Reposted by Marius PachitariuNicole Rust @nicolecrust.bsky.social · 07/08/2026US scientists: Going into fall 26, how are you thinking about things? Following Fall 24 events and a tumultuous spring 25, I remember a convo with a colleague in which we agreed we just needed to wait things out until fall 25 and we'd have some clarity about the landscape (eg for funding). /1 3517861
Reposted by Marius PachitariuKeri Martinowich @martinowk.bsky.social · 08/08/2026I find myself holding seemingly contradictory views. On one hand, this is an extraordinary moment. We are watching discoveries built over decades produce treatments, and things are happening now that I couldn't imagine when I started. It is hard not to look at that and feel enormous optimism. 14512
Reposted by Marius PachitariuTalia Lerner @talialerner.bsky.social · 09/08/2026It has been painfully clear since Fall’24 that US science funding would tank, universities would be targeted, and any assertions about a new “gold standard” disingenuous. The question has not been “will it be that bad,” but “how bad will it be.” 212834
Reposted by Marius PachitariuJed Brown @jedbrown.org · 17/07/2026Editor in Chief of Science: AI in scientific publishing: Slower, worse, and more expensive.doi.orgAI in scientific publishing: Slower, worse, and more expensiveThere’s a saying in the management world, popularized by NASA administrator Daniel Goldin in the 1990s, that the goal of technological improvements is to make products faster, better, and cheaper. Alt... 620586
Reposted by Marius PachitariuDimitra Maoutsa @dimma.bsky.social · 06/07/2026Our Impact Scholars @neuromatch.bsky.social project on 𝗵𝗼𝘄 𝗿𝗲𝘄𝗮𝗿𝗱 𝘃𝘀 𝗲𝘅𝗽𝗲𝗿𝗶𝗲𝗻𝗰𝗲 𝘀𝗵𝗮𝗽𝗲 𝗻𝗲𝘂𝗿𝗮𝗹 𝗽𝗼𝗽𝘂𝗹𝗮𝘁𝗶𝗼𝗻 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀 𝗶𝗻 𝗺𝗼𝘂𝘀𝗲 𝘃𝗶𝘀𝘂𝗮𝗹 𝗰𝗼𝗿𝘁𝗲𝘅 is out! With 𝗝𝗼𝗵𝗻 𝗠𝗮𝗱𝗿𝗶𝗱-𝗖𝗮𝗿𝘃𝗮𝗷𝗮𝗹 @johnmadridcarvajal.bsky.social, 𝗞𝗮𝘁𝗷𝗮 𝗞𝗮𝘂𝗿𝗶𝗻𝗸𝗼𝘀𝗸𝗶, 𝗜𝘀𝗵𝗮𝘁𝗽𝗿𝗲𝗲𝘁 𝗦𝗶𝗻𝗴𝗵, 𝗥𝗼𝗵𝗶𝘁 𝗝𝗲𝘀𝘄𝗮𝗻𝘁𝗵. 🧠 👉 zenodo.org/records/2064... 🧵👇 1/8 23110
Reposted by Marius PachitariuSonja Blumenstock @sblumenstock.bsky.social · 01/07/2026What if part of Huntington's disease wasn't just damage, but a circuit stuck in the wrong pattern? Our new paper, out today in Nature, tests that idea. 34320
Reposted by Marius PachitariuThe Transmitter @thetransmitter.bsky.social · 22/06/2026HHMI’s Janelia Research Campus will close two of its programs dedicated to rodent work, @thetransmitter.bsky.social has learned. #neuroskyence By @callimcflurry.bsky.social www.thetransmitter.org/community/ex...thetransmitter.orgExclusive: Janelia sunsets rodent work, launches transparent fish projectThe Howard Hughes Medical Institute’s Janelia Research Campus is banking on whole-brain imaging in the Danionella fish to advance neuroscience, but some scientists forced to close their labs say that… 02717
Reposted by Marius Pachitariujonny (leachate composite form) @jo.nny.rip · 07/06/2026for "AI" to be profitable, costs need to be aligned with token use rather than subscription, and then everyone needs to use orders of magnitude more tokens. "Agentic" workflows are for making massive token spend palatable by making the point of comparison "20 engineers" despite being the same thing. 1113
Reposted by Marius PachitariuMatteo Carandini @carandinilab.net · 01/06/2026Neuropixels + Optogenetics = Neuropixels Opto Combining high-resolution electrophysiology and optogenetics. 960 sites, 28 emitters, 2 colors. Today in @natmethods.nature.com doi.org/10.1038/s415... Thanks to @wellcometrust.bsky.social, @alleninstitute.org, @hhmijanelia.bsky.social & team. 115753
