Reposted by Ulrich BraunschweigMiguel Ramalho-Santos @mrsantos.bsky.social · 28/09/2026We are recruiting at the Lunenfeld-Tanenbaum Research Institute (LTRI) and the University of Toronto! In the areas of Reproduction, Pregnancy and Developmental Biology, at Assistant or Associate Professor level. Deadline: Nov 29, 2026 Find more and apply👇: 🔗 apply.interfolio.com/192324 0412
Ulrich Braunschweig @braunschweig.bsky.social · 09/09/2026Major update to the prevailing view of how 'repressive' histone modifications and silencing are related: 'nanodomains' of a few nucleosomes switch state (and not wholesale phase transition of a compartment) 010
Reposted by Ulrich BraunschweigGabrijela Dumbović @gabrijelad.bsky.social · 09/09/2026Incredibly happy to share the first publication from our lab, now published in Nature Cell Biology! 🎉 How do cells coordinate RNA processing with nuclear organization and the cell cycle? www.nature.com/articles/s41... 34715
Reposted by Ulrich BraunschweigGenes & Development @genesdev.bsky.social · 08/09/2026RESEARCH PAPER: RBM39 modulates UPR signaling through alternative splicing of IRE1α/ERN1 By Kim et al., and Thomas Gonatopoulos-Pournatzis ➡️ genesdev.cshlp.org/content/40/17-18… #RNA #splicing #stress #UPR 022
Ulrich Braunschweig @braunschweig.bsky.social · 29/08/2026We have to do this again because Toronto, like all cities in Canada, is at the whim of its provincial govt, and ours wants to score points with suburban voters at the expense of people’s physical safety. #Topoli #criticalmass 1/2 1113
Ulrich Braunschweig @braunschweig.bsky.social · 26/08/2026New chapter in the saga of fake documentation on commercial antibodies incoming. 010
Reposted by Ulrich BraunschweigElphege Nora Lab at UCSF @elphegenoralab.bsky.social · 13/05/2026Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇 2197112
Reposted by Ulrich BraunschweigFred Hutch @fredhutch.org · 15/08/2026🔬 Fred Hutch Cancer Center is hiring an Assistant or Associate Professor in the Basic Sciences Division @basicsci.fredhutch.org. Join a world-class research community in Seattle and help advance discoveries in fundamental biology. Apply: apply.interfolio.com/190640 02322
Reposted by Ulrich BraunschweigQuaid Morris @quaidmorris.bsky.social · 07/08/2026Excited to share the results of the Codebook Project, an international effort to identify accurate DNA-binding motifs and genomic binding loci for >300 uncharacterized human transcription factors (TFs) www.nature.com/articles/s41...nature.comAn expanded codebook of human transcription factor DNA-binding specificity - NatureResults from a panel of assays that analyse different aspects of DNA sequence specificity reveal more than 100 new motifs to aid the characterization of putative human transcription factors. 14710
Reposted by Ulrich BraunschweigFred Hutch Basic Sciences Division @basicsci.fredhutch.org · 05/08/2026Join @FredHutch.org's Basic Sciences Division as an Assistant or Associate Professor and help shape the future of fundamental biology. We welcome applicants whose work will complement, extend, or bring new directions to the division.apply.interfolio.comApply - Interfolio 02829
Reposted by Ulrich BraunschweigNoah Whiteman @nkwhiteman.bsky.social · 06/08/2026I’m thrilled to share that our search for a tenure-track colleague in my *truly wonderful and collegial* Genetics, Genomics, Evolution and Development Division in the MCB Department at Berkeley @berkeleymcb.bsky.social is live! Please share this broad search widely: aprecruit.berkeley.edu/JPF05481aprecruit.berkeley.eduAssistant Professor -Genetics, Genomics, Evolution, and Development - Molecular and Cell BiologyUniversity of California, Berkeley is hiring. Apply now! 0183232
Reposted by Ulrich BraunschweigMichael Okun @michael-okun.bsky.social · 10/06/2026I’ve officially resigned as Associate Editor for Frontiers in Systems Neuroscience. It used to be a reputable journal, but became a case study in how forced automation destroys academic integrity. 👇 5435871430
Ulrich Braunschweig @braunschweig.bsky.social · 20/07/2026What happens if you delete large intronic regions? In human tissue culture cells, we found many deletions that decrease growth and some that increase it. In most cases, deletion affected expression or splicing of the gene. www.cell.com/cell-reports... 1/3cell.comA genome-wide functional analysis of conserved intronic regions reveals essential roles for speckle-associated retained intronsFarhangmehr et al. investigate functions of highly conserved intronic sequences in cell fitness using a CRISPR-based deletion screen. Deletions in FNBP4 intron lead to changes in p53 pathway genes. De... 1199
