Sign in

Sascha Kuhn

@sascha-kuhn.bsky.social
211 followers 469 following 1 posts

How do cells see, smell, touch, and talk? Postdoc in the Mignot lab @LCB Marseille. Images -> Numbers (with units!). Also into guitars and amps.

PostsRepliesMedia
Reposted by Sascha Kuhn
Mathilda Lennartz @mathilda95.bsky.social · 30/09/2026
UPDATE!: I am absolutely stoked that the second paper of my PhD is now out in @natcellbio.nature.com :D. We combined lipid imaging, STED microscopy, and mathematical modelling in a super cool team effort to quantify lipid partitioning inside clathrin-coated pits. www.nature.com/articles/s41....
nature.com
Quantification of lipid sorting during clathrin-mediated endocytosis - Nature Cell Biology
Lennartz et al. evaluate lipid enrichment in clathrin-coated pits and observe that the differential lipid partitioning into clathrin-coated pits is largely driven by the lipid asymmetry of the plasma ...
711447
Reposted by Sascha Kuhn
Joachim Goedhart @joachimgoedhart.bsky.social · 08/09/2026
PURELIGHT: a quantitative photon-counting framework unifying intensity and lifetime imaging at video rate across detector technologies by Luca Ravotto and team: www.biorxiv.org/content/10.6...
High-speed FLIM imaging of astrocytic calcium dynamics with Tq-Ca-FLITS
0103
Reposted by Sascha Kuhn
Basler Lab @basler-lab.bsky.social · 27/06/2026
A Garmin watch face with a living microbial battlefield powered by your daily stats that is never the same! 🦠⌚️ The BacFighT6 Watch Face runs a live, #T6SS mediated bacterial simulation on your wrist. apps.garmin.com/apps/eaf881d...
2165
Reposted by Sascha Kuhn
Rauf Salamzade @raufs.bsky.social · 26/06/2026
Microbes that have the greatest genomic potential for secondary metabolism tend to be multicellular. Here, we show that signatures of ancestral BGC expansions within 3 bacterial phyla and 2 fungal lineages coincide with origins of complex multicellularity [1/12] 🧵 www.nature.com/articles/s41...
nature.com
Complex multicellularity is linked with expanded specialized metabolite production in microorganisms - Nature Microbiology
The evolutionary emergence of complex multicellularity in bacteria and fungi, such as the ability for mycelial growth, is strongly associated with increased genomic carriage of biosynthetic machinery ...
16838
Reposted by Sascha Kuhn
MichaelMcMurray lab @mcmurraylab.bsky.social · 23/06/2026
Our new paper was, by definition, an adventure: stepping outside of our comfort zone, embracing the unknown, and engaging in activities where the outcome is uncertain. Includes discovery of a new species and working with a Native American tribe to name it… 🧵👇 onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Comparative Analysis of Stress Adaptation in the Yeast Microbiome of Cactus
Yeasts and related fungi isolated from cacti or nearby non-cactus plants were characterized phenotypically and genomically, revealing differences that hint at modes of adaptation to the cactus host.
32710
Reposted by Sascha Kuhn
Sam Foley @samuelfoley.com · 11/06/2026
🧪⚛️ Our paper is finally published in Phys Rev Research! doi.org/10.1103/cnfz... Can cells make decisions using equilibrium physical principles, without resorting to irreversible, energy-consuming signaling cascades? We say yes, with the help of self-assembling membrane proteins! 🧵(1/7)
Plot of fractional response vs receptor concentration, comparing three different "passive sensing mechanisms": direct binding from solution, membrane-assisted binding, and membrane self-assembly.
2297
Reposted by Sascha Kuhn
Toni Gabaldón @tonigabaldon.bsky.social · 10/06/2026
Our paper "Gene ancestries reveal diverse microbial associations during eukaryogenesis.” is finally out in Nature. Eukaryogenesis was likely a gradual process shaped by multiple microbial partners and virus-mediated gene transfer, rather than a single binary symbiosis. doi.org/10.1038/s415...
