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Jennifer Trowbridge

@trowbridgelab.bsky.social
3.4K followers 2.1K following 86 posts

Professor & Dattels Family Endowed Chair at The Jackson Laboratory studying hematopoietic stem cell biology, aging & cancer. 🇨🇦 🇺🇸

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Jennifer Trowbridge @trowbridgelab.bsky.social · 21/09/2026
The Jackson Laboratory is a wonderful, collaborative place to pursue basic & translational science. On the faculty job market? I strongly encourage you to consider joining us in Bar Harbor, Maine! Apply: go.jax.org/276n55 #JAXresearch #JAXstemcellsdev
go.jax.org
Faculty Positions - Now Accepting Applications
The Jackson Laboratory is inviting applications for Assistant and Associate Professors at our Mammalian Genetics campus in Bar Harbor, Maine.
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Jennifer Trowbridge @trowbridgelab.bsky.social · 21/09/2026
Bittersweet to say goodbye to our lab manager Griffin Nye after 5 years. He's kept the lab running & brought endless enthusiasm along the way. So grateful for all he's given. I'll miss him, but I'm excited to see him follow his dream of becoming a teacher! 🩷
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Jennifer Trowbridge @trowbridgelab.bsky.social · 09/09/2026
I had the privilege and joy of returning yesterday to the @danafarber.bsky.social and @bostonchildrens.bsky.social where I did my postdoctoral training, this time as an invited speaker. Grateful to Zuzana Tothova for hosting me! It was a full circle moment and can't wait for the next time 😁
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Reposted by Jennifer Trowbridge
Nature Cell Biology @natcellbio.nature.com · 10/08/2026
☕ @trowbridgelab.bsky.social & co propose that Dnmt3a-mutant hematopoietic cells induce mesenchymal stromal cell #senescence. Removal of senescent non-hematopoietic cells reduces Dnmt3a-mutant #hematopoiesis. #ClonalHematopoiesis www.nature.com/articles/s41...
nature.com
Stromal cell senescence augments haematopoietic cell fitness in clonal haematopoiesis - Nature Cell Biology
Mistry et al. propose that Dnmt3a-mutant haematopoietic cells induce mesenchymal stromal cell senescence. Removal of senescent non-haematopoietic cells reduces Dnmt3a-mutant haematopoiesis.
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Jennifer Trowbridge @trowbridgelab.bsky.social · 07/08/2026
With mixed emotions, we said farewell to our @jax.org summer student Eva Rios. She was a JOY to have in the lab - thoughtful, engaged, creative, a dot-connector and with a great sense of humor and desire to learn and be challenged 🤩 #SSP26 #JAXGenomicEducation #JAXresearch #JAXstemcellsdev
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Jennifer Trowbridge @trowbridgelab.bsky.social · 06/08/2026
New work from our lab out today in Nature Cell Biology @natureportfolio.nature.com led by Jayna Mistry! www.nature.com/articles/s41556-026-02025-4 🧵 on how clonal hematopoiesis turns the bone marrow niche into an accomplice:
nature.com
Stromal cell senescence augments haematopoietic cell fitness in clonal haematopoiesis - Nature Cell Biology
Mistry et al. propose that Dnmt3a-mutant haematopoietic cells induce mesenchymal stromal cell senescence. Removal of senescent non-haematopoietic cells reduces Dnmt3a-mutant haematopoiesis.
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Jennifer Trowbridge @trowbridgelab.bsky.social · 06/08/2026
A huge congratulations to the newest graduate of the Trowbridge lab at The Jackson Laboratory @jax.org, Dr. Shawn David!! Shawn did a fantastic job defending his thesis today. So proud! 🎉 👏 🎊 #JAXGenomicEducation #UMaineGSBSE #JAXresearch #JAXstemcellsdev
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Jennifer Trowbridge @trowbridgelab.bsky.social · 01/08/2026
📢 BIG NEWS in ISEH's journal Experimental Hematology!!! 2 new article types specifically designed for research often difficult to publish: validated protocols, null results, phenotyping & high-value datasets. Plus fast-track review + a $650 incentive! 🔗 iseh.org/Publications...
iseh.org
ExpHem Journal
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Jennifer Trowbridge @trowbridgelab.bsky.social · 17/07/2026
#ISSCR2026 is a wrap - so what's next? 🔬 The JAX-NYSCF Conference Sept 23–24, 2026 | The Rockefeller University, NYC Topics: Aging · neurodevelopment · gene editing · iPSC tech · cell therapies Fabulous program and registration is open! See you there!! #JAXresearch #JAXstemcellsdev #JAX #NYSCF
conference.nyscf.org
NYSCF Conference
The NYSCF Conference is the premier translational stem cell research conference. Held annually for two decades, it has brought together world-leading experts from various disciplines across biomedicin...