Reposted by Ulrich BraunschweigChristine Mayr @christinemayr.bsky.social · 08/06/2026Finally out in @Cellcellpress! Proteins with long IDRs are prone to misfolding during protein synthesis. This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones. www.cell.com/cell/fulltex...cell.commRNA 3′ UTRs chaperone intrinsically disordered regions to control protein activityHighly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis of fully active proteins. 522597
Reposted by Ulrich BraunschweigReese Richardson @reeserichardson.bsky.social · 05/06/2026The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below) 18590367
Reposted by Ulrich BraunschweigOlga Anczukow @olgaanczukow.bsky.social · 22/05/2026What is the role of #poison-exon in regulating splicing factors in stem cells and development? Check out new work from Nathan Leclair and Mattia Brugiolo and many others in my lab @jax.org #RNA #splicing www.biorxiv.org/content/10.6... 1238
Ulrich Braunschweig @braunschweig.bsky.social · 21/05/2026Introduce yourself with 10 bands you've seen live: Garbage The Cure Chumbawamba The Prodigy Arctic Monkeys White Lies In the Valley Below Massive Attack IAMX Austra 020
Reposted by Ulrich BraunschweigJohannes Zuber @johanneszuber.bsky.social · 31/03/2026Are you a #Masters student interested in translational #cancer research, tumor immunology and #CRISPR screens? Then apply to our lab at the @impvienna.bsky.social in Vienna: www.imp.ac.at/career/open-... #oncology, #cancerresearch, #CRISPR 064
Reposted by Ulrich BraunschweigNathan Kalman-Lamb @nkalamb.bsky.social · 25/03/2026Today in AI: Canada rejected the PR application of a McMaster postdoc from the Sorbonne who works in the immunology of aging because the generative AI being used to process applications (😱) entirely hallucinated her credentials. Everyone involved should be fired. archive.is/ELrCI#select... 401412679
Ulrich Braunschweig @braunschweig.bsky.social · 26/03/2026Alu repeats have played important roles in the evolution of (alternative) splicing via exonization and in other ways. In this paper, we show that they mediate interactions across exons to loop them out. Alus inserted this way in evolution render exons alternative. bit.ly/4t8Yahh 1/2bit.lyAlu-mediated RNA duplexes are associated with widespread exon skipping across primate transcriptomes - Genome BiologyAlternative splicing patterns have diverged rapidly during vertebrate evolution. By integrating genome-wide predictions of stable RNA duplexes, alternative splicing profiles, and proximity ligation-de... 1125
Reposted by Ulrich BraunschweigUniversität Wien / University of Vienna @univie.ac.at · 03/03/2026📣 Call for Applications: The University of Vienna invites applications for more than 40 fully funded doctoral positions across a broad range of disciplines in Life Sciences and Natural Sciences. 👨🔬👩🔬 #PhDSky #PhD #univie 📅 Application period: 2 March – 27 March 2026, 12:00 CET More information: ⤵️careers.univie.ac.atCall for Applications: Doctoral Positions in the Life Sciences and Natural SciencesAmbitious candidates with a strong academic track record who wish to pursue their doctorate in one of the research areas listed below. 02931
Reposted by Ulrich BraunschweigManuel Irimia @mirimiam.bsky.social · 02/03/2026🚨🧬🚨 We're looking for a specialized Research Assistant to spearhead a project aimed at exploring new RNA therapeutics in diabetes and other metabolic disorders. Junior or Senior, we're hoping to recruit a highly motivated and self-driven scientist interested in both basic and applied science. 🦄 0711
Reposted by Ulrich BraunschweigNetherlands Cancer Institute @nkinl.bsky.social · 20/02/2026We;re hiring Junior Group Leaders! 🔬✨ We’re looking for researchers in immunology, chemical biology, AI in biology, or protein design to launch their own independent groups in our collaborative, international environment. www.nki.nl/news-events/... 01829
Reposted by Ulrich BraunschweigMax Perutz Labs Vienna @maxperutzlabs.ac.at · 17/02/2026Join the Vienna BioCenter Scientific Training as a Coordinator and play a key role in supporting the full administrative journey of PhD students! 🙌 If you are organized, enjoy independent work, and thrive in a dynamic setting, apply now ➡️ tinyurl.com/5sc2a37s 024
