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Ulrich Braunschweig

@braunschweig.bsky.social
177 followers 446 following 19 posts

Research associate at UofT's Donnelly Centre. Fascinated by genome organization and RNA processing. Love to have my mind boggled.

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Reposted by Ulrich Braunschweig
Miguel Ramalho-Santos @mrsantos.bsky.social · 28/09/2026
We are recruiting at the Lunenfeld-Tanenbaum Research Institute (LTRI) and the University of Toronto! In the areas of Reproduction, Pregnancy and Developmental Biology, at Assistant or Associate Professor level. Deadline: Nov 29, 2026 Find more and apply👇: 🔗 apply.interfolio.com/192324
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Ulrich Braunschweig @braunschweig.bsky.social · 09/09/2026
Major update to the prevailing view of how 'repressive' histone modifications and silencing are related: 'nanodomains' of a few nucleosomes switch state (and not wholesale phase transition of a compartment)
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Reposted by Ulrich Braunschweig
Gabrijela Dumbović @gabrijelad.bsky.social · 09/09/2026
Incredibly happy to share the first publication from our lab, now published in Nature Cell Biology! 🎉 How do cells coordinate RNA processing with nuclear organization and the cell cycle? www.nature.com/articles/s41...
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Genes & Development @genesdev.bsky.social · 08/09/2026
RESEARCH PAPER: RBM39 modulates UPR signaling through alternative splicing of IRE1α/ERN1 By Kim et al., and Thomas Gonatopoulos-Pournatzis ➡️ genesdev.cshlp.org/content/40/17-18… #RNA #splicing #stress #UPR
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Ulrich Braunschweig @braunschweig.bsky.social · 29/08/2026
We have to do this again because Toronto, like all cities in Canada, is at the whim of its provincial govt, and ours wants to score points with suburban voters at the expense of people’s physical safety. #Topoli #criticalmass 1/2
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Ulrich Braunschweig @braunschweig.bsky.social · 26/08/2026
New chapter in the saga of fake documentation on commercial antibodies incoming.
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Elphege Nora Lab at UCSF @elphegenoralab.bsky.social · 13/05/2026
Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇
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Fred Hutch @fredhutch.org · 15/08/2026
🔬 Fred Hutch Cancer Center is hiring an Assistant or Associate Professor in the Basic Sciences Division @basicsci.fredhutch.org. Join a world-class research community in Seattle and help advance discoveries in fundamental biology. Apply: apply.interfolio.com/190640
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Quaid Morris @quaidmorris.bsky.social · 07/08/2026
Excited to share the results of the Codebook Project, an international effort to identify accurate DNA-binding motifs and genomic binding loci for >300 uncharacterized human transcription factors (TFs) www.nature.com/articles/s41...
nature.com
An expanded codebook of human transcription factor DNA-binding specificity - Nature
Results from a panel of assays that analyse different aspects of DNA sequence specificity reveal more than 100 new motifs to aid the characterization of putative human transcription factors.
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Fred Hutch Basic Sciences Division @basicsci.fredhutch.org · 05/08/2026
Join @FredHutch.org's Basic Sciences Division as an Assistant or Associate Professor and help shape the future of fundamental biology. We welcome applicants whose work will complement, extend, or bring new directions to the division.
apply.interfolio.com
Apply - Interfolio
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Reposted by Ulrich Braunschweig
Noah Whiteman @nkwhiteman.bsky.social · 06/08/2026
I’m thrilled to share that our search for a tenure-track colleague in my *truly wonderful and collegial* Genetics, Genomics, Evolution and Development Division in the MCB Department at Berkeley @berkeleymcb.bsky.social is live! Please share this broad search widely: aprecruit.berkeley.edu/JPF05481
aprecruit.berkeley.edu
Assistant Professor -Genetics, Genomics, Evolution, and Development - Molecular and Cell Biology
University of California, Berkeley is hiring. Apply now!
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Michael Okun @michael-okun.bsky.social · 10/06/2026
I’ve officially resigned as Associate Editor for Frontiers in Systems Neuroscience. It used to be a reputable journal, but became a case study in how forced automation destroys academic integrity. 👇
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Ulrich Braunschweig @braunschweig.bsky.social · 20/07/2026
What happens if you delete large intronic regions? In human tissue culture cells, we found many deletions that decrease growth and some that increase it. In most cases, deletion affected expression or splicing of the gene. www.cell.com/cell-reports... 1/3
cell.com
A genome-wide functional analysis of conserved intronic regions reveals essential roles for speckle-associated retained introns
Farhangmehr et al. investigate functions of highly conserved intronic sequences in cell fitness using a CRISPR-based deletion screen. Deletions in FNBP4 intron lead to changes in p53 pathway genes. De...