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Jennifer Trowbridge @trowbridgelab.bsky.social · 11/07/2026
It's the final day of #ISSCR2026! Today @justinmcdonough.bsky.social from @jax.org receives the 2026 ISSCR Public Service Award as part of Stem Cell COREdinates and CorEUstem. 🏆 79 institutions. Shared standards. Global access. The infrastructure that enables discoveries. 👇
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Jennifer Trowbridge @trowbridgelab.bsky.social · 10/07/2026
Day 3 of #ISSCR2026 🔬 JAX stem cells & development colleagues present new translational work on diabetes and vision loss! 👇 Final day tomorrow, and something special for JAX. Stay tuned. 🏆 #JAXresearch #JAXstemcellsdev
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Jennifer Trowbridge @trowbridgelab.bsky.social · 09/07/2026
Day 2 of #ISSCR2026 🔬 - our @jax.org stem cells & development colleagues are ready to talk with you about their science! 🎤 Stefan Semrau: AI-driven phenotyping of 309 iPSC lines uncovers Parkinson's morphological signatures | 3:00 pm, Room 510a
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Jennifer Trowbridge @trowbridgelab.bsky.social · 08/07/2026
It's Day 1 of #ISSCR2026! Big day for @jax.org: 🍽️ 12:30 pm — JAX-NYSCF Innovation Showcase: scalable iPSC platforms for neurodegeneration | Room 510a (lunch provided) 🎤 3:10 pm — Daniel Paull: scaling iPSC models for drug discovery | Room 510a #JAXresearch #JAXstemcellsdev
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Jennifer Trowbridge @trowbridgelab.bsky.social · 30/06/2026
📣 ISSCR 2026 is almost here (July 8–11, Montréal)! Our JAX Stem Cells & Developmental Biology colleagues (www.jax.org/research-and...) have talks and posters across the meeting, plus a JAX-NYSCF Innovation Showcase and Booth #605. Here's the full picture 👇 #ISSCR2026 #JAXresearch #JAXstemcellsdev
jax.org
Stem Cells & Developmental Biology
By studying how cells are born, integrate, and regenerate, JAX researchers are uncovering the foundations of human health.
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Jennifer Trowbridge @trowbridgelab.bsky.social · 29/06/2026
New preprint from our lab led by Jayna Mistry! 🧬 We asked: what upstream signal ignites the inflammatory cycle that drives clonal hematopoiesis (CH)? Answer: neutrophil-derived S100A8/A9 alarmins. biorxiv.org/content/10.648 98/2026.06.26.734778v1 🧵1/4
biorxiv.org
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Jennifer Trowbridge @trowbridgelab.bsky.social · 17/06/2026
Congrats to Basile Tarchini & team, part of our Stem Cells & Development program @jax.org, on their new paper! Auditory hair cells self-correct their orientation after birth, even without the proteins thought to control it. journals.biologists.com/dev/article/... #JAXresearch #JAXstemcellsdev
journals.biologists.com
Progressive correction of auditory hair cell orientation in the absence of core planar cell polarity and GPR156 signaling
Summary: Misoriented mouse auditory hair cells can spontaneously correct their orientation after birth, revealing unexpected plasticity and a partnership between core planar cell polarity proteins and...
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Jennifer Trowbridge @trowbridgelab.bsky.social · 10/06/2026
Congrats to our Stem Cells & Development colleague Stefan Semrau! Support from the Michael J. Fox Foundation will launch human stem cell models of Parkinson's disease to be shared with the research community. More details below! #JAXresearch #JAXstemcellsdev
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Jennifer Trowbridge @trowbridgelab.bsky.social · 03/06/2026
1/3 Delighted to have visited the University of Pennsylvania this week, hosted by the fantastic Dr. Bobby Bowman who has built an exciting research program on the origins of myeloid malignancies and leukemia relapse.
