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Adrian Wanner

@adrianawanner.bsky.social
134 followers 112 following 19 posts

SERI-funded #ERCStG Group Leader at PSI structuralneurobiology.ch, CV Starr Fellow at Princeton Neuroscience Institute, founder of ariadne.ai

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Reposted by Adrian Wanner
Rainer Friedrich @rainerfriedrichlab.bsky.social · 26/09/2026
Precise structural and functional organization of the olfactory bulb neuropil early in development, revealed by volume EM, dense reconstruction and 2P calcium imaging in zebrafish. Great work by Ruth and others in collaboration with @michalwj.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
Fine ultrastructural organization of glomerular neuropil in the developing zebrafish olfactory bulb
Across animal phyla, odor information is represented in the first olfactory processing center by combinatorial activation of discrete glomeruli. To examine how this organization of olfactory processin...
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Steven Cook @dumpyunc.bsky.social · 24/09/2026
A few words about what I’ve been up to at Flourish. Reach out if this resonates with you and you’d like to talk! fewerbetterfaster.substack.com/p/the-parts-...
fewerbetterfaster.substack.com
The Parts List AI Doesn’t Have
Mapping the human brain with light
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Reposted by Adrian Wanner
Sven Dorkenwald @sdorkenw.bsky.social · 17/09/2026
Applications are now open for the San Juan Winter School 2027 on Connectomics and Brain Simulation! Join us to learn how to analyze and simulate connectomes. sjcabs.com
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Tony Kelly @tonykellyeu.bsky.social · 13/09/2026
Very happy our work on a weird new nanoscale morphological feature is out in @science.org. A massive effort involving different high resolution microscopy techniques, multiple institutes, & years of work to convince ourselves DENDRITIC NARROWINGS EXIST #neuroskyence 🧪 doi.org/10.1126/scia...
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Dendritic shaft constrictions shape synaptic integration in neurons
For nearly 150 years, textbooks have described dendritic morphology as optimized for efficient synaptic voltage transfer from spines to the soma, implemented as a tubular design respecting Rall’s 3/2…
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Rainer Friedrich @rainerfriedrichlab.bsky.social · 10/09/2026
Just out in Nat Neurosci: disentangling of neural odor manifolds in "olfactory cortex" of adult zebrafish after learning. Great work by Bo, Nesibe et al and wonderful collaboration with @sueyeonchung.bsky.social that fundamentally changed my view of olfactory cortex. www.nature.com/articles/s41...
rdcu.be
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Max-Planck-Gesellschaft @maxplanck.de · 09/09/2026
We are hiring! Start at a #MaxPlanckInstitute with your own independent Max Planck Research Group. This position is equivalent to a W2 Professorship at a German university, or Associate Professor internationally. 🔗Apply until October 14th! www.mpg.de/career/max-p... #ScienceCareer #MPRG #TenureTrack
Call for independent Max Planck Research Groups
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Rainer Friedrich @rainerfriedrichlab.bsky.social · 08/09/2026
Ultrastructural reconstruction of hundreds of neurons by volume EM revealed cell types and a precise glomerular organization in the zebrafish olfactory bulb. A heroic effort by Nila! Special thanks to Nila @michalwj.bsky.social and the whole team! www.biorxiv.org/content/10.6...
biorxiv.org
Deep anatomical and ultrastructural classification of neurons in the zebrafish olfactory bulb
Neuronal circuits in the olfactory bulb (OB) perform computations fundamental to pattern classification including a decorrelation and normalization of odor-evoked activity. These computations are medi...
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Reposted by Adrian Wanner
Rainer Friedrich @rainerfriedrichlab.bsky.social · 08/09/2026
Imaging of activity in the telencephalon of adult zebrafish moving through a virtual reality revealed amazingly precise, structured internal representations of spatial environments. And they get better over time! Great work by Kim! Thanks also to Sriram and Jan. www.biorxiv.org/content/10.6...
biorxiv.org
Dynamic cognitive representations in the dorsal pallium of adult zebrafish
Brains rely on internal models of the world to interpret sensory input and to simulate the future. In the mammalian hippocampal-entorhinal network, environments are represented by cognitive maps that ...
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Rainer Friedrich @rainerfriedrichlab.bsky.social · 08/09/2026
New preprint by Tommaso: olfactory cortex (of zebrafish) represents not only odor information but also temporal context, and these multimodal representations are sharpened after learning. And check out Tommaso's new method for 2P imaging in awake adult zebrafish! www.biorxiv.org/content/10.6...
biorxiv.org
Joint experience-dependent representations of odors and temporal context in the zebrafish homolog of piriform cortex
Intelligent behavior requires experience-dependent internal representations of relevant information. We examined representational learning in telencephalic area pDp of adult zebrafish, the homolog of ...
