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Mikala Egeblad

@megeblad.bsky.social
2.3K followers 348 following 69 posts

Bloomberg Distinguished Professor of Tumor Microenvironment. Johns Hopkins University School of Medicine.

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Reposted by Mikala Egeblad
Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 30/07/2025
Delighted to see this story out and collaborate with amazing teams led by @jdegregori.bsky.social Mercedes Rincon & @roelvermeulen.bsky.social. Proud to see science propelled by our lab @cdi-einstein.bsky.social expanded to better understand cancer dormancy. Congrats! www.nature.com/articles/s41...
nature.com
Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature
Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...
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Reposted by Mikala Egeblad
Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 30/07/2025
www.medpagetoday.com/hematologyon...
medpagetoday.com
COVID Infection May Ignite Dormant Cancer in Survivors, Study Says
These patients should consider vaccination against respiratory viruses, according to researcher
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Reposted by Mikala Egeblad
Max Kozlov @maxkozlov.bsky.social · 30/07/2025
Hidden in the lungs of some breast cancer survivors are tumor cells that can remain dormant for decades — until they one day trigger a relapse. Now, experiments show for the first time these rogue cells can be roused from their slumber by common respiratory illnesses such as COVID-19 or the flu.
nature.com
‘Sleeping’ cancer cells in the lungs can be roused by COVID and flu
Inflammation from the respiratory infections seems to be the culprit, study in mice finds.
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Reposted by Mikala Egeblad
Duke Institute for Brain Sciences @dukebrain.bsky.social · 25/07/2025
For early career researchers in our community - this is invaluable. Info here: public.csr.nih.gov/ForReviewers...
public.csr.nih.gov
Early Career Reviewer (ECR) Program | NIH Center for Scientific Review
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Reposted by Mikala Egeblad
Hannah Meyer @hannahvmeyer.bsky.social · 25/07/2025
Check out how we tackled one of the fundamental challenges in immunology, out today @cp-cellsystems.bsky.social: www.cell.com/cell-systems.... Our major innovations are BATCAVE and BATMAN, two new players to get us closer to solving TCR-pMHC predictions!
cell.com
T cell receptor cross-reactivity prediction improved by a comprehensive mutational scan database
Banerjee et al. present a comprehensive T cell receptor cross-reactivity database and a hierarchical Bayesian framework to predict T cell receptor targets. Together, they reveal structural and biochem...
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Reposted by Mikala Egeblad
Elizabeth McKenna @elizsmckenna.bsky.social · 22/07/2025
It's my first #newPI roll call on BlueSky! Calling all new #cancer PIs who just started or who are about to start their labs! Please say hi and what you work on so I can follow you if I don't already! 😃
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Reposted by Mikala Egeblad
Max Perutz Labs Vienna @maxperutzlabs.ac.at · 23/07/2025
📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Mechanistic Cell and Developmental Biology. More details ➡️ tinyurl.com/3fbkp89c
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Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 23/07/2025
@megeblad.bsky.social once more revealing significant cancer biology - Congrats! www.nature.com/articles/s41...
nature.com
Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
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Reposted by Mikala Egeblad
JHU Bloomberg Distinguished Professorships @jhu-bdps.bsky.social · 23/07/2025
A fascinating study reports that neutrophils and NETs actively induce tumor necrosis. Congratulations, BDP @megeblad.bsky.social and @adrover.bsky.social on your latest publication in @nature.com.
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Jacky Goetz @goetzjacky.bsky.social · 18/07/2025
Our latest review !
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Elizabeth McKenna @elizsmckenna.bsky.social · 18/07/2025
Great news! The AACR journals are now on BlueSky! Be sure to follow @aacrjournals.bsky.social!! #FollowFriday
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Reposted by Mikala Egeblad
Aaron J. Waltke @goodaaron.bsky.social · 18/07/2025
I can confirm the PBS Passport is a very good deal for $5/month or $2.50/month if you do yearly. Thousands of hours of top notch content. NOVA is great. The new Ken Burns doc on Leonardo da Vinci is excellent. You can sign up at the link below! www.pbs.org/passport/lea...
pbs.org
PBS: Public Broadcasting Service
Watch full episodes of your favorite PBS dramas, find in-depth news analysis and explore documentaries on history, science, art and more!
