 27/11/2024
Interested in discovering the genetic changes that made us human? Our lab is looking for students and postdocs! 👩‍🔬👨‍🔬 gokhmanlab.com please RT!
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