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Rachel Gilmore @rachelgilmore.bsky.social · 15/07/2026
CBC headline from two weeks ago: “Carney says Trudeau-era climate plan was ‘too expensive’ and ‘divisive’
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Christine Mayr @christinemayr.bsky.social · 08/06/2026
Finally out in @Cellcellpress! Proteins with long IDRs are prone to misfolding during protein synthesis. This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones. www.cell.com/cell/fulltex...
cell.com
mRNA 3′ UTRs chaperone intrinsically disordered regions to control protein activity
Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis of fully active proteins.
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Reese Richardson @reeserichardson.bsky.social · 05/06/2026
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)
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Olga Anczukow @olgaanczukow.bsky.social · 22/05/2026
What is the role of #poison-exon in regulating splicing factors in stem cells and development? Check out new work from Nathan Leclair and Mattia Brugiolo and many others in my lab @jax.org #RNA #splicing www.biorxiv.org/content/10.6...
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Ulrich Braunschweig @braunschweig.bsky.social · 21/05/2026
Introduce yourself with 10 bands you've seen live: Garbage The Cure Chumbawamba The Prodigy Arctic Monkeys White Lies In the Valley Below Massive Attack IAMX Austra
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Johannes Zuber @johanneszuber.bsky.social · 31/03/2026
Are you a #Masters student interested in translational #cancer research, tumor immunology and #CRISPR screens? Then apply to our lab at the @impvienna.bsky.social in Vienna: www.imp.ac.at/career/open-... #oncology, #cancerresearch, #CRISPR
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Nathan Kalman-Lamb @nkalamb.bsky.social · 25/03/2026
Today in AI: Canada rejected the PR application of a McMaster postdoc from the Sorbonne who works in the immunology of aging because the generative AI being used to process applications (😱) entirely hallucinated her credentials. Everyone involved should be fired. archive.is/ELrCI#select...
Kémy Adé was shocked by the immigration refusal letter she received.
In rejecting her permanent residence application, the Immigration Department cited her current job duties, which included wiring and assembling control circuits, building control and robot panels, programming and troubleshooting. The department said these duties didn’t match the Canadian work experience she claimed.
Well, no, they didn’t. Adé is a post-doctoral research fellow and guest teacher at McMaster University — and those skills are not part of her repertoire. Nor are they what she submitted in her immigration application a year ago.
“I saw this language about this job description that has nothing to do with me,” said the health scientist from France, who has a PhD from Sorbonne University in the immunology of aging. “I was disoriented how this could happen.”
But a disclaimer at the bottom of the refusal letter might provide a hint.
It’s believed to be the first time that the department explicitly referred to the use of generative AI to support application processing in immigration refusals. The disclaimer also noted that all generated content was verified by an officer and that generative AI was not used to make or recommend a decision.
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Ulrich Braunschweig @braunschweig.bsky.social · 26/03/2026
Alu repeats have played important roles in the evolution of (alternative) splicing via exonization and in other ways. In this paper, we show that they mediate interactions across exons to loop them out. Alus inserted this way in evolution render exons alternative. bit.ly/4t8Yahh 1/2
bit.ly
Alu-mediated RNA duplexes are associated with widespread exon skipping across primate transcriptomes - Genome Biology
Alternative splicing patterns have diverged rapidly during vertebrate evolution. By integrating genome-wide predictions of stable RNA duplexes, alternative splicing profiles, and proximity ligation-de...
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Universität Wien / University of Vienna @univie.ac.at · 03/03/2026
📣 Call for Applications: The University of Vienna invites applications for more than 40 fully funded doctoral positions across a broad range of disciplines in Life Sciences and Natural Sciences. 👨‍🔬👩‍🔬 #PhDSky #PhD #univie 📅 Application period: 2 March – 27 March 2026, 12:00 CET More information: ⤵️
careers.univie.ac.at
Call for Applications: Doctoral Positions in the Life Sciences and Natural Sciences
Ambitious candidates with a strong academic track record who wish to pursue their doctorate in one of the research areas listed below.
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Manuel Irimia @mirimiam.bsky.social · 02/03/2026
🚨🧬🚨 We're looking for a specialized Research Assistant to spearhead a project aimed at exploring new RNA therapeutics in diabetes and other metabolic disorders. Junior or Senior, we're hoping to recruit a highly motivated and self-driven scientist interested in both basic and applied science. 🦄
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Netherlands Cancer Institute @nkinl.bsky.social · 20/02/2026
We;re hiring Junior Group Leaders! 🔬✨ We’re looking for researchers in immunology, chemical biology, AI in biology, or protein design to launch their own independent groups in our collaborative, international environment. www.nki.nl/news-events/...