Reposted by Ulrich BraunschweigClaus Wilke @clauswilke.com · 13/02/2026AI agent goes nuts on open source maintainer after having its pull request denied. This is a pretty insane story. Open source development as we've been used to for the last few decades is likely over. 1/ theshamblog.com/an-ai-agent-...theshamblog.comAn AI Agent Published a Hit Piece on MeSummary: An AI agent of unknown ownership autonomously wrote and published a personalized hit piece about me after I rejected its code, attempting to damage my reputation and shame me into acceptin… 55939
Reposted by Ulrich BraunschweigRaider @iwillnotbesilenced.bsky.social · 20/01/2026A French judge explains how Trump sent people from the US Embassy to try to intimidate her during Marine Le Pen's trial for embezzlement — something they've done to other judges around the world 18624393
Reposted by Ulrich BraunschweigT. Ryan Gregory 🇨🇦 @tryangregory.bsky.social · 20/01/2026Dear Americans: When you say "The Republicans won't stop Trump and there's nothing we can do", please understand that the rest of us hear "Sorry you may have to fight WW3 against us but it is what it is". 25213
Reposted by Ulrich BraunschweigW. Brent Derry @wbderry.bsky.social · 15/01/2026Job alert! Assistant professor position in the Department of Molecular Genetics (University of Toronto). Amazing department and city. jobs.utoronto.ca/job/Toronto-... Please share.jobs.utoronto.caAssistant Professor - VirologyAssistant Professor - Virology 12250
Reposted by Ulrich BraunschweigMikko Taipale @miketilapia.bsky.social · 19/11/2025We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...nature.comPOSTDOCTORAL FELLOW - Toronto (City), Ontario (CA) job with Taipale Lab, Donnelly Centre, University of Toronto | 12849004The Taipale lab in the Donnelly CCBR and University of Toronto is looking for a highly motivated Postdoctoral Fellow 03244
Reposted by Ulrich BraunschweigeLife @elife.bsky.social · 30/10/20251/ @reviewcommons.org, @embo.org's preprint peer review platform, is taking an important step forward. Multiple publishers, including eLife, are now jointly running the peer-review process on behalf of the platform. 🔗 buff.ly/Rm1XotK 11314
Reposted by Ulrich BraunschweigInstitute of Science and Technology Austria (ISTA) @istaresearch.bsky.social · 27/10/2025Our fully-funded PhD program is open for applications! Join us to conduct cutting-edge research at top facilities with guidance from world-class faculty. Through our interdisciplinary training, you can tailor your PhD experience to match your interests and curiosity. Apply now: phd.ista.ac.at 0144
Reposted by Ulrich BraunschweigAnne Carpenter @drannecarpenter.bsky.social · 10/10/202515 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵 25415152
Reposted by Ulrich BraunschweigRob Patro @robp.bsky.social · 08/10/2025Have you recently completed (or finishing soon) a PhD in CS or a related discipline? Do you want to do research advancing the theory & practice of algorithmic genomics & build tools that people love to use? I'll be looking to hire a postdoc! Official ad coming soon: docs.google.com/document/d/1...docs.google.comPostdoc Description.docxTitle: Postdoctoral Associate Summary statement: The postdoctoral research associate is responsible for developing novel computational methodology for high-throughput sequence genomics tasks, as well ... 01417
Reposted by Ulrich BraunschweigVienna BioCenter Scientific Training @vbcscitraining.bsky.social · 05/10/2025Our PhD program offers many training activities and courses for your future career. Check out the range of fully-funded PhD positions in our Autumn call before 10 October 2025: www.vbcphd.at 174
Reposted by Ulrich BraunschweigThe Francis Crick Institute @crick.ac.uk · 24/09/2025Researchers have discovered a new biological process they've called 'interstasis', which keeps groups of proteins in check, preventing excessive build up and protecting the cell from potential harm. www.crick.ac.uk/news/2025-09...crick.ac.ukBetter together: researchers discover how cells keep groups of proteins in checkResearchers have discovered a new biological process that they’ve called ‘interstasis’, a way for cells to promote the equilibrium of functionally-related proteins, preventing too many from accumulati... 2196
Reposted by Ulrich BraunschweigDaniel Durocher @durocher1.bsky.social · 28/08/2025JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. www.nature.com/naturecareer... Please repost! 0135169
Reposted by Ulrich BraunschweigKara McKinley @karalmckinley.bsky.social · 25/08/2025Is anyone in continental Europe looking for a lab manager? I have a fabulous candidate - let me know and please RT! 02331
