The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely ...

A dynamic atlas of gene regulation was generated by perturbing every expressed gene across 22 million primary human CD4+ T cells under resting conditions and following re-stimulation. The resulting ma...

Super-enhancers have been proposed to cluster in the nucleus when compared to other genomic elements. Le et al. found that super-enhancer clustering was rare and driven by non-specific interactions. P...

Adaptive potential determines how populations respond to environmental change. This study compiles evolvability estimates from over 170 multicellular species, revealing substantial variation across th...

Contribute to pachterlab/paperpush development by creating an account on GitHub.

A rust implementation of STAR. Contribute to scverse/rustar-aligner development by creating an account on GitHub.

Centromeres ensure faithful chromosome segregation despite being embedded within rapidly evolving repetitive DNA, a contradiction known as the centromere paradox. While centromere identity is defined ...

If you work in or around the film industry, there is a decent chance you have used the work of The Numbers this month, whether you realise it or not.

The test could offer a more affordable approach to early disease detection.

An encyclopedia of more than 92 million enhancer–gene regulatory interactions created as part of the ENCODE4 project provides a valuable resource for future studies of gene regulation and human geneti...

Li et al. obtain high-resolution, native structures revealing that cytoplasmic lattices in mammalian eggs organize and store degradative and cytoskeletal complexes for early embryonic development.

Nature Methods - EviAnn surpasses existing genome annotation methods by leveraging gene expression and protein sequence homology evidence to achieve higher accuracy and efficiency.

Animals encode a rapidly evolving, essential cell cycle gene previously thought to be absent.

A grounded take from the messy middle of an AI revolution

Target capture enriched long-read RNA-sequencing uncovers a cleaved aberrant RNA from a ribosome stalling event that is associated with transgene silencing

Analysis of 128 high-coverage Indigenous American genomes shows extensive diversity shaped by several South American dispersals, ancient Australasian admixture, archaic introgression and long-term ada...