Oncogene-driven endoplasmic reticulum (ER) stress is common in cancer. Here, authors show breast cancers extend Golgi anion channel GPR89 to the ER to mitigate this stress, creating a potentially targ...

Lebrec et al. present a FRET-based cGAS reporter and show that cGAS activation by genotoxic stress is rare and uncoupled from micronuclei. The study implicates R-loop structures and subtypes of chroma...

View details and apply for this Software Engineer vacancy in Sutton. Salary : Salary range: £57,190 - £64,000 per annum. Commencement on the salary range is subject to comparable skills and ...

Cryogenic electron microscopy captures nucleotide excision repair complexes assembling on damaged DNA templates.

View details and apply for this Computational Chemist vacancy in Sutton. Salary : £50,825 - £53,500 per annum. Commencement on the salary range is subject to comparable skills and experience...

ICR welcomes FDA approval of capivasertib for advanced prostate cancer

The past two decades of PARP inhibitor synthetic lethality in cancer is explored.

Advances in oncology drug development are driving the emergence of novel therapies, challenging traditional dose-efficacy assumptions in dose-finding oncology t...

Background G-quadruplex (G4) structures are secondary structures that can form in guanine-rich single stranded DNA sequences. These play important roles in biological processes such as regulation of g...

Scientist who established productive growth of HIV in an immortalised cell line, which led to the development of the UK’s first antibody test for the virus

Abi Sherratt, 27, was diagnosed with papillary thyroid cancer in February 2025. She is preparing to run the London Marathon on 26 April.

YouTube video by The Rest Is Science