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Andreas Gschwind

@argschwind.bsky.social
76 followers 29 following 18 posts

Research Scientist at Stanford University. Interested in everything genomics and computational biology.

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Reposted by Andreas Gschwind
Jesse Engreitz @jengreitz.bsky.social · 04/08/2026
Update: scE2G is now online at Nature Genetics! Since the preprint, we added a new benchmark on a fully held-out CRISPR dataset. scE2G continues to show state-of-the-art performance, reinforcing that it generalizes well nature.com/articles/s41588-026-02695-8 1/
Held-out CRISPR benchmark: n=189 positives, 4,175 tested pairs from 5 cell types. Weighted AUPRC bar chart with scE2G-Multiome and scE2G-ATAC highest, above Distance to TSS, ABC, and 8 other single-cell methods.
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Andreas Gschwind @argschwind.bsky.social · 15/07/2026
Thrilled to share that our ENCODE enhancer–gene mapping paper is now out in Nature! An encyclopedia of human enhancer–gene regulatory interactions: www.nature.com/articles/s41... Thread 👇 1/
nature.com
An encyclopedia of human enhancer–gene regulatory interactions - Nature
An encyclopedia of more than 92 million enhancer–gene regulatory interactions created as part of the ENCODE4 project provides a valuable resource for future studies of gene regulation and human geneti...
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Reposted by Andreas Gschwind
Annique Claringbould @anniquec.bsky.social · 12/03/2026
🧬 How do immune disease-relevant variants affect gene regulatory networks in CD4+ T cells? 🧪🖥️ We coupled two large-scale CRISPRi screens (>4M cells) to map the downstream cascades of thousands of SNPs More details in the thread below 👇 or in the article 📖 on biorxiv tinyurl.com/CD4screens
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Reposted by Andreas Gschwind
Jesse Engreitz @jengreitz.bsky.social · 19/09/2025
New preprint from our lab! What can we learn about the properties of gene regulatory elements by CRISPR’ing a random set of accessible sites in human cells? Find out here: www.biorxiv.org/content/10.1... 👇 1/
bioRxiv - An unbiased survey of distal element-gene regulatory interactions with direct-capture targeted Perturb-seq
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Reposted by Andreas Gschwind
Jesse Engreitz @jengreitz.bsky.social · 18/09/2025
Excited for a major milestone in our efforts to map enhancers and interpret variants in the human genome: The E2G Portal! e2g.stanford.edu This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues. Uses cases 👇 1/
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Reposted by Andreas Gschwind
Wei-Lin Qiu @613weilin.bsky.social · 25/11/2024
Excited to share our latest preprint on scE2G – a new model to link enhancers to target genes using single-cell data – with state-of-the-art performance across multiple perturbation benchmarks. biorxiv.org/cgi/content/... Read more below! 1/12
biorxiv.org
Mapping enhancer-gene regulatory interactions from single-cell data
Mapping enhancers and their target genes in specific cell types is crucial for understanding gene regulation and human disease genetics. However, accurately predicting enhancer-gene regulatory interac...
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