Reposted by Marius PachitariuMiguel Nunez @nunezkant.bsky.social · 26/05/20261/ 🚨🚨Preprint alert! "Perfect" isn't always smart 🧠. Anyone can tell apart two stimuli (including our mice). But how do we extract rules that apply to new stimuli? 🧵 biorxiv.org/content/10.6... @marius10p.bsky.social @computingnature.bsky.social #neuroAI #neuroscience #AI 13617
Reposted by Marius PachitariuCarsen Stringer @computingnature.bsky.social · 22/05/2026🚨🧠 Our paper is out! We introduce a simple computational model that generates macroscopic, long-timescale dynamics as seen in large-scale neural recordings. #neuroscience #dynamics @marius10p.bsky.social @zhong-lin.bsky.social @hhmijanelia.bsky.social Link: go.nature.com/4tRNjIu 414053
Reposted by Marius PachitariuKristin Branson @kristinmbranson.bsky.social · 18/05/2026New preprint with @lingqiz.bsky.social: Neurodata Without Boredom: Benchmarking Agentic AI for Data Reuse arxiv.org/abs/2605.12808 1/10 24718
Reposted by Marius PachitariuPaul Kristian LaFosse @lafosse.bsky.social · 15/05/2026🚨 Ever wanted a simple way to control the activity of thousands of neurons? We introduce an all-optical raster photostimulation method to do just that! w/ @computingnature.bsky.social @marius10p.bsky.social #FluorescenceFriday #neuroskyence www.biorxiv.org/content/10.6... 1/n 25921
Reposted by Marius PachitariuStories of WiN @storiesofwin.bsky.social · 23/03/2026We apologize for the delay but our next profile is here! Dr. Ann Kennedy (@antihebbiann.bsky.social) combines theory & biological data to study how internal states shape social behavior by reconfiguring neural circuit dynamics. Follow the link to learn more! www.storiesofwin.org/profiles/202... 04513
Reposted by Marius PachitariuSpencer LaVere Smith @spencerlaveresmith.bsky.social · 27/02/2026Two-photon calcium imaging at 24,000 lines/s, with the resonant axis spanning 4x what other systems can do. Inertia-free. Diffraction-limited. No tradeoffs. Che-Hang Yu developed a 4x angle multiplier for laser scanning. His paper is out today: opg.optica.org/optica/fullt... 1/n #fluorescenceFriday 311627
Reposted by Marius PachitariuCarsen Stringer @computingnature.bsky.social · 16/03/2026👋 Neuromatch is looking for more TAs to help facilitate comp neuro + neuroAI learning this summer! You'll get to work with students from around the world and share your expertise with the global community 🧠 🌎 🤖 🌍💻 🌏 #cosyne2026 #neuroscience 01310
Reposted by Marius PachitariuRuairidh McLennan Battleday @battleday.bsky.social · 05/03/2026📢📢 Announcing this year's conference on the Mathematics of Neuroscience & AI (Rome, 9-12th June). We’ve got a stellar line-up and venue, and invite everyone to join: www.neuromonster.org 23017
Reposted by Marius PachitariuNeuromatch @neuromatch.bsky.social · 25/02/2026Applications for July #CompNeuro, #DeepLearning, #NeuroAI & #ClimateScience are open. Learn in small collaborative pods with a dedicated TA, build real research skills, and join 13,000+ alumni worldwide. ➡️ Apply by 15 March: neuromatch.io/courses/ 0106
Reposted by Marius PachitariuCarsen Stringer @computingnature.bsky.social · 12/02/2026🔬🧠 Releasing the 1.0 version of #Suite2p and THE PAPER w/ @marius10p.bsky.social! Now with GPU acceleration. Want to use Suite2p but don’t have 100,000 neuron recordings? We show you how to get those with a standard 2p microscope #neuroscience #imaging #neuroAI www.biorxiv.org/content/10.6... 210136
Reposted by Marius PachitariuCarsen Stringer @computingnature.bsky.social · 09/02/2026🚨 new work from the lab on how eye movements 👀 versus orofacial movements influence 🐭 visual cortex activity 🧠 #neuroscience #behavior #neuroAI 04611