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Reposted by Adrian Wanner
Dr. Or M. Bialik |📚|🔬|🌊|⚒️ @obialik.bsky.social · 03/09/2026
Fish with electrical senses have unique brain cells specifically to process that information. The real trick they pull is separating the electricity they emit from the ones they sense. 🧪 Link: www.nature.com/articles/s41586-026-…
a, Schematic of the interference problem facing the passive electrosensory system of weakly electric fish. Responses of EAFs to prey are masked by responses to the EOD of the fish, which vary depending on factors such as water conductivity. b, Schematic of prediction and cancellation of responses to the EOD. Predictions are based on electric organ corollary discharge signals conveyed by GCs (granule cell basis) and require specific patterns of synaptic connectivity. c, Summary diagram of the synaptic connectivity patterns revealed in the present study. Only connections comprising >10% of the total synapses to a given cell type are shown in the diagram. d, Two example Output cells (blue and red) are shown along with EAF (pink) and GC (magenta) inputs overlaid on a cutout of the EM volume (424 × 427 × 45 µm; all EM connectomic data are from a single biological specimen). The dorsal–ventral and anterior–posterior dimensions of the skin surface are mapped onto the x- and z-dimensions of the volume, respectively. The top inset shows example excitatory GC synapses (magenta fill and star) onto apical dendritic spines of the ON cell (red fill). The magenta fill marks the example GC axon visualized in the volume; the magenta star marks another GC axon. The white star marks an inhibitory molecular layer interneuron synapse onto the dendritic shaft of the same ON cell. The bottom inset shows an example excitatory EAF synapse (pink fill) onto the ON cell basal dendrite (red fill). mol, molecular layer; ggl, ganglion layer; plex, plexiform layer; gran, granular layer. e–h, Example reconstructions of major ELL cell types. Axons are shown in black. ON/OFF, Output (h); MG+/MG−, medium ganglion (f); SG+/SG−, small ganglion (g); Gr+, granular; SP−, small plexiform (h). The inset in f shows an example inhibitory synapse between an MG+ cell (orange) and an OFF cell soma (blue).
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Janelia FlyEM @janelia-flyem.bsky.social · 04/09/2026
We're thrilled with the publication of the Male CNS Connectome! www.cell.com/cell/fulltex... Also check out this (growing) collection of companion papers: www.cell.com/consortium/m...
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BWJones @bwjones.bsky.social · 18/08/2026
I finally got around to posting the HHMI Connectomics Berlin conference snapshots: bryanwjones.com/2026/07/hhmi... Some of ya'll are in here.
Noctilucent clouds
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Zhihao Zheng @zhihaozheng.bsky.social · 07/08/2026
Happy to share the CA3 dataset is published. First large-scale dense connectomics from hippocampus. First connectomic dataset imaged in @princetonneuro.bsky.social. A harbinger of many larger datasets to come (for both). doi.org/10.1038/s415... #hippocampus But my personal favorite is (1/2)
doi.org
Hippocampal CA3 connectomics reveals a gradient of mossy fiber inputs and selective feedforward inhibition onto pyramidal cells - Nature Neuroscience
The authors present a dense connectomic reconstruction of a 0.1 mm3 hippocampal CA3 volume and reveal spatial gradients, high convergence and cell-type-selective feedforward inhibition of inputs to py...
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Peter Rupprecht @ptrrupprecht.bsky.social · 07/08/2026
Excited to share our work now in Nature Methods! We wrote this manuscript to help others better analyze and interpret calcium imaging data. As a central aspect, we show why nonlinear behavior of calcium indicators matters in practice. Very happy about this work!
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Stanley Heinze @stanley-heinze.bsky.social · 30/07/2026
New preprint! www.biorxiv.org/content/10.6... Nearly a decade after starting the project, the first major results from our comparative connectomics work is online! Comparing the head direction circuits of the central complex in bees, ants and flies, recapitulating >300million years of evolution.
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Constantin Pape @cppape.bsky.social · 09/07/2026
Sharing a big update: I started a group at the MPINAT in Göttingen! We will develop AI for analyzing how proteins interact in the cellular environment based on cutting edge imaging. This appointment is in parallel to the university, where I will retain my current group.