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Claire McCarthy @clairem402.bsky.social · 18/07/2025
Check out some #CoolScienceImages (with music by Victor Leksell) from a @nature.com paper. In the study, @adrover.bsky.social, @megeblad.bsky.social, et al. found that neutrophil extracellular traps (NETs) drive tumor necrosis and metastasis: www.nature.com/articles/s41... #FluorescenceFriday 🧪
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Mikala Egeblad @megeblad.bsky.social · 17/07/2025
As a new postdoc in my lab (@cshlnews.bsky.social → @jhu.edu) @adrover.bsky.social (now @crick.ac.uk) saw NETs in tumors—I shrugged. But he looked closer in 3D: NETs block tumor vessels, driving necrosis, hypoxia, EMT & metastasis. 🔗 www.nature.com/articles/s41... @jhu-bdps.bsky.social @nature.com
nature.com
Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
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Reposted by Mikala Egeblad
Alejandro Brenes @ajbrenes.com · 17/07/2025
Exciting new work at @nature.com showing that Neutrophil Extracellular Traps in the vasculature can actively promote necrosis in cancer and that targeting NETs is can reduce necrosis and metastasis. Great work from @adrover.bsky.social @megeblad.bsky.social
nature.com
Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
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Reposted by Mikala Egeblad
Jose M. Adrover @adrover.bsky.social · 17/07/2025
I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13) www.nature.com/articles/s41...
nature.com
Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
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Reposted by Mikala Egeblad
Jose M. Adrover @adrover.bsky.social · 29/04/2025
I had a wonderful time in the Tumor Microenvironment Working Group session! #AACR25 Thanks everyone for the warm welcome and lively discussion!
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EACR - European Association for Cancer Research @helloeacr.bsky.social · 15/07/2025
EACR-@themarkfdn.bsky.social Postdoctoral Fellowships are awarded for a period of three years and support excellent postdoctoral researchers in laboratories throughout Europe. Is that you? Apply by 20 August: eacr.org/eacr-fellows...
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Reposted by Mikala Egeblad
Ivan Zanoni @lozanzi.bsky.social · 15/06/2025
#WeekendRead! #BeyondNETosis! @caroleparentlab.bsky.social @sbarya.bsky.social &co show @natcellbio.nature.com that neutrophils can secrete nuclear-derived exosomes containing LTB4 & DNA which direct migration but at also favor inflammation resolution via neutrophil retrotransmigration!
go.nature.com
Neutrophils secrete exosome-associated DNA to resolve sterile acute inflammation - Nature Cell Biology
Arya et al. report that migrating neutrophils resolve acute inflammation by releasing exosomes associated with nuclear DNA. This process is distinct from the release of neutrophil extracellular traps,...
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Reposted by Mikala Egeblad
Claus Jorgensen @clausjorgensen.bsky.social · 07/06/2025
We are looking for a postdoctoral fellow to come work with us: www.cruk.manchester.ac.uk/career/mi-25... Please reach out
cruk.manchester.ac.uk
MI/25/33 - Postdoctoral Scientist Systems Oncology Group | Cancer Research UK Manchester Institute
Add brief description here
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Carl T. Bergstrom @carlbergstrom.com · 07/06/2025
Very smart, high ROI initiative from the Spencer Foundation. Providing bridge funding for canceled NSF grants: 1) directs funds to projects already screened by a top-noch review process. 2) avoids imposing proposal prep costs on researchers. 3) ameliorates the disruption from GOP sabotage.
spencer.org
Rapid Response Bridge Funding Program
In the face of recent abrupt shifts in federal funding for education research, including large-scale terminations of National Science Foundation (NSF) research grant awards, we have developed a rap...
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Mike Piacentino @mikepiacentino.bsky.social · 29/05/2025
I'm so excited for #ICDB2025, it's looking like such a great meeting and I'm honored to share our work!
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Society for Immunotherapy of Cancer @sitcancer.bsky.social · 29/05/2025
Only a few days left before The CheckPoints: Rockin’ for a Cure! Join us on Sunday, June 1 at Buddy Guy’s Legends in Chicago. A suggested donation of $30 at the door will support the #SITCForwardFund. Learn more: www.sitcancer.org/about/the-ch...
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Reposted by Mikala Egeblad
Michael Love @mikelove.bsky.social · 29/05/2025
Up until June 2 (Monday) you can apply for scholarship to attend GBCC2025 at Cold Spring Harbor Laboratory. This is the Bioconductor / Galaxy joint conference at the end of June. You should submit a poster abstract to apply for scholarship. Scholarship details below.
Scholarship Tiers:
• Tier 1 (registration + travel support up to $700) is limited and highly competitive.
Only select this if you cannot attend without travel funding. A brief justification is required.
• Tier 2 (registration only) is for applicants who can cover their own travel. You must confirm that travel funding is secured.
• Tier 3 will cover the VIRTUAL conference registration only.