Reposted by Marius PachitariuKonrad Kording @kordinglab.bsky.social · 09/02/2026Planyourscience.com now applauds the good changes you make - and pushes back on the less good one. 0102
Reposted by Marius PachitariuAtika Syeda @atika-syeda.bsky.social · 05/02/2026Excited to share “Orofacial behaviors, not eye movements, govern neural activity in mouse visual cortex” www.biorxiv.org/content/10.6... Summary below... 24112
Reposted by Marius PachitariubioRxiv Neuroscience @biorxiv-neursci.bsky.social · 02/01/2026A System for Live Sorting of Neuronal Spiking Activity from Large-scale Recordings www.biorxiv.org/content/10.64898/20… 061
Reposted by Marius PachitariubioRxiv Neuroscience @biorxiv-neursci.bsky.social · 07/01/2026High performance sorting of motor unit action potentials with EMUsort www.biorxiv.org/content/10.64898/20… 031
Reposted by Marius PachitariuKonrad Kording @kordinglab.bsky.social · 18/11/2025I have so many issues with this podcast with @earlkmiller.bsky.social . I think that this podcast nicely shows why I have trouble with such approaches. Lets go through some of the claims. 87717
Reposted by Marius PachitariuKonrad Kording @kordinglab.bsky.social · 29/10/2025Still beta-testing the app that helps people plan science, make it super clear, design their todos, and write a first version of the paper. Feeling overwhelmed by the countless aspects of doing science? Try this (for free): planyourscience.complanyourscience.comScientific Paper Planner - AI-Powered Research PlanningStructure your scientific research with AI-powered guidance. From hypothesis to methodology, plan your research paper with intelligent mentoring. 2577
Reposted by Marius PachitariuSpencer LaVere Smith @spencerlaveresmith.bsky.social · 09/10/2025Even colleagues who should know better are claiming that we are halting animal research. No, we're not. Now this NYT opinion piece appears (gift link) www.nytimes.com/2025/10/08/o... You can't just move everything to cell culture, organoids, and computers. Even this NYT piece admits that. 1/3 193
Reposted by Marius PachitariuCarsen Stringer @computingnature.bsky.social · 23/09/2025Is visual cortex more like chatGPT or a masked autoencoder? Come to my BCCN seminar tomorrow at 10am ET on zoom (or read the paper) to find out! #neuroscience Zoom: urldefense.com/v3/__https:/... Paper: www.biorxiv.org/content/10.1... 0254
Marius Pachitariu @marius10p.bsky.social · 22/09/2025New work from the lab, mismatch responses consistent with spatial but not temporal predictive coding theory. 0308
Reposted by Marius PachitariuQingqing Zhang @qqzhang.bsky.social · 22/09/2025Does predictive coding work in SPACE or in TIME? Most neuroscientists assume TIME, i.e. neurons predict their future sensory inputs. We show that in visual cortex predictive coding actually works across SPACE, just like the original Rao+Ballard theory #neuroscience www.biorxiv.org/cgi/content/... 48827
Reposted by Marius PachitariuJanelia Research Campus @hhmijanelia.bsky.social · 02/07/2025💻A new class of simplified ‘minimodels’ developed by Fengtong Du, Miguel Angel Núñez-Ochoa, @marius10p.bsky.social & @computingnature.bsky.social can predict the visual responses of individual neurons in the primary visual cortex, helping shed light on how we see.👀 ➡️ www.janelia.org/news/new-com... 0167