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Gaspar Jekely @jekely.biologists.social.ap.brid.gy · 07/07/2026
Here are my slides for #fens2026 “A versatile and affordable array tomography workflow” jekelylab.codeberg.page/FENS_Array_… for the 'Expanding Horizons: Array Tomography in Neuroscience for All' […] [Original post on biologists.social]
ribbons of ultrathin sections in a scanning electron microscope, shown is a preview of the ribbons
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Wei-Chung Allen Lee @darbly.bsky.social · 09/06/2026
Now published - the #BANC! A full central nervous system (CNS) connectome of a limbed animal at single-synapse resolution, enabling us to follow sensory-motor arcs and understand how the CNS controls the body. rdcu.be/fncjS. #neuroscience. Video by @quorumetrix.bsky.social 1/18
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Adrian Wanner @adrianawanner.bsky.social · 19/05/2026
If you’re in or around Baden today, drop by... because Pint of Science Switzerland is back in town for a third time this year! 🧠 "Cracking the Brain's Code" 📆 Today: 19 May, 2026 📍 Kulturhaus Royal, Bahnhofstrasse 39 ⏰ Doors open: 6 PM pintofscience.ch #pintofscience
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Fiona Müllner @fionamuellner.bsky.social · 15/05/2026
🧠We offer 1-2 Postdoc positions in Circuit Neuroscience!🧠 Join us at @dandrite.bsky.social to study thalamic circuits for visual processing, funded by an ERC starting grant and the Lundbeck foundation. Deadline: 14. Juni 2026 Apply here: international.au.dk/about/profil...
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Fiona Müllner @fionamuellner.bsky.social · 15/05/2026
Our group uses cutting-edge neuroscience technologies and offers an intellectually stimulating and supportive environment. Join the vibrant DANDRITE community, enjoy a lab in walking distance to the baltic sea, a competitive Danish salary, and a lot more ☺️ Learn more: thalamic-circuits-lab.eu
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Franz Rieger @riegerfr.bsky.social · 21/04/2026
Can generative AI accelerate neuroscience? Excited to share MoGen at ICLR 2026!🧠 We use point cloud flow matching to generate high-fidelity 3D neuron fragments, capturing intricate details like dendritic spines.
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Georg Keller @georgkeller.bsky.social · 15/04/2026
This work was a collaborative effort between our lab and clinical experts at UPK Basel. The parallel approach of using mouse circuit and human patient data is likely the most promising approach we have to understanding the mechanism of psychiatric treatments. Full paper: doi.org/10.64898/202...
doi.org
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Everton J Agnes @ejagnes.bsky.social · 09/04/2026
New preprint with @sevberg.bsky.social! We map Hopfield-like binary networks onto spiking networks with dendrites … and it works! Same memory capacity, bigger basins of attraction, plus selective recall through dendritic gating, and more. How? Dendrites! See below.
doi.org
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Adrian Wanner @adrianawanner.bsky.social · 02/04/2026
Great opportunity to shape the future of X-ray connectomics (and much more 😉): @psi.ch is looking for a new head of the Center for Photon Science www.psi.ch/en/hr/job-op...
psi.ch
Head PSI Center for Photon Science (CPS)
The Paul Scherrer Institute PSI is the largest research institute for natural and engineering sciences in Switzerland. We design, build and operate the country’s large-scale research infrastructures a...
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Reposted by Adrian Wanner
Carles Bosch @carlesbosch.bsky.social · 24/03/2026
#paper: Drying tissue samples enhances contrast in X-ray phase contrast imaging while largely preserving ultrastructure. 🧠🔬 doi.org/10.1107/S160... @safekhan.bsky.social @andreas-t-schaefer.bsky.social @crick.ac.uk @embl.org @imperialcollegeldn.bsky.social @esrf.fr @uclnpp.bsky.social
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The Francis Crick Institute @crick.ac.uk · 18/03/2026
“We’re hoping doors will open for researchers to ask questions about how connections are made in the brain in mice and maybe, one day, humans.” - @andreas-t-schaefer.bsky.social Read about the new NIH-funded program to map brain circuitry using X-rays: www.crick.ac.uk/news/2026-03...
crick.ac.uk
Can X-rays reveal how the brain is wired?
Neuroscientist Andreas Schaefer is spearheading a new project to capture the intricacies of the mouse brain using X-rays, bringing researchers closer to a complete map of its neural connections.
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Thomas Frank @frankfishlab.bsky.social · 17/03/2026
Exciting new results from our neighbors in the @mace-lab.bsky.social! Using functional ultrasound imaging, they look at brain-wide activity patterns in response to arousing events, showing propagation from subcortical regions to the cortex, and find a surprisingly weak modulation by noradrenaline!
