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Michael Hiller

@hillermich.bsky.social
401 followers 129 following 42 posts

Prof. of Comparative Genomics @ Senckenberg Frankfurt; Genomics, Evolution, Comp Bio & the Phenotype-Genotype Question. hillerlab.com

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Reposted by Michael Hiller
Max Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · 24/09/2026
Study finds that bats most likely originated in Europe around 65 million years ago, before spreading across the world. 30 bat 🦇 genomes 🧬 were sequenced at @mpi-cbg.de & @dcgenomecenter.bsky.social. MPI-CBG Alumni @hillermich.bsky.social & Eugene Myers were involved. www.mpi-cbg.de/news-outreac...
mpi-cbg.de
Bats originated in Europe, not Asia, landmark genome study reveals
Study finds that bats most likely originated in Europe around 65 million years ago, before spreading across the world. 30 bat genomes for the study were sequenced at MPI-CBG. 
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Reposted by Michael Hiller
Dr. Makenzie Mabry @makenziemabryphd.bsky.social · 23/09/2026
📢 Call for abstracts! PAG 34 is coming to San Diego JAN 8–12 2027! 🧬🌱 We’re organizing five interconnected sessions: • Domestication Genomics • Ancient DNA • Comparative Genomics – Animals • One Health Hologenomics • Wildlife Genomics Submit your abstract by *October 9*: forms.gle/EgwFCVyxaf7R...
forms.gle
PAG 2027 Abstract Submission: Ancient DNA, Domestication Genomics, Comparative Genomics of Animals, Wildlife Genomics, One Health Hologenomics
****DEADLINE: FRIDAY OCTOBER 9, 2026**** This is the abstract submission form for the following PAG 34 workshops: Paleogenomics and Degraded DNA Domestication Genomics Comparative Genomics of Animals...
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Michael Hiller @hillermich.bsky.social · 23/09/2026
Happy to share results of the @bat1kgenomes.bsky.social phase 1, providing reference genomes covering 21 bat families. New insights into bat phylogeny, ancestral genome reconstruction, European origin & ancestral echolocation. Great work by a team of 100+ colleagues www.nature.com/articles/s41...
nature.com
Reference genomes and fossils revise bat family phylogeny and biogeography - Nature
An updated phylogeny of bats is presented, based on new genome assemblies and many ancient fossils and including all known bat families.
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Reposted by Michael Hiller
Bat1K Genome Project @bat1kgenomes.bsky.social · 23/09/2026
Where did bats come from?🦇🌍 After decades of debate, the biggest bat genome + fossil study ever done has an answer - and it’s not where anyone expected! 🤩OUR PHASE 1 FLAGSHIP is out today in nature! doi.org/10.1038/s415... A thread 🧵
doi.org
Reference genomes and fossils revise bat family phylogeny and biogeography - Nature
An updated phylogeny of bats is presented, based on new genome assemblies and many ancient fossils and including all known bat families.
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Reposted by Michael Hiller
Sonja Vernes @sonjavernes.bsky.social · 23/09/2026
🦇 Bat1K's biggest paper yet is out. Largest bat genome + fossil study ever: 103 genomes, 44 fossils, 137 researchers. We rewrote the bat family tree! Bats likely originated in Europe ~65 million years ago, not Asia, Africa or Americas. @bat1kgenomes.bsky.social doi.org/10.1038/s41586-026-11007-3
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Michael Hiller @hillermich.bsky.social · 09/07/2026
The #TOGA2 preprint is now at www.biorxiv.org/content/10.6.... Describes the new method and the comparative genomics resource (annotations, orthologs, gene losses/dups, retrogenes and more) generated using a total of 9420 TOGA2 runs for 2173 vertebrate genome assemblies.
biorxiv.org
Accurate, comprehensive gene annotation and ortholog identification across thousands of vertebrate genomes with TOGA2
Inferring orthologs and annotating coding genes remain central challenges in genomics, evident by the growing gap between assembled and annotated genomes. TOGA (Tool to infer Orthologs from Genome Ali...