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Max Perutz Labs Vienna @maxperutzlabs.ac.at · 17/02/2026
Join the Vienna BioCenter Scientific Training as a Coordinator and play a key role in supporting the full administrative journey of PhD students! 🙌 If you are organized, enjoy independent work, and thrive in a dynamic setting, apply now ➡️ tinyurl.com/5sc2a37s
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Claus Wilke @clauswilke.com · 13/02/2026
AI agent goes nuts on open source maintainer after having its pull request denied. This is a pretty insane story. Open source development as we've been used to for the last few decades is likely over. 1/ theshamblog.com/an-ai-agent-...
theshamblog.com
An AI Agent Published a Hit Piece on Me
Summary: An AI agent of unknown ownership autonomously wrote and published a personalized hit piece about me after I rejected its code, attempting to damage my reputation and shame me into acceptin…
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Raider @iwillnotbesilenced.bsky.social · 20/01/2026
A French judge explains how Trump sent people from the US Embassy to try to intimidate her during Marine Le Pen's trial for embezzlement — something they've done to other judges around the world
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T. Ryan Gregory 🇨🇦 @tryangregory.bsky.social · 20/01/2026
Dear Americans: When you say "The Republicans won't stop Trump and there's nothing we can do", please understand that the rest of us hear "Sorry you may have to fight WW3 against us but it is what it is".
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W. Brent Derry @wbderry.bsky.social · 15/01/2026
Job alert! Assistant professor position in the Department of Molecular Genetics (University of Toronto). Amazing department and city. jobs.utoronto.ca/job/Toronto-... Please share.
jobs.utoronto.ca
Assistant Professor - Virology
Assistant Professor - Virology
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Mikko Taipale @miketilapia.bsky.social · 19/11/2025
We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...
nature.com
POSTDOCTORAL FELLOW - Toronto (City), Ontario (CA) job with Taipale Lab, Donnelly Centre, University of Toronto | 12849004
The Taipale lab in the Donnelly CCBR and University of Toronto is looking for a highly motivated Postdoctoral Fellow
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Amelia Cervera 🍉 @ameliacervera.eurosky.social · 05/11/2025
Tumblr post by aylwyyn228:
"My PhD research was focused on grief in the 19th century. I can tell you exactly how much they would have wanted modern medicine. I've read so many accounts of people writing about how they would have done anything to save their children, their spouses, their siblings.

Mothers and fathers who sat up all night praying that their baby would see the morning. People giving huge sums of money to quack doctors in the hope that they could save their wives. Mothers writing about how they would do anything to not leave their children alone. One father after the loss of his fifth child in a month retelling how he had wanted to go outside and scream, but that he was too tired, so he lay down on the dining room floor instead.

After I read all that it feels like an insult that anyone in the modern world would turn down vaccines, when for thousands of years countless people would have given everything they had for the opportunity to save their loved ones."
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eLife @elife.bsky.social · 30/10/2025
1/ @reviewcommons.org, @embo.org's preprint peer review platform, is taking an important step forward. Multiple publishers, including eLife, are now jointly running the peer-review process on behalf of the platform. 🔗 buff.ly/Rm1XotK
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Institute of Science and Technology Austria (ISTA) @istaresearch.bsky.social · 27/10/2025
Our fully-funded PhD program is open for applications! Join us to conduct cutting-edge research at top facilities with guidance from world-class faculty. Through our interdisciplinary training, you can tailor your PhD experience to match your interests and curiosity. Apply now: phd.ista.ac.at
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Anne Carpenter @drannecarpenter.bsky.social · 10/10/2025
15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵
mitochondria from bipolar patients are closer to the nucleus in these images; control patients' are spread out further
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Rob Patro @robp.bsky.social · 08/10/2025
Have you recently completed (or finishing soon) a PhD in CS or a related discipline? Do you want to do research advancing the theory & practice of algorithmic genomics & build tools that people love to use? I'll be looking to hire a postdoc! Official ad coming soon: docs.google.com/document/d/1...
docs.google.com
Postdoc Description.docx
Title: Postdoctoral Associate Summary statement: The postdoctoral research associate is responsible for developing novel computational methodology for high-throughput sequence genomics tasks, as well ...
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Vienna BioCenter Scientific Training @vbcscitraining.bsky.social · 05/10/2025
Our PhD program offers many training activities and courses for your future career. Check out the range of fully-funded PhD positions in our Autumn call before 10 October 2025: www.vbcphd.at
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The Francis Crick Institute @crick.ac.uk · 24/09/2025
Researchers have discovered a new biological process they've called 'interstasis', which keeps groups of proteins in check, preventing excessive build up and protecting the cell from potential harm. www.crick.ac.uk/news/2025-09...
crick.ac.uk
Better together: researchers discover how cells keep groups of proteins in check
Researchers have discovered a new biological process that they’ve called ‘interstasis’, a way for cells to promote the equilibrium of functionally-related proteins, preventing too many from accumulati...
