Optimizations of X-ray nanotomography including the choice of resin allows high-resolution imaging of mouse brain tissue, approaching the resolution of volume electron microscopy. Since it does not re...

u-Segment3D is a universal framework that translates and enhances 2D instance segmentations to a 3D consensus instance segmentation without training data. It performs well across diverse datasets, inc...

Targeting TGFBR1 in transplantable mouse colorectal tumor organoids improves response to anti-PD-L1 therapy. Mechanistically, TGF-β abrogates clonal expansion of T effector and memory phenotypes and i...

Our series of morning lectures sharing science from across the Crick in a simple and accessible way continues.

Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government.

By learning a differentiation potential using an optimal transport-based approach, STORIES models and infers cell fate trajectories using spatiotemporal omics data.

The 64-plex fluorescence imaging of RNA in tissues is achieved in one imaging cycle

Cancerous cells can expand in our tissues by killing neighbouring healthy cells. Researchers in Institut Pasteur, CNRS and the Université Paris Cité found a new mechanism used by cancerous cells to ki...

Researchers find that virgin female mice can become aggressive towards pups when hungry, but only in certain hormonal states.

Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.

Nimbus, a deep learning model, uses a large multiplexed imaging dataset to predict the likelihood of marker positivity in single cells.

Mutual paracrine regulation of the cytokines GREM1 and SPP1 mediate mesenchymal and epithelial cell fate in pancreatic cancer.

Rottmann et al. use multi-omics and functional assays to show that obesity remodels the lung matrisome and enhances fibroblast contractility, exhibiting hallmarks of aging. These changes mirror premature aging signatures in the lung, linking overnutrition to impaired pulmonary function.

CLEM-Reg automates the three-dimensional alignment of volume correlative light and electron microscopy datasets by leveraging probabilistic point cloud registration techniques for fast and accurate re...

Nature Reviews Cancer, Published online: 08 September 2025; doi:10.1038/s41568-025-00868-xIn this Review, Easwaran and Weeraratna outline how ageing leads to epigenetic alterations in the tissue microenvironment, enhancing clonal expansion of mutations and ultimately increasing cancer risk.

Mitophagy, the selective degradation of mitochondria, has been thought to occur via macroautophagy. Here, the authors present data indicating that microautophagy also mediates mitophagy in macrophages...

Mechanical confinement of cancer cells at the tumour–microenvironment interface induces phenotype switching through chromatin remodelling by HMGB2, leading to a more invasive and drug-resistant state ...

The extracellular matrix (ECM) is a complex assembly of proteins surrounding cells. It is a critical component of the tumor microenvironment that plays an active role in tumor progression and modulati...

Genomics; Chromosome organization; Molecular Genetics; Cancer

Large-scale CRISPR screening in stomach organoids reveals gene-drug interactions

Feng et al. develop a computational framework (IGeS-BS) to recommend compounds that enhance immunotherapy responses and generate an immuno-boosting landscape for more than 10,000 compounds and 13 cancer types. Further experiments prove that two compounds could largely alleviate the resistance to anti-PD1 therapy in liver cancer.

The Pre-Cancer Immunology Lab (James Reading Lab) is mapping pre-invasive T cell dynamics during carcinogenesis to detect and intercept cancer development.

Mass spectrometry (MS)-based proteomics remains technically demanding and prohibitively expensive for many large-scale or routine applications, with per-sample costs of hundreds of dollars or more. To...

Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

Highlighted Article: MatriCom is a web application devised to mine single-cell RNA-sequencing datasets to infer extracellular matrix (ECM)–ECM and cell–ECM communication systems across cell population...

Volume electron microscopy has started to gain traction across the bioimaging field, as it allows scientists to see inside cells and tissues in 3D at extraordinary resolution. But what is volume EM, w...

Inactivating PPP2R1A mutations correlate with better survival after immune checkpoint blockade in patients with ovarian clear cell carcinoma, suggesting that targeting the phosphatase 2A (PP2A) pathwa...

Nature - Tool aims to solve the mystery of non-coding sequences — but is still in its infancy.

Single-cell and spatial transcriptomics analysis of stricturing Crohn’s disease highlights cellular heterogeneity in fibrotic tissue and identifies neighborhoods of fibroblasts and immune cells contri...

I'm Matouš, a first-year PhD student at the Francis Crick Institute, funded by Cancer Research UK. I use computer-based methods to study kidney cancer and better understand how tumours interact with t...

Zhu et al. reveal coordinated interplay between innate and adaptive immunity in the transition from precancer to invasive lung cancer. TIM-3 upregulation peaks at precancer stage and its blockade enhances anti-tumor immunity while inhibiting lung precancer progression, suggesting TIM-3 as a potential target for lung precancer interception.