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Benjamin Judkewitz @benjulab.bsky.social · 16/03/2026
How do fish localize sound without interaural cues? @johve.bsky.social et al. found a behavioral algorithm for directional hearing that predicts behavior from a pressure/motion phase comparison and accounts for how this relationship varies with distance. www.cell.com/current-biol...
cell.com
An algorithm underlying directional hearing in fish
Veith et al. show how a fish—Danionella cerebrum—can reliably startle away from sound. It uses the relative phase between particle motion and pressure to infer the direction of sound. This sensorimoto...
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albaneimbert.bsky.social @albaneimbert.bsky.social · 23/02/2026
Job alert! Join the Making Lab at the @crick.ac.uk. As a senior engineer in system design, programming, and hardware–software integration, you'll develop systems that make unique experiments possible. More about the role and apply here: crick.wd3.myworkdayjobs.com/External/job...
crick.wd3.myworkdayjobs.com
Senior/Principal Laboratory Research Scientist
Salary for this Role: SLRS: From £45,700 per annum with benefits, subject to skills and experience PLRS: From £55,555 per annum with benefits, subject to skills and experience Job Title: Senior/Princi...
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Casey Schneider-Mizell @csdashm.com · 20/02/2026
From @bdpedigo.bsky.social: a super efficient, highly reliable, and very generalizable method for mesh structure classification, applied here to spine detection across basically every synapse onto a cell in the MICRoNS dataset.
Mesh analysis pipeline showing feature extraction and spine classification.
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wiley.com @wiley.com · 18/02/2026
The Wiley Foundation is pleased to announce the winners of the 24th annual Wiley Prize in Biomedical Sciences, which recognizes contributions that open new fields of research or advance concepts in a particular biomedical discipline. Learn more: ow.ly/ZaiM50YhCF6
Four diverse individuals honored as winners of the 24th annual Wiley Prize in Biomedical Sciences.
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Gaspar Jekely @jekely.biologists.social.ap.brid.gy · 18/02/2026
In @eLife: Neural connectome of the ctenophore statocyst doi.org/10.7554/eLife.108420 Version of record of our ctenophore nerve-net connectome paper.
elifesciences.org
Neural connectome of the ctenophore statocyst
Volume EM and connectome reconstruction of the apical organ of a ctenophore combined with high-speed imaging reveals a neuronal coordination of balancer cilia in the gravisensory organ.
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Adrian Wanner @adrianawanner.bsky.social · 06/02/2026
What it's like to be a connectome
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National Academy of Sciences @nasonline.org · 22/01/2026
The winner of the 2026 Pradel Research Award is H. Sebastian Seung of @princetonneuro.bsky.social! He is being honored for for transformative advances in computational neuroscience. Learn more about his discoveries: www.nasonline.org/award/pradel... #NASaward #neuroscience
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adamezracohen.bsky.social @adamezracohen.bsky.social · 21/01/2026
What's the relation between voltage and calcium in dendrites? Xiang Wu studied this in CA2 hippocampal pyramidal cells in behaving mice. www.biorxiv.org/content/10.6...
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FocalPlane @focalplane.bsky.social · 14/01/2026
🔬🔦Our latest ‘Imaging spotlight’, by @carlesbosch.bsky.social, Ana Diaz, @adrianawanner.bsky.social & @andreas-t-schaefer.bsky.social, highlights the non-destructive X-ray tomography pipeline that the authors developed to map mouse brain ultrastructure & considers future applications & developments.
focalplane.biologists.com
Imaging spotlight: Revealing mouse brain ultrastructure using non-destructive X-ray tomography - FocalPlane
Imaging spotlight: Revealing mouse brain ultrastructure using non-destructive X-ray tomography - News
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Gaspar Jekely @jekely.biologists.social.ap.brid.gy · 13/01/2026
If you are interested in electron microscopy, registration is still open for the "Electron Microscopy Hands-On Course: sample preparation and imaging of marine environmental samples" at Stazione Zoologica in Naples. WIth great teachers from Naples […] [Original post on biologists.social]
Poster of the EM course in Naples with marine samples. The Electron Microscopy Hands-On Course: sample preparation and imaging of marine environmental samples arises from a very strong and active collaboration between the Stazione Zoologica Anton Dohrn and the EMBL in Heidelberg.
The aim of the course is to provide a theoretical and practical training on electron microscopy starting from the basics to the preparation of samples with high pressure freezing and image acquisition using TEM and SEM.