What Registration Includes (Tiers 1 & 2)
• Full access to sessions, workshops, and networking events
• Daily meals (breakfast, lunch, dinner)
• Welcome reception and banquet
• On-campus housing
• Free on-site parking
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Reposted by Mikala Egeblad
danapeer.bsky.social @danapeer.bsky.social · 14/05/2025
I am pleased to share our recent publication, fruit of a wonderful collaboration with truly amazing colleagues @adrienneboire.bsky.social and @meningojan.bsky.social, whose work was a tour de force demonstrating that immunology in the brain is a different beast -> www.nature.com/articles/s41...
nature.com
Interferon-γ orchestrates leptomeningeal anti-tumour response - Nature
Independent of antigen presentation, migratory CCR7+ dendritic cells orchestrate the influx, proliferation and cytotoxic action of natural killer cells to control cancer cell growth in the leptomening...
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Reposted by Mikala Egeblad
Samara Reck-Peterson @samreckpeterson.bsky.social · 13/05/2025
As the incoming Chair of Biochemistry and Biophysics at Weill Cornell Medicine, I am looking for a Director of Research. Exciting opportunity for a PhD scientist to shape the future of this new Department! Apply here: jobs.weill.cornell.edu/NY/job/New-Y...
jobs.weill.cornell.edu
Director of Research, Biochemistry & Biophysics
Director of Research, Biochemistry & Biophysics
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Johanna Joyce @johannajoyce.bsky.social · 30/04/2025
Thanks to all at #AACR25 for an inspiring and impactful annual meeting! Filled with cutting-edge science 🧪- and the direct impact of those discoveries for patients with #cancer Special thanks to co-chairs @mvhlab.bsky.social @lilliansiu.bsky.social #CancerResearchSavesLives @theaacr.bsky.social
Opening session of #AACR25 annual meeting - with all attendees raising signs in support of cancer research funding #CancerResearchSavesLives
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Mikala Egeblad @megeblad.bsky.social · 29/04/2025
Spring 2009 I opened my lab and accepted two @cshlnews.bsky.social rotation students now reunited at #AACR25: University of Hawaii Cancer Center clinician-scientist Elizabeth Nakasone, and Mount Sinai assistant professor and @theaacr.bsky.social NextGen Star @elvinwag.bsky.social - Made my day!
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Johanna Joyce @johannajoyce.bsky.social · 29/04/2025
We all know how much the microenvironment matters! So grateful that the #TME field has so many fantastic - and supportive - women leaders 🙌 #AACR2025 🧪⚕️ #womeninscience #payitforward @theaacr.bsky.social
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STAT @statnews.com · 28/04/2025
A clinical trial run by the National Cancer Institute seems to confirm that a single dose of the vaccine used to prevent infection with the human papilloma virus is just as effective as two www.statnews.com/2025/04/28/h...
statnews.com
U.S. government researchers present 'phenomenal' new data on HPV vaccines
A new study seems to confirm that a single dose of the vaccine used to prevent HPV infection is just as effective as two — and, therefore, also helps to prevent cancer.
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Fulya Alkan @fulyaalkan.bsky.social · 27/04/2025
@johannajoyce.bsky.social giving a wonderful presentation about she and her team’s successful discoveries on immunosuppressive myeloid cell infiltration and their contribution to recurrence and progression of brain tumors and at the #aacr2025 Plenary Session
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Edna Cukierman - Tumor Microenvironment @tme-caf-ecm.bsky.social · 28/04/2025
Representing the TME working group, @megeblad.bsky.social just presented a mesmerizing talk about the role of #neutrophils and their DNA traps inside vessels at the necrotic and peri necrotic niches and their role in metastasis A true eye opener!!! #AACR25 @theaacr.bsky.social
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Sandy Anderson @sandyanderson.bsky.social · 27/04/2025
Impressive opening plenary presentation from @johannajoyce.bsky.social on Unraveling the complexity of cancer ecosystems. She highlighted the importance of the fibrotic niche and potential therapeutic approaches that target it #AACR25
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American Association for Cancer Research (AACR) @theaacr.bsky.social · 26/04/2025
This year’s 11 NextGen Stars will share their findings on cancer cartography, the dark proteome, cancer-resistant tissues, and more at #AACR25. Learn more about their work and its future implications on the #AACRBlog: www.aacr.org/blog/2025/04...
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soledadsosalab.bsky.social @soledadsosalab.bsky.social · 26/04/2025
Ready for an amazing educational session on tumor dormancy @theaacr.bsky.social with Drs. Isacke and Ganesh.
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American Association for Cancer Research (AACR) @theaacr.bsky.social · 21/04/2025
Meet our #AACR25 Social Media Ambassadors! Follow along for real-time insights, unique takes, and highlights from the AACR Annual Meeting.
