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Carl D. Modes

@carldmodes.bsky.social
222 followers 233 following 2 posts

Physics, biology, geometry, topology in complex biological networks, tissue mechanics, and morphogenesis. MPI-CBG and CSBD.

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Reposted by Carl D. Modes
paveltomancak.bsky.social @paveltomancak.bsky.social · 03/08/2026
www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.6...
biorxiv.org
Multiple contact sites between cells and the vitelline envelope coordinate tissue flows in Drosophila gastrulation
Gastrulation is thought to be driven primarily by forces generated within individual cells. These cell-intrinsic forces collectively induce tissue-scale flows and transform the monolayered embryo into...
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Reposted by Carl D. Modes
paveltomancak.bsky.social @paveltomancak.bsky.social · 03/08/2026
#Twisting embryos and multiple #attachment sites in #Drosophila - now both available as #preprints. Proud of @giuliaserafini.bsky.social & @cuencam15.bsky.social, who worked together & established theory collaborations with @lepuslapis.bsky.social & @carldmodes.bsky.social @mpi-cbg.de at its best
Giulia SerafiniMarina Cuenca
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Reposted by Carl D. Modes
Sbalzarini Lab / MOSAIC Group @mosaicgroup.bsky.social · 01/10/2025
🤩👍🏼💪🏼 Meet #TopoSPAM - a high-performance simulation platform for biological morphogenesis with a friendly Python interface. @tudresden.bsky.social @csbdresden.bsky.social @mpi-cbg.de. Solve both continuous and discrete active mechanics! Released today: arxiv.org/abs/2509.24905
arxiv.org
TopoSPAM: Topology grounded Simulation Platform for morphogenesis and biological Active Matter
We present a topology grounded, multiscale simulation platform for morphogenesis and biological active matter. Morphogenesis and biological active matter represent keystone problems in biology with ad...
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Reposted by Carl D. Modes
Bruno C. Vellutini @bruvellu.bsky.social · 04/09/2025
So happy to see the cephalic furrow combo out back-to-back! This was a wonderful collaborative endeavor 🥹
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Reposted by Carl D. Modes
paveltomancak.bsky.social @paveltomancak.bsky.social · 04/09/2025
The moral of the story is that building the #bridge between #evolution & #morphogenesis is hard. I still think it needs a concerted push, because, to paraphrase the classic: "Everything in biology, even the #CF, starts making sense in the light of evolution." I add, it is #stuff_that_matters (12/12)
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Reposted by Carl D. Modes
paveltomancak.bsky.social @paveltomancak.bsky.social · 04/09/2025
We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)
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Reposted by Carl D. Modes
Max Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · 03/09/2025
Dresden researchers @paveltomancak.bsky.social @bruvellu.bsky.social, Carl Modes, @cuencam15.bsky.social ‬ & colleagues published in @nature.com that a tissue fold in fruit fly embryos buffers mechanical stresses & may have evolved in response to mechanical forces. www.mpi-cbg.de/news-outreac...
mpi-cbg.de
Mechanical forces drive evolutionary change
A small tissue fold present in fruit fly embryos buffers mechanical stresses and may have evolved in response to mechanical forces.
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Reposted by Carl D. Modes
Patricia Ramos @apramos.bsky.social · 01/09/2025
Fantastic interaction with @carldmodes.bsky.social and @liormoneta.bsky.social , who did all the modelling. It was great to work in such an interchangeable setting between biology and physics, to lear about #ShapeProgramming and shed a little more light on how organs gain their 3D shape.
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Reposted by Carl D. Modes
Patricia Ramos @apramos.bsky.social · 01/09/2025
I am thrilled to share the main result of our work at @nordenlab.bsky.social with @liormoneta.bsky.social and @carldmodes.bsky.social . We bridged DevBiology + theoretical physics to understand how the eye becomes round #morphogenesis #devbio #biophysics #zebrafish www.biorxiv.org/content/10.1...
biorxiv.org
The Optic cup is actively shape programmed by independently patterned apical forces
During morphogenesis, initially flat tissues often must transition into complex 3D shapes, reminiscent of shape-programmable systems in physics and engineering. One key question in developmental biolo...
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