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Gaspar Jekely @jekely.biologists.social.ap.brid.gy · 16/12/2025
Our dispatch: www.sciencedirect.com/science/artic… on the recent Hydra volume EM paper by Zhang, Rafa Yuste and colleagues: #connectomics, without synapses www.sciencedirect.com/science/artic… #neuroscience
Two nerve nets are formed in Hydra vulgaris: the endodermal (cyan) and the ectodermal (purple) net. (B) Intraepithelial neurons are randomly scattered between the epithelial cells of the two germ layers. (C) Two types of connections have been found between Hydra’s neurons. (D) Endodermal neurons are in physical touch with each other by forming neural handshakes by digiform endings, which get intertwined. (E) In other places, clusters of vesicles of different types can be released to mediate volume transmission between neurons and between neurons and other cells.
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John Tuthill @tuthill.bsky.social · 09/12/2025
How do neural circuits generate the walking rhythm? Using connectome simulations, @sarahpugly.bsky.social found a minimal central pattern generator (CPG) that produces oscillations in leg motor neurons. Same circuit motif for each 🪰 leg. w @bingbrunton.bsky.social www.biorxiv.org/content/10.1...
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Rui Costa @ruimcosta.bsky.social · 09/12/2025
Last night Adam Kampff, the glue, the light, the catalyst, the builder, the smile, left us. He and his work transformed the lives of many labs, scientists, students. He inspired and was generous to his last transformation, working tirelessly to set up a foundation to continue the work.Thank you!
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Nature Methods @natmethods.nature.com · 08/12/2025
Our Method of the Year 2025 is...drumroll please...EM-based connectomics!! Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬 www.nature.com/articles/s41...
nature.com
Method of the Year 2025: electron microscopy-based connectomics - Nature Methods
A large network of interconnected neurons serves as the basis of brain function and of behavior. Methodological advances have enabled the reconstruction of large-scale and even whole-brain connectomes...
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Moritz Helmstaedter @mhlab.bsky.social · 08/12/2025
Connectomics is Method of the Year 2025!! @natmethods.nature.com just released the news nature.com/articles/s41... In my perspective piece, I afford some predictions into the future and compare how we are doing vs. genomics www.nature.com/articles/s41...
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Adrian Wanner @adrianawanner.bsky.social · 08/12/2025
Connectomics is method of the year 2025: www.nature.com/articles/s41...
nature.com
Method of the Year 2025: electron microscopy-based connectomics - Nature Methods
A large network of interconnected neurons serves as the basis of brain function and of behavior. Methodological advances have enabled the reconstruction of large-scale and even whole-brain connectomes...
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Nature Methods @natmethods.nature.com · 04/12/2025
An optimized X-ray nanotomography method offers an attractive alternative to volume EM for connectomics. @crick.ac.uk @psich.bsky.social psich.bsky.social @adrianawanner.bsky.social @andreas-t-schaefer.bsky.social @ucl.ac.uk @uclnpp.bsky.social www.nature.com/articles/s41...
nature.com
Nondestructive X-ray tomography of brain tissue ultrastructure - Nature Methods
Optimizations of X-ray nanotomography including the choice of resin allows high-resolution imaging of mouse brain tissue, approaching the resolution of volume electron microscopy. Since it does not re...
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Aaron Kuan @kuanawanda.bsky.social · 27/11/2025
Our new paper showcasing molecular connectomics with pan-expansion microscopy is out in @natbiotech.nature.com! www.nature.com/articles/s41... This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
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Carles Bosch @carlesbosch.bsky.social · 27/11/2025
#paper! X-rays can resolve #ultrastructure in tissues non-destructively. www.nature.com/articles/s41... Shoutout to key collaborators at @crick.ac.uk and @psich.bsky.social Ana Diaz, @adrianawanner.bsky.social and @andreas-t-schaefer.bsky.social, and to the whole team that made this possible.
nature.com
Nondestructive X-ray tomography of brain tissue ultrastructure - Nature Methods
Optimizations of X-ray nanotomography including the choice of resin allows high-resolution imaging of mouse brain tissue, approaching the resolution of volume electron microscopy. Since it does not re...
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Adrian Wanner @adrianawanner.bsky.social · 27/11/2025
Happy to share the first paper from my journey at @psich.bsky.social towards X-ray connectomics, now out in @natmethods.nature.com: www.nature.com/articles/s41...
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David A. Markowitz @davidamarkowitz.bsky.social · 17/11/2025
For a decade, my white whale as a neuroscientist has been working to convince public+private funders to "go big" on post-mortem human tissue analysis, so we can define circuit disruptions in disease and just maybe link them with molecular drivers. This remains as tough a sell today as 10 years ago.
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