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Jennifer Trowbridge @trowbridgelab.bsky.social · 28/05/2026
Excited to welcome Dr. Laura Bennett to JAX and our Stem Cells & Developmental Biology group this fall! Trained with Nancy Speck at UPenn, Laura's rigorous & translationally-minded program on HSC development is a perfect fit. Details below! #JAXresearch #JAXstemcellsdev
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Jennifer Trowbridge @trowbridgelab.bsky.social · 21/05/2026
Our Stem Cells & Developmental Biology program is live! We've built something rare: an integrated community of basic & translational scientists, innovative technologies & humanized models — all aimed at improving human health. @jax.org 🔗 go.jax.org/stem-cell-research #JAXresearch #JAXstemcellsdev
go.jax.org
Stem Cells & Developmental Biology
At JAX, we investigate how genetic and epigenetic programs govern stem cell fate, tissue growth and patterning, and regeneration—and how these processes can be restored in disease—by integrating devel...
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Jennifer Trowbridge @trowbridgelab.bsky.social · 07/05/2026
With gratitude to the dynamic Dr. Naveen Pemmaraju for the invitation and opportunity to share our data and discoveries with clinicians and scientists at University of Texas MD Anderson Cancer Center! It was a thought-provoking and fun Q&A discussion.
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Jennifer Trowbridge @trowbridgelab.bsky.social · 17/04/2026
We are actively recruiting a postdoctoral fellow to join our lab @jacksonlab! 😎 Details and link to apply: thejacksonlaboratory.wd503.myworkdayjobs.com/External_JAX...
thejacksonlaboratory.wd503.myworkdayjobs.com
Postdoctoral Associate
Postdoctoral Associate Trowbridge Lab Bar Harbor, ME A Postdoctoral Associate position is available in Dr. Jennifer Trowbridge’s laboratory at The Jackson Laboratory in Bar Harbor, Maine. The Trowbrid...
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Jennifer Trowbridge @trowbridgelab.bsky.social · 11/04/2026
⏲️The clock is ticking.. submit your abstract to the @isehsociety.bsky.social annual meeting by April 17th. Join us and be (re-)introduced to this awesome group of leading hematologists/stem cell biologists in a close-knit environment where you will receive in depth feedback on your work! #ISEH2026
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Jennifer Trowbridge @trowbridgelab.bsky.social · 19/03/2026
Fun lab lunch & farewell to postdoc Jayna Mistry as she leaves us to start her own lab at University of East Anglia!! 🎉 Watch this space - Jayna is a creative and passionate scientist, can't wait to hear about her lab's big discoveries 🤩
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Jennifer Trowbridge @trowbridgelab.bsky.social · 04/03/2026
Institutions are phasing out gamma-irradiators, but can X-ray irradiators replace them for mouse transplant models? We report that with proper dose calibration, X-ray conditioning produces equivalent hematopoietic chimerism and AML transplant outcomes. Encouraging news! 🔗 doi.org/10.1016/j.ex...
sciencedirect.com
Functional equivalence of γ- and x-ray irradiation for long-term peripheral blood chimerism and acute myeloid leukemia transplant outcomes in mice
Total body irradiation is routinely used for myeloablation before a mouse hematopoietic cell transplant. Widespread transition from 137Cs γ irradiator…
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Reposted by Jennifer Trowbridge
ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · 22/01/2026
This week on #SimplyBlood 🩸 we're sitting down with the 2026 ISEH Vice President Jennifer Trowbridge @trowbridgelab.bsky.social, to hear about upcoming work in her role, the benefits of the ISEH community, advice for trainees and much more➡️ iseh.org/Publications... @macnamaralab.bsky.social
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Kate MacNamara @macnamaralab.bsky.social · 23/01/2026
I got the chance to talk to Dr. Jennifer Trowbridge @trowbridgelab.bsky.social about ISEH and how the society supports the hematology community... and what we should be expecting in the year ahead! Have a listen 😊! @isehsociety.bsky.social
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Reposted by Jennifer Trowbridge
Peter van Galen @vangalenlab.bsky.social · 06/09/2025
Excited to share our latest work on blood aging! To find out why the blood system changes as people age, we started at the source: hematopoietic stem cells (HSCs) #hemesky 🩸🧬 doi.org/10.1101/2025... 🧵 1/5
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FASEB @faseborg.bsky.social · 15/05/2025
Celebrate 30 years of #HEMSRC with FASEB! Your research could be presented at the same meeting as hematology experts like @trowbridgelab.bsky.social and @juliamaxson.bsky.social. Submit your abstract by June 1 and save your space: buff.ly/2W1wk85
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Reposted by Jennifer Trowbridge
FASEB @faseborg.bsky.social · 23/04/2025
For 30 years, #HEMSRC has brought together researchers to share their important research. Join organizers @juliamaxson.bsky.social and Sergei Doulatov alongside keynotes @trowbridgelab.bsky.social and George Vassiliou to network, learn, and find new therapies. Save your space: buff.ly/2QuHlti
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Elmira @sciencyelmira.bsky.social · 16/04/2025
Excited to share the @goodell-lab.bsky.social News&Views on 3 exciting studies by Vassiliou Lab, Chan Lab, and @trowbridgelab.bsky.social in @nature.com and @natcomms.nature.com, showing that #DNMT3A mutant (major driver of Clonal Hematopoiesis) blood cells depend on mitochondrial respiration.
