Targeted therapy (with BRAK and MEK inhibitors) and immune checkpoint blockade have improved survival for patients with advanced BRAF-mutant cutaneous melanoma, however, the optimal scheduling for the...

The vision of human-level machine intelligence laid out by Alan Turing in the 1950s is now a reality. Eyes unclouded by dread or hype will help us to prepare for what comes next.

View details and apply for this Postdoctoral Training Fellow - Genomics and Evolutionary Dynimcs vacancy in Sutton. Salary: Dependent on relevant Postdoctoral experience. Durati...

View details and apply for this Data Scientist vacancy in Sutton. Salary : Salary range £39,805 - £53,500 (Salary appointment dependent on experience ) Reporting to: P...

Dr Baker and Professor Graham are developing a non-invasive way to predict bowel cancer risk in people who have inflammatory bowel disease.

Somatic mutations that increase the fitness of hematopoietic stem cells (HSCs) drive their expansion in clonal hematopoiesis (CH) and predispose individuals to blood cancers. Population variation in t...

Cell segmentation and phenotyping in histopathology samples are essential techniques applied across diagnostic and research workflows. However, annotation by human experts requires significant time an...

Prostate cancer progression is driven by heterogenous genetic, phenotypic, and microenvironmental programs that remain challenging to model experimentally. Existing systems such as genetically enginee...

We are seeking a highly motivated and accomplished Associate Scientist to help lead and shape the programme. You will act as an operational deputy to Professor Samra Turajlic, helping to bridge activi...

View details and apply for this Data Scientist vacancy in Sutton. Salary : Salary range £39,805 to £53,500 (Dependent on experience ) Reporting to: Professor Trevor Gra...

This study nominates immune escape as an early event in colorectal cancer and shows how this can be driven through both genetic and epigenetic changes.

EvoMG-DN is a European Doctoral Network funded by the Horizon Europe Marie Skłodowska-Curie Actions (MSCA), composed of 14 beneficiaries and associated partners from both academic and non-academic sectors.

Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

A single-cell sequencing study using more than 30,000 tumour genomes from human ovarian cancers shows that whole-genome doubling is an ongoing mutational process that drives tumour evolution and disru...

In this review, we argue that mathematical modelling is an essential tool for understanding cancer cell evolution and phenotypic plasticity. We show t…

Comparative oncology combines evolutionary biology, ecology, veterinary medicine and clinical oncology to better understand cancer, for example, by identifying the molecular and cellular mechanisms un...

Understanding the dynamics of how drug resistance originates in cancer remains crucial, but it is not possible to observe them directly. Here, the authors construct a mathematical framework to infer d...

The authors show that aberrant epithelial GREM1 expression remodels intestinal stroma to form ectopic stem cell niches in mice. Anti-GREM1 reversed these changes, highlighting a potential strategy for...

View details and apply for this Higher or Senior Scientific Officer vacancy in Sutton. Salary : Salary from 39,805 to 49,023 Reporting to: Prof Trevor Graham Duration of ...

View details and apply for this Data Scientist vacancy in Sutton. Salary : Salary range £39,805 to £49,023 (depending on the experience) Reporting to: Professor Trevor Graham ...

Graham and colleagues analyzed locally advanced esophageal adenocarcinoma clinical trial patient samples and identified major changes in gene expression profiles and immune microenvironment compositio...

xAI trained on >100,000 random peptides predicts and elucidates primary sequence determinants of aggregation.

Abstract. Drug resistance results in poor outcomes for cancer patients. Adaptive therapy is a potential strategy to address drug resistance that exploits competitive interactions between sensitive and...

Epigenetic alterations co-evolve with genetic mutations to drive carcinogenesis and treatment response. Resolving genome-epigenome coevolution requires accurate multi-omic single cell measurement. Her...

View details and apply for this Higher or Senior Scientific Officer vacancy in Sutton. Salary : Salary from 39,805 to 49,023 Reporting to: Prof Trevor Graham Duration of ...