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Daniel Durocher @durocher1.bsky.social · 28/08/2025
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. www.nature.com/naturecareer... Please repost!
Image of Toronto
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Kara McKinley @karalmckinley.bsky.social · 25/08/2025
Is anyone in continental Europe looking for a lab manager? I have a fabulous candidate - let me know and please RT!
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Antoine Molaro @antoinemolaro.bsky.social · 22/08/2025
Hello World! So much going on in the field and much to discover. Lucky to have participated and witnessed all this enlightening science at #ESEB2025. Interested in a postdoc uncovering novel evolutionary conflicts involving chromatin? Please reach out, we are hiring. #MolaroLab #watwat @igred.fr
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Tuuli Lappalainen @tuuliel.bsky.social · 19/08/2025
A postdoc position in genomics available at our infrastructure in Uppsala, Sweden! An interesting R&D role a bit outside the traditional academic environment, great colleagues, work at the forefront of (long-read) sequencing. www.uu.se/en/about-uu/...
uu.se
Postdoctoral position - Uppsala University
Postdoctoral position, Department of Immunology, Genetics and Pathology, Uppsala University
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Karolinska Institutet @ki.se · 25/06/2025
Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. 🔗 All positions: ki.se/en/about-ki/...
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Dr Sian Gramates @drglam.bsky.social · 11/08/2025
I just got the notice that all the FlyBase people at Harvard, including me, will be laid off on October 12. I'm devastated.
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Manuel Irimia @mirimiam.bsky.social · 07/08/2025
Very happy to share the peer-reviewed version of our work on the cis-regulatory determinants of #microexon #splicing regulation by SRRM3/4, published in @natsmb.nature.com! rdcu.be/ezGqT Work led by @sobonnal.bsky.social, with Simon Bajew & @rmartinezcorral.bsky.social. @crg.eu @upf.edu
rdcu.be
Core splicing architecture and early spliceosomal recognition determine microexon sensitivity to SRRM3/4
Nature Structural & Molecular Biology - Using massively parallel splicing assays and mathematical modeling, Bonnal et al. uncover that conserved splice site strength and exon length encode...
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Manuel Irimia @mirimiam.bsky.social · 23/07/2025
🚨🚨🚨 Please RT! We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets. Deadline: 30/09/25👇
upf.edu
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Myllia Biotechnology @mylliabio.bsky.social · 07/08/2025
🗓️ @mylliabio.bsky.social sponsors the first conference on "High-Content CRISPR Screening" from March 18-19, 2026 in Vienna: perturb2026.bio Scientific topics: 🔬 CRISPR-based screening strategies 🧬 Perturb-Seq & CROP-Seq 💻 Computational analyses 💻 AI models of human cells 📸 Image-based screens
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Torben Heick Jensen @heick.bsky.social · 05/08/2025
Final call for postdoc positions in Aarhus, Denmark. Sorting of gene expression and beyond. Please get in touch for further information or apply using this link: mbg.au.dk/en/news-and-...
mbg.au.dk
A postdoc position in the Torben Heick Jensen lab, Aarhus University, Denmark: Mammalian Nuclear RNA Production and Turnover Systems - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University
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Memorial Sloan Kettering Cancer Center @mskcancercenter.bsky.social · 28/07/2025
New in @natbiotech.nature.com: a team led by scientists at MSK and ‪University of Toronto have developed a new platform to facilitate the study of RNA-biding proteins (RBPs) across hundreds of species of plants, insects, and animals.
nature.com
A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function - Nature Biotechnology
RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource.
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The Francis Crick Institute @crick.ac.uk · 29/07/2025
Meet Jernej Ule (@ulelab.bsky.social) and Ben Blencowe, who set up the Brain RNA Regulatory Networks satellite lab here at the Crick. We spoke to Ben and Jernej about their research into RNA auto-gated vectors and their potential applications in gene therapy. www.crick.ac.uk/news/2025-07...
crick.ac.uk
Introducing... Jernej Ule and Ben Blencowe
We spoke to Jernej Ule and Ben Blencowe, who recently set up the Brain RNA Regulatory Networks satellite lab here at the Crick.
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Dante The K9 @dantethek9.bsky.social · 27/07/2025
Well, I'll be damned. It's royalty free and there's already six, generic manufacturers lined up. newatlas.com/infectious-d...
newatlas.com
The first 100% effective HIV prevention drug is approved and going global
An epidemic that's been sustained for 44 years might finally be quelled, with the milestone approval of the first HIV drug that offers 100% protection with its twice-yearly injections. It's a landmark...
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