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Michael Hiller @hillermich.bsky.social · 23/05/2026
Happy to announce the release of TOGA2 data for 68 turtle genomes, generated with a cryptodiran and a pleurodiran turtle reference. The combined TOGA2 annotation consistently improves annotation completeness compared with RefSeq. All data at genome.senckenberg.de/download/TOGA2. Genome browsers ...
genome.senckenberg.de
Index of /download/TOGA2
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Michael Hiller @hillermich.bsky.social · 08/05/2026
We now have genome browsers on our UCSC mirror at genome.senckenberg.de for the 1033 mammal and 866 bird assemblies, showing spliceAi, reference-based and ref-integrated TOGA2 tracks. Tables with links to all browsers are genome.senckenberg.de/TOGA2Mammali... & genome.senckenberg.de/TOGA2Aves.html
genome.senckenberg.de
Hiller Lab UCSC Genome Browser
Senckenberg Genome Browser
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Michael Hiller @hillermich.bsky.social · 12/03/2026
I wrote a short Nature Methods News & Views piece on deep learning based gene finders such as ANNEVO. www.nature.com/articles/s41...
nature.com
Learning genes deeply - Nature Methods
Annevo uses deep learning to achieve unprecedented accuracy in eukaryotic gene annotation, approaching the performance of evidence-based methods.
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Reposted by Michael Hiller
Leon Hilgers @leonhilgers.bsky.social · 10/03/2026
I hear you want novelty🦎->🐢, chromosome evolution 🧬, sex determination🩷, link population history📈 & climate🌏🌡️? Or you share my love for wonderfully weird animals? Side-necked turtle genomes reveal chromosomal dynamics, skeletal innovation and cancer resistance www.biorxiv.org/content/10.6... A 🧵
Chelodina longicollis, Eastern Long-necked Turtle. Melbourne Museum. 
Photographer: David Paul, Source: Museums Victoria
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Michael Hiller @hillermich.bsky.social · 28/02/2026
Happy to share that our work with Ekaterina Osipova, @maggiemcko.bsky.social, Tim Sackton, Maude Baldwin & fantastic collaborators on convergent and lineage-specific genomic adaptations in sugar-feeding birds is published in Science www.science.org/doi/10.1126/.... While high sugar intake ...
science.org
Convergent and lineage-specific genomic changes shape adaptations in sugar-consuming birds
High-sugar diets cause human metabolic diseases, yet several bird lineages convergently adapted to feeding on sugar-rich nectar or fruits. We investigated the underlying molecular mechanisms in hummin...
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Michael Hiller @hillermich.bsky.social · 23/11/2025
Happy to present TOGA2, developed by Yury Malovichko @ymalovichko.bsky.social, the faster, memory-efficient & more accurate TOGA1 successor (github.com/hillerlab/TO...). And annotations, orthologs & gene loss/dup data generated with 4 references for 883 placental mammal and with 5 refs for 676 ...
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Reposted by Michael Hiller
Earth BioGenome Project 🌍 @ebpgenome.bsky.social · 04/09/2025
🚀🧬🔥 Hot off the press — 2025! Don’t miss this must-read publication: bit.ly/4mJwFb7 This groundbreaking paper sets the stage for Earth BioGenome Project Phase II — where EBP is gearing up to scale genome sequencing 10× faster than ever before! 🌍✨
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Michael Hiller @hillermich.bsky.social · 03/09/2025
phenomenal work from Terry's lab !! And unbelievable that funding for such exciting work is cut.
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Michael Hiller @hillermich.bsky.social · 09/08/2025
Back from the Biology of Aging Gordon Research Conference. Fantastic meeting. Great to meet old friends and making new ones.
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Michael Hiller @hillermich.bsky.social · 01/08/2025
Happy to share our review on "Linking phenotype to genotype using comprehensive genomic comparisons" in Current Op with @leonhilgers.bsky.social. Summary of recent work and a discussion of the challenges ahead. www.sciencedirect.com/science/arti...