lab.bsky.social
Bluesky
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Jennifer Trowbridge @trowbridgelab.bsky.social · 16/04/2025
New paper from my lab! Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis: rdcu.be/eh1Nb Complementary to new work from Steven Chan & @georgevassiliou.bsky.social as described by @goodell-lab.bsky.social: www.nature.com/articles/d41...
nature.com
Age-related blood condition counteracted with a common diabetes drug
Metformin could reduce people’s risk of certain age-associated blood cancers, but more work is needed to identify who is likely to benefit.
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Jennifer Trowbridge @trowbridgelab.bsky.social · 11/04/2025
I am honored to have been selected by my colleagues to serve a 4-year term as vice president & president of the International Society of Experimental Hematology. Now, as ever, uniting, empowering and inspiring our collective scientific community to press on is essential.
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Jennifer Trowbridge @trowbridgelab.bsky.social · 18/02/2025
It is an honor to be considered alongside the fantastic @kentlab.bsky.social for the role of Vice President of ISEH. To all @ISEHSociety members: please make an important contribution to the society by voting. It's easy! Good luck to all of the nominees; we are in great hands!!
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Jennifer Trowbridge @trowbridgelab.bsky.social · 20/12/2024
Happy holidays from the Trowbridge lab! The festive games got a wee bit competitive this year 😅 Thanks James for the inspiration!
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Jennifer Trowbridge @trowbridgelab.bsky.social · 11/12/2024
I'm so glad you stayed until the very end @paralkarlab.bsky.social! It was my honor to present a curated subset of the top abstracts presented at #ASH24. For those that couldn't make it, it is available for viewing on the @ash-hematology.bsky.social meeting app & webcasts are available online.
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Jennifer Trowbridge @trowbridgelab.bsky.social · 11/12/2024
That's a wrap #ASH24! Co-chairing the scientific program was an unforgettable experience. Congratulations to the poster presenters, the oral abstract presenters, the invited speakers, the plenary presenters, late-breaking abstracts & those considered for 'Best of ASH'! A thread:
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Jennifer Trowbridge @trowbridgelab.bsky.social · 02/12/2024
Apparently we are using #ASH2024! Can't wait for new science and more sun ☀️
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Jennifer Trowbridge @trowbridgelab.bsky.social · 25/11/2024
#ASH24 badge has arrived ✅ Sant-Rayn Pasricha & I are delighted & excited to see everyone in San Diego. Getting ready for Best of ASH! During the meeting, stay tuned for posts about sessions you do not want to miss. 😎
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Jennifer Trowbridge @trowbridgelab.bsky.social · 11/11/2024
Online now! A very fun and productive collaboration with Bobby Bowman & Ross Levine modeling mutation order & oncogenic dependency in AML. I've always wanted to do this but we were previously limited by available tools... this is a huge step forward! authors.elsevier.com/c/1k4rd5TA51...
authors.elsevier.com
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Reposted by Jennifer Trowbridge
The Jackson Laboratory @jax.org · 21/06/2024
A study published in in the American Society of Hematology journal Blood, by @trowbridgelab.bsky.social & colleagues, reveals how #hematopoietic #stemcells age differently in genetically identical mice, offering new pathways for interventions to preserve health with aging: bit.ly/3XRSYCf 🧪🤝🖥️ 🧬 ⑂
bit.ly
How old is your bone marrow?
Researchers at JAX reveal that hematopoietic stem cells age differently in genetically identical mice, offering new pathways for interventions to preserve health with aging.
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