10278135
Reposted by Sascha Kuhn
Osvaldo Chara @osvaldo-chara.bsky.social · 26/05/2026
🧵 New protocol out in @cp-starprotocols.bsky.social! Step-by-step guide to infer forces in tissues using ForSys, by @borgesaugust.bsky.social, Jeronimo Miranda, Alberto Ceccarelli, Guilherme Ventura, @kuba-sedzinski.bsky.social, @hernanlopez-schier.bsky.social and I, www.cell.com/star-protoco...
1258
Reposted by Sascha Kuhn
Joachim Goedhart @joachimgoedhart.bsky.social · 18/05/2026
Green genetically encoded IP3 biosensor for hierarchical analysis of its signaling network by Tetsuya Kitaguchi and team: www.biorxiv.org/content/10.6...
Figure 1. Schematic drawing of Green iPenguins.
0224
Reposted by Sascha Kuhn
Philip Ball @philipcball.bsky.social · 10/05/2026
i.e. it is just fairly good mimicry of consciousness, parasitic on ours. And this seems so obvious. Yet smart people keep falling for it. Is this really so hard?
3233
Reposted by Sascha Kuhn
the Node @the-node.bsky.social · 25/04/2026
Read @joachimgoedhart.bsky.social's latest post on the Node ⬇️ thenode.biologists.com/unboxing-dat...
thenode.biologists.com
Unboxing data - the Node
Thanks to community campaigns (#barbarplots) and opinionated papers (Drummond & Vowler, 2011; Weisgerber et al 2015) the dynamite plunger plot (a bar
0265
Reposted by Sascha Kuhn
Nature Cell Biology @natcellbio.nature.com · 17/04/2026
👋Our April issue is out! Cover: Visualizing #lipids 👉2 Perspectives: #embryo models 👉Comment on #mitochondria DNA 🔬 #telomeres #leukemia #ferroptosis #pyroptosis #PhaseSeparation #CellAdhesion #BreastCancer #lncRNA #metabolism #autophagy #microscopy & more! www.nature.com/ncb/volumes/...
0163
Reposted by Sascha Kuhn
Pablo J. Sáez @pjsaez.bsky.social · 16/03/2026
This is why we love #CalciumSignaling Look how mechanical damage triggers long range Ca2+ waves in this plant !! By @annalisabellandi.bsky.social, who is now around here ;) Full www.science.org/doi/10.1126/... @science.org #microscopy #cell #mechanobiology 🧪🔬
319860
Reposted by Sascha Kuhn
Bram van Dijk 🏳️‍🌈 @bramvandijk.bsky.social · 25/02/2026
In case you missed it: our review titled "Spatial structure: shaping the ecology and evolution of microbial communities" is out! 🚨 Let me hit you with some highlights on why spatial structure matters. (and why you should care!) Sharing is appreciated 🙏 🧵👇 doi.org/10.1093/fems...
314788
Reposted by Sascha Kuhn
franz @franzanth.bsky.social · 19/02/2026
#InvertebrateShitposting as per @joabaldwin.com's request
6 bad doodles with text under each one.
horseshoe crab is literally the animal horseshoe crab.
shoehorse crab is a crab riding a shoe, cowboy style.
crabshoe horse is a horse wearing literal crabs as shoes.
shoecrab horse is a horse telling a crab to go away.
crabhorse shoe is a pair of shoes, left one crab shaped, right one horse shaped.
horsecrab shoe is literally the same pair of shoes, flipped.
221668566
Reposted by Sascha Kuhn
Carl Zimmer @carlzimmer.com · 18/02/2026
One of the biggest questions in biology is how complex cells evolved about 2 billion years ago. Here's my new story on how scientists are solving the mystery of eukaryotes like us. Gift link: nyti.ms/4qMbo22
A pilot in a submersible vehicle collecting sediments samples in 30 meters of water looking for Asgards (microbial relatives of eukaryotes)
9342105
Reposted by Sascha Kuhn
O Professor Encantado ◤✠◢🇧🇷🇻🇪🇵🇸 @stefanoavatar.bsky.social · 09/02/2026
81529215
Reposted by Sascha Kuhn
Randall Munroe @xkcd.com · 09/02/2026
Dinosaurs And Non-Dinosaurs xkcd.com/3204/
Comic. [2x2 chart. Top left quadrant: seem like dinosaurs x are dinosaurs. Silhouettes of dinosaurs stegosaurus, triceratops, tyrannosaurus, velociraptor, and long-neck dinosaur. Top right quadrant: seem like dinosaurs x are not dinosaurs. Silhouettes of mosasaur, quetzalcoatlus, dimetrodon, plesiosaur, and pteranodon. Bottom left quadrant: don’t seem like dinosaurs x are dinosaurs. Silhouettes of penguin, egret, ostrich, pigeon, falcon. Bottom right: don’t seem like dinosaurs x are not dinosaurs. Silhouettes of squirrel, stapler, plant, person, and bicycle.]