Reposted by Marius PachitariuCarsen Stringer @computingnature.bsky.social · 02/07/2025Doing this might make you smarter ... (www.vice.com/en/article/d...) News coverage of our study on unsupervised learning in mice by @zhong-lin.bsky.social + @marius10p.bsky.social #neuroscience #AI www.nature.com/articles/s41...vice.comDoing This Might Actually Make You SmarterYou’re scrolling through TikTok with the sound off. Waiting in line for a coffee. Watching a guy try to parallel park for the third time... 193
Reposted by Marius PachitariuJanelia Research Campus @hhmijanelia.bsky.social · 24/06/2025🧠Zoning out could be beneficial—and may actually help us learn faster. 🥼New research led by @zhong-lin.bsky.social @marius10p.bsky.social @computingnature.bsky.social 🔗 www.janelia.org/news/zoning-...janelia.orgZoning out could be beneficial—and may actually help us learn fasterActions that may seem unproductive – like aimlessly wandering around a city or exploring a new mall – could play an important role in how our brains learn, according research from HHMI’s Janelia... 0145
Marius Pachitariu @marius10p.bsky.social · 24/06/2025Your brain learns for you even when you're not actively learning. Maybe. (in mice). 1294
Reposted by Marius PachitariuGabriel Stine @gabrielmstine.bsky.social · 23/06/2025Our paper on NHP neuropixels is finally out in Nat Neuro! These probes have already been transformative and will usher in a new era of primate neuroscience. I am extremely proud to have played a very small role in this project. I can't wait to see what our community discovers. tinyurl.com/54u3hrj8tinyurl.comLarge-scale high-density brain-wide neural recording in nonhuman primates - Nature NeuroscienceNeuropixels 1.0 NHP is a 45-mm, high-density silicon probe capable of recording large numbers of neurons with single-neuron resolution from most areas in a macaque’s brain. 16411
Reposted by Marius PachitariuDr Nick @nmwilkinson.eurosky.social · 23/06/2025AI doesn't have to be shit 031
Reposted by Marius PachitariuJanelia Research Campus @hhmijanelia.bsky.social · 23/06/2025🚶Aimlessly wandering around a city or exploring the new mall may seem unproductive, but new research led by @zh0ng0.bsky.social @marius10p.bsky.social @computingnature.bsky.social suggests it could play an important role in how our brains learn. 🧠 🔗 www.janelia.org/news/zoning-... 2258
Reposted by Marius PachitariuHelen Matthews @helenkmatthews.bsky.social · 23/06/2025Everyone in the lab is raving about Cellpose-SAM. Segmenting the previously unsegmentable across a range of different cell types and markers. 0111
Reposted by Marius PachitariuMichał Januszewski @michalwj.bsky.social · 22/05/2025Wouldn't it be great if we could not only image large connectomic volumes but also completely reconstruct them? And if a whole mouse brain project didn't cost billions? With the PATHFINDER preprint (www.biorxiv.org/content/10.1...), we preview a future where it doesn't have to. 23312
Reposted by Marius PachitariuPrinceton University Press @princetonupress.bsky.social · 21/05/2025A neuroscientist’s bold proposal for tackling one of the greatest challenges of our time—brain and mental illnesses. Nicole C. Rust's Elusive Cures publishes June 10. Learn more and preorder yours: press.princeton.edu/books/hardco... (5 August UK pub) @nicolecrust.bsky.social 1122
Reposted by Marius PachitariuMarkus Meister @mameister4.bsky.social · 21/05/2025If you're planning a course with mathematical methods content, or use such methods in your own work, please take a look at "Mathematics in Biology", by Meister, Lee, and Portugues, published at MIT Press. 1/2 @portugueslab.bsky.social mitpress.mit.edu/978026204940...mitpress.mit.eduMathematics in BiologyBiology has turned into a quantitative science. The core problems in the life sciences today involve complex systems that require mathematical expression, ye... 36016
