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Albert Vilella, PhD.

@albertvilella.bsky.social
44K followers 43K following 3.3K posts

Bioinformatics Scientist / Next Generation Sequencing, Single Cell and Spatial Biology, Next Generation Proteomics, Liquid Biopsy, SynBio, AI/ML in biotech // albertvilella.substack.com

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Albert Vilella, PhD. @albertvilella.bsky.social · 29/09/2026
Oxford @nanoporetech.com stock breaks above GBX200: are we near an M&A deal? albertvilella.substack.com/p/oxford-nan...
albertvilella.substack.com
Oxford Nanopore breaks above GBX200 - updated stock price and M&A analysis
Are we near an acquisition deal?
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Albert Vilella, PhD. @albertvilella.bsky.social · 25/09/2026
Steve Eisman (played by S. Carell in the Big Short)
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Albert Vilella, PhD. @albertvilella.bsky.social · 11/09/2026
Interesting new AI stock modelling account @hadestock.bsky.social . Does it reply every time I mention a stock? Let's start with Illumina $ILMN
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Albert Vilella, PhD. @albertvilella.bsky.social · 10/09/2026
Webinar by 10X Genomics $TXG on Atera roadmap
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Albert Vilella, PhD. @albertvilella.bsky.social · 10/09/2026
UBS, Leerink, and Cannacord Genuity continue expanding their coverage of Liquid Biopsy companies albertvilella.substack.com/p/ubs-leerin...
albertvilella.substack.com
UBS, Leerink and Cannacord Genuity continue expanding coverage of Liquid Biopsy companies
Explainer on why it matters for financial analysts to cover biotech stocks
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Albert Vilella, PhD. @albertvilella.bsky.social · 08/09/2026
More information about the capabilities of @elembio.bsky.social Multiomics platform. One can now perform any combination of the following running an AVITI24 instrument during one moth at 75% capacity:
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Albert Vilella, PhD. @albertvilella.bsky.social · 06/09/2026
Newborn genomic sequencing to detect rare diseases albertvilella.substack.com/p/an-update-...
albertvilella.substack.com
An update on newborn genomic sequencing and diagnostics
Illumina and Oxford Nanopore as main contenders in this field
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Albert Vilella, PhD. @albertvilella.bsky.social · 02/09/2026
#VibeCoding
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Albert Vilella, PhD. @albertvilella.bsky.social · 02/09/2026
Commoditizing the $ per million tokens at a fast pace
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Albert Vilella, PhD. @albertvilella.bsky.social · 02/09/2026
Check out my new post with news in the #LiquidBiopsy and #EpigenomicsProfiling segments. albertvilella.substack.com/p/advances-i...
albertvilella.substack.com
Advances in Liquid Biopsy and Epigenomic Profiling
Guardant Health, Senticell and Heidelberg Epignostix updates
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Albert Vilella, PhD. @albertvilella.bsky.social · 01/09/2026
Time of reckoning for Nautilus Bio and Parse Bio (now part of Qiagen), and other NGS and Multiomics news albertvilella.substack.com/p/time-of-re...
albertvilella.substack.com
Time of reckoning for Nautilus Bio and Parse (Qiagen)
And other news in NGS and Multiomics
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Albert Vilella, PhD. @albertvilella.bsky.social · 31/08/2026
Open weight models narrowing the gap against frontier models
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Albert Vilella, PhD. @albertvilella.bsky.social · 30/08/2026
Compute acceleration data transfer speeds
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Albert Vilella, PhD. @albertvilella.bsky.social · 29/08/2026
Memory prices
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Albert Vilella, PhD. @albertvilella.bsky.social · 29/08/2026
Memory vs speed in modern accelerated compute
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Albert Vilella, PhD. @albertvilella.bsky.social · 28/08/2026
#Linux #kernel input new code per release has quadrupled since the new AI/LLM era
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Albert Vilella, PhD. @albertvilella.bsky.social · 28/08/2026
Growth prospects for Illumina $ILMN and other NGS contenders like Oxford @nanoporetech.com and @pacbio.bsky.social in the new reality of personalized cancer vaccines albertvilella.substack.com/p/growth-pro...
albertvilella.substack.com
Growth prospects for Illumina and other NGS contenders
What do the competitors have to offer in this new world of personalized cancer vaccines?
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Albert Vilella, PhD. @albertvilella.bsky.social · 27/08/2026
Something that I thought was bound to happen is starting to be published in preprints like the one below: using Language Models, either protein or DNA, to aide with the sequence alignment of query sequences.
github.com
GitHub - Shoaib-CS/Adaptive-Banding-Needleman-Wunsch-PLM
Contribute to Shoaib-CS/Adaptive-Banding-Needleman-Wunsch-PLM development by creating an account on GitHub.
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Albert Vilella, PhD. @albertvilella.bsky.social · 25/08/2026
More news in #MCED as well as #AIProteinDesign albertvilella.substack.com/p/advances-i...
albertvilella.substack.com
Advances in AI-driven Protein Design, MCED adoption, and more lawsuits!
