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The Batlle Lab

@batllelab.bsky.social
1.7K followers 222 following 70 posts

We work on minimal residual disease and metastasis by colorectal cancer from the perspective of cancer stem cells and their interaction with the tumor microenvironment. @IRBBarcelona,bsky.social

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The Batlle Lab @batllelab.bsky.social · 23/06/2026
A real pleasure
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The Batlle Lab @batllelab.bsky.social · 23/06/2026
A pleasure to be part of it
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EACR - European Association for Cancer Research @helloeacr.bsky.social · 22/06/2026
Already excited for next year's congress? Make sure to save the date in your calendars, and sign up for #EACR2027 updates! eepurl.com/dvcaQf
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IRB Barcelona @irbbarcelona.org · 22/06/2026
📌 Join us in our plenary #seminar this week, with Hugo Snippert, from @themaximacenter.bsky.social. 🤝 Host: @batllelab.bsky.social  Register here ➡️ shorturl.at/pWcSN #IRBBarcelona #CancerResearch
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The Batlle Lab @batllelab.bsky.social · 23/06/2026
Thrilled and grateful 🙏 🌟We have been awarded a new ERC Adv Grant to launch #PlasticCRC, a project that will explore how tumour cell plasticity 🧬🔄 drives adaptation and resistance in metastatic CRC. 🙌🏼Many thanks to everyone in the lab and collaborators. ➡️Looking forward to the science ahead!
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The Batlle Lab @batllelab.bsky.social · 12/02/2026
🙏Thank you to Ràdio Barcelona for the Toresky Award 🎙️ 🏆Although it recognizes a “personality,” the lab’s discoveries are the result of my team’s dedication and passion 🥼PhDs, postdocs, & senior members work relentlessly to make possible the breakthroughs being recognized today 🙌 ✨Huge thanks to all
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The Batlle Lab @batllelab.bsky.social · 12/12/2025
At the Tumor Heterogeneity, Plasticity & Therapy conference in Leuven! 🌟🇧🇪 Huge thanks to the organizers for the invitation. 🙌 Tumour heterogeneity and plasticity are critical areas that are reshaping how we understand therapy resistance and tumour evolution.🔬 www.vibconferences.be/events/tumor...
vibconferences.be
Tumor Heterogeneity, Plasticity and Therapy (3rd edition)
10-12 December 2025, Leuven, Belgium
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IRB Barcelona @irbbarcelona.org · 26/11/2025
Yesterday in Valencia Dr. @nlbigas.bsky.social received the 2025 Premio Rei Jaume I in Biomedical Research. Her work on how cancer mutations arise and evolve has earned major recognition! Congratulations, Núria! 🙌 #ReiJaumeI #CancerResearch @cerca.cat @icreacommunity.bsky.social @bbglab.bsky.social
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Sociedad Española de Bioquímica y Biología Molecular (SEBBM) @sebbm.bsky.social · 25/11/2025
PODCAST: Conversaciones del Premio Nobel Producida por Nobel Prize Outreach y la @fundacionareces.bsky.social, los podcast de la serie "Conversaciones del Premio Nobel " proponen acercar a la sociedad española los logros de estos científicos y sus historias personales.
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The Batlle Lab @batllelab.bsky.social · 07/11/2025
1/17 🧵 🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇 ➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC). Very proud of the team and efforts behind it. www.nature.com/articles/s41...
nature.com
TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages - Nature Genetics
Targeting TGFBR1 in transplantable mouse colorectal tumor organoids improves response to anti-PD-L1 therapy. Mechanistically, TGF-β abrogates clonal expansion of T effector and memory phenotypes and i...
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The Batlle Lab @batllelab.bsky.social · 27/10/2025
Our recent Cancer Discovery study (Centonze et al.) shows that within hours, metastatic CRC cells switch from an EMP1⁺ invasive state to an LGR5⁺ stem-like program, highlighting that Plasticity is a dynamic, regulated cell-state decision #Bluetorial below👇🏼 #KRAS #Plasticity #ColorectalCancer
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CNAG @cnag-eu.bsky.social · 17/11/2025
⏳Countdown to the 14th #CNAGSymposium! 🗣️Don’t miss Dr. Eduard Batlle from @irbbarcelona.org (@icreacommunity.bsky.social), sharing his insights on “Plasticity, therapy resistance, and immune evasion in metastatic colorectal cancer” 🗓️Dec 16, BCN 📎 www.cnag.eu/events/14th-... @batllelab.bsky.social
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The Batlle Lab @batllelab.bsky.social · 23/10/2025
🧵1/17 📣Thrilled to share our latest study just out in Cancer Discovery! ➡️ aacrjournals.org/cancerdiscov...
aacrjournals.org
A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer
Abstract. Inhibitors of the oncogene KRAS hold promise for treating metastatic CRC (mCRC). Here we show that a selective, covalent small molecule inhibitor of the active (ON) conformation of RAS-G12D,...