10587331979
Reposted by Sascha Kuhn
André Nadler @nadlerlab.bsky.social · 26/01/2026
It's always important to carefully characterize the reactivity of your favorite tools to optimize applications. We teamed up with Carla Kirschbaum and Carol V. Robinson to map photolysis reaction pathways of bifunctional lipids www.biorxiv.org/content/10.6...
biorxiv.org
1154
Reposted by Sascha Kuhn
André Nadler @nadlerlab.bsky.social · 26/01/2026
Methods should be used as widely as possible, so here is our detailed lipid imaging protocol, written with @martinba99.bsky.social and Chia-Yi (Christine) Chou authors.elsevier.com/a/1mU4XHRzCb... in Methods in Enzymology. Everything you need to know to do it yourself is in there -
1119
Reposted by Sascha Kuhn
Oded Rechavi @odedrechavi.bsky.social · 26/10/2025
Not everybody knows that B.B. King wrote The Thrill Is Gone during the 2nd round of revisions
4493
Reposted by Sascha Kuhn
natalieadye.bsky.social @natalieadye.bsky.social · 11/10/2025
How are tissue folds stabilized during animal organ development? Our latest preprint helps to answer this question, using the fruit fly wing disc as a model doi.org/10.1101/2025.... @poldresden.bsky.social @mpipks.bsky.social @dfg.de @janafuhrmann.bsky.social @vicioms.bsky.social @mbisg.bsky.social
doi.org
Apical extracellular matrix regulates fold morphogenesis in the Drosophila wing disc
Tissue folding is a fundamental process occurring in animal organ development. Here, we study the progression of fold shape and the underlying mechanics in the development of the Drosophila wing disc....
2368
Reposted by Sascha Kuhn
kuba sędziński @kuba-sedzinski.bsky.social · 22/09/2025
🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x
912336
Reposted by Sascha Kuhn
Journal of Cell Biology @jcb.org · 11/09/2025
In 2019, Anna Jost & @jencwaters.bsky.social reviewed best practices for validating quantitative #microscopy methods & discuss strategies to avoid unconscious bias in imaging experiments rupress.org/jcb/article/... 📕 In #Reproducibility & Best Practices in Cell Biology: rupress.org/jcb/collecti...
12312
Reposted by Sascha Kuhn
Talley Lambert @talley.codes · 05/07/2025
it was already fun to look around the documentation for cmap (cmap-docs.readthedocs.io) but @grosoane.bsky.social just added a very cool feature to toggle between color vision deficiencies. Watch your perceptually uniform color maps gain some kinks 😂 as a mild deutan myself, I appreciate it! 🙏
0299
Sascha Kuhn @sascha-kuhn.bsky.social · 21/08/2025
If you are into imaging and quantitative biology, you should have a field day reading this. Also, of course, everyone who's into lipids ;) Huge congrats to the team!
061
Reposted by Sascha Kuhn
ChimeraX @chimerax.ucsf.edu · 20/08/2025
Here's how to predict binding of tens or hundreds of small molecules to protein assemblies using Boltz 2 in ChimeraX. Accuracy depends on how similar the ligands and binding pockets are to existing experimental structures. www.rbvi.ucsf.edu/chimerax/dat...
0279
Reposted by Sascha Kuhn
Yoann Santin @ysantin.bsky.social · 25/07/2025
Our review on contact-dependent #predation is now out ! We define predation processes and describe how predators kill and eat their prey 😈 Repost appreciated ❤️
0167
Reposted by Sascha Kuhn
The Company of Biologists @biologists.bsky.social · 25/06/2025
This week, we are featuring Joachim Goedhart, one of the most prolific authors on @the-node.bsky.social, as an extraordinary biologist. #100biologists @joachimgoedhart.bsky.social
The Company of Biologists 100 logo to the left and QR code to the right.
 