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Reposted by Michael Hiller
Leon Hilgers @leonhilgers.bsky.social · 24/07/2025
You link #phenotype 🦜 to #genotype 🧬 with #comparative #genomics 💻? This #review is for you 📜: authors.elsevier.com/sd/article/S... We review new #methods, remaining #challenges and #future directions and highlight recent key studies. Thanks @hillermich.bsky.social! Please share! 🙂
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Michael Hiller @hillermich.bsky.social · 11/02/2025
And @pacbio.bsky.social updated the ultralow protocol based on our results. Checkout www.pacb.com/blog/new-amp...
pacb.com
New Ampli-Fi ultra-low-input protocol will support HiFi sequencing from as little as 1 ng of DNA - PacBio
The Ampli-Fi protocol is a new workflow that will enable HiFi sequencing from as little as 1 ng of genomic DNA.
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Michael Hiller @hillermich.bsky.social · 11/02/2025
Our work on long read sequencing of ethanol or difficult-to-sequence samples is out genomebiology.biomedcentral.com/articles/10..... Will help to sequence Earth's biodiversity @ebpgenome.bsky.social. w @bernhardbein.bsky.social & many great colleagues.
genomebiology.biomedcentral.com
Long-read sequencing and genome assembly of natural history collection samples and challenging specimens - Genome Biology
Museum collections harbor millions of samples, largely unutilized for long-read sequencing. Here, we use ethanol-preserved samples containing kilobase-sized DNA to show that amplification-free protoco...
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Michael Hiller @hillermich.bsky.social · 09/02/2025
Checkout @xuelingyi.bsky.social manuscript on diet evolution in bats, with a focus on the super diverse Phyllostomid bat family. www.biorxiv.org/content/10.1...
biorxiv.org
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Michael Hiller @hillermich.bsky.social · 07/02/2025
To all #PSMC users. A prominent PSMC peak followed by a collapse is typically an artifact. @leonhilgers.bsky.social publiation in @currentbiology.bsky.social shows how to avoid this with simple parameter adjustments. www.cell.com/current-biol...
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Reposted by Michael Hiller
Leon Hilgers @leonhilgers.bsky.social · 06/02/2025
I am writing a short #review about linking #phenotype to #genotype 🧬using #comparative #genomics. There is a lot of amazing work and I would love to hear about your favorite studies 🥇 from the last 2-3 years! ✉️ Pls also send your own work here (or DM)🙂!! Please #repost!!! 🔁 (just joined bsky)
media.tenor.com
an owl holding an envelope with a label that says ' envelope ' on it
ALT: an owl holding an envelope with a label that says ' envelope ' on it
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Reposted by Michael Hiller
BatResearch - A.Prof. Aaron Irving @batresearch.bsky.social · 30/01/2025
A news article for a lay summary also: www.nature.com/articles/d41...
nature.com
How flight helped bats become invincible to viruses
The mammals carry immune adaptations that emerged when their ancestors took to the skies.
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Reposted by Michael Hiller
BatResearch - A.Prof. Aaron Irving @batresearch.bsky.social · 29/01/2025
Finally online - Bat genomes illuminate adaptations to viral tolerance and disease resistance www.nature.com/articles/s41... @hillermich.bsky.social @virology.bsky.social @emmateeling.bsky.social
nature.com
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Michael Hiller @hillermich.bsky.social · 29/01/2025
Happy to report that our work on immune system adaptations in bats is now out in @nature.com 🦇🧬 www.nature.com/articles/s41... @ariadnamorales.bsky.social @batresearch.bsky.social @virology.bsky.social @DGKontopoulos.ecoevo.social.ap.brid.gy @sgn.one @bat1kgenomes.bsky.social Read more ...
nature.com
Bat genomes illuminate adaptations to viral tolerance and disease resistance - Nature
A systematic analysis of 115 mammalian genomes, including 10 new bat genomes, reveals prevalent positive selection in immune genes in bats and shows key adaptations in the antiviral gene ISG15 that ai...
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