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James Saenz

@jamessaenz.bsky.social
1.9K followers 2.3K following 232 posts

Geochemist and biologist, Interested in lipids, RNA, pathogens, & synthesis of life.

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James Saenz @jamessaenz.bsky.social · 25/09/2026
We’ve finally installed the beautiful cell membrane wall art that Priyanka Oberoi made for the lab…now hanging in its new home @zmbh.uni-heidelberg.de in Heidelberg. The move is nearly complete! @anh-nhn.bsky.social @varvarakramkova.bsky.social
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The Company of Biologists @biologists.bsky.social · 21/09/2026
Applications are now open for early-career researchers to apply for a funded place at our Workshop on Membrane Function: Insights from Cellular Diversity and Evolution, organised by Snezhana Oliferenko @alebenoit.bsky.social & Cunqi Ye. Find out more and apply www.biologists.com/workshops/ju...
Membrane Function: Insights from Cellular Diversity and Evolution
Date: 13 – 16 June 2027

Location: Buxted Park, East Sussex, UK
Organisers: Snezhana Oliferenko and Cunqi Ye
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@KayTrue (Sarah L. Keller) @kaytrue.bsky.social · 07/08/2026
Applications are now open for the Fall 2026 Heising-Simons 51 Pegasi b postdoctoral fellowship at the University of Washington in Seattle. The fellowship supports research in astrobiology and in exoplanet and planetary science. Great faculty! Details at: depts.washington.edu/astrobio/wor...
depts.washington.edu
Fall 2026 Applications Open for the Heising-Simons 51 Pegasi b Postdoctoral Fellowship at The University of Washington – uwastrobiology
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André Nadler @nadlerlab.bsky.social · 29/07/2026
Lipids build the membranes of all cells, but identifying their precise functions is extremely challenging. Here’s our attempt to change that: How to find and understand lipid-protein interactions, by Katelyn Cook & company. www.biorxiv.org/content/10.6...
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Helena Klara Jambor @helenajambor.bsky.social · 10/07/2026
How scientists simplify their datavis with a few clicks - read more in **Click to plot** article, out in @natureportfolio.nature.com I love these resources, because I know they bridge the experimentalists journeying into advanced plots and coding eventually. Great collab @alex-lex.bsky.social
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Jeremy Baskin @jeremybaskin.bsky.social · 27/06/2026
Thrilled to share this #lipidtime mechanism story in @jcb.org where, led by Shiying Huang and in collaboration with Tamas Balla’s lab, we uncover plasticity in phospholipid metabolism to preserve plasma membrane identity and integrity in the face of disease-relevant perturbations!
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James Saenz @jamessaenz.bsky.social · 26/06/2026
We held lab meeting at McDonalds today…they have air conditioning, and lipids
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Anh Nguyen @anh-nhn.bsky.social · 11/06/2026
It's been a wonderful 4 years and I couldn't have done this without you James! Onwards and upwards!
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Helena Klara Jambor @helenajambor.bsky.social · 19/06/2026
What a week! My first Points of View was published @natmethods.nature.com Happy to start the series in 🏳️‍🌈 month with "On Color scales and the birth of Viridis" - looks good, allows naming of regions, AND is perceptually uniform 🎁 rdcu.be/fnPhk www.nature.com/articles/s41... #dataviz
A mountain ridge shown in different color sclales. Picture: 
Andres Passwirth - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=17166331
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Cees Dekker @ceesdekker.bsky.social · 16/06/2026
WORK: our Bionanoscience department at TU Delft is looking to hire an Assistant Professor in Biophysics of Living Systems. Apply! Deadline 30 July careers.tudelft.nl/job/Delft-As... RT=nice
careers.tudelft.nl
Assistant Professor in Biophysics of Living Systems
Assistant Professor in Biophysics of Living Systems
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Helena Klara Jambor @helenajambor.bsky.social · 16/06/2026
😎 to have this out! --> stay tuned, this is a series about 📊#dataviz for #science 🧪
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Ran Blekhman @blekhman.bsky.social · 15/06/2026
Just start writing. My new post: substack.com/home/post/p-...