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IRB Barcelona @irbbarcelona.org · 07/11/2025
🔬 #ColorectalCancer evades #immunotherapy using a dual barrier: A study by #IRBBarcelona & @cnag-eu.bsky.social reveals how metastatic colorectal tumours block the immune system through two complementary mechanisms. 📰 @natgenet.nature.com ➡️ bit.ly/49BJaC0 #IRBScience @batllelab.bsky.social 🧪
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The Batlle Lab @batllelab.bsky.social · 07/11/2025
1/17 🧵 🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇 ➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC). Very proud of the team and efforts behind it. www.nature.com/articles/s41...
nature.com
TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages - Nature Genetics
Targeting TGFBR1 in transplantable mouse colorectal tumor organoids improves response to anti-PD-L1 therapy. Mechanistically, TGF-β abrogates clonal expansion of T effector and memory phenotypes and i...
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VIB Training & Conferences @vibtrainconf.bsky.social · 05/11/2025
Could understanding how #cancer cells talk to their neighbours help stop the disease? Johanna Joyce, a regular at #VIBConf, will uncover these new ways to predict, prevent, and treat cancer. Join #THPT25 before 26 Nov and decode the therapies that outsmart cancer: vibbio.tech/3Le9oAr #tumorbiology
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The Batlle Lab @batllelab.bsky.social · 06/11/2025
At the Oncode Annual Conference 2025. Fantastic Meeting. Thanks for the invite. Catching up with many colleagues and friends. www.oncodeinstitute.nl/events/oncod...
oncodeinstitute.nl
Oncode Annual Conference 2025 | Oncode Institute
Registration is closed!There are roadworks, so the public transport route is different from previous years. For up-to-date information, please use Reisplanner | GVB or Plan je reis met het OV en deelv...
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EACR - European Association for Cancer Research @helloeacr.bsky.social · 29/10/2025
Registration for Cancer Cell Plasticity closes on Monday 03 November! Join us online to explore the fundamental mechanisms that control cancer cell plasticity at multiple biological levels: eacr.org/conference/c...
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The Batlle Lab @batllelab.bsky.social · 29/10/2025
🙌🏼 What a fantastic meeting this was! Congrats to everyone who contributed! #EESOrgan @events.embo.org 🔝 A huge thank you to the organizers for the invitation, and for putting together such a memorable conference. 📸 A remarkable aspect was seeing together five generations of Clevers’ Lab!!
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The Batlle Lab @batllelab.bsky.social · 29/10/2025
📣 Last chance to register for the EACR virtual conference on Cancer Cell Plasticity You’ll gain new insights into fundamental mechanisms controlling cancer cell plasticity as well as innovative approaches to target them ➡️https://eacr.org/conference/cancercellplasticity2025 @helloeacr.bsky.social
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The Batlle Lab @batllelab.bsky.social · 27/10/2025
Our recent Cancer Discovery study (Centonze et al.) shows that within hours, metastatic CRC cells switch from an EMP1⁺ invasive state to an LGR5⁺ stem-like program, highlighting that Plasticity is a dynamic, regulated cell-state decision #Bluetorial below👇🏼 #KRAS #Plasticity #ColorectalCancer
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The Batlle Lab @batllelab.bsky.social · 24/10/2025
➡️ This important video was missing from yesterday’s #Bluetorial. CRC organoids under treatment with KRAS inhibitor RMC-9945, rapidly acquire a LGR5+ cancer stem cell-like phenotype, allowing them to bypass KRAS inhibition, and eventually resume growth. Centonze et al., in #CancerDiscovery #AACR
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The Batlle Lab @batllelab.bsky.social · 24/10/2025
➡️ This important video was missing from yesterday’s #Bluetorial. CRC organoids under treatment with KRAS inhibitor RMC-9945, rapidly acquire a LGR5+ cancer stem cell-like phenotype, allowing them to bypass KRAS inhibition, and eventually resume growth. Centonze et al., in #CancerDiscovery #AACR
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The Batlle Lab @batllelab.bsky.social · 23/10/2025
🧵1/17 📣Thrilled to share our latest study just out in Cancer Discovery! ➡️ aacrjournals.org/cancerdiscov...
aacrjournals.org
A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer
Abstract. Inhibitors of the oncogene KRAS hold promise for treating metastatic CRC (mCRC). Here we show that a selective, covalent small molecule inhibitor of the active (ON) conformation of RAS-G12D,...