NGS and Multiomics news -- 25th August 2026
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Albert Vilella, PhD. @albertvilella.bsky.social · 21/08/2026
It's an honour to be in the same #Substack ranking table this week with @semianalysis.bsky.social and @ericnewcomer.bsky.social
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Albert Vilella, PhD. @albertvilella.bsky.social · 21/08/2026
Rumours of Oxford @nanoporetech.com being acquired for their nanopore IP pool albertvilella.substack.com/p/rumors-of-...
albertvilella.substack.com
Rumors of Oxford Nanopore being acquired for nanopore IP pool
And other news in NGS, Liquid Biopsy, Single Cell Multiomics and other fields
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Albert Vilella, PhD. @albertvilella.bsky.social · 20/08/2026
The stock is up GBX160, could this be acquisition rumours leaking out?
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Albert Vilella, PhD. @albertvilella.bsky.social · 20/08/2026
A fresh post on Oxford @nanoporetech.com and their prospects in non-research segments. There is always a free section of the post with most of the factual information free for all, including non-subscribers to my Substack. The ONT stock reached GBX150 this morning in UK trading.
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Albert Vilella, PhD. @albertvilella.bsky.social · 20/08/2026
A bump in the #Biotech stocks in recent trading sessions, lifting the likes of Oxford @nanoporetech.com , partly also due to good news by #Moderna on their recent Phase 3 melanoma trial. albertvilella.substack.com/p/oxford-nan...
albertvilella.substack.com
Oxford Nanopore outlines plan to grow into non-research segments
Biotech is given an AI-bump in recent trading sessions
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Albert Vilella, PhD. @albertvilella.bsky.social · 19/08/2026
News in #NGS and #Multiomics for the first half of the not-so-sleepy month of August 2026 albertvilella.substack.com/p/ngs-and-mu...
albertvilella.substack.com
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Albert Vilella, PhD. @albertvilella.bsky.social · 19/08/2026
#AI #DrugDesign
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Albert Vilella, PhD. @albertvilella.bsky.social · 17/08/2026
I had firsthand exposure to the data coming out of Epinoma's EpiAmp technology, which can amplify cfDNA molecules whilst preserving the 5mC methylation marks, and wrote a post with the findings and what it means for Early Cancer detection assays. albertvilella.substack.com/p/methylatio...
albertvilella.substack.com
Methylation liquid biopsy reaches a new level of sensitivity with Epinoma's EpiAmp technology
Overcoming the limitations of blood-based cfDNA Liquid Biopsy with EpiAmp
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Albert Vilella, PhD. @albertvilella.bsky.social · 14/08/2026
Lots of chatter about a possible M&A move in the #NGS #LongReads companies, either Oxford @nanoporetech.com or PacBio $PACB @pacbio.bsky.social or both. There are a few other long-reads companies out there, but not nearly as established.
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Albert Vilella, PhD. @albertvilella.bsky.social · 11/08/2026
I sometimes wondered why Germany wasn't bigger in the Next-Generation Sequencing #NGS and #Multiomics picture. And in general in the spin-outs of universities as the plot shows.
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Albert Vilella, PhD. @albertvilella.bsky.social · 07/08/2026
Both NGS long-reads companies in the stock market, Oxford @nanoporetech.com and @pacbio.bsky.social have now presented H1 2026 results, and I give an analysis of where they are and where they might be going from now on in this piece on my Substack albertvilella.substack.com/p/ngs-long-r...
albertvilella.substack.com
NGS Long Reads H1 2026 financials for PacBio and Oxford Nanopore
And more announcements from both companies
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Albert Vilella, PhD. @albertvilella.bsky.social · 06/08/2026
Elon Musk is yet again giving wild predictions of what his companies are going to be achieving in a few years time, but this time isn't affecting what brand the robotaxi will be, Waymo or Tesla, but rather predicting the future of medicine, or to be more precise, surgery.
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Albert Vilella, PhD. @albertvilella.bsky.social · 06/08/2026
This is truly a reshuffle... They must have lots of ideas they want to pursue outside the Deepmind remit
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Albert Vilella, PhD. @albertvilella.bsky.social · 05/08/2026
This is truly a reshuffle... They must hate lots of ideas they want to pursue outside the Deepmind remit
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Albert Vilella, PhD. @albertvilella.bsky.social · 04/08/2026
Via @aixbiobot.bsky.social A Structural Antibody Benchmark of AlphaFold3 reveals Hallucinated Epitopes and a Bias for Orderness www.biorxiv.org/content/10.6...
biorxiv.org
A Structural Antibody Benchmark of AlphaFold3 reveals Hallucinated Epitopes and a Bias for Orderness
AlphaFold3 has shown promise as a tool for predicting antibody-antigen binding, yet its performance across large datasets has not been fully characterized. In this study, 3401 experimentally validated...