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James Saenz @jamessaenz.bsky.social · 12/06/2026
Some things never change…I put this sign up 15 years ago when I borrowed a few glass vessels from @hymanlab.bsky.social as a postdoc… as of today it’s still there 😅 Did I return the bottles? We may never know! But there’s some bonus unpublished data printed on the back!
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James Saenz @jamessaenz.bsky.social · 11/06/2026
Thrilled to be joining the ZMBH, where my lab will continue to explore the evolution and engineering of living membranes. Farewell @bcube-tud.bsky.social...I couldn't imagine a better place to have started my lab! I'm perpetually grateful to my lab group for making this such a successful adventure!!
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James Saenz @jamessaenz.bsky.social · 10/06/2026
Congratulations 🍾 to @anh-nhn.bsky.social on her successful PhD defense today: Deciphering the role of lipidome complexity using Mesoplasma florum!! Time to celebrate 🎉 @bcube-tud.bsky.social
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James Saenz @jamessaenz.bsky.social · 09/06/2026
Congratulations 🎉🎊 to Dr. Sandra Rizk for defending her PhD thesis today: Functional Characterization of Isoprenoid Lipids in Methylobacterium extorquens PA1!!! @bcube-tud.bsky.social
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Ewan Birney @ewanbirney.bsky.social · 04/06/2026
The fact we can see this machine factory frozen in time (and space), happily making molecular machines, effectively at an atomic level is just jaw dropping. Every time I see these images I am blown away by it. Great work by Xiaohan and what a way for Christoph Müller to retire from @embl.org
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James Saenz @jamessaenz.bsky.social · 02/06/2026
And now I’ve found a catchy new slogan for the lab…MEMBRANES: MORE THAN YOU THINK inpreparation.substack.com/p/biophysica...
inpreparation.substack.com
Biophysical Society Blows Ad Budget On Bus That Reads 'MEMBRANES: MORE THAN YOU THINK'
ROCKVILLE, MD—The Biophysical Society confirmed Tuesday that it has spent its entire $14,000 annual advertising budget on a single advertisement on the side of a Washington, D.C., Metrobus that reads ...
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ZMBH @zmbh.uni-heidelberg.de · 29/05/2026
The ZMBH welcomes Dr. James Sáenz @jamessaenz.bsky.social as new Professor in Molecular Biology. James previously led a research group at B CUBE - Center for Molecular Bioengineering of Dresden University of Technology.
Portrait of Dr. James Sáenz
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Rowan Martindale @rowanmartindale.bsky.social · 27/05/2026
Geoscience teachers, interested in playing my GeoTimeline Game? You can now buy your own copy, these little timescale cards come in a cute mint tin! www.thegamecrafter.com/games/geotim...
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 26/05/2026
“Academic science is not only about productivity, it is also about deep understanding, exploring creative solutions and training critical thinkers to be the next generation of researchers.” www.nature.com/articles/d41...
nature.com
The uncritical adoption of AI in science is alarming — we urgently need guard rails
Artificial intelligence is rapidly accelerating scientific output, but risks narrowing inquiry, weakening judgement and undermining how scientists are trained.
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James Saenz @jamessaenz.bsky.social · 20/05/2026
🍾 🎉 Congratulations to Dr. Isaac Justice for defending his PhD thesis, in which he demonstrated that two lipid species are sufficient (but not optimal) for life! @bcube-tud.bsky.social
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Jonathan Parra @jonathanparra.bsky.social · 20/05/2026
Evolutionary strategies of late-stage diversification in bacterial biosynthetic gene clusters portlandpress.com/essaysbioche... Nice review by @pthiel.bsky.social and Aleksandra Nivina
portlandpress.com
Evolutionary strategies of late-stage diversification in bacterial biosynthetic gene clusters
Abstract. Natural products are complex chemical molecules produced by organisms to carry out a wide range of functions. The remarkable chemical diversity of these compounds arises from the diversity o...