Portrait of Joachim Goedhart to the left, text to the right
 
100 extraordinary biologists

Joachim Goedhart

As one of the most prolific authors on the Node, Joachim Goedhartwrote the Node’s most-read post 'Data Visualization with Flying Colors'. He is an Assistant Professor at the University of Amsterdam, the Netherlands, unravelling G-protein signalling networks in time and space in cells and tissues.

#100biologists #biologists100
35019
Reposted by Sascha Kuhn
Helena Klara Jambor @helenajambor.bsky.social · 18/06/2025
I gave in! After students asking for it, I now made a simple figure design checklist. To help all scientists w/o graphic skills create clear, accessible, and truthful charts! -> Out in @nature Cell Biology: rdcu.be/erwl4 #DataVisualization #PhD #SciComm Thx for review @bethcimini.bsky.social + 2
rdcu.be
A checklist for designing and improving the visualization of scientific data
Nature Cell Biology - Creating clear and engaging scientific figures is crucial to communicate complex data. In this Comment, I condense principles from design, visual perception and data...
15293116
Reposted by Sascha Kuhn
Peter Carlton @carltonlab.org · 01/06/2025
Yep, we sure do! A fine thought technology from Katherine Andrea Rivera-Gomez and Mara Schvarzstein: wbg.wormbook.org/2017/07/18/i...
wbg.wormbook.org
Immobilizing nematodes for live imaging using an agarose pad generated with a Vinyl Record
[insert_php]strip_tagsKatherine Andrea Rivera-Gomez and Mara Schvarzstein[/insert_php]
2122
Reposted by Sascha Kuhn
Heike Kleffner @heikekleffner.bsky.social · 01/06/2025
#KeinVergessen Weil er öffentlich für Menschrechte von Geflüchteten einstand, wurde Walter Lübcke heute vor 6 Jahren von einem Neonazi ermordet. Der Mörder des CDU-Regierungspräsidenten von Kassel war u.a. bei #AfD aktiv und fasste den Tatplan nach AfD- und Neonazi-Mobilisierungen in #Chemnitz 2018.
Das Foto zeigt Walter Lübcke, den von einem Neonazi ermordeten Regierungspräsidenten von Kassel, in einem schwarz-weißen Foto mit einem schwarzen Anzug und einem weißen Hemd.
121222329
Reposted by Sascha Kuhn
E11 Bio @e11bio.bsky.social · 29/05/2025
E11 Bio is launching Volara: an open-source Python library for block-wise processing of large volumetric microscopy datasets! 🧪🔬 Volara features block-wise task abstractions, making scalable image processing more accessible, robust, and repeatable. Read more: e11.bio/blog/volara
23818
Reposted by Sascha Kuhn
André Nadler @nadlerlab.bsky.social · 13/05/2025
Meet GEQO: Genetically-encoded biosensors for absolute small-molecule quantification in single cells brought to you by @sascha-kuhn.bsky.social. For simple absolute quantification of your favourite small molecule or ion, head on over to @bioarxiv and read our new preprint: doi.org/10.1101/2025...
25816
Reposted by Sascha Kuhn
Elisa Nerli @nerlielisa.bsky.social · 09/04/2025
How can organs regenerate fast? Bioelectricity helps -- by coupling sub-second electrical injury signals to regenerative proliferation. First preprint from my potsdoc :D with @liujinghui.bsky.social @ritamateus.bsky.social @mpi-cbg.de and collaborators @mpipks.bsky.social @csbdresden.bsky.social
314337
Reposted by Sascha Kuhn
André Nadler @nadlerlab.bsky.social · 31/01/2025
It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density, which usually isn’t attainable. Lipid-CLEM brought to you by @mathilda95.bsky.social changes that. www.biorxiv.org/content/10.1...
1223778
Reposted by Sascha Kuhn
John Tuthill @tuthill.bsky.social · 23/01/2025
My lab has a tradition that each week one person contributes edits to a Wikipedia page relevant to their scientific work, and then presents it briefly at lab meeting (and we clap). A few of my favorites: en.wikipedia.org/wiki/Proprio... en.wikipedia.org/wiki/Chionea en.wikipedia.org/wiki/Femoral...
en.wikipedia.org
Proprioception - Wikipedia
1020434
Reposted by Sascha Kuhn
Zebrafish Rock! @zebrafishrock.bsky.social · 15/12/2024
Full spectrum of ‘zebrabow’ embryos. Credit to @jhenninger.bsky.social. #ZebrafishZunday 🧪
Line of zebrabow embryos that have different colors based on the cell lineage. They are sorted by color to form a rainbow.
318534
Reposted by Sascha Kuhn
Jana Fuhrmann @janafuhrmann.bsky.social · 11/12/2024
I love seeing so many interesting papers on Bluesky and my reading list keeps growing. So I would like to share a thread about our paper from this year. It was published when we were still at *the other place*, and I didn't feel like writing about it there. www.science.org/doi/full/10.... 1/n
2123
Reposted by Sascha Kuhn
Carl T. Bergstrom @carlbergstrom.com · 06/12/2024
This cover came out when I was 14 but I never heard it. It's hard to explain but I somehow I feel like it would have changed the course of my life if I had.
youtube.com
The Rave-Ups - You Ain't Goin' Nowhere
YouTube video by standingathwart
11496
Reposted by Sascha Kuhn
The Company of Biologists @biologists.bsky.social · 25/11/2024
We are happy to report that our journals and community sites now have Bluesky accounts. Follow them at: @dev-journal.bsky.social @jcellsci.bsky.social @jexpbiol.bsky.social @dmmjournal.bsky.social @biologyopen.bsky.social @the-node.bsky.social @prelights.bsky.social @focalplane.bsky.social
10437211
Reposted by Sascha Kuhn
Anneliese Gest @ammgest.bsky.social · 14/11/2024
And what better introduction than to share a new publication? Check out this review article I’ve been working on (along with my co-first authors) if you need a biosensor or want a comprehensive overview of the field. Now out as an ASAP article at Chemical Reviews! doi.org/10.1021/acs....
doi.org
Molecular Spies in Action: Genetically Encoded Fluorescent Biosensors Light up Cellular Signals
Cellular function is controlled through intricate networks of signals, which lead to the myriad pathways governing cell fate. Fluorescent biosensors have enabled the study of these signaling pathways ...
3195