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The Batlle Lab @batllelab.bsky.social · 17/10/2025
Lab Celebrations are in order. More news to come
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IRB Barcelona @irbbarcelona.org · 24/04/2025
🏆 El lliurament dels Premis Dia del Biòleg 2025 de @biolegscat.bsky.social tindrà lloc demà 25 d'abril a les 16:30 h al COACB. Enhorabona a tots els guardonats! Entre ells, @batllelab.bsky.social, de l'#IRBBarcelona! 🔴 Segueix la cerimònia  en directe aquí: f.mtr.cool/egtmfleqvu
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The Batlle Lab @batllelab.bsky.social · 25/04/2025
Estic molt agraït pel reconeixement rebut. Em sap greu no haver pogut assistir a l’acte de lliurament del premi i a la celebració del Dia del Biòleg. Afortunadament, l’equip hi ha pogut ser present en representació.
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The Batlle Lab @batllelab.bsky.social · 25/04/2025
Un placer y un honor dar la 28a Lección Conmemorativa Teófilo Hernando. Amigos, colaboradores y científicos a los que respeto y admiro entre los ponentes anteriores.
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The Batlle Lab @batllelab.bsky.social · 24/04/2025
It’s a pleasure to present our work at CRG’s annual symposium. Many good friends and colleagues around.
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IRB Barcelona @irbbarcelona.org · 20/02/2025
🗣️«Estamos empezando a entender cómo se genera la #metástasis y a ser capaces de prevenirlas y eliminarlas cuando ya se han producido». 🗨️ @batllelab.bsky.social #DebatesCaixaResearch
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The Batlle Lab @batllelab.bsky.social · 14/02/2025
En Sevilla, en las Jornadas conjuntas CIBERONC CIBER_OBN. @ciberisciii.bsky.social
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IRB Barcelona @irbbarcelona.org · 12/02/2025
🗣️Debate #CaixaResearch: “La incidencia de #CáncerdeColon aumenta entre los jóvenes" Con @batllelab.bsky.social y @tonigabaldon.bsky.social (@irbbarcelona.org), Angélica Figueroa (INIBIC) y Elena Élez (@vhio.bsky.social).  🗓️ Miércoles 19 febrero 🕖 19 h 💻 online ➡️ tinyurl.com/bdda8tsr 🧪
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EMBO @embo.org · 12/02/2025
Hello everyone on Bluesky! 🧪 We are EMBO, the organization of more than 2,100 leading researchers that promotes excellence in #lifesciences in Europe and beyond. Read more: www.embo.org/about-embo/m...
Text: EMBO is on Bluesky.
Butterfly icon with text: @embo.org
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IRB Barcelona @irbbarcelona.org · 29/01/2025
🧪 We are #hiring! 🔵 #Postdoctoral Fellows: @batllelab.bsky.social, Stefanie Wculek 🔵 Personnel Administration Expert 🔵 #FlowCytometry Technician 🔵 Public Procurement Officer 🔵 Programme Secretary ➕ℹ️ here ➡️ s.mtrbio.com/vmyqtfohpj #IRBJobs #Jobs #PostdocJobs #ScienceJobs
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Angélica_Figueroa_Lab @afigueroainibic.bsky.social · 04/02/2025
👉 Debate CaixaResearch “La incidencia de cáncer de colon aumenta entre los jóvenes” Ilusionada por compartir debate con @batllelab.bsky.social y @tonigabaldon.bsky.social 📅 Miércoles 19 de febrero de 2025, a las 19 h. Apúntate aquí👇👇👇 bit.ly/3E5vHoq
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The Batlle Lab @batllelab.bsky.social · 06/02/2025
caixaresearch.org/es/debates-c...
caixaresearch.org
DEBATES CaixaResearch - Aumento del cáncer de colon en jóvenes
Investigadores expertos debaten sobre el incremento de casos del cáncer de colon en los jóvenes en los DEBATES CaixaResearch de la Fundación ”la Caixa”.
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The Batlle Lab @batllelab.bsky.social · 19/01/2025
About to give the Keynote Lecture at the The #KSMetastasis25 @KeystoneSymp on Tumor Microenvironment: Metastasis and the Host. The location at Banff is impressive. Thank you Manuel Valiente and Julio Aguirre-Ghiso for the invitation!