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Albert Vilella, PhD. @albertvilella.bsky.social · 03/08/2026
#LymeDisease
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Albert Vilella, PhD. @albertvilella.bsky.social · 03/08/2026
Illumina $ILMN Q2 2026 results: 83% of the Gigabases for 59% of the Dollars, and the Axelios threat open.substack.com/pub/albertvi...
open.substack.com
Illumina Q2 2026 results: 83% of the Gigabases for 59% of the Dollars, and the Axelios threat
This is the best reported quarter Illumina has printed in three years, and almost none of it came from the line that is supposed to carry the story.
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Albert Vilella, PhD. @albertvilella.bsky.social · 29/07/2026
I did not have this in my bingo card this year: "DeepMind dismantles AlphaFold team in strategy shift" #Alphafold #AI #Biotech #DeepMind
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Albert Vilella, PhD. @albertvilella.bsky.social · 21/07/2026
One of the companies I track in my Substack will begin trading in the stock market today: Freenome $FRNM
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Albert Vilella, PhD. @albertvilella.bsky.social · 21/07/2026
Are we there yet? Biotech stock and VC funds recovering from a long desert crossing period. What would happen if the AI bubble were to burst tomorrow? open.substack.com/pub/albertvi...
open.substack.com
Are we there yet? Biotech stock and VC funds recovering from a long desert crossing period
What would happen if the AI bubble were to burst tomorrow?
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Albert Vilella, PhD. @albertvilella.bsky.social · 20/07/2026
Tempus AI $TEM agrees to acquire Personalis $PSNL for $1.5B And what it means for Cancer Diagnostics, Liquid Biopsy and Early Cancer Screening open.substack.com/pub/albertvi...
open.substack.com
Tempus AI agrees to acquire Personalis for $1.5B
And what it means for Cancer Diagnostics, Liquid Biopsy and Early Cancer Screening
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Albert Vilella, PhD. @albertvilella.bsky.social · 20/07/2026
UniFlow: Unifying protein conformational ensemble generation and machine-learned force fields with a scalable normalizing Flow www.biorxiv.org/content/10.6...
biorxiv.org
UniFlow: Unifying protein conformational ensemble generation and machine-learned force fields with a scalable normalizing Flow
Molecular dynamics (MD) provides a principled method for modeling equilibrium protein conformational energy landscapes, but its computational cost limits access to long timescales and larger protein s...
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Albert Vilella, PhD. @albertvilella.bsky.social · 20/07/2026
About 14.6% of #Bioinformatics #Scientists and #Computational #Biologists now have a @bsky.app account. My estimates is that there are about: 13,000 Bioinformatics Scientists with an active social media profile, and round 2,300 Computational Biologists, out of which around 14.6-14.7% have Bluesky.
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Albert Vilella, PhD. @albertvilella.bsky.social · 15/07/2026
Element Bio @elembio.bsky.social wins a court battle against @illumina in Germany, and what it means for the #NGS and #Multiomics fields moving forward open.substack.com/pub/albertvi...
open.substack.com
Element Bio succeeds in German court battle against Illumina over MiSeq and MiSeqDx instruments
And what it means for the NGS and Multiomics segment moving forward
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Albert Vilella, PhD. @albertvilella.bsky.social · 13/07/2026
I am doing more investigating on the uptake of @bsky.app by the #Bioinformatics and #ComputationalBiology community. I found 2114 accounts where the Bio contains the words "Bioinformatics" or "Computational Biology", out of which the large majority are personal but there are some institutional ones.
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Albert Vilella, PhD. @albertvilella.bsky.social · 13/07/2026
Are we moving into a new world where #Multiomics and #AI can help develop diagnostic tests in a fraction of the time than before? open.substack.com/pub/albertvi...
open.substack.com
Sera Prognostics Company Profile
Are we moving into a new world where Multiomics and AI can help develop diagnostics tests at a fraction of the time than before?
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Albert Vilella, PhD. @albertvilella.bsky.social · 11/07/2026
Remarkable progress in cardiovascular disease
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Albert Vilella, PhD. @albertvilella.bsky.social · 10/07/2026
Freenome has updated the performance metrics for the v2 of their SimpleScreen #CRC assay. But what does it mean for the field of #LiquidBiopsy #NGS #CancerDx ? open.substack.com/pub/albertvi...
open.substack.com
Freenome's updated sensitivity values for their SimpleScreen CRC assay
Updated test version achieved significant performance improvement in detecting advanced precancerous lesions, including those with high-grade dysplasia
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Albert Vilella, PhD. @albertvilella.bsky.social · 09/07/2026
Concentration of the Nifty Fifty over the different decades
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Albert Vilella, PhD. @albertvilella.bsky.social · 09/07/2026
What will happen to #biotech stocks if the #AIBubble suddenly bursts? @stepheninnes thinks part of the money could be reallocated to biotech and other sectors
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Albert Vilella, PhD. @albertvilella.bsky.social · 09/07/2026
#NGS and #Multiomics news 9th July 2026 including @alignedbio new nanowire-based sequencing system to turn Illumina SBS into a single-molecule method. open.substack.com/pub/albertvi...
open.substack.com
NGSX News 9th of July 2026
Aligned Bio new Nanowire Sequencing Technology, and other pieces of NGS and Multiomics news around the world
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