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Mike Feigin 🥯 @mikefeigin.bsky.social · 08/05/2026
Wow. 3’UTRs are pretty amazing.
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Itay Budin @ibudin.bsky.social · 01/05/2026
What membrane properties do cells maintain through regulation of lipid metabolism? In a new paper, we identify intrinsic curvature stress as one such parameter and show how different (eukaryotic) cell types employ different lipids to do that www.cell.com/cell-reports...
cell.com
Active regulation of intrinsic curvature by eukaryotic phospholipid metabolism
Cells maintain membrane function by actively balancing the molecular shape of their lipids. Milshteyn et al. find that, when subjected to high hydrostatic pressure, yeast and human cells, but not bact...
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Misha Kudryashev @mishakudryashev.bsky.social · 07/04/2026
Take a look at the fresh post-Easter paper about lipid regulation of NS5A, a key protein of the hepatitis C virus. We were happy to contribute to the all-star team by Anna, Rebecca, James et al, spearheaded by Christoph Welsch. www.science.org/doi/10.1126/...
science.org
Phospholipid-driven conformational switching of HCV NS5A links protein folding to replication membrane remodeling
A host lipid flips a viral protein’s shape to control membrane remodeling during virus replication.
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James Saenz @jamessaenz.bsky.social · 25/03/2026
I'm thrilled to be starting as Professor for Molecular Biology at Heidelberg University in April. Looking forward to this adventure!
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Helena Klara Jambor @helenajambor.bsky.social · 24/03/2026
Its official, from April civil servant for "the Ländle" - Congratulations @jamessaenz.bsky.social on becoming professor @uniheidelberg.bsky.social - and I am happy to be back in town. @mpi-cbg.de @bcube-tud.bsky.social @tudresden.bsky.social
Rektor of Heidelberg University posing with James Saenz in front of a mirror, holding the certificate of his appointment. In the front the official photographer taking a pic too.
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André Nadler @nadlerlab.bsky.social · 23/03/2026
It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density. Lipid-CLEM, now out in @natcellbio.nature.com brought to you by @mathilda95.bsky.social changes that: www.nature.com/articles/s41...
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Oded Rechavi @odedrechavi.bsky.social · 12/03/2026
Humanity is notorious for leaving problems for the next generations, but animals reveal the biology: C. elegans develop germline tumors if THEIR GRAND GRANDPARENTS’ cells fail to clear garbage from their body cavity… What the hell, you ask? Read our new preprint! 👇 www.biorxiv.org/content/10.6...
biorxiv.org
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paveltomancak.bsky.social @paveltomancak.bsky.social · 11/03/2026
#czechcellence on tap
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Levental Lab @leventallab.bsky.social · 06/03/2026
Agreed!! A very exciting direction in structural biology
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@KayTrue (Sarah L. Keller) @kaytrue.bsky.social · 06/03/2026
Videos of the 2026 @biophysicalsoc.bsky.social Award Lectures are now online, including the Agnes Pockel Award Lecture by @veatchlab.bsky.social! It's here: www.biophysics.org/video-librar...
biophysics.org
2026 Agnes Pockels Award in Lipids and Membrane Biophysics - Sarah Veatch
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Raya Sorkin @sorkinlab.bsky.social · 03/03/2026
Check out our new preprint! We show that tension drives mixing of phase separated membranes!
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James Saenz @jamessaenz.bsky.social · 02/03/2026
Thank you so much for this perspective, Elise...it's exciting to see lipids getting a little time in the spotlight!! 🤩 #lipidtime @elisecutts.bsky.social
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James Saenz @jamessaenz.bsky.social · 02/03/2026
Thank you so much Anirban, I'm humbled! It was a real joy to chair this session on the evolution of membrane phenotypes...it was an incredible lineup from ancient protosterol "fossils" to unified laws of membrane elasticity. I've pasted the key papers from the session below! 🧵 #BPS2026
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James Saenz @jamessaenz.bsky.social · 25/02/2026
Wonderful to meet @ayushpanda2002.bsky.social in person at #BPS2026 in San Francisco! Former master’s student in Dresden, now starting his PhD in biophysics at Michigan…excited to see where his research takes him! 🦠🔬
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James Saenz @jamessaenz.bsky.social · 21/02/2026
Good morning San Francisco, and #BPS2026 … looking forward to the Membrane Structure and Function subsection meeting today!