Reposted by Ulrich BraunschweigAntoine Molaro @antoinemolaro.bsky.social · 22/08/2025Hello World! So much going on in the field and much to discover. Lucky to have participated and witnessed all this enlightening science at #ESEB2025. Interested in a postdoc uncovering novel evolutionary conflicts involving chromatin? Please reach out, we are hiring. #MolaroLab #watwat @igred.fr 0118
Reposted by Ulrich BraunschweigTuuli Lappalainen @tuuliel.bsky.social · 19/08/2025A postdoc position in genomics available at our infrastructure in Uppsala, Sweden! An interesting R&D role a bit outside the traditional academic environment, great colleagues, work at the forefront of (long-read) sequencing. www.uu.se/en/about-uu/...uu.sePostdoctoral position - Uppsala UniversityPostdoctoral position, Department of Immunology, Genetics and Pathology, Uppsala University 03738
Reposted by Ulrich BraunschweigKarolinska Institutet @ki.se · 25/06/2025Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. 🔗 All positions: ki.se/en/about-ki/... 09997
Reposted by Ulrich BraunschweigDr Sian Gramates @drglam.bsky.social · 11/08/2025I just got the notice that all the FlyBase people at Harvard, including me, will be laid off on October 12. I'm devastated. 63376223
Reposted by Ulrich BraunschweigManuel Irimia @mirimiam.bsky.social · 07/08/2025Very happy to share the peer-reviewed version of our work on the cis-regulatory determinants of #microexon #splicing regulation by SRRM3/4, published in @natsmb.nature.com! rdcu.be/ezGqT Work led by @sobonnal.bsky.social, with Simon Bajew & @rmartinezcorral.bsky.social. @crg.eu @upf.edurdcu.beCore splicing architecture and early spliceosomal recognition determine microexon sensitivity to SRRM3/4Nature Structural & Molecular Biology - Using massively parallel splicing assays and mathematical modeling, Bonnal et al. uncover that conserved splice site strength and exon length encode... 13011
Reposted by Ulrich BraunschweigManuel Irimia @mirimiam.bsky.social · 23/07/2025🚨🚨🚨 Please RT! We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets. Deadline: 30/09/25👇upf.edu 14865
Reposted by Ulrich BraunschweigMyllia Biotechnology @mylliabio.bsky.social · 07/08/2025🗓️ @mylliabio.bsky.social sponsors the first conference on "High-Content CRISPR Screening" from March 18-19, 2026 in Vienna: perturb2026.bio Scientific topics: 🔬 CRISPR-based screening strategies 🧬 Perturb-Seq & CROP-Seq 💻 Computational analyses 💻 AI models of human cells 📸 Image-based screens 056
Reposted by Ulrich BraunschweigTorben Heick Jensen @heick.bsky.social · 05/08/2025Final call for postdoc positions in Aarhus, Denmark. Sorting of gene expression and beyond. Please get in touch for further information or apply using this link: mbg.au.dk/en/news-and-...mbg.au.dkA postdoc position in the Torben Heick Jensen lab, Aarhus University, Denmark: Mammalian Nuclear RNA Production and Turnover Systems - Vacancy at Aarhus UniversityVacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University 0139
Reposted by Ulrich BraunschweigMemorial Sloan Kettering Cancer Center @mskcancercenter.bsky.social · 28/07/2025New in @natbiotech.nature.com: a team led by scientists at MSK and University of Toronto have developed a new platform to facilitate the study of RNA-biding proteins (RBPs) across hundreds of species of plants, insects, and animals.nature.comA resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function - Nature BiotechnologyRNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource. 04618
Reposted by Ulrich BraunschweigThe Francis Crick Institute @crick.ac.uk · 29/07/2025Meet Jernej Ule (@ulelab.bsky.social) and Ben Blencowe, who set up the Brain RNA Regulatory Networks satellite lab here at the Crick. We spoke to Ben and Jernej about their research into RNA auto-gated vectors and their potential applications in gene therapy. www.crick.ac.uk/news/2025-07...crick.ac.ukIntroducing... Jernej Ule and Ben BlencoweWe spoke to Jernej Ule and Ben Blencowe, who recently set up the Brain RNA Regulatory Networks satellite lab here at the Crick. 0154
Reposted by Ulrich BraunschweigDante The K9 @dantethek9.bsky.social · 27/07/2025Well, I'll be damned. It's royalty free and there's already six, generic manufacturers lined up. newatlas.com/infectious-d...newatlas.comThe first 100% effective HIV prevention drug is approved and going globalAn epidemic that's been sustained for 44 years might finally be quelled, with the milestone approval of the first HIV drug that offers 100% protection with its twice-yearly injections. It's a landmark... 111127435890