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Emil Lou, MD, PhD, FACP, FASCO @cancerassassin1.bsky.social · 25/04/2025
As we begin #AACR25, I feel obligated to ensure #cellbiology doesn't get short shrift amidst presentations that will focus on molecular oncology and #clinicaltrials (and deservedly so). Cell Bio is important.
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Eric Topol @erictopol.bsky.social · 23/04/2025
Why heart attacks peak in frequency and severity in the early morning hours: a pair of circadian clock-related proteins appears to be the underpinning nature.com/articles/d41... nature.com/articles/s41...
nature.com
Heart-attack outcomes are worse in the morning when activity of protein duo dips
A protein pair that influences how damage to cardiac muscle fluctuates with circadian rhythm could be the key to optimizing heart-attack recovery.
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Delphine Merino @delphine-merino.bsky.social · 23/04/2025
Nice opportunity for ECRs working on metastasis research 👇🏼
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Flora Rutaganira @frutag33.bsky.social · 21/04/2025
Hello Community! Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)
Flyer for the 2025 Next Generation Faculty Symposium (including QR code in top right corner). This symposium highlights the work of exceptional early-career scientists in the broad field of quantitative biological and biomedical sciences, with a track record of excellence in research, leadership, mentorship, and community engagement. These early career scientists are preparing to launch a faculty search. Applications are due May 30th, 2025.
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Cancer Research UK @cancerresearchuk.org · 18/04/2025
🎙 Patricia LoRusso on her journey in cancer drug development, the mentors who shaped her career and how she became AACR President for 2024/25. Read the article to discover Pat’s inspiring career and what to watch out for at this year’s AACR Annual Meeting: bit.ly/3Yrnoe3
bit.ly
From inner-city Detroit to AACR president - Cancer Research UK - Cancer News
Lars Erwig chats to Pat LoRusso about her career, being this year’s AACR president, and her role as chair of our New Agents Committee.
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EACR - European Association for Cancer Research @helloeacr.bsky.social · 18/04/2025
We know it's a challenging time for researchers. Due to unprecedented demand and a record number of abstracts, we’ve re-opened #EACR2025 submissions for a short time! 🗓 Deadline: 22 April 📌 Poster only 💸 Early reg: 28 April Submit your research & join us in Lisbon! 🔗 2025.eacr.org/abstracts
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Juliane Winkler @jwinkler.bsky.social · 17/04/2025
One week left to apply! Join my lab in beautiful Vienna for your #PhD studying #metastasis.
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Gabriele Bergers @bergerslab.bsky.social · 17/04/2025
Don't forget to register - only one week left!
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VIB @viblifesciences.bsky.social · 17/04/2025
𝗥𝗲𝗮𝗱𝘆 𝘁𝗼 𝘁𝗮𝗸𝗲 𝘆𝗼𝘂𝗿 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗳𝘂𝗿𝘁𝗵𝗲𝗿? Join VIB – where top science meets global talent! PhD, postdoc or PI – grow your career in a vibrant, cutting-edge research environment in Belgium. 👉 vib.be/en/careers #LifeAtVIB #ResearchExcellence #MoveToBelgium
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OncoDaily @oncodaily.bsky.social · 03/04/2025
Meet the New AACR Board of Directors for 2025-2028 Term @theaacr.bsky.social @megeblad.bsky.social oncodaily.com/societies/aa... #OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #AACR #BoardOfDirectors
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Max-Planck-Gesellschaft @maxplanck.de · 01/04/2025
🚀 Apply now 🚀 The new Max Planck #Postdoc Program offers a guaranteed contract of at least 3 years, targeted mentoring, and career workshops. postdocprogram.mpg.de #ScienceCareer #PostdocProgram
Early-career reseachers at one of our Max Planck Institutes.
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Michael Papanicolaou @micpapanicolaou.bsky.social · 31/03/2025
Awesome opportunity for metastasis researchers! 🚀✨ MRS Travel Bursaries are open. Get funding to attend conferences and share your work!
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Mark Cuban @mcuban.bsky.social · 29/03/2025
Just in NIH grants, It looks like beautiful Iowa City, home of the U of Iowa, will lose $71m in funding. That's almost $1k per resident. And that's before all the other cuts to SSA, FDA, etc. Anyone in Iowa City that can offer more insight? scienceimpacts.org H/T to Prathima !
scienceimpacts.org
SCiMaP
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Jose M. Adrover @adrover.bsky.social · 30/03/2025
I had a wonderful time! Great conference and speakers! Thanks @casanova-acebes.bsky.social @sancholab.bsky.social and Carlos Silvestre for the great work organizing such an amazing meeting!
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