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Helena Klara Jambor @helenajambor.bsky.social · 19/02/2026
😍 - also a great outcome of a meeting at #TCTEAC #WoodstockOfBio
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Sam Foley @samuelfoley.com · 19/02/2026
Lipid geeks rise up!
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Coskun Lipid Cellar @ ZML Dresden @lipid.bsky.social · 19/02/2026
"James' brain seemed to have had a little short-circuit when I asked him what kind of scientist he is." YES that our beloved #lipidlove @jamessaenz.bsky.social . Great interview and even better a fun old picture of him. I have a lot more, just in case 😂
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Elise Cutts @elisecutts.bsky.social · 19/02/2026
Lipids are kind of the ignored middle children of origins of life research. It's time they got a bit of attention, too! This week's post is a Q&A with geoscientist-turned-??? (interdisciplinary folks know the struggle) @jamessaenz.bsky.social about why there's no cutting the fat from origins. 🧪
reviewertoo.com
The origin of life wasn't fat-free
James Sáenz studies how fatty molecules might have helped life get started
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Carl Zimmer @carlzimmer.com · 18/02/2026
Scientists have seen Asgard archaea crawling for the first time. When it comes to the origin of eukaryotes, this is like seeing a feathered dinosaur in the wild. (Video courtesy of Philipp Ralder)
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Brett Baker @archaeal.bsky.social · 18/02/2026
New paper from my team detailing a greatly expanded genomic database of Asgard archaea revealing of high energy metabolism those related to eukaryotes! Led by @katyappler.bsky.social lots of help from @jameslingford.bsky.social @valdeanda.bsky.social @kassipan.bsky.social doi.org/10.1038/s415...
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Amanda Moehring @flybehaviour.bsky.social · 13/02/2026
Ooooh. Cool new paper on origins of life. A simple 45-nucleotide RNA molecule that can perfectly copy itself. www.science.org/doi/10.1126/...
science.org
A small polymerase ribozyme that can synthesize itself and its complementary strand
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...
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Junior RNA scientists @jrrnascientists.bsky.social · 10/02/2026
Junior RNA Scientists, tomorrow Feb 11th at 10AM ET is the first RNA Collaborative Seminar Series of 2026 hosted by the University of Rochester Center for RNA & the Bay Area RNA Club! Join us to hear about emerging RNA research. Sign up for zoom registration here: us02web.zoom.us/webinar/regi...
us02web.zoom.us
Welcome! You are invited to join a webinar: RNA Collaborative - University of Rochester & Bay Area RNA Club (BARC) . After registering, you will receive a confirmation email about joining the webinar.
Featuring: "HEXIM1 Directs a Cell Type-Specific Transcriptional Program" Laurie Steiner, MD (U Rochester) & "Mechanistic insights into complete transgene insertion by R2 retrotransposon proteins" ...
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eLife @elife.bsky.social · 06/02/2026
Lipids challenge ligands to control receptors The behaviour of a receptor protein can be influenced by the presence of certain lipids in the membrane it is embedded in. 🔗 buff.ly/G1Zl6cZ
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Joel Boerckel @jboerckel.bsky.social · 05/02/2026
I present the most interesting graph ever made. HUMAN ON BICYCLE beats every other living thing. www.scientificamerican.com/article/a-hu...
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Jeremy Baskin @jeremybaskin.bsky.social · 07/01/2026
Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance? www.nature.com/articles/s41... More info 👇
nature.com
Membrane editing with proximity labeling reveals regulators of lipid homeostasis - Nature Chemical Biology
Coupling an optogenetic lipid-modifying enzyme with proximity labeling reveals protein networks and mechanisms regulating lipid homeostasis in the membranes of target organelles.
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