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The Batlle Lab @batllelab.bsky.social · 16/01/2025
Big day today for Maria Salvany! Defence about to start!
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The Batlle Lab @batllelab.bsky.social · 07/01/2025
www.lavanguardia.com/ciencia/2025...
lavanguardia.com
El científico Joan Massagué recuerda a su mentor, Joan Guinovart, fallecido a los 77 años
El 1 de enero, la ciencia perdió a Joan Guinovart, un líder ejemplar y un mentor excepcional que deja una profunda huella en la comunidad científica y en la sociedad.
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Anna Obenauf @obenaufa.bsky.social · 06/01/2025
🌟Keystone Cancer Immunotherapy conference 2025 🌟 #KSCancerImmune25 Speaker Highlight #1 Dr. Carl June, the father of CAR T-cell therapy and 2024 #BreakthroughPrize winner will share critical advances in cancer immunology in his talk “Cell Therapies: Current State of the Art”.
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EACR - European Association for Cancer Research @helloeacr.bsky.social · 06/01/2025
What practical measures can we take to help break the glass ceiling for women in cancer research? Listen to episode 10 of The Cancer Researcher Podcast for an insightful discussion with three expert guests including @johannajoyce.bsky.social: magazine.eacr.org/how-to-break...
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Anna Obenauf @obenaufa.bsky.social · 06/01/2025
🌟Keystone Cancer Immunotherapy conference 2025 🌟 Speaker Highlight #2 at #KSCancerImmune25: Dr. Ton N. Schumacher @nkinl.bsky.social will discuss how T cells detect tumors in “Dissecting T Cell Recognition of Cancer.” Don’t miss his cutting-edge immunology insights!
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The Batlle Lab @batllelab.bsky.social · 03/01/2025
elpais.com/espana/catal...
elpais.com
Muere a los 77 años Joan Guinovart, fundador y exdirector del Institut de Recerca Biomèdica (IRB)
El científico y catedrático, Creu de Sant Jordi en 2014, fue una figura clave en el ámbito de la bioquímica
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The Batlle Lab @batllelab.bsky.social · 03/01/2025
www.ara.cat/ciencia-medi...
ara.cat
Joan Guinovart: una raó per no descansar
El traspàs de Joan Guinovart és per a tots els que l’estimàvem una bufetada. Ho veiem venir, però no ens hi aveníem i al final ens ha agafat per sorpresa.
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The Batlle Lab @batllelab.bsky.social · 03/01/2025
www.lavanguardia.com/ciencia/2025...
lavanguardia.com
Lo que la ciencia le debe a Joan Guinovart, fallecido a los 77 años
Si la ciencia en Catalunya y en el conjunto de España ha logrado la hazaña de salir de la mediocridad y alcanzar la excelencia en los últimos 25 años, ha sido en
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The Batlle Lab @batllelab.bsky.social · 03/01/2025
www.abc.es/sociedad/joa...
abc.es
Joan Guinovart, el científico que salió del laboratorio
Fundó y dirigió el IRB de Barcelona, pero sobre todo este bioquímico fue una figura clave en el despertar de la ciencia en España
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The Batlle Lab @batllelab.bsky.social · 01/01/2025
Today, Joan Guinovart, the founder and former director of IRB Barcelona, passed away. A great person and a good friend is gone. Without his contribution, the success of IRB Barcelona cannot be explained, nor that of our laboratory. He brought Elena Sancho and me to IRB, and for more than 15 years, he supported us. A cultured, intelligent, committed, tenacious person with great humanity, he transmitted these values to the institution, transforming it into a magnificent place to perform research. 

Sharing the day-to-day over the years led us to develop affection and friendship beyond work. Just yesterday, we were exchanging WhatsApp messages. Unfortunately, my last one this morning, wishing him a happy New Year and telling him we loved him, was one he was not able to respond to. We are devastated by his loss.

Thank you for everything, Joan. We will miss you dearly. Rest in peace.
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The Batlle Lab @batllelab.bsky.social · 11/12/2024
On the move! Nice Landing!
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Jens Puschhof @jenspuschhof.bsky.social · 05/12/2024
#Organoid #Starterpack #1 is now full (go.bsky.app/RmXgs6d). Time for #Organoids #2/2: go.bsky.app/JVA5H2a Already many great new arrivals & finds such as @batllelab.bsky.social, @saurlab.bsky.social & more!
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