Reposted by Marius PachitariuCarlos Brody @carlosbrody.bsky.social · 08/05/2025we're crowd-sourcing a searchable repository of tangible benefits stemming from federally-funded research. Come enjoy the great stories; or send in an idea; or volunteer to join the team. publicusaresearchbenefits.com please share and re-share so we get more great stories in there!publicusaresearchbenefits.comSearchable database of tangible benefits that federally-funded research gave us.A crowd-sourced site. Health and Well-being. National Security. Prosperity. 1139113
Marius Pachitariu @marius10p.bsky.social · 03/05/2025🚀🔬🦠 Releasing 🤖Cellpose-SAM🤖, a cellular segmentation algorithm with superhuman generalization 🦸♀️. Try it now on 🤗 huggingface.co/spaces/mouse... paper: www.biorxiv.org/content/10.1... w/ @computingnature.bsky.social 1/n 215851
Reposted by Marius PachitariuNeuromatch @neuromatch.bsky.social · 17/03/2025🌟 Teaching Assistants are who make Neuromatch Academy run! 🌟 Thinking of becoming a Teaching Assistant (TA) for Neuromatch or Climatematch Academy? Here’s why you should GO FOR IT! 🚀 Learn more and apply here: neuromatch.io/courses/ #Education #TA #TeachingOpportunity #mentorship 163
Reposted by Marius PachitariuNeuromatch @neuromatch.bsky.social · 24/02/2025🚨 Neuromatch Academy Course Applications are OPEN for 2025!! 🚨 Get your application in early to be a student or teaching assistant for this year’s courses! Applications are due Sunday, March 23. Apply & learn more: neuromatch.io/courses/ #mlsky #compneurosky #ai #climatesolutions #ScienceEdu 🧪 08674
Reposted by Marius PachitariuHHMI @hhmi-science.bsky.social · 17/02/2025Bring your samples into focus! A new version of the #Cellpose cell boundary mapping tool, developed at @hhmijanelia.bsky.social by @computingnature.bsky.social and @marius10p.bsky.social, now works on less-than-perfect microscopy images that are noisy, blurry, or undersampled. buff.lyNewest version of Cellpose can spot cell boundaries even in cloudy conditionsPicking out individual cells in distorted microscopy images is now as easy as clicking a button. A new version of Cellpose – the popular tool that maps the boundaries of diverse cells in microscopy 02813
Reposted by Marius PachitariuJason Keller @neurojak.bsky.social · 13/02/2025(1/11) Today I preprinted a lot of work from my postdoc with @dudman.bsky.social, which started with a question of how the nervous system balances flexibility with efficiency of learning. The thread below gives some background.... www.biorxiv.org/content/10.1...biorxiv.orgCortical control of innate behavior from subcortical demonstrationMotor control in mammals is traditionally viewed as a hierarchy of descending spinal-targeting pathways, with frontal cortex at the top. Many redundant muscle patterns can solve a given task, and this... 45924
Reposted by Marius PachitariuCarsen Stringer @computingnature.bsky.social · 12/02/2025#Cellpose 3 paper now out. Not all images are perfect. Restore your images with Cellpose3 to get better segmentations, w/ @marius10p.bsky.social www.nature.com/articles/s41... 613749
Reposted by Marius PachitariuJanelia Research Campus @hhmijanelia.bsky.social · 13/02/2025🖥️ A new version of #Cellpose – the popular tool developed by @computingnature.bsky.social & @marius10p.bsky.social that maps the boundaries of diverse cells in microscopy images – now works on less-than-perfect pictures that are noisy, blurry, or undersampled. 🔗 www.janelia.org/news/newest-... 0238